Abstracts Archive - Page 840 of 2607 - ACR Meeting Abstracts

Abstract Number: 0053 • ACR Convergence 2020
¿Comprende? Assessing the Readability of Freely Available Spanish-Language Online Patient Education Materials for Rheumatologic Diseases
Carleigh Zahn¹, Bharat Kumar¹ and Cindy Puga², ¹University of Iowa Hospitals and Clinics, Iowa City, IA, ²Carver College of Medicine, Iowa City
Background/Purpose: Spanish is the second most popular language in the United States and third most commonly spoken language internationally. Despite the high prevalence of Spanish…
Abstract Number: 0055 • ACR Convergence 2020
Racial and Sex-based Disparities in Health Care Utilization: Eye Inflammation as a Paradigm
Krati Chauhan¹ and James Rosenbaum², ¹Southern Illinois University - School of Medicine, Springfield, IL, ²Oregon Health & Science University, Portland, OR
Background/Purpose: Disparities in health care utilization based on sex, race, education, or income affect outcomes in rheumatologic care. We have used ocular inflammatory and infectious…
Abstract Number: 0056 • ACR Convergence 2020
Role of Socioeconomic and Cultural Factors in Racial Disparities in Disease Severity and Health Status of Patients with Axial Spondyloarthritis
Leila Muhieddine¹, Shakaib Hayat², Katja Reuter³, Charles Thomas⁴ and Marina Magrey⁵, ¹Case Western Reserve University- Metrohealth Medical Center, Cleveland, OH, ²Case Western Reserve University-Metrohealth Medical Center, Cleveland, OH, ³University of Southern California, Keck School of Medicine, Los Angeles, CA, ⁴Case Western Reserve University, School of Medicine, Cleveland, OH, ⁵Case Western Reserve University School of Medicine, Cleveland, OH
Background/Purpose: To confront the persistent racial and ethnic disparities in health outcomes in the United States, it is imperative to study cultural and socioeconomic differences…
Abstract Number: 0057 • ACR Convergence 2020
Increased Susceptibility to Measles in Patients from Central America and Mexico in a U.S. Rheumatology Clinic
Alice Fike¹, Abhimanyu Amarnani², Yanira Ruiz-Perdomo³, Sarfaraz Hasni³, Michael Ward³ and James Katz⁴, ¹NIAMS, Bethesda, MD, ²SUNY Downstate Health Sciences University, Brooklyn, NY, ³National Institutes of Health, Bethesda, MD, ⁴NIH NIAMS, Bethesda, MD
Background/Purpose: Infections in patients with rheumatic disease are a leading cause of morbidity and mortality. Preventive measures such as immunizations can reduce the burden of…
Abstract Number: 0058 • ACR Convergence 2020
Drug Retention and Discontinuation of Biological DMARDs and Novel Small Molecules: Data from the Singapore National Biologics Registry
Li Wearn Koh¹, Man Hua Aw², Preeti Dhanasekaran³, Rosa Lim Mui San¹, Stephanie Wong⁴, Xanthe Chua⁵, Wei Joo Choy¹, Manjari Lahiri⁶ and Siaw Ing Yeo², ¹Tan Tock Seng Hospital, Singapore, Singapore, ²Singapore General Hospital, Singapore, Singapore, ³National University of Singapore, Singapore, Singapore, ⁴Clinical Research and Innovation Office, Tan Tock Seng Hospital Singapore, Singapore, Singapore, ⁵Tan Tock Seng Hospital, Singapore, Singapore, Singapore, ⁶National University Hospital, Singapore, Singapore
Background/Purpose: To describe drug retention rate and reasons for discontinuation of biological disease modifying anti-rheumatic drugs ( bDMARD) and novel small molecules in patients from…
Abstract Number: 0059 • ACR Convergence 2020
EHR-Supported Staff Protocol Improves Smoking Cessation in a Diverse Rheumatology Clinic: Results of Quit Connect Dissemination Project
Jennifer Brandt¹, S. Sam Lim¹, Edmond Ramly², Monica Messina³ and Christie Bartels⁴, ¹Emory University, Atlanta, GA, ²University of Wisconsin School of Medicine and Public Health, Department of Family Medicine and Community Health;, Madison, ³University of Wisconsin School of Medicine and Public Health, Department of Medicine, Rheumatology Division, Madison, WI, ⁴University of Wisconsin School of Medicine and Public Health, Department of Medicine, Division of Rheumatology, Madison, WI
Background/Purpose: Smoking is a key risk factor for rheumatologic conditions such as rheumatoid arthritis and lupus that disproportionately impacts disadvantaged patients and predicts worse outcomes.…
Abstract Number: 0060 • ACR Convergence 2020
ANCA-associated Vasculitis in Caucasian and Hispanics of the Inland Empire of Southern California
Sandy Lee¹, Patil Injean¹, Paulina Tran², Deepa Panikkath¹ and Christina Downey¹, ¹Loma Linda University Medical Center, Redlands, CA, ²UC Riverside School of Medicine, Riverside, CA
Background/Purpose: ANCA-associated vasculitis (AAV) is often studied in the Caucasian population with few studies looking at the disease in other races. Disease presentation and treatment…
Abstract Number: 0061 • ACR Convergence 2020
Rheumatologists’ Attitudes Toward Palliative Care and Medical Assistance in Dying
Alexandra Saltman¹, Caroline McGuinty², Gursimran Chandhoke³, Simon Oczkowski⁴, Heather McDonald-Blumer¹, Ebru Kaya⁵ and Kirsten Wentlandt⁶, ¹University Health Network and Sinai Health System, University of Toronto Faculty of Medicine, Toronto, ON, Canada, ²Ottawa Heart Institute and University of Ottawa, Ottawa, ON, Canada, ³Lakeridge Health, Oshawa, ON, Canada, ⁴Juravinski Hospital and McMaster University, Hamilton, ON, Canada, ⁵University Health Network,, University of Toronto Faculty of Medicine, Toronto, ON, Canada, ⁶University Health Network, University of Toronto Faculty of Medicine, Toronto, ON, Canada
Background/Purpose: Despite major advances in the treatment of systemic rheumatic diseases, a population remains—including those with systemic vasculitis, inflammatory myositis and systemic sclerosis—who suffer from…
Abstract Number: 0062 • ACR Convergence 2020
The Role of PGLYRP1 in the Pathogenesis of Lyme Disease
Akash Gupta¹, Gunjan Arora¹, Connor Rosen², Yongguo Cao¹, Jiri Cerny³, Carmen Booth⁴, Noah Palm², Aaron Ring² and Erol Fikrig¹, ¹Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, ²Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ³Faculty of Tropical AgriSciences, Czech University of Life Sciences in Prague, Prague, Czech Republic, ⁴Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT
Background/Purpose: Lyme Disease is caused by the spirochete Borrelia Burgdorferi (Bb). The infection often begins in the skin, following a tick bite, and spreads to…
Abstract Number: 0063 • ACR Convergence 2020
Novel Repurposed Drugs Against Joint Inflammation Reveal Potential Use for Gout Treatment: An In Silico, In Vitro and Clinical Study
Eloi Franco-Trepat¹, Ana Alonso-Pérez¹, Maria Guillán-Fresco¹, Miriam López-Fagundez¹, Andrés Pazos-Pérez¹, Ana Lois Iglesias², Susana Belén Bravo³, Alberto Jorge-Mora¹, JJ Gómez-Reino⁴ and Rodolfo Gómez¹, ¹IDIS-CHUS - Musculoskeletal Pathology Group, Santiago de Compostela, Spain, ²IDIS-CHUS - Musculoskeletal Pathology Group, A Coruna, Spain, ³IDIS-CHUS - Proteomics Unit, Santiago de Compostela, Galicia, Spain, ⁴IDIS-CHUS - Rheumatology Group, Santiago de Compostela, Spain
Background/Purpose: Joint inflammation is a common feature across multiple rheumatic diseases. To deal with the induction of innate immune factors, targeting therapeutic targets such as…
Abstract Number: 0064 • ACR Convergence 2020
Neutrophil Extracellular Traps Are Sufficient to Activate the Alternative Pathway of Complement
Rebecca Schriefer¹, Michelle Elvington², Priyan Weerappuli³ and Alfred Kim⁴, ¹Washington University School of Medicine, Saint Louis, MO, ²Kypha, Inc., Saint Louis, MO, ³University of Michigan, Ann Arbor, MI, ⁴Washington University School of Medicine, St. Louis, MO
Background/Purpose: Systemic lupus erythematosus (SLE) replies on complement activation to drive many of the pathophysiologic features of disease. We and others have noted that SLE…
Abstract Number: 0065 • ACR Convergence 2020
The Energy-dependent Hierarchy of Immune Functions in Human Monocytes
Pierre-Louis Krauß¹, Thomas Buttgereit², Yuling Chen¹, Moritz Pfeiffenberger¹, Timo Gaber¹ and Frank Buttgereit³, ¹Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ²Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology, and Allergology, Berlin, Germany, ³Charité University Medicine, Berlin, Germany
Background/Purpose: At sites of inflammation, monocytes carry out specific immunological functions while facing challenging bioenergetic restrictions. Here, we investigated the potential of human monocytes to…
Abstract Number: 0066 • ACR Convergence 2020
AMP Deaminase 2 Is Expressed on the Surface of Human Immune Cells as a Novel Regulator of Extracellular Adenosine Metabolism
Lisa Ehlers¹, Aditi Kuppe¹, Marieluise Kirchner², Alexandra Damerau¹, Cindy Strehl¹, Frank Buttgereit³ and Timo Gaber¹, ¹Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ²Max Delbrück Center for Molecular Medicine, BIH Core Facility Proteomics, Berlin, Germany, ³Charité University Medicine, Berlin, Germany
Background/Purpose: Adenosine and its nucleotides represent crucial immunomodulators in the extracellular environment. ATP and ADP are released from stressed cells in states of inflammation, whereas…
Abstract Number: 0067 • ACR Convergence 2020
Functionally Mature CD1c+ Dendritic Cells Contribute to Synovial Inflammation in Rheumatoid Arthritis via STAT3
Mary Canavan¹, Viviana Marzaioli¹, Vipul Bhargava², Sunil Nagpal³, Phil Gallagher⁴, Conor Hurson⁵, Ronan Mullan⁶, Douglas Veale⁷ and Ursula Fearon¹, ¹Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, ²Janssen Research & Development, Springhouse, PA, ³Janssen Research & Development, Collegeville, PA, ⁴St Vincents University Hospital, UCD, Dublin, Ireland, ⁵St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, ⁶Adelaide and Meath Hospital, Dublin, Dublin, Ireland, ⁷EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland
Background/Purpose: Myeloid Dendritic Cells (DC) are potent antigen presenting cells that can be subdivided into CD141+ and CD1c+ DC. We have previously reported an unacknowledged…
Abstract Number: 0068 • ACR Convergence 2020
Single Cell RNA-seq to Characterize Monocyte Subtypes in the Autoinflammatory Interferonopathy, SAVI and the Inflammasomopathy, NOMID
Ying Zhang¹, Bernadette Marrero², Adriana de Jesus³, Sara Alehashemi⁴, Jinguo Chen⁵, Rongye Shi⁶, Huizhi Zhou⁶, Clifton Dalgard⁷, Manfred Boehm⁸ and Raphaela Goldbach-Mansky⁹, ¹Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, ²Computational Systems Biology Section/NIAID/NIH, Bethesda, MD, ³Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD, ⁴Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, ⁵Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, ⁶Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, ⁷Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, ⁸Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, ⁹Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD
Background/Purpose: Monocytes are pivotal producers of key inflammatory cytokines that drive autoinflammatory diseases. In SAVI, constitutive STING activation causes chronic activation with increased type-I IFN…

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