Abstracts Archive - Page 842 of 2425 - ACR Meeting Abstracts

Abstract Number: 1254 • 2019 ACR/ARP Annual Meeting
A Retrospective Medical Chart Review of Patients with Periodic Fever Syndromes Initiating Canakinumab in the United States
Peter Hur¹, Kathleen G. Lomax ¹, Raluca Ionescu-Ittu ², Ameur M. Manceur ², Jipan Xie ³, Jordan Cammarota ⁴, Navneet Sanghera ⁵ and Alexei A. Grom ⁶, ¹Novartis Pharmaceuticals Corporation, East Hanover, NJ, ²Analysis Group, Inc., Montreal, QC, Canada, ³Analysis Group, Inc., Los Angeles, CA, ⁴Analysis Group Inc.,, Washington, DC, ⁵Novartis Pharmaceuticals Corporations, East Hanover, NJ, ⁶Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Periodic fever syndromes (PFS) is a group of rare autoinflammatory diseases that includes cryopyrin-associated periodic syndromes (CAPS), hyperimmunoglobulin D syndrome/mevalonate kinase deficiency (HIDS/MKD), TNF…
Abstract Number: 1255 • 2019 ACR/ARP Annual Meeting
Is Exon 2 Associated with FMF or a New Disease?
Bilal Kulaksiz ¹, Bugra Han Egeli ², Okan Aydin ³ and Serdal Ugurlu⁴, ¹Istanbul University- Cerrahpasa, istanbul, Turkey, ²İstanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ³Istanul University-Cerrahpasa, istanbul, Turkey, ⁴Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, istanbul, Turkey
Background/Purpose: In Familial Mediterranean Fever (FMF), patients having exon 10 mutations, specifically M694V, M680I, and V726A are more common and their disease profiles tend to…
Abstract Number: 1256 • 2019 ACR/ARP Annual Meeting
Comparison of FMF Patients with Age of Onset Before 20 versus 40 Years and Over
Serdal Ugurlu¹, Okan Aydin ² and Huri Ozdogan ², ¹Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, istanbul, Turkey, ²Istanul University-Cerrahpasa, istanbul, Turkey
Background/Purpose: Familial Mediterranean fever (FMF) is a disease with an onset before 20 years of age in 90% of the patients. However late onset FMF defined…
Abstract Number: 1257 • 2019 ACR/ARP Annual Meeting
Recommendation on Colchicine Dosing and Definition of Colchicine Resistance/Intolerance in the Management of Familial Mediterranean Fever
Seza Ozen¹, Erdal Sag ², Eldad Ben-Chetrit ³, Marco Gattorno ⁴, Ahmet Gul ⁵, Philip Hashkes ⁶, Isabelle Kone-Paut ⁷, Helen Lachmann ⁸, Elena Tsitsami ⁹, Marinka Twilt ¹⁰, Fabrizio De Benedetti ¹¹ and Jasmin B. Kuemmerle-Deschner ¹², ¹Hacettepe University Hospital, Ankara, Turkey, ²Hacettepe University, Ankara, Turkey, ³Hebrew University, Jerusalem, Israel, ⁴IRCCS Istituto Giannina Gaslini, Genova, Italy, ⁵Istanbul University, Istanbul, Turkey, ⁶Shaare-Zedek Medical Center, Jerusalem, Israel, ⁷Rhumatologie pédiatrique et CEREMAIA,, Université Paris-Sud Saclay, Paris, France, ⁸The Royal Free Hospital & University College London, London, United Kingdom, ⁹National and Kapodistrian University of Athens, Athens, Greece, ¹⁰University of Calgary, Calgary, AB, Canada, ¹¹Bambino Gesù Children’s Hospital, Rome, Italy, ¹²University Hospital Tuebingen, Tuebingen, Germany
Background/Purpose: Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease and colchicine is the drug of choice for its treatment. However, about 5-10%…
Abstract Number: 1258 • 2019 ACR/ARP Annual Meeting
Effects of Intravenous Golimumab, an Anti-TNFα Monoclonal Antibody, on Health-Related Quality of Life in Patients with Ankylosing Spondylitis: 1-Year Results of a Phase III Trial
John Reveille¹, Atul Deodhar ², Diane Harrison ³, Elizabeth Hsia ⁴, Eric K H Chan ³, Shelly Kafka ⁵, Kim Hung Lo ³, Lilianne Kim ³ and Chenglong Han ³, ¹University of Texas McGovern Medical School, Houston, ²Oregon Health & Science University, Portland, OR, ³Janssen Research & Development, LLC, Spring House, PA, ⁴Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA, ⁵Janssen Scientific Affairs, LLC, Horsham, PA
Background/Purpose: In patients with ankylosing spondylitis (AS), IV administration of the anti-TNFa antibody golimumab (GLM-IV) resulted in improvements in composite measures of various aspects of…
Abstract Number: 1259 • 2019 ACR/ARP Annual Meeting
Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO): A Case Series
Devanshu Verma¹, Samir Shah ² and Arundathi Jayatilleke ³, ¹Drexel University, Philadelphia, ²Thomas Jefferson University, Philadelphia, ³Drexel, Philadelphia, PA
Background/Purpose: SAPHO is a chronic multisystemic illness with predominantly skin and joint manifestations. Disease presentation is heterogenous; proposed diagnostic criteria include chronic multifocal aseptic osteomyelitis…
Abstract Number: 1260 • 2019 ACR/ARP Annual Meeting
The Study of Peripheral Blood Lymphocyte Subsets and CD4+T Subsets in Recurrent Polychondritis
Fang Yuan Hu¹, Ning Yan ¹, Jie Liang ¹, Xiao feng li ² and Cai-hong Wang ³, ¹The second hospital of shanxi medical university, Taiyuan, China (People's Republic), ²The Second hospital of Shanxi Medical University, Taiyuan, China (People's Republic), ³The Second Hospital of Shanxi Medical University, Tai Yuan, China (People's Republic)
Background/Purpose: Relapsing polychondritis (RP) is an uncommon systemic connective tissue disorder characterized by recurrent and episodic inflammation of cartilaginous tissues, such as ear, nose, joint,…
Abstract Number: 1261 • 2019 ACR/ARP Annual Meeting
The Time Lag – the Race in Diagnosis and Management of Hemophagocytic Lymphohistiocytosis
Sneha Patel¹, Bibi Ayesha ², Anna Broder ³, Inessa Gendlina ², Irina Murakhovskaya ⁴, Manish Ramesh ², Yevgeniy Balagula ² and Anand Kumthekar ², ¹Montefiore Hospital/Albert Einstein College of Medicine, Bronx, NY, ²Montefiore Hospital/Albert Einstein College of Medicine, Bronx, ³Rheumatology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, ⁴Hematologist, Bronx
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of disordered immune activation marked by excessive inflammation. Immunosuppression remains the mainstay of therapy after…
Abstract Number: 1262 • 2019 ACR/ARP Annual Meeting
Clinical Features of Elderly-onset Adult Still’s Disease
Sayaka Takenaka¹, Takehisa Ogura ¹, Yuto Takakura ¹, Takaharu Katagiri ¹, Yuki Inoue ¹, Ayako Hirata ¹ and Hideto Kameda ², ¹Division of Rheumatology, Department of Internal medicine Toho University Ohashi Medical Center, Tokyo, Japan, ²Toho University, Tokyo, Japan, Tokyo, Japan
Background/Purpose: The peak age at the onset of adult Still's disease (ASD) has been between 20 and 35 years old. However, the proportion of elderly-onset…
Abstract Number: 1263 • 2019 ACR/ARP Annual Meeting
The Prevalence and Patterns of Celiac Disease Associated Arthropathy and Coexistence of Celiac Disease with Rheumatic Disorders in a Single Tertiary Medical Center
Anita Moudgal¹, Pooja Bhadbhade ¹, Ammar Haikal ¹ and Mehrdad Maz ¹, ¹The University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically predisposed individuals. Arthropathy has been reported as an extra-intestinal manifestation of CD. The…
Abstract Number: 1264 • 2019 ACR/ARP Annual Meeting
Quality of Life in Patients with SAPHO Syndrome: A Single-center Survey of 588 Patients
Zhaohui Li ¹, Chen Li², Yihan Cao ³, Yirong Xiang ¹, Yueting Li ⁴ and Wen Zhang ⁵, ¹Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing, Beijing, China (People's Republic), ²Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing, Beijing, China (People's Republic), ³Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing, China (People's Republic), ⁴Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College; The Ministry of Education Key Laboratory, Beijing, China, Beijing, China (People's Republic), ⁵Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (People's Republic)
Background/Purpose: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoimmune disease with heterogeneous presentation and severe disease burden. Factors influencing the quality…
Abstract Number: 1265 • 2019 ACR/ARP Annual Meeting
Mandibular Involvement in SAPHO Syndrome: A Single-center Retrospective Study of 26 Patients
Yueting Li¹, Chen Li ², Mu Wang ³, Yihan Cao ⁴, Yirong Xiang ⁵, Zhaohui Li ⁶, Wen Zhang ⁷ and Jizhi zhao ⁸, ¹Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College; The Ministry of Education Key Laboratory, Beijing, China, Beijing, China (People's Republic), ²Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing, Beijing, China (People's Republic), ³Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Beijing, China (People's Republic), ⁴Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing, China (People's Republic), ⁵Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing, Beijing, China (People's Republic), ⁶Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College. No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China, Beijing, China (People's Republic), ⁷Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (People's Republic), ⁸Department of Stomatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College. No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China, Beijing, China (People's Republic)
Background/Purpose: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a heterogeneous chronic inflammatory disease of unknown etiology. Mandibular involvement appeared in approximately 10% of…
Abstract Number: 1266 • 2019 ACR/ARP Annual Meeting
AGBL3 as a Novel Gene Associated with Hereditary Hypocomplementemic Urticarial Vasculitis and Favorable Response to Rituximab
Ahmet Gul¹, Nesllihan Abaci ² and Sema Sirma-Ekmekci ², ¹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, Istanbul, Turkey, ²Department of Genetics, Istanbul University Institute for Experimental Medical Research, Istanbul, Turkey, Istanbul, Turkey
Background/Purpose: Urticarial skin lesions are well-known features of autoinflammatory disorders associated with NLRP3 and NLRP12 variants. However hereditary forms of hypocomplementemic urticarial vasculitis (HUV) with…
Abstract Number: 1267 • 2019 ACR/ARP Annual Meeting
Epidemology, Clinical Features and Relationship to Biological Therapy of Uveitis in Axial Spondyloarthritis: Single Center University Study
Iñigo Gonzalez-Mazon¹, Lara Sanchez-Bilbao ², Javier Rueda-Gotor ³, DAVID MARTINEZ-LOPEZ ⁴, DIANA PRIETO- PENA ¹, Mónica Calderón-Goercke ⁵, Jose Luis Martín-Varillas ², Belén Atienza-Mateo ², Miguel A Gonzalez-Gay ² and Ricardo Blanco ², ¹Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ²Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, ³Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ⁴Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, ⁵Hospital Marqués de Valdecilla, Santander, Cantabria, Spain
Background/Purpose: Uveitis is one of the most frequent extra articular manifestation of spondyloarthritis (SpA). Biological therapy, especially monoclonal TNF inhibitors, are useful to prevent and…
Abstract Number: 1268 • 2019 ACR/ARP Annual Meeting
Different Colchicine Preparations for Familial Mediterranean Fever: Are They the Same?
Hakan Emmungil¹, Ufuk İlgen ¹, Sezin Turan ¹, Samet Yaman ² and Orhan Küçükşahin ³, ¹Trakya University, Edirne, Turkey, ²Yıldırım Beyazıt University, Ankara, Turkey, ³Liv Hospital, Ankara, Turkey
Background/Purpose: Colchicine is the mainstay of treatment for prevention of attacks and associated amyloidosis in Familial Mediterranean Fever (FMF). Two approved colchicine preparations are currently…

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