Abstracts Archive - Page 864 of 2425 - ACR Meeting Abstracts

Abstract Number: 1584 • 2019 ACR/ARP Annual Meeting
Factors Associated with Accrual of Damage over Time in Patients with SLE: Results from a Multinational Latin American Cohort
Milena Mimica¹, Oslando Padilla ², Felipe Aguilera ³, Fernando Cavalcanti ⁴, Eduardo Borba ⁵, Marlene Guibert-Toledano ⁶, Rosa Chacon-Diaz ⁷, Gloria Vasquez ⁸, Guillermo Pons-Estel ⁹, Mario Cardiel ¹⁰, Oscar Neira ¹¹, Mary-Carmen Amigo ¹², Eloisa Bonfa ¹³, Graciela Alarcón ¹⁴, Bernardo A. Pons-Estel ¹⁵ and Loreto Massardo ¹⁶, ¹Centro de Biología Celular y Biomedicina, Facultad de Medicina y Ciencia. Universidad San Sebastián, Santiago, Chile., Santiago, Region Metropolitana, Chile, ²Pontificia Universidad Católica de Chile, Santiago, Region Metropolitana, Chile, ³Universidad San Sebastián, Santiago, Region Metropolitana, Chile, ⁴Hospital das Clínicas da Universidade Federal de Pernambuco, Recife, Brazil, ⁵Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Brazil, ⁶Servicio Nacional de Reumatología, Centro de Investigaciones Médico Quirúrgicas (CIMEQ), La Habana, Cuba, ⁷Servicio de Reumatología, Policlínica Méndez Gimón, Caracas, Venezuela., Caracas, Venezuela, ⁸University of Antioquia, Medellin, Antioquia, Colombia, ⁹Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, ¹⁰Centro de Investigación Clínica de Morelia, SC, Morelia, México., Morelia, Mexico, ¹¹Sección Reumatología, Hospital del Salvador. Universidad de Chile. Unidad de Reumatología. Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo., Santiago, Chile, Santiago, Chile, ¹²Servicio de Reumatología, Centro Médico ABC, Ciudad de México, México., Mexico, Mexico, ¹³Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Sao Paulo, Brazil, ¹⁴University of Alabama at Birmingham, Birmingham, ¹⁵Centro Regional de Enfermedades Autoinmunes y Reumáticas (CREAR), Grupo Oroño, Rosario, Rosario, Argentina, ¹⁶Centro de Biología Celular y Biomedicina, Facultad de Medicina y Ciencia. Universidad San Sebastián, Santiago, Chile., Santiago, Chile
Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) are at risk of accumulating damage, having an impaired quality of life and experiencing a premature death. The…
Abstract Number: 1585 • 2019 ACR/ARP Annual Meeting
Endothelial Dysfunction and Arterial Stiffness in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis
Claudia Mendoza-Pinto¹, Adriana Rojas-Villarraga ², Nicolás Molano-González ³, Pamela Munguía-Realpozo ⁴, Socorro Méndez-Martínez ⁴, Aurelio López-Colombo ⁴ and Mario García-Carrasco ¹, ¹Systemic Autoimmune Diseases Research Unit, Hospital de Especialidades, UMAE CMNMAC - CIBIOR, Instituto Mexicano del Seguro Social. Department of Rheumatology and Immunology, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Puebla, Mexico, ²FUCS -Fundación Universitaria de Ciencias de la Salud, Bogotá, Distrito Capital de Bogota, Colombia, ³Universidad del Rosario, Bogotá, Distrito Capital de Bogota, Colombia, ⁴Instituto Mexicano del Seguro Social, Puebla, Puebla, Mexico
Background/Purpose: Studies have reported increased cardiovascular (CV) morbidity and mortality in patients with SLE. In recent years, several non-invasive surrogates of CV disease risk have…
Abstract Number: 1586 • 2019 ACR/ARP Annual Meeting
All-cause Hospitalizations and Mortality in Systemic Lupus Erythematosus in the US- results from a National Inpatient Database
Rashmi Dhital¹, Dilli Ram Poudel ², Ramesh Kumar Pandey ³ and Paras Karmacharya ⁴, ¹Reading Hospital ,PA, Shillington, PA, ²University of Pennsylvania, Philadelphia, ³Fox Chase Hospital, Philadelphia, ⁴Reading Hospital, Mayo Clinic, Rochester
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune disorder with variable presentation. While several studies have outlined the risk factors for hospitalization and…
Abstract Number: 1587 • 2019 ACR/ARP Annual Meeting
Oxidized Human Serum Albumin Is Increased in Systemic Lupus Erythematosus, but Not in Rheumatoid Arthritis
Hideto Takada¹, Keiko Yasukawa ², Suguru Honda ¹, Masako Majima ¹, Naoko Konda ¹, Yasuhiro Katsumata ¹, Michi Tsutsumino ¹, Yutaka Yatomi ³ and Masayoshi Harigai ¹, ¹Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan, ²Department of Clinical Laboratory, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan, ³Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Background/Purpose: Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are at high risk of atherosclerosis and have high mortality due to cardiovascular disease.…
Abstract Number: 1588 • 2019 ACR/ARP Annual Meeting
Disease Activity and Dysregulated Iron Metabolism: A Potentially Overlooked Mechanism for Anaemia in Patients with Systemic Lupus Erythematosus?
Chris Wincup¹, Thomas McDonnell ¹, George Robinson ¹, Filipa Farinha ¹, Anna Radziszewska ¹ and Anisur Rahman ¹, ¹University College London, London, United Kingdom
Background/Purpose: Haematological manifestations of SLE are common with anaemia reported in approximately 50% of cases, yet the role of altered iron metabolism is poorly understood.…
Abstract Number: 1589 • 2019 ACR/ARP Annual Meeting
Prevalence of Cognitive Impairment in an Inception Lupus Cohort as Assessed by a Comprehensive Neuropsychological Battery
Bahar Moghaddam¹, Dorcas Beaton ², Robin Green ³, Maria Tartaglia ⁴, Lesley Ruttan ³, Mahta Kakvan ⁵, Marvin Fritzler ⁶, May Choi ⁶, Moe Zandy ⁵, Jiandong Su ⁵, Michelle Vitti ⁷, Dennisse Bonilla ⁵, Joan Wither ⁸, Sabrina Lombardi ³ and Zahi Touma ⁵, ¹University of Toronto, Toronto, ON, Canada, ²St. Michael's Hospital, Toronto, ON, Canada, ³University Health Network, Toronto, ON, Canada, ⁴University Health Network, University of Toronto, Toronto, ON, Canada, ⁵University Health Network, University of Toronto, Toronto, ON, Canada, ⁶Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁷University Health Network/University of Toronto, Toronto, NU, Canada, ⁸University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Systemic Lupus Erythematosus (SLE) can lead to a number of neuropsychiatric manifestations including cognitive impairment (CI). Previous meta-analyses have reported the prevalence of CI…
Abstract Number: 1590 • 2019 ACR/ARP Annual Meeting
Clinical and Sociodemographic Associates of Depression and Anxiety in Systemic Lupus Erythematosus
David Eldeiry¹, Moe Zandy ², Oshrat Tayer-Shifman ², Andrew Kwan ³, Sherief Marzouk ², Jiandong Su ², Kathleen Bingham ² and Zahi Touma ², ¹Royal College of Surgeons in Ireland, Dublin, Ireland, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³Queens University, Kingston, ON, Canada
Background/Purpose: In our recent systematic review, we have shown a high prevalence for depression (35%) and anxiety (25.8%) in Systemic Lupus Erythematosus (SLE)1. A better…
Abstract Number: 1591 • 2019 ACR/ARP Annual Meeting
Anti-ovarian Antibodies Are Not Associated with Premature Menopause in SLE Treated with Cyclophophosphamide
Martha Tsaliki ¹, Kristi Koelsch ¹, Ambre Chambers ¹, Mitali Talsania ², Eliza Chakravarty ³ and Robert Scofield³, ¹University of Oklahoma health Sciences Center, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoam City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Treatment of systemic lupus erythematosus (SLE) with cyclophosphamide is associated with premature menopause, especially those at an older age of treatment and those receiving…
Abstract Number: 1592 • 2019 ACR/ARP Annual Meeting
Defining the SLE-Associated Pulmonary Arterial Hypertension Phenotype
Marisa Mizus¹, Jessica Li ¹, Daniel Goldman ² and Michelle Petri ¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Pulmonary arterial hypertension (PAH) is a leading cause of death in SLE patients. Hypocomplementemia, antiphospholipid antibodies, and elevated antibodies to RNP and Ro are…
Abstract Number: 1593 • 2019 ACR/ARP Annual Meeting
Heart Rate Visit-to-Visit Variability in Patients with Systemic Lupus Erythematosus Is Associated with Increased Mortality
Tyler Reese¹, Alyson Dickson ¹, Jocelyn Gandelman ¹, Sarah Bayefsky ¹, April Barnado ¹, Katherine Barker ¹, C. Michael Stein ¹, Vivian Kawai ¹ and Cecilia Chung ¹, ¹Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased mortality compared to the general population. Heart rate visit-to-visit variability (HRVVV) has emerged as an adverse…
Abstract Number: 1594 • 2019 ACR/ARP Annual Meeting
High Expression of CD38 on CD8 T Cells Predicts Increased Burden of Infections in Patients with SLE
Lama Mulki¹, Abel Suarez-Fueyo ², Eri Katsuyama ², Vasileios Kyttaris ² and George Tsokos ², ¹Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: We have previously reported that CD38 gene expression in the peripheral blood T cell from patients with SLE is increased. CD8+CD38+ T cells have…
Abstract Number: 1595 • 2019 ACR/ARP Annual Meeting
Role of Aerobic Exercise in Modulating Fatigue in Women with Systemic Lupus Erythematosus
Marquis Chapman ¹, Sarthak Gupta², Jun Chu ¹, Mohammad Naqi ³, Zerai Manna ³, Mir Ali Mazhar ¹, Adam Munday ¹, Marybeth Stockman ⁴, Bart Dinkard ⁴, Lisa Chin ⁴, Mariana Kaplan ¹, Randall Keyser ⁵, Leighton Chan ⁴ and Sarfaraz Hasni ⁶, ¹National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda, ²Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, ³NIAMS/NIH, Bethesda, ⁴Rehabilitation Medicine Department, Clinical Center, NIH, Bethesda, ⁵Department of Rehabilitation Science, George Mason University, Bethesda, ⁶National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominantly afflicts women. One of the most debilitating symptoms experienced by SLE patients is…
Abstract Number: 1596 • 2019 ACR/ARP Annual Meeting
Assessing the Validity of QRISK3 at Predicting Cardiovascular Events in Systemic Lupus Erythematosus Patients
Lisa Zhu¹, Manpreet Singh ¹, Sonia Lele ¹, Mei Liang ², Lori Sahakian ¹, Jennifer Grossman ¹ and Maureen McMahon ¹, ¹UCLA David Geffen School of Medicine, Los Angeles, CA, ²Williams College, Williamstown, MA
Background/Purpose: It has been well established that patients with systemic lupus erythematosus (SLE) have an increased risk of developing cardiovascular disease (CVD). Traditional CVD risk…
Abstract Number: 1597 • 2019 ACR/ARP Annual Meeting
Assessing Long-term Poor Outcomes in Systemic Lupus Erythematosus Patients with Acute Coronary Syndromes
Paramjit Singh¹, ¹Kaiser Permanente Fontana, Fontana
Background/Purpose: Systemic lupus erythematosus (SLE) is a significant risk factor for coronary atherosclerosis, independent of the classic risk factors. Previous studies have found poor acute…
Abstract Number: 1598 • 2019 ACR/ARP Annual Meeting
Disability Among Subtypes of SLE
Jennifer Rogers¹, Raeann Whitney ¹, Megan Clowse ¹, Lisa Criscione-Schreiber ¹, Jayanth Doss ¹, David Pisetsky ², Rebecca Sadun ¹, Kai Sun ¹ and Amanda Eudy ¹, ¹Duke University, Durham, ²Duke University, Durham VAMC, Durham
Background/Purpose: The rate of medical disability among patient with systemic lupus erythematosus (SLE) ranges from 20-40% and is associated with a number of socioeconomic, disease-related…

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