Abstracts Archive - Page 904 of 2425 - ACR Meeting Abstracts

Abstract Number: 2185 • 2019 ACR/ARP Annual Meeting
MRI-detected Abnormalities in Prediction Models of Incident Radiographic Knee Osteoarthritis over 10 Years of Follow-up
C. Kent Kwoh¹, Frank Roemer ², Erin Ashbeck ³, ChengCheng Hu ¹, Edward Bedrick ¹, Leena Sharma ⁴ and Ali Guermazi ⁵, ¹University of Arizona, Tucson, AZ, ²University of Erlangen-Nuremberg, Erlangen, Germany, ³The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁴Northwestern University, Chicago, IL, ⁵Boston Medical Center, Boston
Background/Purpose: MRI Osteoarthritis Knee Score (MOAKS) is a semi-quantitative scoring system used to assess MRI-detected structural abnormalities including over 100 raw scores representing multiple joint…
Abstract Number: 2186 • 2019 ACR/ARP Annual Meeting
What Is an Important Difference in Gait Speed in Adults with Knee Osteoarthritis?
Jing Song ¹, David Cella ², Abigail Gilbert³, Rowland Chang ² and Dorothy Dunlop ², ¹Northwestern University Feinberg School of Medicine, Worthington, OH, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³University of North Carolina, Chapel Hill, NC
Background/Purpose: Little is known regarding what difference in functional performance measures are clinically significant in individuals with a chronic medical disease. This study examines the…
Abstract Number: 2187 • 2019 ACR/ARP Annual Meeting
A Low Cartilage Formation & Repair Endotype Predicts Radiographic Progression in Symptomatic Knee Osteoarthritis Patients and Identifies Optimal Responders to a Potential OA Treatment
Yunyun Luo ¹, Jonathan Samuels ², Svetlana Krasnokutsky ³, Inger Byrjalsen ¹, Jeppe Andersen ⁴, Asger Bihlet ⁵, Yi He ¹, Morten Karsdal ⁶, Steven Abramson ⁷, Mukundan Attur ³ and Anne Bay-Jensen¹, ¹Nordic Bioscience, Herlev, Denmark, ²NYU Langone Medical Center, New Yort, NY, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY, ⁴Nordic Bioscience, Clinical development, Herlev, Denmark, ⁵Nordic Bioscience Clinical Development, Herlev, Denmark, ⁶Nordic Bioscience, Copenhagen, Denmark, ⁷NYU School of Medicine and NYU Langone Orthopedic Hospital, New York, NY
Background/Purpose: Osteoarthritis (OA) is a highly heterogeneous disease, which suggest that multiple endotypes exist. Identification and characterization of such endotypes may assist in precision medicine…
Abstract Number: 2188 • 2019 ACR/ARP Annual Meeting
The Association of Plasma Fatty Acids Levels with Hand and Knee Osteoarthritis
Marieke Loef¹, Andreea Ioan-Facsinay ¹, Dennis O Mook-Kanamori ², Ko Willems van Dijk ¹, Renée de Mutsert ¹, Margreet Kloppenburg ¹ and Frits R Rosendaal ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Obesity is one of the most important risk factors for osteoarthritis, and is strongly associated with increased levels of circulating fatty acids, which may…
Abstract Number: 2189 • 2019 ACR/ARP Annual Meeting
Reference Curves for the Knee Injury and Osteoarthritis Outcome Score in the Middle-aged Dutch Population
Marieke Loef¹, Féline PB Kroon ¹, Stephan Böhringer ¹, Frits R Rosendaal ¹ and Margreet Kloppenburg ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
Background/Purpose: The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire is a widely used patient-reported outcome tool, developed to evaluate short- and long-term knee symptoms…
Abstract Number: 2190 • 2019 ACR/ARP Annual Meeting
Multi-vendor Multi-site T1ρ and T2 Quantification of Knee Cartilage
Jeehun Kim ¹, Kenji Mamoto ², Richard Lartey ¹, Kaipin Xu ¹, Matthew Tanaka ³, Emma Bahroos ³, Carl Winalski ², Thomas Link ³, Peter Hardy ⁴, Qi Peng ⁵, Angie Botto-van Bemden ⁶, Kecheng Liu ⁷, Robert Peters ⁸, Can Wu ⁹ and Xiaojuan Li¹⁰, ¹Program of Advanced Musculoskeletal Imaging, Cleveland Clinic Foundation, Cleveland, ²Cleveland Clinic Foundation, Cleveland, ³University of California, San Francisco, San Francisco, ⁴University of Kentucky, Lexington, ⁵Albert Einstein College of Medicine, New York City, ⁶Arthritis Foundation, Atlanta, ⁷Siemens Medical Solution Inc, Malvern, ⁸GE Healthcare, Milwaukee, ⁹Philips Healthcare, Andover, ¹⁰Program of Advanced Musculoskeletal Imaging, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease characterized by deterioration of articular cartilage in the joints. MRI T1ρ and T2 relaxation times have been…
Abstract Number: 2191 • 2019 ACR/ARP Annual Meeting
Construct Validity of OMERACT Ultrasound Knee Scores with Pain, Other Symptoms, Radiographic and MRI Findings
Win Min Oo¹, James Linklater ², Kimberly Bennell ³, Shirley Yu ¹, Xia Wang ¹, Vicky Duong ¹ and David Hunter ¹, ¹Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Australia, Sydney, New South Wales, Australia, ²Department of Musculoskeletal Imaging, Castlereagh Sports Imaging Center, St. Leonards, Sydney, Australia, Sydney, New South Wales, Australia, ³Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, Faculty of Medicine Dentistry & Health Sciences, The University of Melbourne, Melbourne, VIC, Australia., Parkville, Victoria, Australia
Background/Purpose: To investigate the construct validity of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain, other symptoms, and OA severity…
Abstract Number: 2192 • 2019 ACR/ARP Annual Meeting
Stabilization of Patellar Bone-Shape Correlates Significantly with Reduced Knee Pain Frequency After IA TPX-100 in Subjects with Bilateral Patellofemoral OA
Dawn McGuire¹, Michael Bowes ², Alan Brett ², Neil Segal ³, Meghan Miller ⁴, David Rosen ⁴ and Yoshinari Kumagai ⁴, ¹OrthoTrophix, Orinda, CA, ²Imorphics, Manchester, England, United Kingdom, ³University of Kansas Medical Center, Kansas City, KS, ⁴OrthoTrophix, Oakland, CA
Background/Purpose: Based on data from the Osteoarthritis Initiative (OAI), MRI-based analyses of bone shape changes in the knee predict symptomatic and radiographic progression of knee…
Abstract Number: 2193 • 2019 ACR/ARP Annual Meeting
“If It Was Unicorn Dust I’d Have It Again.” Patient Experiences of Hip Osteoarthritis and Treatments in the Hip Injection Trial
Clare Jinks ¹, Ashley Hawarden ¹, Edward Roddy², Zoe Paskins ³, Christian Mallen ⁴ and Melanie Holden ⁵, ¹Research Institute for Primary Care and Health Sciences, Keele University, Keele, England, United Kingdom, ²Research Institute for Primary Care and Health Sciences and Keele Clinical Trials Unit, Keele, United Kingdom, ³Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom, ⁴Research Institute for Primary Care and Health Sciences, Keele University, UK, Keele, United Kingdom, ⁵Research Institute for Primary Care and Health Sciences and Keele CTU, Keele University, Keele, England, United Kingdom
Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of…
Abstract Number: 2194 • 2019 ACR/ARP Annual Meeting
Surgical and Medical Weight Loss Threshold Dictates Decreases in Knee Osteoarthritis Pain but Not Reductions in Inflammatory Biomarkers
Fernando Bomfim¹, Shannon Chen ¹, Stephen Zak ², Taylor Jazrawi ¹, Madeline Kundler ², Vivienne Qie ², Laura Peralta ², Jose Aleman ², Christine Ren-Fielding ², Holly Lofton ², Jyoti Patel ², Mukundan Attur ³, Steven B. Abramson ³ and Jonathan Samuels ¹, ¹NYU Langone Health, New York, ²NYU Langone Health, New York, NY, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY
Background/Purpose: Weight loss in obese patients can reduce knee osteoarthritis (OA) pain, even when physical therapy and intra-articular injections have failed. The impacts of either…
Abstract Number: 2195 • 2019 ACR/ARP Annual Meeting
BMI Has Minimal Effect on Reduction of Symptoms in Patients with Osteoarthritis of the Knee Treated with Diclofenac 1% Gel
Joel A. Block¹, Bharat Patel ² and Sandy Yacoub Garas ³, ¹Rush University Medical Center, Chicago, IL, ²GlaxoSmithKline Consumer Healthcare, Weybridge, United Kingdom, ³GlaxoSmithKline Consumer Healthcare, Warren, NJ
Background/Purpose: Clinical trials demonstrate that diclofenac sodium gel 1% (DSG 1%), a topical NSAID, provides significantly better pain relief than vehicle placebo for patients with…
Abstract Number: 2196 • 2019 ACR/ARP Annual Meeting
Machine Learning Defines the Relationship Between Structural Knee Osteoarthritis and Patient-Important Outcomes: An 8-year Study of 47,858 Knee MRIs from the Osteoarthritis Initiative (OAI)
Michael Bowes¹, Katherine Kacena ², Oras Alabas ³, Alan Brett ¹, Bright Dube ⁴, Neil Bodick ⁵ and Philip G Conaghan ⁶, ¹Imorphics, Manchester, England, United Kingdom, ²BioBridges, Wellesley Hills, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ⁴University of Leeds, LEEDS, England, United Kingdom, ⁵Flexion Therapeutics, Burlington, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: Osteoarthritis (OA) is a slowly progressing disease which may be asymptomatic for many years. Therapy development has been hampered by poor understanding of both…
Abstract Number: 2197 • 2019 ACR/ARP Annual Meeting
Clinically Relevant Improvements in Knee Osteoarthritis Pain with Diclofenac Sodium Gel 1%
Marc C. Hochberg¹, Bharat Patel ², Sandy Yacoub Garas ³ and Roy Altman ⁴, ¹University of Maryland School of Medicine, Baltimore, MD, ²GlaxoSmithKline Consumer Healthcare, Weybridge, United Kingdom, ³GlaxoSmithKline Consumer Healthcare, Warren, NJ, ⁴University of California, Los Angeles
Background/Purpose: Topical agents are recommended for the initial treatment of patients with knee osteoarthritis (OA). Diclofenac sodium gel 1% (DSG 1%), a topical nonsteroidal anti-inflammatory…
Abstract Number: 2198 • 2019 ACR/ARP Annual Meeting
Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis
Kevin Ong¹, Maria Runa ¹, Wilson Ngai ², Zhimin Xiao ³, Edmund Lau ⁴ and Roy Altman ⁵, ¹Exponent, Inc., Philadelphia, ²Sanofi, U.S. Medical Affairs, Bridgewater, ³Sanofi US, Cambridge, ⁴Exponent, Inc., Menlo Park, ⁵University of California, Los Angeles
Background/Purpose: Some concerns have been raised about subsequent severe acute localized reactions (SALR) (flares, pseudoseptic reactions, etc.) following hyaluronic acid (HA) injections for pain relief…
Abstract Number: 2199 • 2019 ACR/ARP Annual Meeting
Is There an Association of Serum LDL, HDL and Total Cholesterol with the Development of Knee Osteoarthritis?
Jessica Barlow¹, Xianbang Sun ², Michael Nevitt ³, James Torner ⁴, Beth Lewis ⁵, Nirupa Matthan ⁶, Alice Lichtenstein ⁶ and David Felson ⁷, ¹Boston University School of Medicine, Department of Rheumatology, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³University of California at San Francisco, San Francisco, CA, ⁴University of Iowa at Iowa City, Iowa City, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Tufts University, Boston, MA, ⁷Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Recent data have suggested an association between elevated serum cholesterol levels, particularly low density lipoprotein (LDL), and the development of osteoarthritis (OA). Within the…

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