Abstracts Archive - Page 826 of 2607 - ACR Meeting Abstracts

Abstract Number: 1813 • ACR Convergence 2021
Clinical Characteristics & Outcomes Associate with Work Productivity in Bio-naïve Patients with Active Psoriatic Arthritis Through Week 24 of the DISCOVER-2 Study
Jeffrey Curtis¹, Iain McInnes², Proton Rahman³, Dafna Gladman⁴, Feifei Yang⁵, Steven Peterson⁶, Prasheen Agarwal⁷, Alexa Kollmeier⁸, Elizabeth Hsia⁹, Chenglong Han⁹, May Shawi¹⁰, William Tillett¹¹ and Philip Mease¹², ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ²University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom, ³Department of Medicine, Eastern Health and Memorial University of Newfoundland, St John's, NL, Canada, ⁴Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁵Janssen Immunology Global Commercial Strategy Organization, Horsham, PA, ⁶Janssen Immunology Global Commercial Strategy Organization, Raritan, NJ, ⁷Department of Biostatics, Janssen Research & Development, LLC, Spring House, Spring House, PA, ⁸Janssen Research & Development, LLC, La Jolla, CA, ⁹Janssen Research & Development, LLC, Spring House, PA, ¹⁰Janssen Immunology Global Commercial Strategy Organization, Toronto, ON, Canada, ¹¹Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ¹²Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA
Background/Purpose: PsA, a chronic inflammatory disease characterized by peripheral arthritis, axial inflammation, dactylitis, enthesitis and skin/nail psoriasis, causes impaired physical function, disability, and loss of…
Abstract Number: 1814 • ACR Convergence 2021
Patient Characteristics and Clinical Features Associate with Health-Related Quality of Life in Bio-naïve Patients with Active Psoriatic Arthritis Through Week 24 of the DISCOVER-2 Study
Jeffrey Curtis¹, Iain McInnes², Proton Rahman³, Dafna Gladman⁴, Feifei Yang⁵, Steven Peterson⁶, Prasheen Agarwal⁷, Alexa Kollmeier⁸, Elizabeth Hsia⁹, Chenglong Han⁹, May Shawi¹⁰, William Tillett¹¹ and Philip Mease¹², ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ²University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom, ³Department of Medicine, Eastern Health and Memorial University of Newfoundland, St John's, NL, Canada, ⁴Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁵Janssen Immunology Global Commercial Strategy Organization, Horsham, PA, ⁶Janssen Immunology Global Commercial Strategy Organization, Raritan, NJ, ⁷Department of Biostatics, Janssen Research & Development, LLC, Spring House, Spring House, PA, ⁸Janssen Research & Development, LLC, La Jolla, CA, ⁹Janssen Research & Development, LLC, Spring House, PA, ¹⁰Janssen Immunology Global Commercial Strategy Organization, Toronto, ON, Canada, ¹¹Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ¹²Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA
Background/Purpose: PsA is a chronic inflammatory disease characterized by peripheral arthritis, axial inflammation, dactylitis, enthesitis, & skin/nail psoriasis. Patients (pts) with PsA often experience reduced…
Abstract Number: 1815 • ACR Convergence 2021
Randomised, Double-blind, Placebo-controlled Study of Iguratimod in the Treatment of Active Spondyloarthritis
yan li¹, Kunpeng Li¹, Zheng Zhao¹, yanyan wang¹, Jingyu Jin¹, jianglin zhang¹, Jian Zhu¹ and feng huang², ¹First Medical Center, General Hospital of Chinese People's Liberation Army, Beijing, China (People's Republic), ²Chinese PLA General Hospital, Beijing, China (People's Republic)
Background/Purpose: Iguratimod, also known as T-614, is a new type of small molecule compound with anti-inflammatory and immunomodulatory effects; It was listed in China(2011) and…
Abstract Number: 1816 • ACR Convergence 2021
Treatment of Non-biologic-DMARD-IR PsA Patients with Upadacitinib or Adalimumab Results in the Modulation of Distinct Functional Pathways: Proteomics Analysis of a Phase 3 Study
Thierry Sornasse¹, Jaclyn Anderson², Koji Kato³, Apinya Lertratanakul⁴, Christopher Ritchlin⁵ and Iain McInnes⁶, ¹AbbVie Inc, Redwood City, CA, ²AbbVie Inc, Gurnee, IL, ³AbbVie Inc, Shinagawa- Ku, Japan, ⁴AbbVie Inc., North Chicago, IL, ⁵Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, ⁶University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom
Background/Purpose: Treatment of non-biologic-DMARD-IR (DMARD-IR) PsA patients with upadacitinib (UPA) at 15 mg QD, an oral JAK1 selective inhibitor, resulted in improvement in musculoskeletal symptoms,…
Abstract Number: 1817 • ACR Convergence 2021
Comparison of Composite Indices for Disease Activity in Patients with Psoriatic Arthritis Treated with Upadacitinib: A Post-Hoc Analysis from SELECT-PsA 1
Josef Smolen¹, Ennio Lubrano², Mitsumasa Kishimoto³, Andra R Bălănescu⁴, Vibeke Strand⁵, Tianming Gao⁶, Nancy Vranich⁶, Ralph Lippe⁷ and William Tillett⁸, ¹Medical University of Vienna, Vienna, Austria, ²Department of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy, ³Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, ⁴“Carol Davila” University of Medicine and Pharmacy, Department of Internal Medicine and Rheumatology “Sf. Maria” Hospital, Bucharest, Romania, ⁵Stanford University School of Medicine, Portola Valley, CA, ⁶AbbVie Inc., North Chicago, IL, ⁷AbbVie Deutschland GmbH & Co. KG, Berlin, Germany, ⁸Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom
Background/Purpose: Achieving low disease activity (LDA) or remission is a main treatment target in PsA. Composite indices used to assess disease activity include Disease Activity…
Abstract Number: 1818 • ACR Convergence 2021
Real-World Efficacy of TNF Inhibitors for Treatment of Psoriatic Arthritis by Disease Domains: 6-Month Findings from the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry
Philip Mease¹, Taylor Blachley², Jacqueline O’Brien², Nicole Middaugh², Greg Kricorian³, Scott Stryker³, David Collier⁴ and Alexis Ogdie-Beatty⁵, ¹Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, ²CorEvitas, LLC, Waltham, MA, ³Amgen Inc., Thousand Oaks, CA, ⁴Amgen Inc., Simi Valley, CA, ⁵University of Pennsylvania, Philadelphia, PA
Background/Purpose: The burden of PsA and its chronic symptoms may have considerable impact on patient function and quality of life. Real-world research is limited on…
Abstract Number: 1819 • ACR Convergence 2021
Tildrakizumab Efficacy and Safety in Patients with Psoriatic Arthritis by Metabolic Syndrome Status
Arthur Kavanaugh¹, Siba Raychaudhuri², Christopher Ritchlin³, Akihiko Asahina⁴, Proton Rahman⁵, Fred Murphy⁶, Stephen Rozzo⁷, Siu-Long Yao⁷, Richard C Chou⁸ and Elaine Husni⁹, ¹Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy & Clinical Immunology, University of California School of Medicine, Davis, Sacramento, CA, ³Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, ⁴Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan, ⁵Department of Medicine, Eastern Health and Memorial University of Newfoundland, St John's, NL, Canada, ⁶Altoona Center for Clinical Research, Duncansville, PA, ⁷Sun Pharmaceutical Industries, Inc., Princeton, NJ, ⁸University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, Buffalo, NY, ⁹Cleveland Clinic, Cleveland, OH
Background/Purpose: Metabolic syndrome (MetS) is a combination of specific risk factors for cardiovascular disease.1 The prevalence of MetS in patients (pts) with PsA has been…
Abstract Number: 1820 • ACR Convergence 2021
Efficacy of Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 Inhibitor, in Musculoskeletal Manifestations of Active PsA in a Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial
Philip Mease¹, Atul Deodhar², Désirée van der Heijde³, Frank Behrens⁴, Alan Kivitz⁵, Tom Lehman⁶, Lan Wei⁶, Marleen Nys⁷, Subhashis Banerjee⁶ and Miroslawa Nowak⁶, ¹Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, ²Oregon Health & Science University, Portland, OR, ³Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, ⁴CIRI/Rheumatology and Fraunhofer Institute, Translational Medicine and Pharmacology ITMP, Goethe University, Frankfurt, Germany, ⁵Altoona Center for Clinical Research, Duncansville, PA, ⁶Bristol Myers Squibb, Princeton, NJ, ⁷Bristol Myers Squibb, Braine-l'Alleud, Belgium
Background/Purpose: Tyrosine kinase 2 (TYK2) is an intracellular kinase that mediates IL-23, IL-12, and IFNα/β signaling. Deucravacitinib is a novel, oral selective inhibitor of TYK2…
Abstract Number: 1821 • ACR Convergence 2021
Role of Patient Organizations in Implementation of Recommended Non-pharmacological Treatment Modalities in Spondyloarthritis: Evidence for the Effectiveness of Self-management Strategies
Dirk Meyer-Olson¹, Kirsten Hoeper², Ludwig Hammel³, Sebastian Lieb⁴, Andreas Haehle⁴ and Uta Kiltz⁵, ¹m&i Fachklinik Bad Pyrmont, Hannover, Germany, ²Regionales Kooperatives Rheumazentrum Niedersachsen e. V.; Medizinische Hochschule Hannover, Department of Rheumatology and Immunology, Hannover, Germany,, Hannover, Germany, ³Deutsche Vereinigung Morbus Bechterew e.V.,, Schweinfurt, Germany, ⁴Novartis Pharma GmbH, Immunology, Hepatology and Dermatology, Nürnberg, Germany, ⁵Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany
Background/Purpose: This study aimed to characterize the impact of pt advocacy group membership and its association with NPTM frequency and clinical parameters in axSpA pts.…
Abstract Number: 1822 • ACR Convergence 2021
Relationships Between Dermatologic Symptoms and Health-related Quality of Life in Patients with Psoriatic Arthritis: Post Hoc Analysis of Two Phase 3 Studies
Peter C Taylor¹, Andrew G Bushmakin², Joseph C Cappelleri², Pamela Young³, Rebecca Germino², Joseph Merola⁴ and Gil Yosipovitch⁵, ¹University of Oxford, Oxford, United Kingdom, ²Pfizer Inc, Groton, CT, ³Pfizer Inc, Collegeville, PA, ⁴Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, ⁵University of Miami Miller School, Florida, FL
Background/Purpose: Dermatologic symptoms of PsA can substantially impact patient (pt) health‑related quality of life (HRQoL);1 itch is the most commonly reported, and among the most…
Abstract Number: 1823 • ACR Convergence 2021
Efficacy of Upadacitinib in Patients with Active Psoriatic Arthritis and a Low or High Swollen Joint Count: A Subgroup Analysis of 2 Phase 3 Studies
Laure Gossec¹, Dafna Gladman², Erin McDearmon-Blondell³, Philipp Sewerin⁴, Christopher Ritchlin⁵, Dai Feng⁶, Apinya Lertratanakul⁷, Roberto Ranza⁸, Lai-Shan Tam⁹, Antonio Marchesoni¹⁰, Laura Coates¹¹ and Peter Nash¹², ¹Sorbonne Université; APHP, Rheumatology Department, Pitié-Salpêtrière Hospital, Paris, France, ²Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³AbbVie Inc., Elmhurst, IL, ⁴Department and Hiller Research Unit of Rheumatology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany, ⁵Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, ⁶AbbVie Inc., East Brunswick, NJ, ⁷AbbVie Inc., North Chicago, IL, ⁸Hospital de Clinicas, Universidade Federal de Uberlândia, Uberlandia, MG, Brazil, ⁹Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China (People's Republic), ¹⁰Dipartimento di Reumatologia, ASST Gaetano Pini-CTO, Milano, Italy, ¹¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ¹²Griffith University, Brisbane, Australia
Background/Purpose: Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on…
Abstract Number: 1824 • ACR Convergence 2021
Secukinumab Treatment Provides Sustained Resolution of Enthesitis at Individual Joints Through 52 Weeks in a Phase 3b, Double-Blind, Randomized, Active-Controlled Study
Gurjit Kaeley¹, Georg Schett², Philip Conaghan³, Dennis McGonagle⁴, Frank Behrens⁵, Philippe Goupille⁶, Corine Gaillez⁷, Bhumik Parikh⁸, Xiangyi Meng⁸ and Catherine Bakewell⁹, ¹University of Florida, Jacksonville, FL, ²Universitätsklinikum Erlangen, Department of Internal Medicine 3 – Rheumatology and Immunology, Erlangen, Germany, Erlangen, Germany, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴University of Leeds, Leeds, United Kingdom, ⁵Rheumatology and Fraunhofer ITMP - Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany, ⁶University hospital of Tours, Rheumatology department, Tours, France, ⁷Novartis Pharma AG, Basel, Switzerland, ⁸Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁹Intermountain Healthcare Medical Group, Salt Lake City, UT
Background/Purpose: Enthesitis is a key musculoskeletal manifestation of psoriatic arthritis (PsA). In the double-blind, head-to-head EXCEED study (NCT02745080), although the primary endpoint of superiority of…
Abstract Number: 1825 • ACR Convergence 2021
Secukinumab Provides Clinical Improvements in Patients with Active Oligoarticular Psoriatic Arthritis: Results from a Pooled Analysis of 5 Phase 3 Studies
Alexis Ogdie¹, Dafna Gladman², Laura Coates³, Effie Pournara⁴, Xiangyi Meng⁵, Bhumik Parikh⁵ and Philip Mease⁶, ¹University of Pennsylvania, Philadelphia, PA, ²Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁶Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA
Background/Purpose: Oligoarticular psoriatic arthritis (PsA), defined as involvement of ≤ 4 joints, affects approximately 50% of the PsA population.1,2 Disease burden is comparable for patients…
Abstract Number: 1826 • ACR Convergence 2021
Reduced Burden on Paid and Household Work Productivity with Stringent Thresholds of Disease Control: Further Results from Long-Term Certolizumab Pegol Treatment in Patients with Psoriatic Arthritis
William Tillett¹, Laura Coates², Sandeep Kiri³, Vanessa Taieb³ and Philip Mease⁴, ¹Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ³UCB Pharma, Slough, United Kingdom, ⁴Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA
Background/Purpose: Psoriatic arthritis (PsA) is associated with a reduction in workplace productivity,1 which may extend into household productivity.2 Certolizumab pegol (CZP) is a tumor necrosis…
Abstract Number: 1827 • ACR Convergence 2021
Psoriatic Arthritis, Female Sex and Increased Baseline Skin Severity Are Associated with Drug Persistence in Ustekinumab-Treated Patients with Psoriasis in the BADBIR Cohort
Alexis Ogdie¹, William Tillett², Alun Passey³ and Patricia Gorecki⁴, ¹University of Pennsylvania, Philadelphia, PA, ²Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ³Janssen Real World Evidence, HEMAR EMEA, High Wycombe, United Kingdom, ⁴Janssen Medical Affairs, London, United Kingdom
Background/Purpose: Skin and joint symptoms both contribute to the burden of disease in psoriatic arthritis (PsA).1 More severe skin symptoms in patients with both skin…

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