Session Type: ARHP Concurrent Abstract Session
Session Time: 2:30PM-4:00PM
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is associated with a higher mortality due to higher risk of cardiovascular events. Although physical activity is known to decrease cardiovascular morbidity and mortality, sedentary behavior highly prevails in SLE patients. The purpose of this study was to determine whether leisure-time physical activity level is associated with a better quality of life at one year.
Methods: Patients (n=287) in the Health Improvement and Prevention Program in SLE (HIPP) were randomized either into the « now » group (n=144) which received a comprehensive behavioral intervention including a supervised exercise program in the first 12 months or the « later » group (n=143) which received the intervention after 12 months. At baseline, 12 and 24 months, patients were asked to complete questionnaires assessing leisure-time physical activity (LTPA) measured by the Aerobics Centre Longitudinal Study physical activity questionnaire or ACLS, quality of life using the physical (PCS) and mental (MCS) component scales of the Short-Form 36, disease damage (Systemic Lupus International Collaborating Clinics Damage Index or SLICC), disease activity (Systemic Lupus Erythematosus Disease Activity Index or SLEDAI) and coronary heart disease risk factor using the Framingham risk score. LTPA levels were separated on the basis of hour of metabolic equivalent (MET) performed weekly: 1) sedentary group (no LTPA activity), 2) insufficiently active (<7.5 MET-h/week) and 3) active (>7.5 MET-h/week). Logistic and linear regressions were used to assess the effect of LTPA level, study group and their interactions on dichotomous and continuous outcomes respectively. Models were also adjusted for age at baseline.
Results: A total of 276 patients were included in this analysis. At baseline, no associations with the LTPA level were found regarding the SLEDAI, SLICC and Framingham scores. However, for the PCS, there was a significant difference for the LTPA levels (p<0.001). The active group reported statistically and clinically better physical health (43.78±0.92 vs. 36.97±1.30, p<0.001) when compared with the insufficiently active group and the sedentary group (37.12±1.35, p=0.0002), while there were no differences between the insufficiently active and the sedentary groups. At one year, those same associations are found between the LTPA levels (p=0.003). For the MCS , there was no statistical difference between the study groups but there was a difference between the LTPA level only in the unadjusted analysis, where the active group (47.97±0.99) had a significantly better score than the insufficiently active (43.60±1.38, p <0.05)
Conclusion: Our data suggests that the LTPA level is associated with better physical activity at baseline and a good predictor of the physical activity status at one year but is only associated with mental status at baseline. Further research are needed to better understand the LTPA level in SLE patients and to tailor appropriate exercise-based interventions.
To cite this abstract in AMA style:St-Aubin A, Julien AS, Neville C, Aghdassi E, Morrison S, Su J, Pope JE, Hewitt S, Pineau C, Harvey P, Abrahamowicz M, Da Costa D, Poirier P, Fortin PR. Predictive Value of Leisure-Time Physical Activity in Women with Systemic Erythematosus Lupus on Physical and Mental Health [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/predictive-value-of-leisure-time-physical-activity-in-women-with-systemic-erythematosus-lupus-on-physical-and-mental-health/. Accessed August 13, 2020.
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