Abstracts Archive - Page 997 of 2425 - ACR Meeting Abstracts

Abstract Number: 640 • 2019 ACR/ARP Annual Meeting
Elevated Serum Interleukin-23 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity, Clinical and Immunological Markers
Milena Vukelic¹, Anita Laloo ² and Vasileios Kyttaris ³, ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Rheumatology Practice, Fort Lauderdale, FL, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Systemic lupus erythematosus (SLE) is a autoimmune disease characterized by deregulated cytokine production. IL-23 bridges innate and adaptive immunity by inducing the differentiation of…
Abstract Number: 641 • 2019 ACR/ARP Annual Meeting
A Novel Method to Analyze Circulating Immune Complexes Predicts Disease Activity and Severity in Systemic Lupus Erythematosus and Rheumatoid Arthritis
Anders Bengtsson ¹, Helena Tyden ¹, Tiffany Pan ², J. Lee Nelson ³ and Christian Lood², ¹Lund University, Lund, Sweden, ²University of Washington, Seattle, ³Fred Hutchinson Cancer Research Center, Seattle
Background/Purpose: Circulating immune complexes (IC) are detectable in a variety of systemic inflammatory diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), reflecting the…
Abstract Number: 642 • 2019 ACR/ARP Annual Meeting
Complement Deposition C4d on Platelets Is Associated with Vascular Events in Systemic Lupus Erythematosus
Elisabet Svenungsson ¹, Johanna Gustavsson ², Giorgia Grosso ², Iva Gunnarsson ², Bo Nilsson ³, Anders Larsson ³, Anders Bengtsson ⁴ and Christian Lood⁵, ¹Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ²Karolinska Institutet, Stockholm, Sweden, ³Uppsala University, Uppsala, Sweden, ⁴Lund University, Lund, Sweden, ⁵University of Washington, Seattle
Background/Purpose: Complement components, including C4d, can be detected on the surface of activated platelets and they have been associated with vascular disease in systemic lupus…
Abstract Number: 643 • 2019 ACR/ARP Annual Meeting
Association Between Neutrophil to Lymphocyte, Monocyte to Lymphocyte, and Platelet to Lymphocyte Ratios and Lupus Disease Activity and Lupus Nephritis
Philip Carlucci¹, Elliot Luttrell-Williams ¹, Rohit Bhan ¹, Catherine Trad ¹, Hanane El Bannoudi ¹, Peter Izmirly ¹, H. Michael Belmont ², Jill Buyon ³ and Jeffrey Berger ¹, ¹New York University School of Medicine, New York, ²New York University School of Medicine, Ney York, ³New York University School of Medicine, New York, NY
Background/Purpose: Subjects with Systemic Lupus Erythematosus (SLE) are at elevated risk for end-organ damage. Lupus nephritis continues to be the complication with the highest standardized…
Abstract Number: 644 • 2019 ACR/ARP Annual Meeting
Decreased HVEM Expression in Lupus Patients and Impact of HVEM Knockout Mouse Model of Lupus Suggest a Role for BTLA Signaling in Disease Pathogenesis
Andrew Vendel¹, Kimberly Griffiths ¹, Antje Rhode-Kurnow ², Eve Merriman ¹, Mark Daniels ¹, William Chang ¹ and Carl Ware ², ¹Lilly Biotechnology Center, San Diego, CA, ²Sanford Burnham Prebys Medical Research Institute, La Jolla, CA
Background/Purpose: B and T Lymphocyte Attenuator (BTLA; CD272) is an Ig superfamily member and part of a family of checkpoint receptors that negatively regulate immune…
Abstract Number: 645 • 2019 ACR/ARP Annual Meeting
Association of Co-positivity for Anti-dsDNA, -Nucleosome, and -Histone Antibodies and Disease Activity in Patients with Lupus Nephritis: Results from the KORNET Registry
Seong-Eun Choi¹, Dong-Jin Park ¹, Ji-Hyoun Kang ¹, Haimuzi Xu ¹ and Shin-Seok Lee ², ¹Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea, ²Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea
Background/Purpose: Recent studies have shown that the simultaneous positivity of anti-double stranded DNA, -nucleosome, and -histone antibodies (3-pos) is prevalent in lupus nephritis (LN) patients…
Abstract Number: 646 • 2019 ACR/ARP Annual Meeting
A Meta-Analysis of Anti-Ribosomal P Autoantibodies in Systemic Lupus Erythematosus: A Misunderstood Autoantibody
May Choi¹, Rachael Brown ², Katherine Buhler ³, Michael Mahler ⁴ and Marvin Fritzler ¹, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²University of Victoria, Victoria, Canada, ³University of Calgary, Calgary, Canada, ⁴Inova Diagnostics, San Diego, CA
Background/Purpose: Anti-ribosomal P (Rib-P) antibodies have become known as a highly specific biomarker for the diagnosis of SLE and potentially a biomarker for neuropsychiatric SLE…
Abstract Number: 647 • 2019 ACR/ARP Annual Meeting
Is ANA-status at Disease Inception Associated with Long-term Damage Accrual and Direct and Indirect Health Care Costs in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort?
May Choi¹, Megan Barber ², Marvin Fritzler ¹, John G Hanly ³, Murray Urowitz ⁴, Yvan St-Pierre ⁵, Juanita Romero-Diaz ⁶, Caroline Gordon ⁷, Sang-Cheol Bae ⁸, Sasha Bernatsky ⁹, Daniel J Wallace ¹⁰, David A Isenberg ¹¹, Anisur Rahman ¹², Ellen M Ginzler ¹³, Michelle Petri ¹⁴, Ian Bruce ¹⁵, Paul Fortin ¹⁶, Dafna Gladman ¹⁷, Jorge Sanchez-Guerrero ¹⁸, Rosalind Ramsey-Goldman ¹⁹, Munther A Khamashta ²⁰, Cynthia Aranow ²¹, Meggan Mackay ²², Graciela Alarcón ²³, Susan Manzi ²⁴, Ola Nived ²⁵, Andreas Jönsen ²⁵, Asad Zoma ²⁶, Ronald van Vollenhoven ²⁷, Manuel Ramos-Casals ²⁸, Guillermo Ruiz-Irastorza ²⁹, S Sam Lim ³⁰, Kenneth C Kalunian ³¹, Murat Inanc ³², Diane Kamen ³³, Christine Peschken ³⁴, Soren Jacobsen ³⁵, Anca Askanase ³⁶, Vernon Farewell ³⁷ and Ann E Clarke ³⁸, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²University of Calgary, Calgary, Canada, ³Dalhousie University, Halifax, NS, Canada, ⁴University Health Network, University of Toronto, Toronto, ON, Canada, ⁵McGill University Health Centre, Montreal, QC, Canada, ⁶Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico, ⁷University of Birmingham, Birmingham, United Kingdom, ⁸Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ¹⁰Cedars-Sinai Medical Centre, Beverly Hills, CA, ¹¹Centre for Rheumatology, London, United Kingdom, ¹²University College London, London, United Kingdom, ¹³State University of New York Downstate Medical Center, Brooklyn, NY, ¹⁴Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁵University of Manchester, Manchester, United Kingdom, Manchester, England, United Kingdom, ¹⁶Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Canada, Quebec, QC, Canada, ¹⁷University of Toronto, Toronto, ON, Canada, ¹⁸Toronto Western Hospital, Toronto, ON, Canada, ¹⁹Northwestern University, Chicago, IL, ²⁰King's College London School of Medicine, London, United Kingdom, ²¹Feinstein Institute for Medical Research, Manhasset, NY, ²²Feinstein Institute for Medical Research, New York, ²³University of Alabama at Birmingham, Birmingham, ²⁴Allegheny Health Network, Pittsburg, PA, ²⁵Lund University, Lund, Sweden, ²⁶Hairmyres Hospital, East Kilbride, United Kingdom, ²⁷Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, the Netherlands, Amsterdam, Netherlands, ²⁸Josep Font Autoimmune Diseases Laboratory, Barcelona, Spain, ²⁹Autoimmune Diseases Unit, Hospital Universitario Cruces, Barakaldo, Spain, Barakaldo, Spain, ³⁰Emory University, Atlanta, GA, ³¹UC San Diego School of Medicine, LaJolla, CA, ³²Istanbul University, Istanbul, Turkey, ³³Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC, ³⁴University of Manitoba, Winnipeg, Canada, ³⁵Copenhagen Lupus and Vasculitis Clinic, Copenhagen, Denmark, ³⁶Columbia University Medical Center, New York, NY, ³⁷University of Cambridge, Cambridge, United Kingdom, ³⁸University of Calgary, Calgary, AB, Canada
Background/Purpose: We reported that 7.7% (88/1137) of patients in an international inception cohort were ANA-negative at enrolment (Arthritis Care Res 2018 doi:1002/acr23712). There are no…
Abstract Number: 648 • 2019 ACR/ARP Annual Meeting
Patients of African Descent Score Higher on Quality of Life Indices Despite Their Known Disease Severity
Katie Zuech¹, Ly Tran ², Teresa Aberle ¹, Cristina Arriens ³, Eliza F. Chakravarty ³, Joan T. Merrill ⁴ and Judith James ³, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, ³Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Okalahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus (SLE) may have a significant impact on multiple dimensions of quality of life. Patient-reported outcome (PRO) tools may provide valuable insights for…
Abstract Number: 649 • 2019 ACR/ARP Annual Meeting
Potentially Reversible Associations with Fatigue in SLE Patients – Results from a Single-centre Study
Christina Duesing¹, Gamal Chehab ², Jutta Richter ³, Oliver Sander ⁴, Rebecca Fischer-Betz ⁵, Benedikt Ostendorf ¹, Hasan Acar ¹, Ralph Brinks ⁶ and Matthias Schneider ⁵, ¹Policlinic of Rheumatology and Hiller Research Unit Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, Duesseldorf, Nordrhein-Westfalen, Germany, ²Policlinic of Rheumatology and Hiller Research Unit Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, ³Department and Hiller Research Unit of Rheumatology, Heinrich-Heine University Duesseldorf, Duesseldorf, Nordrhein-Westfalen, Germany, ⁴Department and Hiller Research Unit of Rheumatology, Heinrich-Heine University Duesseldorf, Duesseldorf, ⁵Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany, ⁶Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
Background/Purpose: Fatigue is the most common symptom in SLE patients with a strong impact on patients’ reported quality of life. The cause of fatigue is…
Abstract Number: 650 • 2019 ACR/ARP Annual Meeting
Performance of the Proposed American College of Rheumatology/European League Against Rheumatism Classification Criteria for Systemic Lupus Erythematosus in Korean Patients
Eunyoung Lee¹, Eun Bong Lee ², Eun Young Lee ¹, Jin Kyun Park ³, Se Han Ahn ⁴ and Yeong-Wook Song ⁵, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Seoul-t'ukpyolsi, Republic of Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Gwacheon-si, Kyonggi-do, Republic of Korea, ⁵Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: To evaluate the performance of the proposed American College of Rheumatology/European League against Rheumatism (ACR/EULAR) classification criteria for systemic lupus erythematosus (SLE) in Korean…
Abstract Number: 651 • 2019 ACR/ARP Annual Meeting
Predictors of Renal Damage in Systemic Lupus Erythematosus Patients from Latin America
Cristina Reátegui-Sokolova¹, Manuel Ugarte-Gil ², Guillermina B Harvey ³, Guillermo Pons-Estel ⁴, Rosana Quintana ⁵, Luis Catoggio ⁶, Enrique Soriano ⁷, Mercedes Garcia ⁸, Veronica Saurit ⁹, Francisco Caeiro ¹⁰, Eloisa Bonfa ¹¹, Nílzio da Silva ¹², Emilia Sato ¹³, Gloria Vasquez ¹⁴, Loreto Massardo ¹⁵, Oscar Neira ¹⁶, Mario Cardiel ¹⁷, Ignacio Garcia De-La Torre ¹⁸, Mary-Carmen Amigo ¹⁹, Marlene Guibert-Toledano ²⁰, Margarita Portela-Hernandez ²¹, Rosa Chacon-Diaz ²², Graciela Alarcón ²³ and Bernardo A. Pons-Estel ²⁴, ¹Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²Universidad Científica del Sur, Lima, Peru, ³GLADEL, Rosario, Argentina, ⁴Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, ⁵Centro Regional de Enfermedades Autoinmunes y Reumáticas (CREAR), Grupo Oroño,Rosario, Rosario, Argentina, ⁶Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina., Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ⁷Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina., Buenos Aires, Buenos Aires, Argentina, ⁸Hospital San Martín, La Plata, Argentina, ⁹Hospital Privado, Centro Médico de Córdoba, Córdoba, Argentina, Cordoba, Argentina, ¹⁰Hospital Privado de Córdoba, Cordoba, Argentina, ¹¹Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Sao Paulo, Brazil, ¹²Universidade Federal de Goiás, Goiânia, Goias, Brazil, ¹³Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil., San Pablo, Brazil, ¹⁴University of Antioquia, Medellin, Antioquia, Colombia, ¹⁵Centro de Biología Celular y Biomedicina, Facultad de Medicina y Ciencia. Universidad San Sebastián, Santiago, Chile., Santiago, Chile, ¹⁶Sección Reumatología, Hospital del Salvador. Universidad de Chile. Unidad de Reumatología. Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo., Santiago, Chile, Santiago, Chile, ¹⁷Centro de Investigación Clínica de Morelia, SC, Morelia, México., Morelia, Mexico, ¹⁸Departamento de Inmunología y Reumatología,Htal General de Occidente y Universidad de Guadalajara.Mexico, Guadalajara, Mexico, ¹⁹Servicio de Reumatología, Centro Médico ABC, Ciudad de México, México., Mexico, Mexico, ²⁰GLADEL, La Habbana, Cuba, ²¹Departamento de Reumatología, Hospital de Especialidades CMN SXXI, IMSS, Ciudad de México, Mexico, Mexico, ME, ²²Servicio de Reumatología, Policlínica Méndez Gimón, Caracas, Venezuela., Caracas, Venezuela, ²³University of Alabama at Birmingham, Birmingham, ²⁴Centro Regional de Enfermedades Autoinmunes y Reumáticas (CREAR), Grupo Oroño, Rosario, Rosario, Argentina
Background/Purpose: Lupus nephritis and renal damage are serious complications in patients with SLE. Proteinuria < 0.8 g/24 hours at 12 months has proven to be a…
Abstract Number: 652 • 2019 ACR/ARP Annual Meeting
Clinical Relevance According to Staining Patterns and Titers of Antinuclear Antibody
Mi Ryoung Seo¹, Ji Na Yeo ², Hee Jung Ryu ³, Hyo-Jin Choi ³ and Han Joo Baek ³, ¹, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, ²Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, ³Division of Rheumatology / Department of Internal Medicine / Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea
Background/Purpose: Immunofluorescent antinuclear antibody (ANA) test using HEp-2 cells still plays an important role in the diagnosis of autoimmune diseases. The aim of this study…
Abstract Number: 653 • 2019 ACR/ARP Annual Meeting
Newly Diagnosed Lupus Nephritis in Elderly Predicts Good Renal Outcome: A Distinct Disease Subset from Young-onset Lupus Nephritis
Kazuoto Hiramoto¹, Hironari Hanaoka ¹, Jun Kikuchi ¹, Shuntaro Saito ¹, Hiroshi Takei ², Tatsuhiro Oshige ¹, Noriyasu Seki ³, Hideto Tsujimoto ³, Yuko Kaneko ¹ and Tsutomu Takeuchi ¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, ³Mitsubishi Tanabe Pharma Corporation Sohyaku. Innovative Research Division, Toda-shi, Saitama, Japan
Background/Purpose: Elderly-onset SLE is recognized to be benign disease entity with a favorable nature course. Although late-onset lupus nephritis (LN), long interval between onset of…
Abstract Number: 654 • 2019 ACR/ARP Annual Meeting
Applying Systemic Lupus International Collaborating Clinics (SLICC) and Provisional ACR/EULAR Systemic Lupus Erythematosus Classification Criteria in a Cohort of Patients with Undifferentiated Connective Tissue Disease
Kyle Drehmel¹, Alan Erickson ¹, Bryant England ² and Michelene Hearth-Holmes ¹, ¹University of Nebraska Medical Center, Omaha, NE, ²VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha
Background/Purpose: Undifferentiated Connective Tissue Disease (UCTD) describes the clinical scenario where a patient demonstrates characteristics of a connective tissue disease but does not meet criteria…

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