ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0115

Risk Factors of First Thrombosis in Obstetric Antiphospholipid Syndrome

liang luo1, Qingmeng Cai2, xiangjun liu2, Yuke Hou3 and Chun Li4, 1Department of Chinese Medicine, the People's Hospital of Yubei District of Chongqing City, Chongqing, China; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 2Department of Rheumatology and Immunology, Peking University People's Hospital, Xicheng District, Beijing, China, 3Peking University People's Hospital, Beijing, China, 4Peking University People’s Hospital, Beijing, China

Meeting: ACR Convergence 2023

Keywords: , ,

Session Information

Date: Sunday, November 12, 2023

Title: (0096–0116) Antiphospholipid Syndrome Poster

Session Type: Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Limited evidence exists regarding the long-term risk of thrombosis in patients with obstetric antiphospholipid syndrome (OAPS). This study aimed to investigate the clinical features and risk factors associated with the first thrombosis in isolated OAPS patients.

Methods: Clinical and laboratory data from female patients with isolated OAPS were collected. All patients were followed up until the first thrombotic event or until the end of the study. The first thrombotic event during or after delivery was recorded. Logistic regression analysis was used to identify independent risk factors associated with the first thrombosis in isolated OAPS patients.

Results: A total of 186 OAPS patients were included in the study. During a mean follow-up period of 5.4 years, 11 patients experienced thrombotic events, resulting in a 15-year cumulative thrombotic incidence of 6.7%. Triple positive antiphospholipid antibodies [aPLs, odds ratio (OR) = 11.662, 95% confidence interval (CI) = 2.117–64.243, P = 0.005] and hypocomplementemia (OR = 9.047, 95% CI = 1.530–53.495, P = 0.015) were identified as independent risk factors for the first thrombosis in OAPS patients. Additionally, the use of low-dose aspirin (LDA, OR = 0.143, 95% CI = 0.023–0.876, P = 0.035) and hydroxychloroquine (HCQ, OR = 0.109, 95% CI = 0.020–0.596, P = 0.011) were associated with a decreased risk of thrombosis.

Conclusion: Triple positive aPLs and hypocomplementemia are risk factors for the first thrombosis in OAPS patients. The use of LDA and HCQ may be associated with a reduced risk of thrombosis.

Supporting image 1

* P <0.05, compared between the two groups.
OAPS, obstetric antiphospholipid syndrome; BMI, body mass index; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; SS, Sjögren syndrome; FGR, fetal growth restriction; LA, lupus anticoagulant; aβ2GPI, anti-β2-glycoprotein I antibodies; aCL, anticardiolipin antibodies; aPLs, antiphospholipid antibodies; LMWH, low-molecular-weight heparin; LDA, low-dose aspirin; HCQ, hydroxychloroquine.

Supporting image 2

FIG. 1 Multivariate logistic regression of first thrombosis in OAPS patients. OAPS, obstetric antiphospholipid syndrome; CI, confidence interval; aPLs, antiphospholipid antibodies; LDA, low-dose aspirin; HCQ, hydroxychloroquine.

Supporting image 3

FIG. 2 Kaplan-Meier survival analysis. (A) Cumulative incidence of thrombosis in OAPS patients. (B) Cumulative incidence of thrombosis in the LA-negative and LA-positive groups. OAPS, obstetric antiphospholipid syndrome; LA, lupus anticoagulant.

Disclosures: l. luo: None; Q. Cai: None; x. liu: None; Y. Hou: None; C. Li: None.

To cite this abstract in AMA style:

luo l, Cai Q, liu x, Hou Y, Li C. Risk Factors of First Thrombosis in Obstetric Antiphospholipid Syndrome [abstract]. Arthritis Rheumatol. 2023; 75 (suppl 9). https://acrabstracts.org/abstract/risk-factors-of-first-thrombosis-in-obstetric-antiphospholipid-syndrome/. Accessed .

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