ACR Meeting Abstracts

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  • Abstract Number: 2908 • 2019 ACR/ARP Annual Meeting

    Remission in Patients with Rheumatoid Arthritis Receiving Triple Therapy Compared to Biological Therapy – A Swedish Nationwide Register Study

    Hanna Källmark1, Jon Einarsson 2, Jan-Åke Nilsson 3 and Meliha Kapetanovic 2, 1Lund University, Lund, Sweden, 2Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Section of Rheumatology, Lund and Malmö, Sweden, Lund, Sweden, 3Skane University Hospital, Lund and Malmö, Sweden, Lund, Sweden

    Background/Purpose: Current treatment guidelines for rheumatoid arthritis (RA) recommend a treat-to-target approach with early treatment initiation of disease-modifying antirheumatic drugs (DMARDs), most commonly methotrexate (MTX),…
  • Abstract Number: 2909 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety of the Selective Interleukin-1 Receptor Associated Kinase 4 Inhibitor, PF-06650833, in Patients with Active Rheumatoid Arthritis and Inadequate Response to Methotrexate

    Spencer I Danto1, Negin Shojaee 1, Ravi Shankar P Singh 1, Zorayr Manukyan 2, Jessica Mancuso 1, Elena Peeva 1, Michael Vincent 1 and Jean Beebe 1, 1Pfizer Worldwide Research & Development, Immunology, and Inflammation Research Unit, Cambridge, MA, 2Pfizer Worldwide Research & Development, Immunology, and Inflammation Research Unit, ..

    Background/Purpose: Adaptive and innate immune pathways are involved in inflammation and pathogenesis of rheumatoid arthritis (RA). Toll-like receptor (TLR) stimulation activates the innate immune system,…
  • Abstract Number: 2910 • 2019 ACR/ARP Annual Meeting

    Improving the Efficiency of Clinical Trial Recruitment Using Electronic Health Record Data, Natural Language Processing, and Machine Learning

    Tianrun Cai1, Fiona Cai 2, Kumar Dahal 3, Chuan Hong 4 and Katherine Liao 1, 1Brigham and Women's Hospital, Boston, 2Stuyvesant High School, New York, 3Brigham and Women's Hospital, Boston, MA, 4Harvard Medical School, Boston, MA

    Background/Purpose: Efficiently identifying eligible patients is an important component of a successful clinical trial.  Billing codes from electronic health record (EHR) data are commonly used…
  • Abstract Number: 2911 • 2019 ACR/ARP Annual Meeting

    A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response – Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy

    Frances humby 1, Maya H. Buch 2, Patrick Durez 3, Myles Lewis 1, Michele Bombardieri 1, Hasan Rizvi 4, Stephen Kelly 4, Liliane Fosatti 1, Rebecca Hands 1, Giovanni Giorli 1, Arti Mahto 1, Carlomaurizio Montecucco 5, Bernard Lauwerys 6, Vasco Romao 7, Arthur Pratt 8, Serena Bugatti 9, Nora Ng 10, Felice Rivellese 1, Pauline Ho 11, Mattia Bellan 12, Mattia Congia 13, Patrick Verschueren 14, Pier Paolo Sainaghi 12, Nagui Gendi 15, Bhaskar Dasgupta 16, Alberto Cauli 17, Piero Reynolds 18, Juan Cañete 19, Robert J. Moots 20, Peter Taylor 21, Christopher Edwards 22, John Isaacs 8, Peter Sasieni 23, João Eurico Fonseca 24, Ernest Choy 25 and Costantino Pitzalis26, 1Queen Mary University of London, London, United Kingdom, 2University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 3Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, UCL Saint-Luc, Brussels, Belgium, 4Barts Health NHS Trust, London, United Kingdom, 5Department of Rheumatology, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Pavia, Italy, Pavia, Italy, 6University of Louvain, Louvain, Belgium, 7University of Lisbon, Lisbon, Portugal, 8University of Newcastle, Newcastle, United Kingdom, 9University of Pavia, Pavia, Italy, 10Guys and St Thomas NHS Trust, London, United Kingdom, 11University of Manchester, Manchester, United Kingdom, 12University of Novara, Novara, Italy, 13University of Cagliari, Cagliari, Italy, 14University of Leuven, Leuven, Belgium, 15Basildon Hospital NHS Trust, Basildon, United Kingdom, 16Southend University Hospital, NHS Foundation Trust, Westcliff-on-Sea, United Kingdom, 17Rheumatology Unit, University Clinic AOU and University of Cagliari, Cagliari, Italy, 18Homerton University NHS Trust, London, United Kingdom, 19Rheumatology Department, Hospital Clínic and IDIBAPS,, Barcelona, Spain, 20Institute of Ageing and Chronic Disease, Liverpool, United Kingdom, 21University of Oxford, Oxford, United Kingdom, 22University of Southampton, Southampton, United Kingdom, 23Kings College London, London, United Kingdom, 24Rheumatology and Bone Diseases Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte; Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa; Centro Académico de Medicina de Lisboa; Lisbon, Portugal., Lisbon, Portugal, 25Cardiff University School of Medicine, Cardiff, United Kingdom, 26Centre for Experimental Medicine & Rheumatology, Queen Mary University of London, London, United Kingdom

    Background/Purpose: Although biologic therapies have transformed the outlook for rheumatoid arthritis (RA), the lack of a major treatment response in over 50% of patients, the…
  • Abstract Number: 2912 • 2019 ACR/ARP Annual Meeting

    Predictive Factors for Treatment Related Mortality and Event-Free Survival After Autologous Hematopoietic Stem Cell Transplantation for Systemic Sclerosis: Results of a Long Term Follow-up Multi-centre Study

    Sandra van Bijnen 1, Maaike Boonstra 2, Els van den Ende 3, Lucia Kroft 2, Bram Geurts 1, Miranda Snoeren 1, Anne Schouffoer 2, Julia Spierings 4, Jacob van Laar 5, Thomas Huizinga 6, Alexandre Voskuyl 7, Walter van der Velden 1, Frank van den Hoogen 3, Jeska de Vries-Bouwstra 6 and Madelon Vonk8, 1Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands, 2Leiden University Medical Centre, Leiden, Zuid-Holland, Netherlands, 3Department of Rheumatology, Radboud University Medical Center, Nijmegen, Gelderland, Netherlands, 4Utrecht Medical Centre, Utrecht, Utrecht, Netherlands, 5UMC Utrecht, Department of Rheumatology & Clinical Immunology, Utrecht, The Netherlands, Utrecht, Netherlands, 6Leiden University Medical Center, Leiden, Netherlands, 7Amsterdam Univiversity Medical Centre, Amsterdam, Noord-Holland, Netherlands, 8Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen, Gelderland, Netherlands

    Background/Purpose: Autologous hematopoietic stemcell transplantation (HSCT) has shown to improve survival of SSc patients with poor prognosis, but is hampered by treatment related mortality (TRM).…
  • Abstract Number: 2913 • 2019 ACR/ARP Annual Meeting

    Serum Interferon Score Predicts Clinical Outcome at 12 Months in Diffuse Cutaneous Systemic Sclerosis as Measured by Global Ranked Composite Score (GRCS) and Composite Response Index in SSc (CRISS)

    Antonio Carriero 1, Giuseppina Abignano 2, MIchelle Hutchinson 3, Karri Ballard 4 and Francesco Del Galdo5, 1University of Leeds, Leeds, England, United Kingdom, 23Rheumatology Institute of Lucania (IReL) and University of Leeds, Leeds, United Kingdom, 3University of Leeds and LTHT NIHR Biomedical Research Centre, Leeds, England, United Kingdom, 4Myriad RBM, austin, TX, 5University of Leeds and LTHT NIHR Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is a highly heterogeneous disease orphan of effective disease modifying agents. The diffuse cutaneous clinical subset (dcSSc) is currently targeted in…
  • Abstract Number: 2914 • 2019 ACR/ARP Annual Meeting

    Predictors to Develop Definite Systemic Sclerosis (SSc): Results from an International Multicentre Study on Very Early DiagnOsis of Systemic Sclerosis (VEDOSS)

    Silvia Bellando-Randone1, Gemma Lepri 1, Dorte Huscher 2, Tunde Minier 3, Serena Guiducci 4, Cosimo Bruni 1, Laszlo Czirjak 3, Maurizio Cutolo 5, Vanessa Smith 6, Jerome Avouac 7, Daniel Furst 8, Yannick Allanore 7, Oliver Distler 9 and Marco Matucci-Cerinic 10, 1Dept. Experimental and Clinical Medicine, Division of Rheumatology, Azienda Ospedaliera Universitaria Careggi – University of Florence, Florence, Italy, 2Charitè-Universitaetsmedizin Berlin, Berlin, Germany, 3University of Pecs, Pecs, Hungary, 4Dept. of Clinical and Experimental Medicine, Section of Rheumatology, University of Florence, Italy, Florence, Italy, 5Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, 6Dept. of Rheumatology, Ghent University Hospital, Ghent, Belgium; Dept. of Internal Medicine, Ghent University, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium, Gent, Belgium, 7Paris Descartes University, Cochin Hospital, Rheumatology department, Paris, France, 8University of California, Los Angeles, CA, 9Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 10University of Florence, Department of Medicine, Florence, Italy, Florence, Italy

    Background/Purpose: The very early diagnosis of SSc is a challenge today. The aim of the VEDOSS project was to study in an at-risk population, the…
  • Abstract Number: 2915 • 2019 ACR/ARP Annual Meeting

    Machine-learning Classification Identifies a Subset of Patients That Improve on Abatacept via Modulation of a CD28-Related Pathway

    Bhaven Mehta 1, Jennifer Franks 1, Yiwei Yuan 2, Yue Wang 1, Veronica Berrocal 3, Tammara Wood 1, Cathie Spino 4, David Fox 5, Dinesh Khanna 6 and Michael Whitfield7, 1Geisel School of Medicine at Dartmouth, Hanover, NH, 2Geisel School of Medicine at Dartmouth, Hanover, 3Department of Biostatistics, School of Publich Health, University of Michigan, Ann Arbor, MI, 4University of Michigan, Ann Arbor, MI, 5University of Michigan, Ann Arbor, 6Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, 7Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hannover, NH

    Background/Purpose: We analyzed a phase 2 study designed to assess the efficacy of abatacept in patients with diffuse Systemic Sclerosis (SSc). In this work, we…
  • Abstract Number: 2916 • 2019 ACR/ARP Annual Meeting

    Ancestry-Specific Classical HLA Alleles Define Phenotypic Subsets in the African American Scleroderma Population

    Pravitt Gourh 1, Sarah Safran2, Steven Boyden 3, Ami Shah 4, Maureen Mayes 5, Ayo Doumatey 6, Amy Bentley 6, Daniel Shriner 6, Robyn Domsic 7, Thomas Medsger Jr 8, Paula Ramos 9, Richard Silver 10, Virginia Steen 11, John Varga 12, Vivien Hsu 13, Lesley Saketkoo 14, Elena Schiopu 15, Dinesh Khanna 16, Jessica Gordon 17, Brynn Kron 18, Lindsey Criswell 19, Heather Gladue 20, Chris Derk 21, Elana Bernstein 22, S Louis Bridges 23, Victoria Shanmugam 24, Kathleen Kolstad 25, Lorinda Chung 26, Suzanne Kafaja 27, Reem Jan 28, Marcin Trojanowski 29, Avram Goldberg 30, Benjamin Korman 31, Peter Steinbach 32, Settara Chandrasekharappa 6, James Mullikin 6, Adebowale Adeyemo 6, Charles Rotimi 6, Frederick Wigley 33, Daniel Kastner 34, Francesco Boin 35, Elaine Remmers 6 and Theresa Alexander 36, 1National Institutes of Rheumatology, Bethesda, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, 3University of Utah, SALT LAKE CITY, UT, 4Johns Hopkins Hospital, Baltimore, MD, 5Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, 6National Human Genome Research Institute (NHGRI), Bethesda, MD, 7University of Pittsburgh, Pittsburgh, PA, 8University of Pittsburg School of Medicine, Pittsburg, PA, 9Medical University of South Carolina, Charleston, 10Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 11Georgetown University, Washington, D.C., USA, Georgetown, 12Northwestern University, Chicago,, IL, 13Rutgers- RWJ Medical School, SOUTH PLAINFIELD, NJ, 14New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans; Tulane University School of Medicine, University Medical Center – Comprehensive Pulmonary Hypertension Center, USA, New Orleans, 15Department of Rheumatology, University of Michigan, Ann Arbor, 16Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, 17Hospital for Special Surgery, New York, NY, 18University of California San Francisco, San Francisco, CA, 19University of California, San Francisco, San Francisco, 20Arthritis & Osteoporosis Consultants Of The Carolinas, Charlotte, NC, 21University of Pennsylvania, Philadelphia, PA, 22Division of Rheumatology, Columbia University, New York, NY, 23University of Alabama at Birmingham, Birmingham, 24George Washington University, Georgetown, DC, 25Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, 26Stanford University, Palo Alto, CA, 27Department of Medicine. Rheumatology Division. UCLA, Los Angeles, CA, 28University of Chicago Pritzker School of Medicine, Chicago, IL, 29Boston University Medical Center, Boston, MA, 30New York University Langone Medical Center, New York, NY, 31University of Rochester Medical Center, Rochester, NY, 32Center for Molecular Modeling, Center for Information Technology, National Institutes of Health, Bethesda, MD, 33Johns Hopkins University, Division of Rheumatology, Baltimore, 34National Institutes of Health, Bethesda, MD, 35UCSF, San Francisco, CA, 36University of Maryland, College Park, MD

    Background/Purpose: Systemic sclerosis (SSc), or scleroderma, is a heterogeneous disease that is divided into limited cutaneous (lcSSc) and diffuse cutaneous (dcSSc) forms based on the…
  • Abstract Number: 2917 • 2019 ACR/ARP Annual Meeting

    Geographic Disparities in Systemic Sclerosis Mortality in the United States: 1999 to 2017

    Alicia Rodriguez-Pla1 and Robert W Simms 2, 1University of Arizona/Banner Health Medical Center, Tucson, AZ, 2Boston University, Boston, MA

    Background/Purpose: Population mortality studies in the United States have previously reported a progressive increase in the scleroderma (SSc) mortality rates from 1959 to 2002. Identification…
  • Abstract Number: 2918 • 2019 ACR/ARP Annual Meeting

    Metabolic Signatures of Pathogenic T Cells in Medium and Large Vessel Vasculitis

    Mitsuhiro Akiyama 1, Hui Zhang 1, Ryu Watanabe 1, Toshihisa Maeda 2, Gerald Berry 1, Jorg Goronzy 1 and Cornelia Weyand1, 1Stanford University, Stanford, CA, 2Matsubara Mayflower Hospital, Kobe, Japan

    Background/Purpose: Giant cell arteritis (GCA) is an autoimmune vasculitis that causes aortic arch syndrome, blindnesss, and stroke. Embedded in granulomatous infiltrates, CD4 T cells persist…
  • Abstract Number: 2919 • 2019 ACR/ARP Annual Meeting

    Endothelial Protein C Receptor and Scavenger Receptor Class B Type 1 Negatively Regulate Vascular Inflammation and Are Major Autoantigens in Takayasu Arteritis

    Tomoyuki Mutoh1, Tsuyoshi Shirai 1, Tomonori Ishii 2, Yuko Shirota 3, Hideo Harigae 1 and Hiroshi Fujii 1, 1Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 2Tohoku University Hospital, Sendai, Japan, 3Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan

    Background/Purpose: Takayasu arteritis (TAK) is a chronic vasculitis which predominantly affects large vessels. Although anti-endothelial cell antibodies (AECA) had been reported to be involved in…
  • Abstract Number: 2920 • 2019 ACR/ARP Annual Meeting

    Comparison of Arterial Patterns of Disease in Takayasu’s Arteritis and Giant Cell Arteritis

    K Bates Gribbons1, Cristina Ponte 2, Anthea Craven 3, David Cuthbertson 4, Simon Carette 5, Gary S. Hoffman 6, Nader A. Khalidi 7, Curry L. Koening 8, Carol Langford 9, Kathleen Maksimowicz-McKinnon 10, Carol A. McAlear 11, Paul Monach 12, Larry Moreland 13, Christian Pagnoux 14, Kaitlin Quinn 15, Joanna Robson 16, Philip Seo 17, Antoine Sreih 18, Ravi Suppiah 19, Kenneth Warrington 20, Steven Ytterberg 21, Raashid Luqmani 3, Richard Watts 22, Peter Merkel 18 and Peter C. Grayson 23, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Department of Rheumatology, Hospital de Santa Maria, Lisbon, Portugal, 3University of Oxford, Oxford, United Kingdom, 4University of South Florida, Tampa, FL, 5Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, Canada, 6Cleveland Clinic Foundation, Cleveland, OH, 7McMaster University, Hamilton, ON, Canada, 8University of Utah Hospital, Salt Lake City, UT, 9Cleveland Clinic, Cleveland, OH, 10Henry Ford Hospital, Wayne State University, Detroit, MI, 11University of Pennsylvania - VCRC Project Manager, Philadelphia, PA, 12Brigham and Women's Hospital, Boston, MA, 13University of Pittsburgh, PITTSBURGH, PA, 14Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, 15Georgetown University Hospital/National Institutes of Health, Washington, DC, 16Faculty of Health and Applied Sciences, University of the West of England, Bristol, United Kingdom, 17Johns Hopkins Medicine, Baltimore, MD, 18University of Pennsylvania, Philadelphia, PA, 19Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, 20Mayo Clinic Rochester, Rochester, MN, 21Mayo Clinic College of Medicine, Rochester, MN, 22Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 23National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health, Bethesda, MD, Bethesda, MD

    Background/Purpose: Current classification criteria differentiate between Takayasu’s arteritis (TAK) and giant cell arteritis (GCA), the two most common forms of large-vessel vasculitis, based primarily on…
  • Abstract Number: 2921 • 2019 ACR/ARP Annual Meeting

    High Resolution 3D Fast Spin-Echo T1 Black-Blood Imaging for the Diagnosis of Giant Cell Arteritis

    Christine rodriguez 1, Wagih Ben Hassen 1, Pierre Seners 2, Catherine Oppenheim 1 and Alexis Régent3, 1Département d’imagerie, pôle Neuro Sainte Anne, GHT Paris – Psychiatrie & Neurosciences, 1 rue Cabanis, 75014 Paris, Paris, Ile-de-France, France, 2Service de neurologie, pôle Neuro Sainte Anne, GHT Paris – Psychiatrie & Neurosciences, 1 rue Cabanis, 75014 Paris, Paris, Ile-de-France, France, 3National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France

    Background/Purpose: Giant cell arteritis (GCA) is the most common form of vasculitis of large arteries affecting people older than 50 years. Temporal artery biopsy (TAB)…
  • Abstract Number: 2922 • 2019 ACR/ARP Annual Meeting

    Imaging Acquisition Technique Influences Interpretation of Positron Emission Tomography Vascular Activity in Large-Vessel Vasculitis

    Kaitlin Quinn1, Joel S. Rosenblum 2, Casey A. Rimland 3, K Bates Gribbons 4, Mark A. Ahlman 5 and Peter C. Grayson 6, 1Georgetown University Hospital/National Institutes of Health, Washington, DC, 2National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, Bethesda, MD, 3National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, Chapel Hill, NC, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 5Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health, Bethesda, MD, Bethesda, MD

    Background/Purpose: 18F-flurodeoxyglucose (FDG) positron emission tomography (PET) is one of several imaging modalities used in the assessment of patients with large-vessel vasculitis (LVV).  Conventionally PET…
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