ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1433

Persistent Dyslipidemia Is a Risk Factor of Progression to Chronic Kidney Disease in Patients with Lupus Nephritis

Dong-Jin Park1, Kyung-Eun Lee1, Tae-Jong Kim1, Yong-Wook Park1 and Shin-Seok Lee2, 1Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 2Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords:

Session Information

Title: Systemic Lupus Erythematosus: Clinical Aspects

Session Type: Abstract Submissions (ACR)

Background/Purpose: To investigate the effect of dyslipidemia at baseline and during follow-up period on the progression to chronic kidney disease (CKD) in patients with biopsy-proven lupus nephritis (LN).

Methods: We studied 68 patients who had kidney biopsy prior to the start of induction treatment, and who subsequently were treated with immunosuppressive drugs for at least 6 months. Sociodemographic, clinical, laboratory including lipid profile, and treatment-related data at the time of kidney biopsy and during follow-up were obtained by reviewing patients’ charts. In addition, lipid profile data were collected at 6 months and 1 year of follow-up periods. Patients were divided into two groups based on mean levels of LDL cholesterol: the ≥100 mg/dl group with 25 patients and the < 100 mg/dl group with 43 patients. Cox- proportional regression analyses were performed to identify independent predictors of progression to CKD in these patients.

Results: The higher LDL cholesterol group had a significantly older age at onset of LN, had higher WBC counts, and excreted more 24-hour urine protein than the lower LDL cholesterol group (p=0.010, p=0.035, and p=0.048, respectively). The high LDL cholesterol levels during the follow-up period was a significant predictor of CKD in LN patients in unadjusted model (hazard ratio [HR] 3.997, 95% CI 1.193~13.388, p=0.025), and this association remained significant after adjustment for confounders including estimated glomerular filtration rate (HR 3.592, 95% CI 1.067~12.094, p=0.039).

Conclusion: Our findings suggested that persistent dyslipidemia during 1-year follow-up after the onset of LN was an independent risk factor to predict the development of CKD in LN patients. Therefore, lipid profile should be monitored regularly and dyslipidemia should be managed aggressively to prevent deterioration of kidney function in these patients.

Disclosure:

D. J. Park,
None;

K. E. Lee,
None;

T. J. Kim,
None;

Y. W. Park,
None;

S. S. Lee,
None.

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