ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 0335

Performances of Different Classification Criteria for Systemic Lupus Erythematosus in a Single Center Cohort from Turkey

Ege Sinan Torun1, Erdem Bektaş1, Fatih Kemik2, Murat Bektaş3, Cigdem Cetin4, Yasemin Yalcinkaya4, Bahar Esen4, Ahmet Gül5 and Murat Inanc6, 1Istanbul University Istanbul Faculty of Medicine, İstanbul, Turkey, 2Istanbul Faculty of Medicine, Istanbul University, Department of Internal Medicine, İstanbul, Turkey, 3Istanbul Faculty of Medicine, Istanbul, Turkey, 4Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 5Division of Rheumatology, Istanbul University Istanbul School of Medicine, Istanbul, Turkey, 6Istanbul University Faculty of Medicine, Istanbul, Turkey

Meeting: ACR Convergence 2021

Keywords: classification criteria, Systemic lupus erythematosus (SLE)

  • Tweet
  • Email
  • Print
Session Information

Date: Saturday, November 6, 2021

Session Title: SLE – Diagnosis, Manifestations, & Outcomes Poster I: Diagnosis (0323–0356)

Session Type: Poster Session A

Session Time: 8:30AM-10:30AM

Background/Purpose: Recently developed EULAR/ACR classification criteria for systemic lupus erythematosus (SLE) has important differences compared to the 2012 Systemic Lupus International Collaborating Clinics (SLICC) SLE classification criteria and the revised 1997 American College of Rheumatology (ACR) criteria:The obligatory entry criterion of antinuclear antibody (ANA) positivity is introduced and a “weighted” approach is used.Sensitivity and specificity of these three criteria have been debated and may vary in different populations and clinical settings. We aim to compare the performances of three criteria sets/rules in a large cohort of patients and relevant diseased controls from a reference center with dedicated clinics for SLE and other autoimmune/inflammatory connective tissue diseases from Turkey.

Methods: We reviewed the medical records of SLE patients and diseased controls for clinical and laboratory features relevant to all sets of criteria. Criteria sets/rules were analysed based on sensitivity, positive predictive value, specificity and negative predictive value, using clinical diagnosis with at least 6 months of follow-up as the gold standard. A subgroup analysis was performed in ANA positive patients for both SLE group and control group. SLE patients that did not fulfil 2012 SLICC criteria and 2019 EULAR/ACR criteria and diseased controls that fulfilled these criteria were evaluated.

Results: A total of 392 SLE patients and 294 non-SLE diseased controls (48 undifferentiated connective tissue disease, 51 Sjögren’s syndrome, 43 idiopathic inflammatory myopathy, 50 systemic sclerosis, 52 primary antiphospholipid syndrome (APS), 15 rheumatoid arthritis, 15 psoriatic arthritis and 20 ANCA associated vasculitis) were included in the study. Hundred and fourteen patients (16.6%) were ANA negative.

Sensitivity was more than 90% for both 2012 SLICC criteria and 2019 EULAR/ACR criteria and positive predictive value was more than 90% for all three criteria (Table 1). Specificity was the highest for 1997 ACR criteria. Negative predictive value was 76.4% for ACR criteria, 88.1% for SLICC criteria and 91.7% for EULAR/ACR criteria.

In ANA positive patients, sensitivity was 79.1% for 1997 ACR criteria, 91.9% for 2012 SLICC criteria and 96.1% for 2019 EULAR/ACR criteria. Specificity was 92.6% for ACR criteria, 87.8% for SLICC criteria and 85.1% for EULAR/ACR criteria.

Eleven clinically diagnosed SLE patients had insufficient number of items for both 2012 SLICC and 2019 EULAR/ACR criteria. Both criteria were fulfilled by 16 diseased controls: 9 with Sjögren’s syndrome, 5 with APS, one with dermatomyositis and one with systemic sclerosis.

Conclusion: In this cohort, although all three criteria have sufficient specificity, the sensitivity and negative predictive value of 1997 ACR criteria are the lowest. Overall, 2019 EULAR/ACR and 2012 SLICC criteria have a comparable performance, but if only ANA positive cases and controls are analysed, the specificity of both criteria decrease to less than 90%. Some SLE patients with a clinical diagnosis lacked sufficient number of criteria. Mostly, patients with Sjögren’s syndrome or antiphospholipid syndrome are prone to misclassification by both recent criteria.

Table 1-Sensitivity, positive predictive value, specificity and negative predictive value of 1997 ACR, 2012 SLICC and 2019 EULAR/ACR classification criteria


Disclosures: E. Torun, None; E. Bektaş, None; F. Kemik, None; M. Bektaş, None; C. Cetin, None; Y. Yalcinkaya, None; B. Esen, None; A. Gül, None; M. Inanc, None.

To cite this abstract in AMA style:

Torun E, Bektaş E, Kemik F, Bektaş M, Cetin C, Yalcinkaya Y, Esen B, Gül A, Inanc M. Performances of Different Classification Criteria for Systemic Lupus Erythematosus in a Single Center Cohort from Turkey [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/performances-of-different-classification-criteria-for-systemic-lupus-erythematosus-in-a-single-center-cohort-from-turkey/. Accessed January 30, 2023.
  • Tweet
  • Email
  • Print

« Back to ACR Convergence 2021

ACR Meeting Abstracts - https://acrabstracts.org/abstract/performances-of-different-classification-criteria-for-systemic-lupus-erythematosus-in-a-single-center-cohort-from-turkey/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences