ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016 ACR/ARHP Annual Meeting
    • 2015 ACR/ARHP Annual Meeting
    • 2014 ACR/ARHP Annual Meeting
    • 2013 ACR/ARHP Annual Meeting
    • 2012 ACR/ARHP Annual Meeting
    • 2011 ACR/ARHP Annual Meeting
    • 2010 ACR/ARHP Annual Meeting
    • 2009 ACR/ARHP Annual Meeting
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2232

Prevalence of Gout in the Surviving U.S. Solid Organ Transplant Population

Mark D. Brigham1, Thilan Tudor1, Gavin Miyasato1, Jeffrey D. Kent2, Brian LaMoreaux3 and Brian F. Mandell4, 1Trinity Partners, Waltham, MA, 2Medical Affairs, Horizon Pharma USA, Inc, Lake Forest, IL, 3Horizon Pharma USA, Inc, Lake Forest, IL, 4Rheumatology, Cleveland Clinic, Cleveland, OH

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Co-morbidities, Epidemiologic methods, gout and transplantation, Kidney

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Tuesday, October 23, 2018

Session Title: Metabolic and Crystal Arthropathies – Basic and Clinical Science Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Although incidence and survival are frequent topics within the solid organ transplant (SOT) literature, there are no recent publications on the total size of the surviving SOT population. Existing studies of gout in SOT have focused on the incident SOT population. This analysis was performed to characterize the prevalent SOT population and the prevalence of gout within it.

Methods: 2017 U.S. population sizes of kidney, heart, liver, and lung recipients were estimated by combining Organ Procurement and Transplantation Network (OPTN) primary transplant cohort sizes (1988-2017) with previously published survival rates for each annual cohort’s time since transplant (0-29 yrs), adjusted for recent improvements in 1-5 yr survival. Gout among prevalent SOT patients was assessed via 2 administrative claims databases: Medicare Fee-For-Service Limited Data Set (5% sample) and a commercial claims sample (IQVIATM Real-World Data Adjudicated Claims – US). Definitions used were – SOT: a claim with an SOT procedure code OR any claim with a history of SOT status code; Gout: ≥1 claim with any gout diagnosis code. Total gout prevalence was calculated by weighting Medicare and commercially insured patient estimates by OPTN payer distribution.

Results: 637,231 U.S. patients received a primary kidney (393,953), liver (142,186), heart (66,637), or lung (34,455) transplant between 1988 and 2017. An estimated 355,000 (55.8%) recipients were alive in 2017, comprising 233,000 kidney, 78,700 liver, 29,300 heart, and 14,700 lung recipients. Gout was identified in 11% of prevalent SOT patients in 2016. Higher rates of gout were seen in kidney (13%) and heart (13%) recipients compared to liver (6.4%) and lung (5.3%) recipients (p<0.0001 in both datasets).

Conclusion: Hundreds of thousands of U.S. patients are living with an organ transplant today and these numbers are likely to increase. Within the SOT clinical picture, gout is a frequent co-morbidity of which physicians should be aware. This study suggests a markedly higher rate of gout for the most common SOT types (11%) compared to established rates reported for the general population (e.g. 3.9%). Kidney and heart recipients, with the highest rates of gout, bear much of this disease burden.



Disclosure: M. D. Brigham, Horizon Pharma, 2; T. Tudor, Horizon Pharma, 2; G. Miyasato, Horizon Pharma, 2; J. D. Kent, Horizon Pharma, 3; B. LaMoreaux, Horizon Pharma, 3; B. F. Mandell, Horizon Pharma, 2, 5.

To cite this abstract in AMA style:

Brigham MD, Tudor T, Miyasato G, Kent JD, LaMoreaux B, Mandell BF. Prevalence of Gout in the Surviving U.S. Solid Organ Transplant Population [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/prevalence-of-gout-in-the-surviving-u-s-solid-organ-transplant-population/. Accessed December 5, 2019.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/prevalence-of-gout-in-the-surviving-u-s-solid-organ-transplant-population/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

Annual Meeting in Atlanta, Georgia

© COPYRIGHT 2019 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.