Session Type: Abstract Submissions (ACR)
Background/Purpose: To evaluate the performances at diagnosis (sensitivity [Se], specificity [Spe], positive and negative predictive values) and study visit (classification purpose) of the ASAS criteria in axial spondyloarthritis (SpA) in patients visiting their rheumatologist for chronic back pain (CBP). Secondary objectives: identifying the most contributive item to diagnosis/classification of SpA, evaluating the performances of each arm of the ASAS criteria and other SpA criteria’s performances.
Methods: Multi-centric, cross-sectional. Patients: history of CBP before the age of 40 visiting a rheumatologist in France. Data: a) items of the different sets of criteria, checking if present at diagnosis or at study visit; b) diagnosis of the rheumatologist at study visit. Statistical analysis: description of the population. Rheumatologist’s diagnosis was considered as the “gold standard” for the estimation of all psychometric properties.
Results: 1210 patients were included for our analysis. At diagnosis, Se was 0.76 and Spe 0.94 for ASAS axial criteria and Se 0.87 and Spe 0.92 for classification. LR+ of the ASAS axial criteria was 13.6 for diagnosis and 10.30 for classification. The most contributive item to diagnosis and classification was X-ray sacroiliitis, followed by MRI sacroiliitis for diagnosis and history of uveitis for classification. MRI+ imaging ASAS criteria were more sensitive for diagnosis and classification, but as specific as ASAS clinical criteria.
Conclusion: we confirm the validity of the ASAS criteria in diagnosis and classification, in a clinical rheumatological setting of patients with CBP, with good performances compared to the other axial SpA criteria, and for any of their arms.
Abbott Immunology Pharmaceuticals,
D. van der Heijde,
Abbott Laboratories; Amgen; AstraZeneca; BMS; Centocor: Chugai; Eli-Lilly; GSK; Merck; Novartis; Pfizer; Roche; Sanofi-Aventis; Schering-Plough; UCB; Wyeth,
« Back to 2012 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/performances-of-the-asas-axial-spondyloarthritis-criteria-for-diagnosis-and-classification-purposes-in-patients-visiting-a-rheumatologist-because-of-chronic-back-pain-the-declic-study/