Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Fibromyalgia (FM) is a chronic pain syndrome characterized by lowered pain thresholds and other FM-related symptoms such as fatigue, anxiety and depression. Recent studies have focused on genetic factors that influence pain sensitivity and development of FM. There are emerging evidences that transient receptor potential vanilloid (TRPV) channels have been contributed to pain hypersensitivity. However, whether polymorphisms of TRPV are associated with FM is unknown. The aim of present study was to evaluate association between polymorphisms of TRPV2 and TRPV3 gene and FM susceptibility, and FM symptoms in a Korean population.
Methods: A total of 409 patients with FM and 423 controls were enrolled from 10 medical centers which participated in the Korean nationwide fibromyalgia survey. The alleles and genotypes at 3 positions [rs3813768(C>G), rs8121(C>T) and rs1129235(C>A)] in the TRPV 2 gene and 2 positions [rs7216486 (G>A) and rs395357(C>T)] in the TRPV 3 gene were genotyped from peripheral blood DNA. The associations of TPPV 2 and TRPV3 genes polymorphisms with FM susceptibility and clinical symptoms of FM were assessed.
Results: The frequencies of alleles and genotypes of individual TRPV2 and TRPV3 genes were not significantly associated with susceptibility of FM. However, the GTA haplotype of TRPV2 gene showed protective against fibromyalgia susceptibility after age- and sex adjusted analysis (OR 0.637; 95% CI; 0.418-0.969; P=0.035). Furthermore, SNP rs395357 of TRPV3 was associated with scores of Brief Fatigue Inventory (BFI) (P=0.017) in FM patients. Although haplotypes of TRPV3 did not show different distribution between FM patients and healthy controls, haplotypes of TRPV3 was associated with BFI and the Short Form-36 Health Status Questionnaire (SF-36) physical health summary scores (P=0.036, respectively)
Conclusion: This large-scale study is the first to evaluate association of TRPV gene polymorphisms with fibromyalgia susceptibility and symptom severity of FM. Our results suggested that certain TRPV2 haplotype have a protective role against FM, and also some genotype and haplotype of TRPV3 contribute to fibromyalgia symptoms. Further researches needed to be confirmed.
To cite this abstract in AMA style:Yim YR, Park DJ, Kim SH, Nah SS, Lee JH, Kim SK, Lee YA, Hong SJ, Kim HS, Lee HS, Kim HA, Joung CI, Kim SH, Lee SS. Polymorphisms of Transient Receptor Potential Vanilloid (TRPV) 2 and TRPV3 Gene Polymorphisms Were Associated with Fibromyalgia in a Korean Population [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/polymorphisms-of-transient-receptor-potential-vanilloid-trpv-2-and-trpv3-gene-polymorphisms-were-associated-with-fibromyalgia-in-a-korean-population/. Accessed January 27, 2022.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/polymorphisms-of-transient-receptor-potential-vanilloid-trpv-2-and-trpv3-gene-polymorphisms-were-associated-with-fibromyalgia-in-a-korean-population/