Background/Purpose: To investigate the prognostic implication of HLA-B*51 and HLA-A*26:01on visual outcome in Korean Behcet’s disease (BD) patients with uveitis.
Methods: Seventy-seven Korean BD patients with uveitis (F:M=29;48) who met the classification criteria by the International Study Group were enrolled. The presence of HLA-B*51 was determined by polymerase chain reaction (PCR) using sequence specific primers. Genotyping for HLA-Alocus was performed with PCR-Luminex typing method. Patient visual acuity (VA) was measured using Snellen chart at every visit to ophthalmology clinic. Loss of useful vision (LUV) was defined as VA worse than 20/200 for more than 6 months and near blindness (NB) was defined as VA of light perception or worse.
Results: The onset of uveitis was 36.6 ± 10.8 (mean ± standard deviation) years of age and the duration of uveitis was 10.8 ± 7.2 years. Posterior uveitis was found in 64.9% (50/77) of patients. Forty-seven (61.0%) patients were treated with one or more systemic immunosuppressants other than steroids; azathioprine (n=38), cyclosporine (n=24), methotrexate (n=7), mycophenolate mofetil (n=7), cyclophosphamide (n=6), tacrolimus (n=2), or anti-TNF-a agents (n=2). HLA-B*51 was positive in 44.2% (34/77) while HLA-A*26:01 in 18.2% (14/77) of patients. In multivariate analyses, LUV was associated with male gender (p=0.032), duration of uveitis (p = 0.016), and posterior uveitis (p=0.010). HLA-A*26:01 was not directly associated with LUV but with posterior involvement (p<0.001). HLA-B*51 did not show any significant associations with LUV or posterior involvement. NB was associated with duration of uveitis (p=0.022) and glaucoma (p=0.026) in multivariate analysis. When patients with posterior uveitis were analyzed, the single most important factor for LUV was duration of uveitis (p=0.036) in multivariate analysis. NB in posterior uveitis patients was associated with the presence of HLA-B*51 (p = 0.025 in univariate analysis, p=0.062 in multivariate analysis).
Conclusion: HLA-A*26:01 was found to be associated with posterior involvement of uveitis in BD patients while HLA-B*51 tended to be associated with NB in those who develop posterior uveitis.
Disclosure:
J. W. Park,
None;
E. H. Kang,
None;
H. W. Kim,
None;
C. Park,
None;
H. G. Yu,
None;
E. Y. Lee,
None;
Y. J. Lee,
None;
E. B. Lee,
None;
Y. W. Song,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/prognostic-impact-of-hla-b51-and-hlaa2601-on-ocular-behcets-disease/