ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2332

Rheumatoid Arthritis Effect´s on Bone Mass and Muscle

María Lorena Brance1, Bernardo A Pons-Estel2, Javier Quagliatto3, Marisa Jorfen4, Noel Cortese4, Guillermo Berbotto5, Juan Carlos Raggio6, Juan Soldano3, Mariano Palatnik1, Ignacio Chavero1, Carolina Dieguez1, Silvana Di Gregorio7 and Lucas Ricardo Brun8, 1Centro de Reumatología, Rosario, Argentina, 2Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Rosario, Argentina, 3Hospital Provincial, Rosario, Argentina, 4Municipalidad de Rosario, Rosario, Argentina, 5Hospital Escuela Eva Perón, Granadero Baigorria, Argentina, Granadero Baigorria, Argentina, 6Hospital Eva Perón, Granadero Baigorria, Argentina, 7Centre Medic Cetir, Barcelona, Spain, 8School of Medicine. Rosario National University, Bone Biology Laboratory, Rosario, Argentina

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: , ,

Session Information

Date: Tuesday, October 23, 2018

Title: Osteoporosis and Metabolic Bone Disease – Basic and Clinical Science Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Rheumatoid arthritis (RA) is a progressive auto-immune disease characterized by chronic inflammation which leads to joint deformity and disability. However, the bone and muscle are also affected. The aim of this study was to evaluate the total bone mineral density (tBMD) and total lean mass in rheumatoid arthritis patients.

Methods: A total of 50 adult´s women with RA and a control group (CG, n=34) matched by sex, age and body mass index (BMI) were included. All patients had more than 18 years and were from Rosario city (32º52´18´´S), Argentina. Exclusion criteria: pregnancy, intestinal malabsorption, chronic liver or kidney disease, cancer and drug which could affected the bone mass except glucocorticoids. The whole body composition was performed by Dual X-Ray Absorptiometry (DXA) (Hologic discovery Wi). The muscle strength was evaluated by handgrip strength (Baseline Hydraulic Hand Dynamometer, USA) and the physical performance by sit to stand test and timed up and go test. Date are expressed as mean±SD. Differences between groups were analyzed using the Student t test or Mann-Whitney test as appropriate. Correlations were performed with Pearson or Spearman’s correlation test. Contingency tables were evaluated with c2 test. The difference was considered significant if p<0.05.

Results: No differences in age (CG: 55.1±12.7 y, RA: 53.5±11.7 y), BMI (CG: 26.0±5.1, RA: 27.8±4.6) and percentage of pre and postmenopausal women were included. According to BMI no differences in total mass by DXA were observed (CG: 66.9±13.1 kg, RA: 68.0±13.1 kg). The total bone mineral content (tBMC) and tBMD were found decreased in RA patients (tBMC= CG: 2111±319 g, RA: 1874±343 g, p=0.0036; tBMD= CG: 1.072±0.094 g/cm2, RA: 1.016±0.109 g/cm2, p=0.0255). Furthermore, a tendency to low lean mass in RA patients were observed (CG: 57.3±5.2, RA: 55.7±5.3, p=0.06). The muscular involvement was confirmed in muscle strength and physical performance tests. The RA group had significantly lower handgrip strength (CG: 21.4±4.9 kg, RA: 12.3±6.7, p<0.0001), lower performance in the sit to stand test (CG: 14.7±4.5 s, RA: 17.9±5.7 s, p=0.0126) and timed up and go test (CG: 8.8±1.9 s, RA: 11.6±3.7, p=0.0003). A significant correlation between tBMD and total lean mass were found (r: 0.3, p=0.0128). In addition, significant correlation between regional BMD (left arm, right arm, left leg and right leg) and the lean mass of each region were observed. Therefore the loss of lean mass could explain the loss of bone mass. On the other hand, higher percentage of fat was found in RA patients (CG: 39.4±5.7, RA: 41.9±5.7, p=0.06).

Conclusion: the disease activity could affect not only the joint and bone mass, but also the muscle which contributes to bone loss and lead to osteopenia and osteoporosis in RA patients.

Disclosure: M. L. Brance, None; B. A. Pons-Estel, None; J. Quagliatto, None; M. Jorfen, None; N. Cortese, None; G. Berbotto, None; J. C. Raggio, None; J. Soldano, None; M. Palatnik, None; I. Chavero, None; C. Dieguez, None; S. Di Gregorio, None; L. R. Brun, None.

To cite this abstract in AMA style:

Brance ML, Pons-Estel BA, Quagliatto J, Jorfen M, Cortese N, Berbotto G, Raggio JC, Soldano J, Palatnik M, Chavero I, Dieguez C, Di Gregorio S, Brun LR. Rheumatoid Arthritis Effect´s on Bone Mass and Muscle [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/rheumatoid-arthritis-effects-on-bone-mass-and-muscle/. Accessed .

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