ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2769

Predictive Value of Leisure-Time Physical Activity in Women with Systemic Erythematosus Lupus on Physical and Mental Health

Alix St-Aubin1, Anne-Sophie Julien2, Carolyn Neville3, Ellie Aghdassi4, Stacey Morrison5, Jiandong Su6, Janet E. Pope7, Sara Hewitt8, Christian Pineau9, Paula Harvey10, Michal Abrahamowicz11, Deborah Da Costa12, Paul Poirier13 and Paul R. Fortin14, 1Division of Rheumatology, Department of Medicine, CHU de Québec – Université Laval, Quebec, QC, Canada, 2CHU de Quebec - Universite Laval, Quebec City, QC, Canada, 3Department of Medicine, McGill University Health Center, Montreal, QC, Canada, 4Epidemiology Division, The Toronto Western Hospital, Toronto, ON, Canada, 5Rheumatology, Krembil Research Institute, Toronto, ON, Canada, 6Rheumatology, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 7Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, 8Department of Medicine, Division of Rheumatology, University of Western Ontario, St-Joseph Health Care, London, ON, Canada, 9Rheumatology, McGill University Health Center, Montreal, QC, Canada, 10Cardiology, Women's College Hospital, University of Toronto, Toronto, ON, Canada, 11Department of Medicine, McGill University Health Centre, Montreak, QC, Canada, 12Department of Medicine, McGill University Health Center, Montréal, Quebec, Canada., Montreal, QC, Canada, 13Deparment of Medicine, Division of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec and Université Laval, Quebec City, QC, Canada, 14Medicine, CHU de Quebec - Universite de Laval, Quebec, QC, Canada

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: , ,

Session Information

Date: Tuesday, November 7, 2017

Title: ARHP Rehabilitation Science

Session Type: ARHP Concurrent Abstract Session

Session Time: 2:30PM-4:00PM

Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is associated with a higher mortality due to higher risk of cardiovascular events. Although physical activity is known to decrease cardiovascular morbidity and mortality, sedentary behavior highly prevails in SLE patients. The purpose of this study was to determine whether leisure-time physical activity level is associated with a better quality of life at one year.

Methods: Patients (n=287) in the Health Improvement and Prevention Program in SLE (HIPP) were randomized either into the « now » group (n=144) which received a comprehensive behavioral intervention including a supervised exercise program in the first 12 months or the « later » group (n=143) which received the intervention after 12 months. At baseline, 12 and 24 months, patients were asked to complete questionnaires assessing leisure-time physical activity (LTPA) measured by the Aerobics Centre Longitudinal Study physical activity questionnaire or ACLS, quality of life using the physical (PCS) and mental (MCS) component scales of the Short-Form 36, disease damage (Systemic Lupus International Collaborating Clinics Damage Index or SLICC), disease activity (Systemic Lupus Erythematosus Disease Activity Index or SLEDAI) and coronary heart disease risk factor using the Framingham risk score. LTPA levels were separated on the basis of hour of metabolic equivalent (MET) performed weekly: 1) sedentary group (no LTPA activity), 2) insufficiently active (<7.5 MET-h/week) and 3) active (>7.5 MET-h/week). Logistic and linear regressions were used to assess the effect of LTPA level, study group and their interactions on dichotomous and continuous outcomes respectively. Models were also adjusted for age at baseline.

Results: A total of 276 patients were included in this analysis. At baseline, no associations with the LTPA level were found regarding the SLEDAI, SLICC and Framingham scores. However, for the PCS, there was a significant difference for the LTPA levels (p<0.001). The active group reported statistically and clinically better physical health (43.78±0.92 vs. 36.97±1.30, p<0.001) when compared with the insufficiently active group and the sedentary group (37.12±1.35, p=0.0002), while there were no differences between the insufficiently active and the sedentary groups. At one year, those same associations are found between the LTPA levels (p=0.003). For the MCS , there was no statistical difference between the study groups but there was a difference between the LTPA level only in the unadjusted analysis, where the active group (47.97±0.99) had a significantly better score than the insufficiently active (43.60±1.38, p <0.05)

Conclusion: Our data suggests that the LTPA level is associated with better physical activity at baseline and a good predictor of the physical activity status at one year but is only associated with mental status at baseline. Further research are needed to better understand the LTPA level in SLE patients and to tailor appropriate exercise-based interventions.

Disclosure: A. St-Aubin, None; A. S. Julien, None; C. Neville, None; E. Aghdassi, None; S. Morrison, None; J. Su, None; J. E. Pope, AbbVie, Amgen, Bayer, BMS, Celtrion, Eli Lilly and Company, Merck, Novartis, Pfizer, Roche, UCB, 5,Amgen, Bayer, BMS, GSK, Merck, Novartis, Pfizer, Roche, UCB, 2; S. Hewitt, None; C. Pineau, None; P. Harvey, None; M. Abrahamowicz, None; D. Da Costa, None; P. Poirier, None; P. R. Fortin, None.

To cite this abstract in AMA style:

St-Aubin A, Julien AS, Neville C, Aghdassi E, Morrison S, Su J, Pope JE, Hewitt S, Pineau C, Harvey P, Abrahamowicz M, Da Costa D, Poirier P, Fortin PR. Predictive Value of Leisure-Time Physical Activity in Women with Systemic Erythematosus Lupus on Physical and Mental Health [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/predictive-value-of-leisure-time-physical-activity-in-women-with-systemic-erythematosus-lupus-on-physical-and-mental-health/. Accessed .

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