Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Systemic Lupus Erythematosus (SLE) is the paradigm of the autoimmune diseases that primarily affects women in a ratio of 9: 1. In England and America the prevalence varies from 12 to 42 cases / 100,000 inhabitants and the incidence of 1-3 cases / 100,000 inhabitants. No data on incidence and prevalence of SLE in Argentina is available. The aim of this study is to determine the prevalence and incidence of SLE in the province of Tucuman, Argentina.
Methods: A cross-sectional study was conducted. Medical records of outpatient and inpatient of 4 hospitals in the province and attended by all doctors of Rheumatology Society of Tucuman (n = 28) except for a center, were reviewed retrospectively. We included patients over 16 years with diagnosis of SLE (4 ACR criteria 1982/1997) residents in the province of Tucuman and with at least two clinic visits between January 2005 and December 2012. We excluded patients with other concomitant diagnosis of autoimmune disease. Demographic variables related to the disease (diagnosis date, age, mortality, cause of death and clinical) were analyzed. The population data were taken from the National Census of 2010. The province of Tucuman has 17 departments with a population of 1,448,716 inhabitants, 45% are in the center area and the remaining 65% distributed in the areas west and south. The population over 16 years is 1,011,188 inhabitants. The prevalence was calculated as the number of cases per 100,000 inhabitants in the period 2005 – 2012 and the annual incidence in the same period.
Results: 353 patients were identified. The mean age at diagnosis was 30.5 ± 11.7 years, 93.5% were women. The prevalence was 25.6 cases / 100,000 inhabitants (95% CI 22.6-28.8) and adjusted for age (≥ 16 years) of 36.7 cases / 100,000 inhabitants (95% CI 32.8-41.1). The annual incidence in 2005: was 1.8 cases / 100,000 inhabitants (95% CI 1-2.9) 2006: of 2 cases / 100,000 inhabitants (95% CI 1.2-3.2), 2007: 1.4 cases / 100,000 inhabitants (95% ; 0.7-2.4), 2008: 2.1 cases / 100,000 inhabitants (95% CI 1.2-2.9), 2009: 2.2 cases / 100,000 inhabitants (95% CI 1.3-3.3), 2010: 2.2 cases / 100,000 population (95 % 1.2-3.3), 2011: of 2.8 cases / 100,000 inhabitants (95% CI, 1.9-4) and 2012: of 4.2 cases / 100,000 inhabitants (95% CI 2.9-5.8). A significant increase of incidence was found comparing the periods 2005 and 2012 (p = 0.0019). Mortality was 9.1%, the most common cause were infections (14/32) .The change rate of deaths corrected by year follow-up is similar to the change in the incidence rate corrected by year of follow up through periods.
Conclusion: The prevalence of SLE in the province of Tucuman was of 36.7 cases / 100,000 inhabitants. The annual incidence in 2005 was 1.8 and in 2012 4.2casos / 100,000 inhabitants. This is the first study of prevalence and incidence of SLE in a population of Argentina.
To cite this abstract in AMA style:Gonzalez Lucero L, Sueldo R, Torres AI, Cristofari A, Barbaglia AL, Olea A, Quinteros A, Seleme G, Colombres F, Vásquez DL, Arquez G, Carrizo GA, Lazaro H, Molina MJ, Juarez L, Bertolaccini MC, Leal MO, Yacuzzi MS, Espindola Echazu M, Robles De Garrone N, Dip RO, Romano O, Pera O, Paz S, Bellomio V, Machado Escobar M, Rengel S, Galindo L, Santana M, Lucero E. Prevalence and Incidence of Systemic Lupus Erythematosus in Tucuman -Argentina [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/prevalence-and-incidence-of-systemic-lupus-erythematosus-in-tucuman-argentina/. Accessed November 25, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/prevalence-and-incidence-of-systemic-lupus-erythematosus-in-tucuman-argentina/