Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Increasing evidence suggests that characteristic changes in retinal vessel morphometry are biomarkers for vascular health. Polymyalgia Rheumatica (PMR) has been associated with increased risk of vascular disease in some epidemiological studies, but to date there are limited data on objective changes in blood vessels in patients with this condition. This study examines the retinal vessel morphology of individuals with PMR in a population-based cohort.
Results: In total, 10,494 good quality images were obtained from 5959 participants were analysed. Median arteriolar and venular widths were 68.5µm (5th to 95th centiles 49.4, 91.0µm), and 99.1µm (5th to 95th centiles 83.1, 116.4µm) respectively. There were 298 incident diagnoses of PMR (72.5% female) during the follow-up period. The median age at diagnosis was 75.6 years of which 140 had good quality retinal imaging. Those with PMR diagnoses showed wider venules compared to those without disease (mean difference 3.1µm. 95% CI 1.1,5.1µm); there were no appreciable differences in arteriolar diameter (mean difference 0.3µm, 95% CI -2.1,2.8 µm).
Conclusion: These results provide the first objective evidence of a biomarker for vascular health in patients with PMR, a disease in which there is an absence of adequate clinical process and outcome measures. Although limited by the cross-sectional design, the findings indicate that retinal morphometric analysis could prove a useful monitoring tool for vascular complications in patients with rheumatic disease.
To cite this abstract in AMA style:Yates M, Hayat S, Luben RN, Welikala R, Rudnicka A, Owen C, Barman S, O'Sullivan E, Mackie S, Watts R, Foster P, Khaw KT, Wareham N, Macgregor AJ. Retinal Vessel Morphometry Associations with Polymyalgia Rheumatica; Findings from the European Prospective Investigation of Cancer (EPIC) in Norfolk [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/retinal-vessel-morphometry-associations-with-polymyalgia-rheumatica-findings-from-the-european-prospective-investigation-of-cancer-epic-in-norfolk/. Accessed November 29, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/retinal-vessel-morphometry-associations-with-polymyalgia-rheumatica-findings-from-the-european-prospective-investigation-of-cancer-epic-in-norfolk/