Abstracts Archive - Page 810 of 2607 - ACR Meeting Abstracts

Abstract Number: 1573 • ACR Convergence 2021
Vascular Monosodium Urate Crystal Deposition in Gout: A Dual-energy CT and Microscopy Study of Cadaveric Donors
Nicola Dalbeth¹, Mariam Alhilali¹, Peter Riordan¹, Ravi Narang¹, Ashika Chhana¹, Sue McGlashan¹, Anthony Doyle¹ and MARIANO ANDRES², ¹University of Auckland, Auckland, New Zealand, ²Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
Background/Purpose: Cardiovascular disease is a common comorbidity in people with gout. A hypothesized link between cardiovascular disease and gout is the deposition of monosodium urate…
Abstract Number: 1574 • ACR Convergence 2021
Comparison of Urate Quantification in Gout and Asymptomatic Hyperuricemia by Ultrasound and Dual Energy Computed Tomography
Rachael Flood¹, Aamir Saeed², Kate Harrington¹, Conor Shortt¹, Ronan Mullan¹ and David Kane¹, ¹Tallaght University Hospital, Dublin, Ireland, ²Worcestershire Acute Hospitals NHS Trust., Worcester, United Kingdom
Background/Purpose: The diagnostic gold standard for gout remains aspiration and identification of monosodium urate (MSU) crystals under polarised light microscopy. Joint aspiration is invasive and…
Abstract Number: 1575 • ACR Convergence 2021
Urate Crystals Regulate a Distinct JNK-Dependent Metabolic and Inflammatory Response
Anyan Cheng¹, Isidoro Cobo¹, Jessica Murillo Saich¹, Roxana Coras², Alyssa Torres³, Addison Lana¹, Johannes Schlachetzki¹, Ru Liu Bryan⁴, Robert Terkeltaub⁵, Elsa Sanchez-Lopez³, Christopher Glass¹ and Monica Guma⁶, ¹University of California San Diego, La Jolla, CA, ²University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, ³University of California San Diego, San Diego, CA, ⁴University of California San Diego and VASDHS, San Diego, CA, ⁵VA/UCSD, San Diego, CA, ⁶University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Although metabolic reprograming and its regulation in macrophages after TLR activation is well established, little is known about the regulation and the role of…
Abstract Number: 1576 • ACR Convergence 2021
Development of a Plain Radiographic Scoring System for New Bone Formation in Gout
Chang-Nam Son¹, Ken Cai², John Ferrier³, Yun-Jung Tsai³, Thomas Bardin⁴, Anthony Doyle⁵ and Nicola Dalbeth⁵, ¹Keimyung University School of Medicine, Daegu, Republic of Korea, ²University of Auckland, Sydney, Australia, ³Department of Radiology, Auckland District Health Board, Auckland, New Zealand, ⁴Hôpital Lariboisiere, Paris, France, ⁵University of Auckland, Auckland, New Zealand
Background/Purpose: Features of new bone formation (NBF) such as sclerosis and spurs are common on plain radiography in tophaceous gout. While a plain radiographic damage…
Abstract Number: 1577 • ACR Convergence 2021
Interleukin-37: Associations of Plasma Levels and Genetic Variants in Gout
Adela Navratilova¹, Veronika Voclonová², Hana Hulejová², Lucie Andrés Cerezo¹, Markéta Pavlíková³, Viktor Bečvář², Jakub Zavada¹, Karel Pavelka⁴, Ladislav Senolt⁴ and Blanka Stiburkova⁵, ¹Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, ³Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology and Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: IL-37 is an anti-inflammatory cytokine, member of IL-1 family, related to inflammatory and autoimmune diseases. Here we aimed to investigate the association of genetic…
Abstract Number: 1578 • ACR Convergence 2021
NLRP3 Inflammasome Pathway Expression at Atheroma Plaques from Peripheral Artery Disease According to the Uricemic Status
MARIANO ANDRES¹, Leticia Mendieta², Elena Argente-delcastillo¹, Miguel Trigueros³ and Alberto Miñano³, ¹Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ²Universidad Miguel Hernández, San Juan de Alicante, Spain, ³Hospital General Universitario de Alicante-ISABIAL, Alicante
Background/Purpose: Both hyperuricemia and monosodium urate crystals induce persistent inflammation. In vitro, soluble urate can prime innate immune cells and promote NLRP3 inflammasome activation and…
Abstract Number: 1579 • ACR Convergence 2021
Phenome-Wide Association of Gout Risk Loci
Oleg Stens¹, Vivian Trang², Steven Cao², Robert Terkeltaub¹ and Rany Salem², ¹University of California San Diego School of Medicine, La Jolla, CA, ²University of California San Diego School of Public Health, La Jolla, CA
Background/Purpose: Gout is a complex disease involving changes in urate biology and inflammatory responses, and is associated with comorbidities including metabolic syndrome and cardiorenal disease.…
Abstract Number: 1580 • ACR Convergence 2021
Whole Blood Gene Expression and eQTL Analysis Implicate GGT7 and FADS2 in Gout Pathogenesis
Richard Reynolds¹, Riku Takei¹, Jeffrey Edberg¹, Nicholas Sumpter¹, Tony Merriman² and Megan Leask¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Dunedin, New Zealand
Background/Purpose: Gene expression studies of whole blood represent a powerful approach for understanding the pathogenesis of gout because differentially expressed transcripts may reflect the activation…
Abstract Number: 1581 • ACR Convergence 2021
Genetic Effects on the Transition from Hyperuricemia to Gout
Nicholas Sumpter¹, Riku Takei¹, Richard Reynolds¹ and Tony Merriman², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Dunedin, New Zealand
Background/Purpose: There is clear evidence of genetic control of hyperuricemia resulting in increased gout risk, however genetic control of the transition from hyperuricemia to gout…
Abstract Number: 1582 • ACR Convergence 2021
Diagnostic Accuracy and Reliability of Conventional Radiography of the Knee in Calcium Pyrophosphate Deposition Disease by Using New Definitions: An Ancillary Study of the OMERACT Ultrasound – CPPD Group
Silvia Sirotti¹, Fabio Becce², Luca Maria Sconfienza³, Carlos Pineda⁴, Marwin Gutierrez⁵, Teodora Serban⁶, Daryl MacCarter⁷, Antonella Adinolfi⁸, Anna Scanu⁹, Carlo Alberto Scire¹⁰, Ingrid Moller¹¹, Esperanza Naredo¹², Piercarlo Sarzi-Puttini¹³, Abhishek Abhishek¹⁴, Hyon K. Choi¹⁵, Nicola Dalbeth¹⁶, Sara Tedeschi¹⁷, Maria-Antonietta D'Agostino¹⁸, Nemanja Damjanov¹⁹, Helen Keen²⁰, Lene Terslev²¹, Annamaria Iagnocco²² and Georgios Filippou²³, ¹Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy, ²Lausanne University Hospital, Lausanne, Switzerland, ³Department of Biomedical Sciences for Health, Università Degli Studi di Milano, Milan, Italy, ⁴Instituto Nacional de Rehabilitacion, Mexico City, Federal District, Mexico, ⁵Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitacion, Mexico City, Mexico, ⁶Ospedale La Colletta, ASL3 Genovese, Genoa, Italy, ⁷Rheumatology Department, North Valley Hospital, Whitefish, MT, ⁸Rheumatology Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy, ⁹Department of Medicine-DIMED, Rheumatology Unit, University of Padova, Padoa, Italy, ¹⁰SIR Epidemiology, Research Unit, Pavia, Italy, ¹¹University of Barcelona, Barcelona, Spain, ¹²Department of Rheumatology and Joint and Bone Research Unit, Hospital Fundación Jiménez Díaz and Autónoma University, Madrid, Spain, ¹³Rheumatology Department, Luigi Sacco University Hospital, Milano, Italy, ¹⁴University of Nottingham, Nottingham, United Kingdom, ¹⁵Massachusetts General Hospital, Lexington, MA, ¹⁶University of Auckland, Auckland, New Zealand, ¹⁷Brigham and Women's Hospital, Boston, MA, ¹⁸Rheumatology Department, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy, ¹⁹University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade, Serbia, ²⁰University of Western Australia, Daglish, Australia, ²¹Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University, Glostrup, Denmark, ²²University of Turin, Roma, Italy, ²³Rheumatology Department, Luigi Sacco University Hospital, Siena, Italy
Background/Purpose: Conventional Radiography (CR) has been widely used in Calcium Pyrophosphate Deposition Disease (CPPD) and is considered an important tool for the diagnosis. However, there…
Abstract Number: 1583 • ACR Convergence 2021
Creation of an Ultrasonographic Scoring System for CPPD Extent: Results from a Delphi Process by the OMERACT US Working Group – CPPD Subgroup
Silvia Sirotti¹, Antonella Adinolfi², Fabio Becce³, Tomas Cazenave⁴, Sara Nysom Christiansen⁵, Edoardo Cipolletta⁶, Andrea Delle Sedie⁷, Mario Enrique Diaz Cortes⁸, Fabiana Figus⁹, Emilio Filippucci¹⁰, Peter Mandl¹¹, Daryl MacCarter¹², Ingrid Moller¹³, Mohamed Mortada¹⁴, Gael Mouterde¹⁵, Maria Esperanza Naredo Sanchez¹⁶, Carlos Pineda¹⁷, Francesco Porta¹⁸, Wolfgang Schmidt¹⁹, Teodora Serban²⁰, Lene Terslev²¹, Florentin Vreju²², Richard Wakefield²³, Pascal Zufferey²⁴, Piercarlo Sarzi-Puttini²⁵, Maria-Antonietta D'Agostino²⁶, Nemanja Damjanov²⁷, Annamaria Iagnocco²⁸, Helen Keen²⁹ and Georgios Filippou³⁰, ¹Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy, ²Rheumatology Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy, ³Lausanne University Hospital, Lausanne, Switzerland, ⁴Instituto de Rehabilitación Psicofisica, Buenos Aires, Argentina, Buenos Aires, Argentina, ⁵Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁶Polytechnic University of Marche, Jesi, Italy, ⁷University of Pisa, Pisa, Italy, ⁸Rheumatology Unit, University Hospital Fundación Santa Fe de Bogota, Bogotà, Colombia, ⁹University of Torino, Torino, Italy, ¹⁰Rheumatology Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Jesi, Italy, ¹¹Medical University of Vienna, Vienna, Austria, ¹²Rheumatology Department, North Valley Hospital, Whitefish, MT, ¹³University of Barcelona, Barcelona, Spain, ¹⁴Zagazig University, Zagazig, Egypt, ¹⁵Rheumatology department, CHU Montpellier, Montpellier, France, ¹⁶Department of rheumatology, Joint and Bone research Unit, Hospital Universitario Fundación Jiménez díaz and Autónoma University, Madrid, Spain, ¹⁷Instituto Nacional de Rehabilitacion, Mexico City, Federal District, Mexico, ¹⁸INS, Institute of Neurosciences, Florence, Italy, ¹⁹Immanuel Krankenhaus Berlin, Berlin, Germany, ²⁰ASL 3 Genovese, Genova, Italy, ²¹Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University, Glostrup, Denmark, ²²Rheumatology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania, ²³Rheumatology, Leeds University, Leeds, United Kingdom, ²⁴Rheumatology Department, University of Lausanne, CHUV, Lausanne, Switzerland, ²⁵L.Sacco University Hospital, Milano, Italy, ²⁶Rheumatology Department, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy, ²⁷University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade, Serbia, ²⁸University of Turin, Roma, Italy, ²⁹University of Western Australia, Daglish, Australia, ³⁰Rheumatology Department, Luigi Sacco University Hospital, Siena, Italy
Background/Purpose: Ultrasound (US) has proven to be an excellent technique for detecting Calcium Pyrophosphate (CPP) deposits, however there are no grading systems that allow for…
Abstract Number: 1584 • ACR Convergence 2021
Relation of Depressive Symptoms to Alterations in Conditioned Pain Modulation in Knee Osteoarthritis: The Multicenter Osteoarthritis Study (MOST)
Kosaku Aoyagi¹, Lisa Carlesso², Laura Frey-Law³, Gabriela Rabasa⁴, Cora Lewis⁵, Michael Nevitt⁶ and Tuhina Neogi⁷, ¹Boston University, Quincy, MA, ²McMaster University, Hamilton, ON, Canada, ³University of Iowa, Iowa City, IA, ⁴Boston University, Boston, MA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of California San Francisco, Orinda, CA, ⁷Boston University School of Medicine, Boston, MA
Background/Purpose: Inefficiency of descending conditioned pain modulation (CPM) is present in 42-55% of individuals with knee osteoarthritis (OA), which can contribute to more pain and…
Abstract Number: 1585 • ACR Convergence 2021
Suprascapular Nerve Block for the Treatment of Adhesive Capsulitis
Ernst Shanahan¹, Elizabeth Briggs¹, Tiffany Gill², Catherine Hill³ and Tim Morris⁴, ¹SA Health, Adelaide, Australia, ²University of Adelaide, Adelaide, Australia, ³Queen Elizabeth Hospital, Woodville, Australia, ⁴Flinders University, Adelaide, Australia
Background/Purpose: To investigate the value of suprascapular nerve block (SSNB) as a treatment option for adhesive capsulitis.Methods: Patients with adhesive capsulitis confirmed by a rheumatologist…
Abstract Number: 1586 • ACR Convergence 2021
Individuals with Pre-arthritic Hip Pain Walk with Hip Motion Alteration Common in Individuals with Hip OA
Cara Lewis¹, Anne Halverstadt², Kerri Graber², Zoe Perkins², Emily Keiser², Hadwin Belcher² and Anne Khuu², ¹Boston University, Brookline, MA, ²Boston University, Boston, MA
Background/Purpose: Individuals with hip osteoarthritis (OA) commonly walk with less hip extension compared to individuals without hip OA. This alteration is often attributed to walking…
Abstract Number: 1587 • ACR Convergence 2021
Do Physical Therapists Use Recommended Treatments for Chronic Low Back Pain?
Debbie Feldman¹, Jonathan El-Khoury², Tatiana Orozco¹, François Desmeules³, Maude Laliberté¹ and Kadija Perreault⁴, ¹Université de Montréal, Montréal, QC, Canada, ²Université de Sherbrooke, Sherbrooke, QC, Canada, ³Research Centre of Hôpital Maisonneuve Rosemont, Montréal, QC, Canada, ⁴Université Laval, Québec City, QC, Canada
Background/Purpose: Chronic low back pain has been the subject of many studies in medicine and physical therapy for over half a century. Clinical practice guidelines…

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