Periodontal Disease Is Associated with an Increased Risk of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis

Patompong Ungprasert¹, Karn Wijarnpreecha² and Wisit Cheungpasitporn³, ¹Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ²Internal medicine, Bassett medical center, cooperstown, NY, ³Medicine, University of Mississippi Medical center, Jackson, MS

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Ankylosing spondylitis (AS), Co-morbidities, Epidemiologic methods, meta-analysis and spondylarthropathy

Session Information

Date: Monday, October 22, 2018

Title: Epidemiology and Public Health Poster II: Gout, Ankylosing Spondylitis, Osteoarthritis, Osteoporosis, Pain, and Function

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Periodontal Disease is Associated with an Increased Risk of Ankylosing Spondylitis: A Systematic Review and Meta-analysis

Abstract

Background/Purpose: The association between periodontal disease and rheumatoid arthritis is well-recognized. Recent studies have suggested a similar association between periodontal disease and ankylosing spondylitis although the data are still limited. The current systematic review and meta-analysis was conducted with the aims to identify all available studies on this association and summarize their results together.

Methods: Two investigators independently searched for published studies indexed in MEDLINE and EMBASE database from inception to April 2018 using the search strategy that included the terms for periodontal disease and ankylosing spondylitis. Studies were included if they fulfilled all the following criteria: (1) Case-control or cohort studies comparing the risk of ankylosing spondylitis in individuals with and without periodontal disease (2) Individuals without periodontal disease were used as comparators in cohort studies while individuals without ankylosing spondylitis were used as controls in case-control studies and (3) Effect estimates and 95% confidence intervals (CI) of the association were provided. Point estimates and standard errors from each study were extracted and combined together using the random effect, generic inverse variance technique of DerSimonian and Laird.

Results: Of 524 retrieved articles, a total of 7 case-control studies comprising of 41,575 participants met the inclusion criteria and were included in this meta-analysis. The risk of ankylosing spondylitis among patients with periodontal disease was significantly higher than individuals without periodontal disease with the pooled odds ratio of 2.16 (95% CI, 1.48–3.16). The statistical heterogeneity was low with an I² of 45%. The forest plot of this meta-analysis is shown as figure 1.

Conclusion: A significantly increased risk of ankylosing spondylitis among patients with periodontal disease was observed in this study.

Figure 1: Forest plot of this meta-analysis

Disclosure: P. Ungprasert, None; K. Wijarnpreecha, None; W. Cheungpasitporn, None.

To cite this abstract in AMA style:

Ungprasert P, Wijarnpreecha K, Cheungpasitporn W. Periodontal Disease Is Associated with an Increased Risk of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/periodontal-disease-is-associated-with-an-increased-risk-of-ankylosing-spondylitis-a-systematic-review-and-meta-analysis/. Accessed .

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