ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1137

REMS Technology for the Assessment of Bone Health in a Male Population

Delia Ciardo1, Paola Pisani1, Fiorella Anna Lombardi1, Marco Di Paola1, Roberto Franchini1, Maurizio Muratore2, Francesco Conversano1 and Sergio Casciaro1, 1National Research Council, Institute of Clinical Physiology, Lecce, Italy, Lecce, Italy, 2Vito Fazzi Hospital, ASL-LE, O.U. of Rheumatology, Lecce, Italy, Lecce, Italy

Meeting: ACR Convergence 2021

Keywords: ,

Session Information

Date: Monday, November 8, 2021

Title: Osteoporosis & Metabolic Bone Disease – Basic & Clinical Science Poster (1135–1149)

Session Type: Poster Session C

Session Time: 8:30AM-10:30AM

Background/Purpose: This study aimed to evaluate the diagnostic accuracy of the ultrasound-based densitometric technology called Radiofrequency Echographic Multi Spectrometry (REMS) in the diagnosis of osteoporosis in a population of adult male patients based on lumbar spine scans, compared to Dual-energy X-ray Absorptiometry (DXA), considered as a reference.

Methods: Inclusion criteria were: Caucasian male patients, aged between 30 and 90 years, body mass index (BMI) less than 40 kg/m2, no significant walking impairments, referral for lumbar spine DXA. Signed informed consent was obtained. The patients underwent a lumbar spine scans with both DXA and REMS.

The correlation between REMS and DXA-measured BMD was expressed by Pearson correlation coefficient. Bland-Altman plot was also obtained. Patients were classified as “with osteoporosis” or “without osteoporosis” on the base of the T-score value using the conventional threshold (-2.5) for both techniques independently. Considering the DXA outcome as reference, the accuracy of the diagnostic classification was assessed as sensitivity, specificity, Cohen’s K and 3-classes diagnostic concordance.

Results: Three hundred and thirteen patients were considered, with mean age of 57.7 years (range: 30 to 87 years). The Pearson correlation coefficient between REMS- and DXA-measured BMD values was r=0.92 (r2=0.85). At Bland-Altman analysis, bias ± 2 standard deviations were -0.002 ± 0.092 g/cm2.

The agreement in diagnostic classification performed by REMS and by DXA was very high, with a sensitivity of 89.1% and specificity of 90.7%. Cohen’s K was 0.71. Considering the 3 diagnostic classes (normal bone, osteopenia, osteoporosis), the diagnostic concordance between technologies was 81.5%.

Conclusion: REMS, applied to the lumbar spine site, is a reliable technology for the diagnosis of osteoporosis in men, thus confirming the diagnostic performance already observed in studies carried out in female populations [1, 2].

References

  1. Di Paola P et al. Osteoporos Int. 30(2):391-402.
  2. Adami G et al. Bone 2020 May;134:115297
Disclosures: D. Ciardo, None; P. Pisani, None; F. Lombardi, None; M. Di Paola, None; R. Franchini, None; M. Muratore, None; F. Conversano, None; S. Casciaro, None.

To cite this abstract in AMA style:

Ciardo D, Pisani P, Lombardi F, Di Paola M, Franchini R, Muratore M, Conversano F, Casciaro S. REMS Technology for the Assessment of Bone Health in a Male Population [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/rems-technology-for-the-assessment-of-bone-health-in-a-male-population/. Accessed .

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