Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: The prevalence of HLA-B27 varies between different ethnicities. Its presence is associated with susceptibility to axial spondyloarthritis (axSpA). The aim of this study is to evaluate the prevalence of HLA-B27 in the normal population and in patients with axSpA.
Methods: The prevalence of HLA-B27 in the normal population was evaluated in cord blood and healthy organ transplant donor databases. HLA typing was conducted with sequence-specific oligonucleotide probing and sequence-specific primer technologies. The data of patients with axSpA were collected retrospectively from five different hospitals. Patients with inflammatory bowel disease and psoriasis were excluded. Demographics, age at symptom onset/diagnosis, presence of extra-articular manifestations and use of biologics were obtained.
Results: A total of 136 axSpA patients were included, with a male predominance of 67.4%. The mean (±SD) ages at symptom onset and disease diagnosis were 29 (±10.9) and 33.4 (±10.7) years, respectively. The mean diagnosis delay was 51.7 (± 54.7) months. HLA-B27 was positive in 73 (53.7%) of patients. Male gender and HLA-B27 positive subtype were associated with a younger age at symptom onset/diagnosis (p<0.04), but no significant difference was observed in diagnosis delay, with a mean delay of 53.9±58.2 versus 49.1±50.6 months for HLA-B27-positive and negative patients, respectively (p=0.61). HLA-B27-positive patients were more likely to be on biologics (p=0.037), with no difference in the median number of biologics used. HLA-B27 was found in 82/3332 (2.5%) and 27/1164 (2.3%) in the cord blood and healthy organ transplant donor databases, respectively.
Conclusion: The prevalence of HLA-B27 is low in the Saudi population. A significant diagnosis delay has been observed in patients with axSpA regardless of HLA-B27 status and gender. HLA-B27 is positive in only half of axSpA patients limiting its usefulness.
To cite this abstract in AMA style:alduraibi F, Omair M, Al Awwami M, Abdulaziz S, Husain W, El Dessougi M, Aljurf M, Alhumaidan H, Al Khabbaz H, Alahmadi I, Al Saleh S. Prevalence of HLA-B27 in the Normal Population and Patients with Axial Spondyloarthritis in Saudi Arabia [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/prevalence-of-hla-b27-in-the-normal-population-and-patients-with-axial-spondyloarthritis-in-saudi-arabia/. Accessed September 26, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/prevalence-of-hla-b27-in-the-normal-population-and-patients-with-axial-spondyloarthritis-in-saudi-arabia/