Abstracts Archive - Page 956 of 2425 - ACR Meeting Abstracts

Abstract Number: 25 • 2019 ACR/ARP Annual Meeting
Altered Distribution and Enhanced Osteoclastogenesis of Mucosal-associated Invariant T Cells in Gouty Arthritis
Yong-Wook Park¹, Young-Nan Cho ¹, Hae-Seong Jeong ¹, Hye-Mi Jin ¹ and Seung-Jung Kee ¹, ¹Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are subsets of innate invariant T cells and rapidly produce Th1/Th17 cytokines including interferon (IFN)-γ, tumor necrosis factor (TNF)-α,…
Abstract Number: 26 • 2019 ACR/ARP Annual Meeting
Increased Sodium Accumulation Detected by 23Na-Magnetic Resonance Imaging in Inflamed Knees of Patients with Autoimmune Joint Disease
Emma de Moel¹, Wouter Teeuwisse ², Thomas Huizinga ³, René Toes ³, Andrew Webb ² and Diane van der Woude ¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Radiology, C.J. Gorter Center for High-Field MRI, Leiden University Medical Center, Leiden, Netherlands, ³Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Salt, or sodium, has recently emerged as a potent factor involved in modulating inflammatory responses. Sodium is implicated as a dietary risk factor for…
Abstract Number: 27 • 2019 ACR/ARP Annual Meeting
Altered Inflammatory Response of Macrophages in the Fosl-2 Transgenic Mouse Model of Systemic Sclerosis
Chantal Rufer ¹, Michal Rudnik¹, Siim Uhtjärv ¹, Mara Stellato ¹, Florian Renoux ², Oliver Distler ³ and Gabriela Kania ¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, ³Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Fos-like 2 (Fosl-2) is a transcription factor belonging to the Fos family of proteins which is part of the AP-1 transcription complex. The Fosl-2…
Abstract Number: 28 • 2019 ACR/ARP Annual Meeting
Novel Ex Vivo Model of Septic Arthritis Identifies Role of Neutrophils in Joint Destruction
Kathryn McCall¹, Caroline Atherton ², Neal Millar ², Carl Goodyear ³, Tom Evans ⁴ and Iain McInnes ², ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Galsgow, United Kingdom, ²Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ³University of Glasgow, Glasgow, United Kingdom, ⁴Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow
Background/Purpose: Septic arthritis (SA) caused by bacterial species, such as Staphylococcus aureus, has high morbidity and mortality1. Currently diagnosis is often prolonged and unreliable, with…
Abstract Number: 29 • 2019 ACR/ARP Annual Meeting
Therapeutic Anti-TNF Biologic Agents Exhibit Functional Differences in Blocking TNF-induced Effects on Human Monocytes In Vitro
Bohdan Harvey¹ and Zehra Kaymakcalan ¹, ¹AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: Therapeutic anti-TNF biologic agents can be distinct in their structure and/or in their binding to TNF. Whether these differences affect the functional properties of…
Abstract Number: 30 • 2019 ACR/ARP Annual Meeting
Aberrant M1 Polarization of Macrophages in Behcet’s Disease
Jing Shi¹, Xiuhua Wu ², Jinjing Liu ¹, Hua Chen ³ and Wenjie Zheng ¹, ¹Peking Union Medical College Hospital, Beijing, China (People's Republic), ²General Hospital of Tianjin Medical University, Tianjin, China (People's Republic), ³Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College; The Ministry of Education Key Laboratory, Beijing, China, Beijing, Beijing, China (People's Republic)
Background/Purpose: Behcet’s disease (BD) is systemic inflammatory vasculitis with unknown etiology. As a critical compartment in innate immunity, macrophages may play a role in BD.…
Abstract Number: 31 • 2019 ACR/ARP Annual Meeting
Regulation of Neutrophil Extracellular Traps by Apremilast (phosphodiesterase 4 Inhibition)
Shane van Breda¹, Simona Rossi ¹ and Paul Hasler ², ¹University Hospital Basel, Department of Biomedicine, Basel, Switzerland, ²Kantonsspital Aarau, Department of Rheumatology, Aarau, Switzerland
Background/Purpose: Increased propensity for neutrophil extracellular trap generation has been described in autoimmune diseases such as rheumatoid arthritis. Neutrophil extracellular traps are thought to contribute…
Abstract Number: 32 • 2019 ACR/ARP Annual Meeting
Aberration of Histone Lysine Methylation in Adult-Onset Still’s Disease Are Novel Biomarker Candidates Associated with the Disease Activity
Yoshimi Aizaki¹, Yasuto Araki ¹, Kojiro Sato ² and Toshihide Mimura ¹, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan
Background/Purpose: Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disorder characterized by spiking fever, transient rash, arthritis and leukocytosis. Macrophage and neutrophil activation is a…
Abstract Number: 33 • 2019 ACR/ARP Annual Meeting
GS-4875, a First-in-Class TPL2 Inhibitor Suppresses MEK-ERK Inflammatory Signaling and Proinflammatory Cytokine Production in Primary Human Monocytes
Matthew Warr¹, Angie Hammond ¹, Grace Park ¹, Zhi-Hua Cui ¹, Nathan Wright ¹ and James Taylor ¹, ¹Gilead Sciences, Inc., Foster City, CA
Background/Purpose: Tumor progression locus 2 (TPL2, also known as MAP3K8) is a mitogen-activated protein kinase kinase kinase and the primary regulator of ERK-mediated gene transcription…
Abstract Number: 34 • 2019 ACR/ARP Annual Meeting
The Role of NFAT5-p65 Complex Enhanceosome in the Inflammatory Responses of Rheumatoid Arthritis Synovial Fibroblasts via TLR4 Signaling
Kunihiko Umekita¹, Yumi Kariya ¹, Chihiro Iwao ¹, Masatoshi Kimura ¹, Risa Kudo ¹, Yuki Rikitake ¹, Shunichi Miyauchi ² and Akihiko Okayama ¹, ¹University of Miyazaki, Miyazaki, Japan, ²University of Miyazaki, Miyazaki
Background/Purpose: Transcription factors belonging to the family of nuclear factors of activated T cells (NFAT) play an essential role in diverse biological processes, such as…
Abstract Number: 35 • 2019 ACR/ARP Annual Meeting
Mass Cytometry Identifies Enhanced Histone H3 Citrullination and TNFα Production by CD14 Monocytes in Subjects At-Risk for Future Development of Rheumatoid Arthritis
Yuko Okamoto¹, Elena W.Y. Hsieh ², Ronald P. Schuyler ³, Jennifer Seifert ⁴, Marie Feser ⁵, Jill Norris ⁶, M. Kristen Demoruelle ⁷, Kevin Deane ⁵ and V. Michael Holers ⁴, ¹University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA and Tokyo Women’s Medical University School of Medicine, Department of Rheumatology, Tokyo, Japan, Denver, ²University of Colorado School of Medicine, Department of Immunology and Microbiology, Aurora, CO, USA and University of Colorado School of Medicine, Children’s Hospital Colorado, Department of Pediatrics, Section of Allergy & Immunology, Aurora, CO, USA, Denver, ³University of Colorado School of Medicine, Department of Immunology and Microbiology Aurora, CO, USA, Denver, ⁴University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ⁵University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, ⁶Colorado School of Public Health, Department of Epidemiology, Aurora, CO, USA, Denver, ⁷University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora
Background/Purpose: Our group previously demonstrated that sputum neutrophils from subjects At-Risk for future rheumatoid arthritis (RA) spontaneously form neutrophil extracellular traps with elevated histone H3…
Abstract Number: 36 • 2019 ACR/ARP Annual Meeting
Discovery, Verification and Validation of Rheumatoid Arthritis Activity Monitoring Biomarkers
Lucía González-Rodríguez¹, Valentina Calamia ¹, Rocío Paz-González ¹, Patricia Fernández-Puente ¹, Cristina Ruiz-Romero ¹, Antonio Julià ², Antonio Fernández-Nebro ³, Jesús Tornero ⁴, Sara Marsal ⁵ and Francisco J. Blanco ⁶, ¹Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña,15006 A Coruña-Spain, A Coruña, Galicia, Spain, ²Rheumatology Research Group, Vall d’Hebron Hospital Research Institute, Barcelona, Spain., Barcelona, Catalonia, Spain, ³UGC Reumatología, Instituto de Investigación Biomédica (IBIMA), Hospital Regional Universitario de Málaga, Spain., Málaga, Andalucia, Spain, ⁴Hospital Universitario Guadalajara, Guadalajara, Spain., Guadalajara, Castilla-La Mancha, Spain, ⁵Vall d’Hebron Hospital, Barcelona, Catalonia, Spain, ⁶Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a long-lasting inflammatory autoimmune disorder that ultimately leads to the destruction of joint architecture. The activity of this disease is…
Abstract Number: 37 • 2019 ACR/ARP Annual Meeting
Intestinal Microbiota Dynamics in the Progression of Rheumatoid Arthritis
Yanli Tong¹, Yunqiang Bai ², Yi Zhao ², Yi Liu ² and Yubin Luo ², ¹Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China (People's Republic), ²Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China (People's Republic)
Background/Purpose: Intestinal microbial dysbiosis in patients with rheumatoid arthritis (RA) has raised the interest in studying the role of intestinal microbes in the pathogenesis of…
Abstract Number: 38 • 2019 ACR/ARP Annual Meeting
Autophagy Receptor Optineurin in Synovial Fibroblasts Plays a Protective Role Against Joint Destruction in Rheumatoid Arthritis
Wen Shi Lee¹, Masaru Kato ¹, Eri Sugawara ¹, Michihiro Kono ¹, Yuki Kudo ², Michihito Kono ³, Yuichiro Fujieda ¹, Toshiyuki Bohgaki ¹, Olga Amengual ¹, Kenji Oku ¹, Shinsuke Yasuda ¹ and Tatsuya Atsumi ⁴, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Hokkaido University Graduate School of Medicine, Sapporo, Japan, ³Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, ⁴Hokkaido University, Sapporo, Japan
Background/Purpose: Joint destructions progress throughout the course of rheumatoid arthritis (RA) without complete remission. Optineurin (OPTN) is an autophagy receptor with multiple functions related to…
Abstract Number: 39 • 2019 ACR/ARP Annual Meeting
Role of Sialic Acid in the Aggressive Phenotype of RA FLS
Patricia Oliveira¹, Brian Pedersen ¹, Nissi Varki ², Mark Fuster ¹, Gary Firestein ³ and Monica Guma ⁴, ¹UCSD, San Diego, CA, ²UCSD, San Diego, ³University of California, San Diego, San Diego, ⁴Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: A comprehensive epigenomic characterization of rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) has recently been described and can help to identify new critical pathways for…

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