ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1523

Presence Of Peripheral Arthritis Delays Spinal Radiographic Progression In Ankylosing Spondylitis: Observation Study Of Korean Spondyloarthropathy Registry (OSKAR) Over 5 Years

Tae-Jong Kim1, Seunghun Lee2, Kyung-Bin Joo3, Dong-Jin Park4, Yong-Wook Park4, Shin-Seok Lee5 and Tae-Hwan Kim6, 1Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 2Department of Radiology, Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 3Department of Radiology, Department of Radiology, Hanynag University Hospital for Rheumatic Diseases, Seoul, South Korea, 4Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 5Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 6Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Title: Spondylarthropathies and Psoriatic Arthritis: Clinical Aspects and Treatment: II

Session Type: Abstract Submissions (ACR)

Background/Purpose: The most unique feature in ankylosing spondylitis (AS) is subchondral eburnation and syndesmophytes, possibly leading to ankylosis and spinal fusion. So far a clear relationship between spinal bone formation and peripheral arthritis in patients with AS has not been established. The aim of this study was to determine whether presence of peripheral arthritis can affect the progression of structural damage in patients with AS.

Methods: A total of 915 patients with AS from the Observation Study of Korean spondyloArthropathy Registry (OSKAR) cohort were enrolled for this analysis. We used a two-step approach to explore the relationships between the peripheral arthritis and the progression of spinal structural damage in AS. First, all OSKAR data were analyzed in relation to the history of peripheral arthritis on cross-sectional survey. Second, we analyzed the radiographic spinal progression over 5 years according to the presence or absence of peripheral arthritis. The modified Stoke AS Spinal Score (mSASSS) were examined by two experienced radiologists to validate the results. The collection of the clinical parameters was conducted to investigate the associations between clinical factors and the radiographic progression.

Results: The agreement between the two readers regarding mSASSS was very good: ICC coefficient 0.75 (95% CI 0.61-0.82) and 0.71 (95% CI 0.58-0.82) at each time. On cross-sectional survey, in spite of adjusting for multiple comparisons by Bonferroni correction, the patients with history of peripheral arthritis had fewer mSASSS unit than those without history of peripheral arthritis (19.56±1.06 vs 22.67±0.81, p=0.005). In a analysis over 5 years, the mean progression of mSASSS in patients with peripheral arthritis was 3.26±0.58 units, while that of mSASSS in patients without peripheral arthritis was 4.97±0.44 units (p=0.024).

Conclusion: The patients with the peripheral arthritis had slower radiographic spinal damage progression than those without peripheral arthritis.

Disclosure:

T. J. Kim,
None;

S. Lee,
None;

K. B. Joo,
None;

D. J. Park,
None;

Y. W. Park,
None;

S. S. Lee,
None;

T. H. Kim,
None.

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