ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2420

Pregnancy Outcome and Perinatal Complications of Neonate Born to Mothers with Juvenile Idiopathic Arthritis in Asia

Chao-Yi Wu1, Shang-Chun Changchien2, Huang-Yu Yang3, Kuo-Wei Yeh4 and Jing-Long Huang1,2, 1Division of Allergy, Asthma and Rheumatology. Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, 2Medicine, Chang-Gung University, Taoyuan city, Taiwan, 3Department of Nephrology,, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, 4Division of Allergy, Asthma and Rheumatology. Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan, Taiwan

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: , ,

Session Information

Date: Tuesday, October 23, 2018

Title: Reproductive Issues in Rheumatic Disorders Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Juvenile idiopathic arthritis (JIA) is the leading pediatric rheumatic disease affecting 30 out of a million women. Although spontaneous remission may occur in most patients, physical defects and the associated psychological conditions may impact patients’ all aspects of life, including pregnancy. To date, very few studies looked into the maternal and neonatal outcomes among women with JIA, and most of them are focused on the Caucasian population. The aim of this research is to provide proper health counsel for women with Asian descent suffering JIA about the possible complications during pregnancy.

Methods:

Using the National Health Insurance database and National Birth Registry, we identified a cohort of all live-births in Taiwan between 2004 and 2014. First child born to mothers with JIA were identified and matched with up to 5 controls by maternal age and birth year. Raw odds ratio (OR) with 95% confidence intervals (CI) and OR with age, infant sex, Charlson comorbidity index, urbanization, income, occupation, birth year, maternal nationality adjustment were used to analyze fetal/neonatal outcomes and maternal outcomes during pregnancies.

Results:

Of the 2,100,143 newborn, 0.037% (n=778) were born to JIA mothers. The result for neonatal outcomes suggested that babies born to mothers with JIA were more likely to have low birth body weight, with an adjusted OR of 1.35(95% CI: 1.02 to 1.79) when compared to babies born to mothers without. No significant differences were found in prematurity, small for gestational age as well as Apgar score <7 at 1 and 5 minutes even after adjustment. In addition, no differences were observed in maternal outcomes between women with and without JIA.

Conclusion:

Infants of mother with JIA and women with JIA themselves did not have an increased risk for pregnancy related adverse events. Intensive obstetric and neonatal care may not be necessary for pregnant women with JIA and their infants.

Disclosure: C. Y. Wu, None; S. C. Changchien, None; H. Y. Yang, None; K. W. Yeh, None; J. L. Huang, None.

To cite this abstract in AMA style:

Wu CY, Changchien SC, Yang HY, Yeh KW, Huang JL. Pregnancy Outcome and Perinatal Complications of Neonate Born to Mothers with Juvenile Idiopathic Arthritis in Asia [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/pregnancy-outcome-and-perinatal-complications-of-neonate-born-to-mothers-with-juvenile-idiopathic-arthritis-in-asia/. Accessed .

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