ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2726

Prevalence of HLA-B27 in the Normal Population and Patients with Axial Spondyloarthritis in Saudi Arabia

Fatima alduraibi1, Mohammed Omair2,3, Moheeb Al Awwami4, Sultana Abdulaziz5, Waleed Husain6, Maha El Dessougi7, Mahmoud Aljurf8, Hind Alhumaidan9, Hana Al Khabbaz10, Ibrahim Alahmadi11 and Salman Al Saleh12, 1Department of Internal Medicine, Section of Rheumatology ,Department of Internal Medicine,King Faisal Specialsed Hospital, Saudi Arabia, Riyadh, Saudi Arabia, 2Rheumatology, King Khalid Hospital, Riyadh, ON, Saudi Arabia, 3Division of Rheumatology, Department of Medicine, King Saud University, Riyadh, Saudi Arabia, 4Histocompatibility and Immunogenetics Laboratory, Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 5Dept of Medicine/Unit of Rheumatology, King Fahad Hospital, Jeddah, Saudi Arabia, 6Hera Hospital , Division of Rheumatology, Department of Medicine, Makkah, Saudi Arabia, 7Security Forces Hospital Division of Rheumatology, Department of Medicine, Riyadh, Saudi Arabia, 8Department of Adult Hematology/Oncology and Stem Cell Transplantation, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 9Blood Bank/Stem Cell/Cord Blood , Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 10Riyadh Colleges of Dentistry and Pharmacy, Riyadh, Saudi Arabia, 11Organ Transplant Center, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 12King Faisal Specialsed Hospital, Riyadh, Saudi Arabia

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: ,

Session Information

Date: Tuesday, November 15, 2016

Session Title: Spondylarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment - Poster III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: The prevalence of HLA-B27 varies between different ethnicities. Its presence is associated with susceptibility to axial spondyloarthritis (axSpA). The aim of this study is to evaluate the prevalence of HLA-B27 in the normal population and in patients with axSpA.

Methods: The prevalence of HLA-B27 in the normal population was evaluated in cord blood and healthy organ transplant donor databases. HLA typing was conducted with sequence-specific oligonucleotide probing and sequence-specific primer technologies. The data of patients with axSpA were collected retrospectively from five different hospitals. Patients with inflammatory bowel disease and psoriasis were excluded. Demographics, age at symptom onset/diagnosis, presence of extra-articular manifestations and use of biologics were obtained.

Results: A total of 136 axSpA patients were included, with a male predominance of 67.4%. The mean (±SD) ages at symptom onset and disease diagnosis were 29 (±10.9) and 33.4 (±10.7) years, respectively. The mean diagnosis delay was 51.7 (± 54.7) months. HLA-B27 was positive in 73 (53.7%) of patients. Male gender and HLA-B27 positive subtype were associated with a younger age at symptom onset/diagnosis (p<0.04), but no significant difference was observed in diagnosis delay, with a mean delay of 53.9±58.2 versus 49.1±50.6 months for HLA-B27-positive and negative patients, respectively (p=0.61). HLA-B27-positive patients were more likely to be on biologics (p=0.037), with no difference in the median number of biologics used. HLA-B27 was found in 82/3332 (2.5%) and 27/1164 (2.3%) in the cord blood and healthy organ transplant donor databases, respectively.

Conclusion: The prevalence of HLA-B27 is low in the Saudi population. A significant diagnosis delay has been observed in patients with axSpA regardless of HLA-B27 status and gender. HLA-B27 is positive in only half of axSpA patients limiting its usefulness.

Disclosure: F. alduraibi, None; M. Omair, None; M. Al Awwami, None; S. Abdulaziz, None; W. Husain, None; M. El Dessougi, None; M. Aljurf, None; H. Alhumaidan, None; H. Al Khabbaz, None; I. Alahmadi, None; S. Al Saleh, None.

To cite this abstract in AMA style:

alduraibi F, Omair M, Al Awwami M, Abdulaziz S, Husain W, El Dessougi M, Aljurf M, Alhumaidan H, Al Khabbaz H, Alahmadi I, Al Saleh S. Prevalence of HLA-B27 in the Normal Population and Patients with Axial Spondyloarthritis in Saudi Arabia [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/prevalence-of-hla-b27-in-the-normal-population-and-patients-with-axial-spondyloarthritis-in-saudi-arabia/. Accessed February 18, 2020.

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