ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 383

Potential Biomarkers of Disease Activity in Juvenile Idiopathic Arthritis – Data from the Portuguese Register, Reuma.Pt

Ana Filipa Mourão1,2,3, MJ Santos4, Mónica Eusébio5, Ana Lopes6, Filipa Ramos7, Manuel Salgado8, Paula Estanqueiro9, Jose Antonio Melo Gomes10, Fernando Magalhaes Martins11, José Antonio Costa12, Ana Carolina Furtado13, Ricardo Figueira14, Iva Brito15,16,17, Jaime Branco18,19, João E. Fonseca20 and Helena Canhão21, 1NOVA Medical School - Faculdade Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal, 2Centro Hospitalar Lisboa Ocidental (CHLO- E.P.E.), Lisbon, Portugal, 3Rheumatology, Instituto de Medicina Molecular, Lisbon, Portugal, 4Rheumatology Research Unit Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal, 5Sociedade Portuguesa de Reumatologia, LIsboa, Portugal, 6Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 7Rheumatology and Metabolic Bone Diseases Department, Santa Maria Hospital,CHLN, Lisbon, Portugal, 8Pediatrics, Centro Hospitalar de Coimbra, Coimbra, Portugal, 9Pediatrics, Centro Hospitalar da Universidade de Coimbra, Coimbra, Portugal, 10Instituto Português de Reumatologia, Lisbon, Portugal, 11Portuguese Society of Rheumatology, Lisbon, Portugal, 12Rheumatology, Centro Hospitalar do Alto Minho, Hospital de Ponte de Lima, Ponte de Lima, Portugal, 13Rheumatology, Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Portugal, 14Rheumatology, Hospital Dr. Nélio Mendonça, Funchal, Portugal, 15Rheumatology, Centro Hospitalar do Pirto, Hospital de São João, Porto, Portugal, 16Rua Raul Caldevilla 126-2 Dto, Hospital Sao Joao, Porto, Portugal, 17Faculdade de Medicina da Universidade do Porto, Porto, Portugal, 18Rheumatology, CHLO, Hospital Egas Moniz, Lisbon, Portugal, 19CEDOC, Nova Medical School, Lisbon, Portugal, 20Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Lisboa, Portugal, 21Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon, Portugal

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: , , ,

Session Information

Date: Sunday, November 13, 2016

Title: Pediatric Rheumatology – Clinical and Therapeutic Aspects - Poster I: Juvenile Idiopathic Arthritis, Uveitis

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:   The classical inflammatory markers, C-reactive protein and erythrocyte sedimentation rate often do not adequately reflect JIA disease activity. Our objective was to assess the serum levels of DKK1, OPG, SOST, RANKL, greline, BAFF, leptine, APRIL, ACPA, CTD, RF IgA and IgM, INFy, IL1β, IL6, IL10, IL17 and TNF in patients with JIA, and detect their relation to disease activity.

Methods:  Serum levels of selected cytokines were determined by ELISA in JIA patients registered in Reuma.pt. The Juvenile Arthritis Disease Activity score in 27 joints (JADAS27) and Childhood Health Assessment Questionnaire (CHAQ) were calculated. Multivariate linear regression was used for analyzing the relation between the potential serum biomarkers levels and JADAS27 and CHAQ, adjusting for gender, body mass index, age, disease duration and JIA categories.

Results:   281 patients, 66% female, mean age 17.3±10 years and mean disease duration 10.9±8.7 years. Ninety-eight were persistent oligoarticular (OligoP), 48 extended oligoarticular (OligoE), 45 polyarticular RF negative (poly RF-), 26 Poly RF+­­, 22 systemic, 28 enthesitis-related arthritis (ERA) and 14 psoriatic arthritis. The global analysis including all JIA patients revealed that APRIL, RF IgA and IL17 levels were correlated with JADAS27 (β=0.14, p=0.02; β=0.12, p=0.006; β=0.36, p=0.014; respectively) and IL6 was inversely correlated with JADAS27 (β=-0.06, p=0.03). Regarding CHAQ, we have found that APRIL, INFγ and TNF were correlated with CHAQ (β=0.01, p=0.001; β=0.003, p=0.02; β=0.003, p=0.04; respectively). In the separate analysis by JIA category, in OligoP, RF IgM, INFy, IL1β, and TNF were correlated with CHAQ (β=0.007, p=0.005; β=0.004, p=0.019; β=0.008, p=0.033; β=0.007, p=0.038; respectively), and, on the other hand, IL10 was inversely correlated with CHAQ (β=-0.007, p=0.023). In OligoE, RF IgA levels were correlated with JADAS27 and CHAQ (β=0.91, p=0.016; β=0.05, p=0.037). In patients with Poly RF+ the serum levels of OPG and ACPA were correlated with JADAS27 (β=0.06, p=0.024; β=0.03, p=0.05), and OPG was also correlated with CHAQ (β=0.004, p=0.032). In PolyRF- patients, DKK1 was correlated with JADAS27 (β=0.014, p=0.047), and serum levels of APRIL and RF IgM were associated with CHAQ (β=0.03, p<0.001; β=0.03, p<0.001). In systemic JIA, CTD lev
els were correlated with JADAS27 (β=82.67, p=0.002), and DKK1 was inversely associated with JADAS27 (β=-0.009, p=0.035). In ERA category we have found leptin was correlated with JADAS27 and CHAQ (β=0.9, p=0.005; β=0.05, p=0.029), and ACPA with CHAQ (β=0.005, p=0.031). Lastly, for psoriatic arthritis patients, APRIL and RF IgA levels were correlated with CHAQ (β=0.17, p=0.046; β=0.13, p=0.008), and DKK1 and SOST were inversely correlated with CHAQ (β=-0.0003, p=0.037; β=-0.001, p=0.030).

Conclusion:   Our data underline the heterogeneity of different juvenile idiopathic arthritis categories. Interestingly, we have identified potential biomarkers of disease activity/functional status in JIA categories. Larger studies are needed in order to validate these results.  

Disclosure: A. F. Mourão, None; M. Santos, None; M. Eusébio, None; A. Lopes, None; F. Ramos, None; M. Salgado, None; P. Estanqueiro, None; J. A. Melo Gomes, None; F. Magalhaes Martins, None; J. A. Costa, None; A. C. Furtado, None; R. Figueira, None; I. Brito, None; J. Branco, None; J. E. Fonseca, None; H. Canhão, None.

To cite this abstract in AMA style:

Mourão AF, Santos M, Eusébio M, Lopes A, Ramos F, Salgado M, Estanqueiro P, Melo Gomes JA, Magalhaes Martins F, Costa JA, Furtado AC, Figueira R, Brito I, Branco J, Fonseca JE, Canhão H. Potential Biomarkers of Disease Activity in Juvenile Idiopathic Arthritis – Data from the Portuguese Register, Reuma.Pt [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/potential-biomarkers-of-disease-activity-in-juvenile-idiopathic-arthritis-data-from-the-portuguese-register-reuma-pt/. Accessed .

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