Abstracts Archive - Page 944 of 2425 - ACR Meeting Abstracts

Abstract Number: 2786 • 2019 ACR/ARP Annual Meeting
Renal Histopathological Classifications Predict the Renal Outcomes of Plasma Exchange-Treated ANCA-Associated Vasculitides with Renal Failure
Dorian Nezam ¹, Pauline Morel ¹, Stanislas Faguer ², Alexandre Karras ³, Julien Aniort ⁴, Dimitri Titeca-Beauport ⁵, Justine Solignac ⁶, Didier Ducloux ⁷, Rafik Mesbah ⁸, Pierre-Louis Carron ⁹, Cédric Rafat ¹⁰, Pierre Gobert ¹¹, Vincent Audard ¹², Séverine Beaudreuil ¹³, François Maurier ¹⁴, Nihal Martis ¹⁵, Aurélien Tiple ⁴, Stéphane Bally ¹⁶, Aurélie Hummel ¹⁷, Claire de Moreuil ¹⁸, Tiphaine Goulenok ¹⁷, Dominique Nochy ¹⁹, Noémie Jourde-Chiche ²⁰, Alexis Régent ²¹, Loic Guillevin ²¹ and Benjamin Terrier²¹, ¹Cochin Hospital, Paris, France, ²CHU Toulouse, Toulouse, France, ³Paris HEGP, Paris, France, ⁴CHU, Clermont-Ferrand, France, ⁵CHU, Amiens, France, ⁶CHU, Marseille, France, ⁷CHU, Besancon, France, ⁸CH, Boulogne sur Mer, France, ⁹Grenoble, Grenoble, France, ¹⁰Tenon Hospital, Paris, France, ¹¹Clinique Rhone Durance, Avignon, France, ¹²Henri Mondor Hospital, Créteil, France, ¹³Bicetre Hospital, Le Kremlin Bicetre, France, ¹⁴Service de Médecine Interne, Hôpital Belle Isle, Metz, Metz, France, ¹⁵CHU, Nice, France, ¹⁶CH, Chambery, France, ¹⁷APHP, Paris, France, ¹⁸CHU Brest, Brest, France, ¹⁹HEGP Hospital, Paris, France, ²⁰APHM, Marseille, Marseille, France, ²¹National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France
Background/Purpose: ANCA-associated vasculitides (AAVs) are the most frequent cause of rapidly progressive glomerulonephritis (RPGN), for which the major prognostic issue is the risk of developing…
Abstract Number: 2787 • 2019 ACR/ARP Annual Meeting
Predictors of Renal Involvement in ANCA-Associated Vasculitis
Andreas Kronbichler ¹, Jae Il Shin ², Keum Hwa Lee ², Daiki Nakagomi ³, Luis Quintana ⁴, Martin Busch ⁵, Anthea Craven ⁶, Raashid Luqmani ⁶, Peter Merkel⁷, Gert Mayer ¹, David Jayne ⁸ and Richard Watts ⁹, ¹Medical University Innsbruck, Innsbruck, Austria, ²Yonsei University College of Medicine, Seoul, Republic of Korea, ³University of Yamanashi, Yamanashi, Japan, ⁴University of Barcelona, Barcelona, Spain, ⁵University of Jena, Jena, Germany, ⁶University of Oxford, Oxford, United Kingdom, ⁷University of Pennsylvania, Philadelphia, PA, ⁸Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Cambridge, United Kingdom, ⁹University of East Anglia, Norwich, United Kingdom
Background/Purpose: Renal involvement in the context of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is associated with significant morbidity and higher mortality rates. This study examined…
Abstract Number: 2788 • 2019 ACR/ARP Annual Meeting
Longitudinal Changes in the Nasal Microbiome and Disease Activity in Patients with Granulomatosis with Polyangiitis
Rennie Rhee¹, Antoine Sreih ², Jung-Jin Lee ³, Kyle Bittinger ³, Lisa Mattei ³, Ronald Collman ⁴ and Peter Merkel ², ¹University of Pennsylvania, Division of Rheumatology, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Children's Hospital of Philadelphia, Philadelphia, ⁴University of Pennsylvania, Philadelphia
Background/Purpose: Microbial organisms have been theorized to contribute to disease activity in granulomatosis with polyangiitis (GPA) but little is known about what changes occur in…
Abstract Number: 2789 • 2019 ACR/ARP Annual Meeting
Neutrophil Extracellular Traps Induce Tissue-Invasive Macrophages in Granulomatosis with Polyangiitis Dominated by Ear, Nose and Throat Manifestations
Mitsuhiro Akiyama¹, Nour Ibrahim ², Markus Zeisbrich ¹, Peter Hwang ¹, Jorg Goronzy ¹ and Cornelia Weyand ¹, ¹Stanford University, Stanford, CA, ²Stanford University, Stanford University
Background/Purpose: Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis characterized by acute and chronic tissue destruction in the nose, sinuses, lungs and kidneys. In…
Abstract Number: 2790 • 2019 ACR/ARP Annual Meeting
Platelet Mediates Neutrophil Extracellular Traps Formation via TLR Signaling in ANCA-associated Vasculitis
Kotaro Matsumoto¹, Hidekata Yasuoka ², Katsuya Suzuki ¹ and Tsutomu Takeuchi ¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Fujita Health University School of Medicine, Shinjuku-ku, Aichi, Japan
Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease that affects small- to medium-sized blood vessels and causes vascular inflammation and multiple organ…
Abstract Number: 2791 • 2019 ACR/ARP Annual Meeting
Treatment Response Criteria for Anti-neutrophil Cytoplasmic Antibodies (ANCA)-vasculitis: Results of a Scoping Review
Sara Monti¹, Kaitlin Quinn ², Robin Christensen ³, Alfred Mahr ⁴, Christian Pagnoux ⁵, Carol Langford ⁶, David Jayne ⁷, Peter Merkel ⁸ and Gunnar Tomasson ⁹, ¹University of Pavia, Pavia, Italy, ²Georgetown University Hospital/National Institutes of Health, Washington, DC, ³Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital & Department of Rheumatology, Institute of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark, ⁴Hospital Saint-Louis, University Paris Diderot, Paris, France, ⁵Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ⁶Cleveland Clinic, Cleveland, OH, ⁷Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Cambridge, United Kingdom, ⁸University of Pennsylvania, Philadelphia, PA, ⁹Faculty of Medicine, University of Iceland and Landpitali University Hospital, Reykjavik, Iceland
Background/Purpose: A comprehensive assessment of outcome measures to assess response to treatment in ANCA-associated vasculitis (AAV) is necessary to implement.Methods: We performed a scoping review…
Abstract Number: 2792 • 2019 ACR/ARP Annual Meeting
The Need for Personalized, Non-Pharmacological Intervention Programmes in Autoimmune Connective Tissue Disorders: Results of a EULAR-Funded Scoping Review with a Nested, Descriptive Meta-Analysis
Valentin Ritschl¹, Ricardo Ferreira ², Rúben Fernandes ², Eduardo Santos ², Essi Juutila ³, Erika Mosor ¹, Kim Fligelstone ⁴, Helena Gaspar ⁵, Linda Schraven ⁶, Judy Ammerlaan ⁷, Georg Stummvoll ⁸, Maria João Salvador ², Janet Poole ⁹, Cornelia van den Ende ¹⁰, Carina Boström ¹¹ and Tanja Stamm ¹, ¹Medical University of Vienna, Vienna, Austria, ²Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ³Metropolia University of Applied Sciences, Helsinki, Finland, ⁴Federation of European Scleroderma Associations, Tournai, Belgium, ⁵Portuguese League Against Rheumatic Diseases, Portugal, Portugal, ⁶Federation of European Scleroderma Associations, Sweden, Sweden, ⁷University Medical Centre, Utrecht, Netherlands, ⁸Klinikum Malcherhof Baden, Baden, Austria, ⁹University of New Mexico, Albuquerque, NM, ¹⁰Sint Maartenskliniek Nijmegen, Nijmegen, Netherlands, ¹¹Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Autoimmune Connective Tissue Disorders (CTDs), including Mixed Connective Tissue Disorders (MCTD), systemic sclerosis (SSc) and systemic lupus erythematous (SLE) can lead to Raynaud phenomenon,…
Abstract Number: 2793 • 2019 ACR/ARP Annual Meeting
Methotrexate Intolerance: A Qualitative Descriptive Study of the Adult Rheumatoid Arthritis Patients’ Perspectives
Elizabeth Salt¹, Mary Kay Rayens ², Leslie Crofford ³ and Jamie Studts ², ¹University of Kentucky, Lexington, KY, ²University of Kentucky, Lexington, ³Vanderbilt University, Nashville
Background/Purpose: An estimated 11% to 33% of persons taking methotrexate for rheumatoid arthritis (RA) are reported to be at least moderately intolerant to this medication.…
Abstract Number: 2794 • 2019 ACR/ARP Annual Meeting
Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project
Adam Goode¹, Rebecca Cleveland ², David Hu ³, Steven George ⁴, Virginia Byers Kraus ⁵, Todd Schwartz ⁶, Richard Gracely ⁷, Louis DeFrate ⁸, Joanne Jordan ⁹ and Yvonne Golightly ¹⁰, ¹Duke University, Department of Orthopedic Surgery, Duke Clinical Research Institute, and Department of Population Health Sciences, Durham, NC, ²Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Center, University of North Carolina - Chapel Hill, Chapel Hill, NC, ⁴Duke University, Department of Orthopedic Surgery and Duke Clinical Research Institute, Durham, NC, ⁵Duke University, Department of Orthopedic Surgery, Duke Molecular Physiology Laboratory, Durham, NC, ⁶University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁷Department of Endodontics, Adams School of Dentistry, University of North Carolina, Chapel Hill, Chapel Hill, NC, ⁸Duke University, Department of Orthopedic Surgery, Department of Mechanical Engineering and Materials Science and Department of Biomedical Engineering, Durhham, NC, ⁹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ¹⁰University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: Our aim was to determine whether demographics, clinical characteristics or appendicular joint osteoarthritis predict the incidence and worsening of lumbar spine disc space narrowing…
Abstract Number: 2795 • 2019 ACR/ARP Annual Meeting
Patterns of Ambulatory Health Care Utilization and Medication Adherence Among Transition-Age Youth with Systemic Lupus Erythematosus
Joyce Chang¹, Andrea Knight ² and Erica Lawson ³, ¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ³University of California San Francisco Benioff Children’s Hospital, San Francisco, CA
Background/Purpose: Youth with child-onset systemic lupus erythematosus (SLE) transitioning from pediatric to adult health care systems may be at higher risk for poor outcomes than…
Abstract Number: 2796 • 2019 ACR/ARP Annual Meeting
The Association Between Omega-3 Supplementation and Disease Activity in a Rheumatoid Arthritis (RA) Observational Cohort
Adel Andemeskel¹, Vivi Feathers ¹, Christine Iannaccone ¹, Jing Cui ¹ and Nancy Shadick ¹, ¹Brigham and Women's Hospital, Boston, MA
Background/Purpose: Omega-3 supplementation is one of a few complementary and alternative medicine (CAM) therapies that has shown promise in improving RA symptoms through small, randomized…
Abstract Number: 2797 • 2019 ACR/ARP Annual Meeting
Exploring Possible Predictors of Physical Activity in Knee Replacement Patients
Brandy Tanenbaum ¹, Aileen Davis², Deborah Kennedy ³ and Junaid Bhatti ⁴, ¹Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ²Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Sunnybrook Health Sciences Centre - Holland Bone and Joint Program, Toronto, ON, Canada, ⁴Institute of Clinical Evaluative Studies, Toronto, ON, Canada
Background/Purpose: Following total knee replacement (TKR), patients do not achieve recommended physical activity for overall health. The implications of physical inactivity on individuals and the…
Abstract Number: 2798 • 2019 ACR/ARP Annual Meeting
Trajectories of Opioid Filling Patterns After Total Knee Replacement
Chandrasekar Gopalakrishnan ¹, Jessica Franklin ², Yinzhu Jin ³, Daniel Solomon ⁴, Jeffrey Katz ⁵, Yvonne Lee ⁶, Patricia Franklin ⁶, Joyce Lii ², Rishi Desai ⁷ and Seoyoung C. Kim³, ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Harvard Medical School, Boston, ³Brigham and Women’s Hospital and Harvard Medical School, Boston, ⁴Brigham and Women´s Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, ⁵Brigham and Women's Hospital/Harvard Medical School, Boston, ⁶Northwestern University Feinberg School of Medicine, Chicago, ⁷Brigham and Women's hospital, Boston
Background/Purpose: Patients undergoing total knee replacement (TKR) are at increased risk of persistent opioid use and opioid dependence. Group-based trajectory models can identify clusters of…
Abstract Number: 2799 • 2019 ACR/ARP Annual Meeting
Does Early Anterior Cruciate Ligament Reconstruction Prevent Further Meniscal Damage? Secondary Analysis of a Randomized Controlled Trial
Barbara Snoeker ¹, Frank Roemer ², Aleksandra Turkiewicz ¹, Stefan Lohmander ³, Richard Frobell ¹ and Martin Englund¹, ¹Lund University, Lund, Sweden, ²University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden, Lund, Sweden
Background/Purpose: It has been suggested that recurrent instability episodes in a non-reconstructed anterior cruciate ligament (ACL) injured knee increase the risk for an incident meniscal…
Abstract Number: 2800 • 2019 ACR/ARP Annual Meeting
Five Year Structural Changes in Patients with Meniscal Tear and Osteoarthritis from an RCT of Arthroscopic Partial Meniscectomy vs. Physical Therapy
Swastina Shrestha¹, Jeffrey Katz ², Elena Losina ³ and Jamie Collins ⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital/Harvard Medical School, Boston, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston
Background/Purpose: Meniscal tear is an independent risk factor of structural progression in OA; Arthroscopic partial meniscectomy (APM) is also associated with progression, though it is…

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