Date: Monday, October 22, 2018
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: To clarify the relationship between Body Mass Index (BMI) and lower limb dysfunction in patients with rheumatoid arthritis (RA).
Methods: The data of 8,332 Japanese female patients with RA registered in the nation-wide observational cohort of RA in Japan (National database of rheumatic diseases in Japan: NinJa) in 2015 were used in this study. According to the BMI category, they were divided into 4 groups; Underweight (n=1,275), Normal weight (n=5,538), Overweight (n=1287), and Obese (n=232). “Lower limbs dysfunction” was defined here as the values (≧2) of questionnaire related to the lower limbs function in health assessment questionnaire (HAQ). Operation related to the lower limbs included replacement of hip, knee, or ankle joint. We examined the relationship between BMI and lower limbs dysfunction and/or operation. This study was reviewed and approved by Research Ethics Committees in each facilities. Informed consent was obtained from all study participants. This study was conducted in accordance with the principles expressed in the Declaration of Helsinki.
Results: Rates of lower limbs dysfunction were significantly higher not only in Overweight (16.9%) and Obese (23.7%) but also in Underweight (17.3%) than in Normal weight (12.6%) (p<0.0001). Operation rate of lower limbs was also significantly higher in Overweight (17.6%), Obese (20.3%) and Underweight (15.6%) than those in Normal weight (12.9%). Patients with operation showed significantly elder and longer disease duration than those without operation in all groups. Lower limbs dysfunction by disease duration was smallest in Normal weight except early onset patients. Compared with Normal weight, other groups showed higher values of DAS28-CRP and HAQ-DI.
Conclusion: This study indicated that both higher and lower BMI correlated with lower limbs dysfunction in female patients with RA. It is difficult to interpret whether this relationship is the cause or the result, but total care considering nutritional guidance and weight management is important as well as medication in RA patients.
To cite this abstract in AMA style:Matsui T, Hashimoto A, Masuda K, Tohma S. Relationship between BMI and Lower Limb Dysfunction in Japanese Female Patients with Rheumatoid Arthritis (the data from NinJa registry) [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/relationship-between-bmi-and-lower-limb-dysfunction-in-japanese-female-patients-with-rheumatoid-arthritis-the-data-from-ninja-registry/. Accessed October 27, 2020.
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