ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1119

Preliminary Descriptive Analysis of the RADIAL Cohort Study About the Prevalence and the Clinical Characteristics of Patients with CPPD in Daily Clinical Practice

Silvia Sirotti1, Joao Madruga-Dias2, Antonella Adinolfi3, Garifallia Sakellariou4, Davide Rozza5, Greta Carrara5, Gianpiero Landolfi5, Carlo Alberto Scire5, Annamaria Iagnocco6 and Georgios Filippou1, 1IRCCS Galeazzi - Sant'Ambrogio Hospital, Milan, Italy, 2Centro Hospitalar do Médio Tejo, NOVA Medical School, Lisbon, Portugal, 3Rheumatology Unit, Grande Ospedale Metropolitano Niguarda, Milano, Italy, 4Department of Internal Medicine and Therapeutics, Università di Pavia, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy, 5Società Italiana di Reumatologia, Epidemiology Research Unit, Milan, Italy, 6University of Turin, Roma, Italy

Meeting: ACR Convergence 2023

Keywords: Cohort Study, CPPD, Ultrasound

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Monday, November 13, 2023

Title: (1100–1123) Metabolic & Crystal Arthropathies – Basic & Clinical Science Poster II

Session Type: Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: The RADIAL study is aimed to evaluate the performance of a composite approach, based on clinical, laboratory and ultrasound (US) data in the differential diagnosis among the main inflammatory arthropathies and Osteoarthritis (OA). In this preliminary analysis, based on partial data, we present the prevalence and the clinical characteristics of the patients affected by Calcium Pyrophosphate Deposition (CPPD) as diagnosed by US.

Methods: The RADIAL study is a multicenter, international, mixed design (retrospective, cross-sectional, prospective) diagnostic accuracy study. Consecutive patients reaching the rheumatology outpatients clinic for the first time, with suspicion of an inflammatory arthropathy, aged 18 or older and with recent standard blood exams were enrolled in the study. All patients underwent a US examination of an extended set of target joints for the assessment of specific lesions for Rheumatoid Arthritis, Psoriatic Arthritis, Gout, CPPD, Polymyalgia Rheumatica and OA. Demographic and clinical data were also collected. The presence of typical deposits in at least one joint classified patient as affected by CPPD for this preliminary analysis. After the first visit, all patients entered in routine follow up and treatment strategies were adopted according to guidelines after the diagnosis was made. To increase certainty of the diagnosis, patients will be classified after one year of follow-up (ongoing at the time of submission). In this analysis, we assessed the prevalence of CPPD in the cohort of the RADIAL study, stratified by age and US findings.

Results: 550 patients were enrolled, 58.9% female with a mean age of 60.1 yo (±14.4). 57.8% of the patients were affected by CPPD (318/550) considering the entire cohort, with a mean age of 63 yo (±13.1), significantly higher when compared to no CPPD patients [mean age 56.2 yo (±15.3)]. Stratifying by ageing, the prevalence increases to 66.2% considering the patients older than 60 (188/284) and 73% considering 80 yo or older subjects (30/41). From the US point of view, patients with CPPD had a significantly higher inflammatory involvement of wrists and knees at US (both in grey scale and power Doppler assessment – p< 0.001) compared to patients with any other disease and no CPPD, while no differences have been emerged between CPPD and the other arthropathies about the comorbidities and the general clinical profile.

Conclusion: CPPD is commonly encountered in a routine rheumatological setting, reaching a prevalence of more than 65% in patients older than 60. Symptom attribution is challenging as many conditions may be associated and even a higher presence of synovitis in patients with CPPD cannot be unequivocally attributed to it. There is an impellent need to raise awareness on CPPD and its possible implications. We expect RADIAL study to supply additional data on these findings.


Disclosures: S. Sirotti: None; J. Madruga-Dias: None; A. Adinolfi: None; G. Sakellariou: None; D. Rozza: None; G. Carrara: None; G. Landolfi: None; C. Scire: None; A. Iagnocco: None; G. Filippou: None.

To cite this abstract in AMA style:

Sirotti S, Madruga-Dias J, Adinolfi A, Sakellariou G, Rozza D, Carrara G, Landolfi G, Scire C, Iagnocco A, Filippou G. Preliminary Descriptive Analysis of the RADIAL Cohort Study About the Prevalence and the Clinical Characteristics of Patients with CPPD in Daily Clinical Practice [abstract]. Arthritis Rheumatol. 2023; 75 (suppl 9). https://acrabstracts.org/abstract/preliminary-descriptive-analysis-of-the-radial-cohort-study-about-the-prevalence-and-the-clinical-characteristics-of-patients-with-cppd-in-daily-clinical-practice/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to ACR Convergence 2023

ACR Meeting Abstracts - https://acrabstracts.org/abstract/preliminary-descriptive-analysis-of-the-radial-cohort-study-about-the-prevalence-and-the-clinical-characteristics-of-patients-with-cppd-in-daily-clinical-practice/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology