ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2136

Rheumatoid Arthritis Erosion Detection and Measurement in Longitudinal Datasets Using High-Resolution Peripheral Quantitative Computed Tomography

Stephanie Finzel1, Cheryl Barnabe2, Kathryn Stok3, A. Scharmga4, Andrew J. Burghardt5, Ellen-Margrethe Hauge6, Hubert Marotte7, Stephanie Boutroy8, Klaus Engelke9, Dominique Toepfer10, Sebastian Kraus11, Roland Kocijan12, Xiaojuan Li13 and J. de Jong4, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 3Hpi F 26, Worfgang-Paul Str. 1, ETH Zurich Institute for Biomechanics, Zurich, Switzerland, 4Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 5Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, 6Reumatologisk Afdeling, Aarhus Universitetshospital, Aarhus C, Denmark, 7Rheumatology, University Hospital of Saint Etienne, Saint Etienne, France, 8INSERM U1033 and University of Lyon, Hôpital Edouard Herriot, Lyon, France, 9Henkestr. 91, Institute of Medcial Physics Synarc, Hamburg, Germany, 10Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany, 11Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 12Medical Department II, St. Vincent Hospital, Vienna, Austria, 13Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: , , ,

Session Information

Title: Imaging of Rheumatic Diseases: Various Imaging Techniques

Session Type: Abstract Submissions (ACR)

Background/Purpose An operational case definition for identification of erosions imaged by HR-pQCT was achieved and tested in a first reliability exercise (RELEX-1) using cross-sectional data. Aim of the study: oo test the case definition and define landmarks for measurement of erosion size in 2D in a longitudinal dataset.

Methods

Patients meeting the new ACR/EULAR classification criteria for RA at various stages of disease duration and severity received a HR-pQCT scan of the 2nd and 3rd MCP joints at 0 and 12 months. Standard image acquisition and segmentation was performed for a 2.7 cm scan area. Images were evaluated for erosions at 8 surfaces per joint (ulnar, radial, dorsal, palmar surfaces of the proximal phalanx and metacarpal head). The erosion case definition requires the presence of a definite interruption in the cortical bone extending over at least 2 consecutive slices, visualized in 2 orthogonal planes, with loss of underlying trabecular bone and being non-linear in shape. The maximal width of the cortical break is identified and measured in the axial multiplanar resolution (MPR), with the maximal depth recorded perpendicular to this line. This same method is repeated in the corresponding MPR. Five readers blinded to patient identity and time sequence of the scan scored 36 baseline and follow-up images (18 joints from 9 patients). Percent agreement and a kappa score for erosion detection (minimum of 2 readers in agreement) was calculated. The variation in width and depth measurements of erosions in axial and perpendicular planes between readers was calculated using the root-mean-square coefficient of variance (RMSCV). McNemar’s test was used to test for a significant change in the number of erosions identified from 0 to 12 months. Paired t-tests were used to calculate the average width and depth changes from 0 to 12 months.

Results Agreement for the presence or absence of an erosion was 92.9% (k=0.711, 95%CI 0.539-0.839). Mean (SD) dimensions of the erosions were: axial width 1.66 (SD 0.99) mm, perpendicular width 1.60 (SD 0.78) mm, axial depth 1.16 (SD 0.66) mm, and perpendicular depth 1.17 (SD 0.57) mm. The respective RMSCV were 36.4%, 30.3%, 15.7% and 27.3%. Seven erosions were detected at both 0 and 12 month timepoints (k=0.755, 95%CI 0.616-0.895) and all readers agreed on a single new erosion developing between 0 and 12 months for 1 subject (McNemar’s test p=1.00). Erosion dimensions did not significantly change over 1 year but a trend to reduction in mean size was observed, with an axial width decrease of 0.171 mm (95%CI -0.168, 0.509, p=0.310), perpendicular width decrease of 0.014 mm (95%CI -0.202, 0.230, p=0.898), axial depth increase of 0.007 mm (95%CI -0.147, 0.133, p=0.917), perpendicular depth decrease of 0.133 mm (95%CI -0.075, 0.340, p=0.201).

Conclusion

The case definition for erosions imaged by HR-pQCT is valid in longitudinal datasets. Despite variability in measurements, a trend towards changes in erosion size is demonstrated.

Disclosure:

S. Finzel,
None;

C. Barnabe,
None;

K. Stok,
None;

A. Scharmga,
None;

A. J. Burghardt,
None;

E. M. Hauge,
None;

H. Marotte,
None;

S. Boutroy,
None;

K. Engelke,
None;

D. Toepfer,
None;

S. Kraus,
None;

R. Kocijan,
None;

X. Li,
None;

J. de Jong,
None.

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