Abstracts Archive - Page 926 of 2425 - ACR Meeting Abstracts

Abstract Number: 2515 • 2019 ACR/ARP Annual Meeting
Disease Activity Influences Cardiovascular Risk Reclassification Based on Carotid Ultrasound in Patients with Psoriatic Artrhitis
Natalia Palmou-Fontana¹, DAVID MARTINEZ-LOPEZ ², ALFONSO CORRALES ³, Fernanda Genre ⁴, SUSANA ARMESTO ⁵, MARCOS GONZALEZ ⁶, PATRICIA VICENTE-GOMEZ ⁷, JAVIER GARCIA-FERNANDEZ ⁶, VIRGINIA PORTILLA- GONZALEZ ⁵, MONICA PEREZ-ANDRES ⁵, Mónica Calderón-Goercke ⁸, DIANA PRIETO- PENA ¹, Ricardo Blanco ⁹, JOSE LUIS HERNANDEZ ¹⁰, MIGUEL ANGEL GONZALEZ-GAY ¹¹ and Iván Ferraz-Amaro ¹², ¹Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ²Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, ³Universitary Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, ⁴Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ⁵UNIVERSITARY HOSPITAL MARQUES DE VALDECILLA, Santander, Cantabria, Spain, ⁶UNIVERSITARY HOSPITAL MARQUES DE VALDECILLA, Santander, Cantabria, Spain, ⁷Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ⁸Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, ⁹Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, ¹⁰UNIVERSITARY HOSPITAL MARQUES DE VALDECILLA, Santander, ¹¹UNIVERSITARY HOSPITAL MARQUES DE VALDECILLA, Santander, ¹²Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain, Tenerife, Spain
Background/Purpose: Objectives. The addition of carotid ultrasound CU into composite cardiovascular risk (CVR) scores has been found useful in the identification of high CVR in…
Abstract Number: 2516 • 2019 ACR/ARP Annual Meeting
Development of a Biomarker Panel for Prediction of Disease Flares in Systemic Lupus Erythematosus
Serena Fasano¹, Luciana Pierro ¹, Alessia Borgia ¹, Melania Coscia ¹, Ranieri Formica ¹, antonella Riccardi ¹ and Francesco Ciccia ¹, ¹University of Campania L. Vanvitelli, Naples, Italy
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a relapsing-remitting course. Uncontrolled lupus flares might lead to organ damage. The routinely performed biomarkers…
Abstract Number: 2517 • 2019 ACR/ARP Annual Meeting
Hydroxychloroquine Is a Modifiable Predictor of Durable LLDAS
Hakan Babaoglu¹, Jessica Li ², Daniel Goldman ³, Laurence Magder ⁴ and Michelle Petri ², ¹Gazi University School of Medicine, Ankara, Turkey, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: The Lupus Low Disease Activity State (LLDAS), a potential treat to target goal in systemic lupus erythematosus (SLE), has been found to correlate with…
Abstract Number: 2518 • 2019 ACR/ARP Annual Meeting
Time to Lupus Low Disease Activity State: Role of African-American Ethnicity
Hakan Babaoglu¹, Jessica Li ², Daniel Goldman ³, Laurence Magder ⁴ and Michelle Petri ², ¹Gazi University School of Medicine, Ankara, Turkey, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Lupus Low Disease Activity State (LLDAS) is a potential treat to target goal in systemic lupus erythematosus (SLE). It is well established that SLE…
Abstract Number: 2519 • 2019 ACR/ARP Annual Meeting
Cenerimod, a Potent, Selective and Orally Active Sphingosine 1-phosphate Receptor 1 Modulator, Reduced Blood Antibody-secreting Cells in Patients with SLE
Daniel Strasser ¹, Virginie Sippel ¹, Ursula Grieder ¹, Andrea Kieninger-Graefitsch ², Gabin Pierlot ¹, Hervé Farine ¹, Paulina Kulig ¹, Geoffroy Bourquin ¹, Marcel Keller ¹, Peter Groenen ¹, Marten Trendelenburg ² and Mark Murphy¹, ¹Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland, ²University Hospital Basel, Basel, Switzerland
Background/Purpose: SLE is an autoimmune disease driven by autoreactive T and B lymphocytes. Lymphocytes infiltrate self-antigen expressing tissues, in which tertiary lymphoid structures are often…
Abstract Number: 2520 • 2019 ACR/ARP Annual Meeting
Treatment of SLE Patients with the Immunoproteasome Inhibitor KZR-616: Results from the First 3 Cohorts of an Open-Label Phase 1b Dose Escalation Trial
Richard Furie¹, Darrin Bomba ², Maria Dall'Era ³, Amber Khan ⁴, Miguel Soneira ⁴, Janet Anderl ², Jinhai Wang ², Christopher Kirk ² and Niti Goel ⁵, ¹Northwell Health, Great Neck, NY, ²Kezar Life Sciences, SOUTH SAN FRANCISCO, CA, ³University of California, San Francisco, San Francisco, CA, ⁴Accurate Clinical Research, Houston, TX, ⁵Kezar Life Sciences, Duke University School of Medicine, South San Francisco, CA
Background/Purpose: Nonspecific proteasome inhibitors, eg, bortezomib (BTZ), target both the constitutive and immuno- proteasome and are approved for the treatment of multiple myeloma. While BTZ…
Abstract Number: 2521 • 2019 ACR/ARP Annual Meeting
Rituximab Treatment Is Not Associated with Increased Risk of Infection or Mortality in Refractory SLE Patients: Results from the British Isles Lupus Assessment Group Biologics Registry (BILAG-BR)
Stephen McDonald¹, Eoghan McCarthy ², Aysun Aksoy ³, Ben Parker ⁴ and Ian Bruce ⁵, ¹University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom; Manchester University Foundation Trust, The Kellgren Centre, Manchester, United Kingdom, Belfast, Northern Ireland, United Kingdom, ²Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, Manchester, England, United Kingdom, ³Marmara University Faculty of Medicine, Division of Internal Medicine, Department of Rheumatology, Istanbul, Turkey; University of Manchester, Division of Musculoskeletal and Dermatological Sciences, Manchester, United Kingdom, Istanbul, Istanbul, Turkey, ⁴University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom; Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, Manchester, United Kingdom, ⁵University of Manchester, Manchester, United Kingdom, Manchester, England, United Kingdom
Background/Purpose: Mortality in Systemic Lupus Erythematosus (SLE) is increased compared to the general population. We sought to investigate mortality rates and associated factors in a…
Abstract Number: 2522 • 2019 ACR/ARP Annual Meeting
Frequency and Early Prediction of Hydroxychloroquine Induced Retinopathy in SLE
Jessica Li¹, Daniel Goldman ² and Michelle Petri ¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: In 2016, the American Academy of Ophthalmology (AAO) published recommendations designed to reduce hydroxychloroquine induced retinopathy via early detection and reduction of hydroxychloroquine dosing…
Abstract Number: 2523 • 2019 ACR/ARP Annual Meeting
Contemporary Prescription Opioid Use and Predictors Among Patients with Systemic Lupus Erythematosus
April Jorge¹, Na Lu ² and Hyon K. Choi ¹, ¹Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hosptial, Boston, MA
Background/Purpose: SLE is a complex illness that can be associated with chronic pain. In recent years, an international opioid epidemic has become a major public…
Abstract Number: 2524 • 2019 ACR/ARP Annual Meeting
24-Month Outcomes Associated with Belimumab in Black/African-American Patients with Systemic Lupus Erythematosus in a Clinical Practice Setting in the United States
Christopher Collins ¹, Gail Kerr ², Joan Von Feldt ³, Bernie Rubin ⁴, Arie Katz ³, Vanessa Castellano ⁵, Jake Chung ⁴ and Christopher Bell⁵, ¹MedStar Washington Hospital Center, Department of Rheumatology, Washington, DC, ²Washington DC VA Medical Center, Georgetown and Howard Universities, Washington DC, DC, ³GSK, Philadelphia, PA, ⁴GSK, Phildelphia, PA, ⁵GSK, Research Triangle Park, NC
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by diverse clinical manifestations and organ damage accrual. Black/African-American (B/AA) race is associated with…
Abstract Number: 2525 • 2019 ACR/ARP Annual Meeting
Within-Trial Cost Analysis of Flares from a Phase 3 Clinical Trial Evaluating Subcutaneous Belimumab for the Treatment of Systemic Lupus Erythematosus
Tasneem Lokhandwala ¹, Binglin Yue ¹, Anna Coutinho ¹ and Christopher Bell², ¹Xcenda AmerisourceBergen, Palm Harbour, FL, ²GSK, Research Triangle Park, NC
Background/Purpose: SLE is a chronic autoimmune disease characterized by diverse clinical manifestations and flares associated with organ damage, resulting in substantial short-term management costs. Results…
Abstract Number: 2526 • 2019 ACR/ARP Annual Meeting
Antimalarial Agents Improve Physical Functioning in Patients with Systemic Lupus Erythematosus
Ioannis Parodis¹, Sofia Soukka ¹, Alvaro Gomez ¹, Yvonne Enman ¹, Petter Johansson ¹, Sharzad Emamikia ¹ and Katerina Chatzidionysiou ¹, ¹Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Patients with systemic lupus erythematosus (SLE) suffer an impaired health-related quality of life (HRQoL), and the majority of them experience fatigue as a major…
Abstract Number: 2527 • 2019 ACR/ARP Annual Meeting
Cytokine and Autoantibody Profiles During Treatment with Belimumab in Patients with Systemic Lupus Erythematosus
Ioannis Parodis¹, Emil Åkerström ¹, Christopher Sjöwall ², Azita Sohrabian ³, Andreas Jönsen ⁴, Alvaro Gomez ¹, Martina Frodlund ², Agneta Zickert ¹, Anders Bengtsson ⁴, Johan Rönnelid ³ and Iva Gunnarsson ¹, ¹Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden, ³Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁴Lund University, Lund, Sweden
Background/Purpose: The anti-BAFF monoclonal belimumab is approved for the treatment of systemic lupus erythematosus (SLE) since 2011. Effects of belimumab on anti-double stranded (ds)DNA levels,…
Abstract Number: 2528 • 2019 ACR/ARP Annual Meeting
Effect of Additional Administration of HCQ on Pro-inflammatory Cytokine Expression, Especially in Lupus Nephritis
Risa Wakiya¹, Kiyo Ueeda ², Hiromi Shimada ², Shusaku Nakashima ¹, Mai Mahmoud Fahmy Mansour ¹, Mikiya Kato ¹, Taichi Miyagi ¹, Tomohiro Kameda ¹ and Hiroaki Dobashi ², ¹Kagawa University, Kagawa, ²Kagawa University, Kagawa, Japan
Background/Purpose: Hydroxychloroquine(HCQ) is recommended for all patients with SLE in EULAR recommendation 2019, however, there are not enough data about the effect of additional HCQ…
Abstract Number: 2529 • 2019 ACR/ARP Annual Meeting
Safety of Chloroquine and Hydroxychloroquine During Pregnancy: A Systematic Review and Meta-Analysis
Thibaut Naveau ¹, Olivier Lichau ¹, Thomas Barnetche ¹, Thierry Schaeverbeke ¹, Estibaliz Lazaro ², Marie-Elise Truchetet ³ and Christophe Richez⁴, ¹FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, ²FHU ACRONIM, Department of Internal Medecine, Centre Hospitalier Universitaire, Bordeaux, France, Pessac, France, ³FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France. Bordeaux University, CNRS 5164, 33000 Bordeaux, France, Bordeaux, France, ⁴Pellegrin Hospital, University Hospital of Bordeaux, Bordeaux, France
Background/Purpose: Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been used for years during pregnancy for multiple indications (malaria prevention, autoimmune disorders, etc.…). Recently, some countries face…

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