Abstracts Archive - Page 958 of 2425 - ACR Meeting Abstracts

Abstract Number: 55 • 2019 ACR/ARP Annual Meeting
A Novel Subclass of Intravascular Non-classical, Tissue Resident Synovial Monocyte Is Critical for Rheumatoid Arthritis Pathogenesis
Anna Montgomery ¹, Shang-Yang Chen ¹, Deborah Winter ² and Harris Perlman², ¹Northwestern University, Chicago, ²Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago
Background/Purpose: There are at least three populations of circulating monocytes; classical, intermediate and non-classical. We demonstrated that circulating non-classical monocytes are required for the effector…
Abstract Number: 56 • 2019 ACR/ARP Annual Meeting
Choline Metabolite Is Associated with Inflammation in Arthritis in the Elderly
francesca cedola¹, Roxana Coras ², Elsa Sanchez-Lopez ³, Lourdes Mateo ⁴, Anders Pedersen ⁵, Anahy Brandy-Garcia ⁴, Águeda Prior-Español ⁴, Brin S rosenthal ⁶, Melania Martínez-Morillo ⁴ and Monica Guma ⁷, ¹University of California San Diego, Rome, Italy, ². Department of Medicine, School of Medicine. University of California, San Diego, ³Department of Pharmacology, University of California San Diego, La Jolla, San Diego, ⁴Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁵University of Gothenburg, Gothenburg, Sweden, ⁶University of California San Diego, san diego, ⁷Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: Elderly-onset RA (EORA) and polymyalgia rheumatica (PMR) are common rheumatic disease in the elderly and their pathogenesis are still not completely understood. Perturbations caused…
Abstract Number: 57 • 2019 ACR/ARP Annual Meeting
Endothelial Progenitor Cells in the Pathophysiology of Interstitial Lung Disease Associated with Rheumatoid Arthritis
Veronica Pulito-Cueto¹, Sara Remuzgo-Martínez ¹, Fernanda Genre ¹, Leticia Lera-Gomez ¹, Veronica Mijares ¹, Pilar Alonso Lecue ², Victor Manuel Mora Cuesta ², David Iturbe ³, Sonia M. Fernández Rozas ², Ricardo Blanco ⁴, Alfonso Corrales ¹, Jose Manuel Cifrian Martínez ², Raquel López-Mejías ¹ and Miguel A Gonzalez-Gay ⁴, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL; and Pneumology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, ³Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain; and Pneumology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, ⁴Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain
Background/Purpose: Interstitial lung disease (ILD) is one of the most significant comorbidities that contributes to the increased mortality observed in patients with rheumatoid arthritis (RA)…
Abstract Number: 58 • 2019 ACR/ARP Annual Meeting
In Rheumatoid Arthritis (RA) Decreases in Conventional Dendritic Cell Lineages Are Associated with Adverse Measures of Myocardial Function and Expansions of Anomalous HLA-DR+ Myeloid Subsets
Christian Geier¹, Jon Giles ², Gilad Gibor ³, Joan Bathon ² and Robert Winchester ³, ¹Columbia University, New York, NY, ²Division of Rheumatology, Columbia University, New York, NY, ³Columbia University, New York
Background/Purpose: Dendritic cells (DC) are specialized antigen-presenting cells (APC) that have a central role in the initiation of immune responses. However, prior studies showed numeric decreases…
Abstract Number: 59 • 2019 ACR/ARP Annual Meeting
Evaluation of Potential Mechanisms Underlying the Safety Observations of Filgotinib in Clinical Studies in RA
Julie Di Paolo¹, Bryan Downie ², Amy Meng ³, Nevena Mollova ³, Yuanjiang Yu ³ and Pei Han ³, ¹Gilead Sciences, Foster City, CA, ²Gilead Sciences, Inc., Foster Citty, CA, ³Gilead Sciences, Inc., Foster City, CA
Background/Purpose: Inhibition of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway have demonstrated efficacy in immune-mediated diseases and haves been identified as therapeutic…
Abstract Number: 60 • 2019 ACR/ARP Annual Meeting
mTORC1-phosphorylated CXCR3+memory B Cells and Their Potential as a New Mode of Action of TNF Inhibitors in RA
Shigeru Iwata¹, Mingzeng Zhang ¹, Maiko Hajime ¹, Naoaki Ohkubo ¹, Yukihiro Kitanaga ¹, Gulzhan Trimova ¹, Kazuhisa Nakano ², Shingo Nakayamada ¹, Kaoru Yamagata ¹, Kei Sakata ¹ and Yoshiya Tanaka ³, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, ³University of Occupational and Environmental Health Japan, Kitakyushu, Japan
Background/Purpose: B cells play a crucial role through producing autoantibodies and activating osteoclasts in synovium in rheumatoid arthritis (RA). Recently “Immunometabolism” attract much attention, and…
Abstract Number: 61 • 2019 ACR/ARP Annual Meeting
Lyn-Deficient Murine Lupus Is Exacerbated by Glucocorticoid-Induced Leucine Zipper (GILZ) Deficiency
Champa Nataraja¹, Jacqueline Flynn ¹, Wendy Dankers ¹, James Harris ¹, Sarah Jones ¹ and Eric Morand ¹, ¹Monash University, Melbourne, Victoria, Australia
Background/Purpose: Lyn-deficient mice develop hyperactive B cells, excess IL-6 production, and nephritis. Mice deficient in glucocorticoid-induced leucine zipper (GILZ), an intracellular protein involved in glucocorticoid…
Abstract Number: 62 • 2019 ACR/ARP Annual Meeting
Human Gingiva-derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis Through Targeting of CD39-CD73 Signaling Pathway
Song Guo Zheng¹, Julie Wang ², Junlong dang ³, Nancy Olsen ⁴ and Wael Jarjour ¹, ¹Ohio State College of Medicine, Columbus, OH, ²Ohio State University, columbus, ³Sun Yat-sen University, Guangzhou, ⁴Penn State University, Hershey, PA
Background/Purpose: Cell specific and cytokine targeted therapeutics have underperformed in systemic lupus erythematosus (SLE) in spite of numerous targets examined and clinical trials conducted. Mesenchymal…
Abstract Number: 63 • 2019 ACR/ARP Annual Meeting
The Role of the Intestinal Microbiota in Lupus Nephritis
Giancarlo Valiente¹, Armin Munir ¹, Marcia Hart ², Takuma Tsuzuki Wada ³, Perry Blough ¹, Emma Dalan ¹, William Willis ¹, Lai-Chu Wu ¹, Aharon Freud ¹ and Wael Jarjour ⁴, ¹The Ohio State University, Columbus, ²The Ohio State University, Columbia, ³Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: The bacterial gut microbiota (GM) exerts substantial influence over the host immune system and dysbiosis of this microbial community has been associated with end-organ…
Abstract Number: 64 • 2019 ACR/ARP Annual Meeting
Rab4A Controls mTOR Pathway Activation, Pro-inflammatory Lineage Development, and Disease Pathogenesis in Lupus-prone Mice
Nick Huang¹, Zhiwei Lai ², Brandon Wyman ², Thomas Winans ², Manuel Duarte ², Joshua Lewis ², Mark Haas ³, Laurence Morel ⁴ and Andras Perl ⁵, ¹Upstate Medical University, Syracuse, NY, ²Upstate Medical University, Syracuse, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of Florida, Gainesville, FL, ⁵SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Mouse models of SLE have been indispensable tools for studying disease pathogenesis; however, each model only recapitulates limited aspects of lupus. SLE1.2.3. (TC) mice…
Abstract Number: 65 • 2019 ACR/ARP Annual Meeting
CD6 Modulation Ameliorates Skin and Kidney Disease in a Spontaneous Murine Model of SLE
Samantha Chalmers¹, Sayra Garcia ¹, Rajalakshmy Ayilam Ramachandran ², Chandra Mohan ², Jeanette Ampudia ³, Cherie Ng ³, Stephen Connelly ³ and Chaim Putterman ⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²University of Houston, Houston, ³Equillium, Inc, San Diego, CA, ⁴Albert Einstein College of Medicine, New York, NY
Background/Purpose: T cells are an important contributor the pathogenesis of SLE and its various end organ manifestations. Thus, they present themselves as potential therapeutic targets;…
Abstract Number: 66 • 2019 ACR/ARP Annual Meeting
Amelioration of Immune Complex-Mediated Glomerulonephritis by CD6 Modulation
Samantha Chalmers¹, Sayra Garcia ¹, Jeanette Ampudia ², Cherie Ng ², Stephen Connelly ² and Chaim Putterman ³, ¹Albert Einstein College of Medicine, Bronx, NY, ²Equillium, Inc, San Diego, CA, ³Albert Einstein College of Medicine, New York, NY
Background/Purpose: CD6 is a co-stimulatory receptor on T cells, that binds to activated leukocyte cell adhesion molecule (ALCAM), a ligand expressed on antigen presentation cells…
Abstract Number: 67 • 2019 ACR/ARP Annual Meeting
Dermal Lymphatic Dysfunction Is Associated with Disease Activity in the MRL/lpr Lupus Model
Noa Schwartz¹, Thomas Li ², Susan Chyou ², William Shipman ³ and Theresa Lu ⁴, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, ³Weill Cornell Tri-Institutional MD-PhD Program, New York, NY, ⁴Hospital for Special Surgery, Weill Cornell Medicine (Microbiology and Immunology), New York
Background/Purpose: Lymphatic vessels are important in limiting the extent and duration of peripheral immune response, both by transporting cellular debris, inflammatory cells and excess interstitial…
Abstract Number: 68 • 2019 ACR/ARP Annual Meeting
Inactivation of Transaldolase and HRES-1/Rab4 Predisposes to Hepatitis in a Mouse Model of Systemic Lupus Erythematosus
Akshay Patel¹, Nick Huang ² and Andras Perl ³, ¹SUINY Upstate Medical University, Syracuse, NY, ²Upstate Medical University, Syracuse, NY, ³SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Deficiency of transaldolase (TAL) in systemic lupus erythematosus (SLE) predisposes to oxidative stress mediated autoimmune hepatitis[1, 2]. Along with TAL, HRES-1/Rab4 (Rab4A), a small…
Abstract Number: 69 • 2019 ACR/ARP Annual Meeting
Treatment of Lupus-prone MRL-lpr Mice with the Mitochondrial Antioxidant MitoQ
Ralph Budd¹, Karen Fortner ¹, Luz Blanco ², Mariana Kaplan ³, Andras Perl ⁴, Iwona Busliewicz ⁵, Greg MacPherson ⁶ and Mike Murphy ⁷, ¹The University of Vermont Larner College of Medicine, Burlington, VT, ²NIH NIAMS, Bethesda, MD, ³National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda, ⁴SUNY Upstate Medical University, Syracuse, NY, ⁵Upstate Medical Center, Syracuse, NY, ⁶MitoQ, Aukland, New Zealand, ⁷Wellcome MRC Mitochondrial Biology Unit, Cambridge, United Kingdom
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by a type I Interferon (IFN-I) gene signature in peripheral blood lymphocytes (PBL), which contain enlarged mitochondria and…

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