Abstracts Archive - Page 803 of 2607 - ACR Meeting Abstracts

Abstract Number: 1468 • ACR Convergence 2021
Intra-articular (IA) Injection of Empty Large Multilamellar Vesicles Liposomes Reduces Cartilage Degeneration in Rat Osteoarthritis Model
Alison Bendele¹, Jacob Favret¹, Gadi Sarfati², Ronny Pinkus² and Roni Wechsler², ¹Bolder BioPATH Inc., Boulder, CO, ²Moebius Medical LTD, Tel Aviv, Israel
Background/Purpose: A suspension of empty large multilamellar vesicles (MLV) liposomes composed of dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC), is currently under clinical development for symptomatic knee…
Abstract Number: 1469 • ACR Convergence 2021
Lorecivivint (SM04690), an Intra-articular, Small-Molecule CLK/DYRK Inhibitor That Modulates the Wnt Pathway, as a Potential Treatment for Meniscal Injuries
Timothy Seo¹, Vishal Deshmukh¹ and Yusuf Yazici², ¹Biosplice Therapeutics, Inc., San Diego, CA, ²New York University School of Medicine, La Jolla, CA
Background/Purpose: Meniscal injuries are the most common pathology of the knee and are associated with pain, stiffness, and localized swelling. Meniscal damage is a frequent…
Abstract Number: 1470 • ACR Convergence 2021
Cartilage Epigenetic Changes Induced by Microbial DNA Amplified from Human OA Samples
Vladislav Izda¹, Christopher Dunn², Cassandra Sturdy¹, Jake Martin¹, Cassandra Velasco², Paul Jacob³ and Matlock Jeffries¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Oklahoma Joint Reconstruction Institute, Oklahoma City, OK
Background/Purpose: Strong links between epigenetic changes, particularly alterations in DNA methylation, have been linked with the onset and progression of knee osteoarthritis (OA); however, the…
Abstract Number: 1471 • ACR Convergence 2021
Oral Administration of Berberine Limits Post-traumatic Osteoarthritis Development and Associated Pain via AMP-activated Protein Kinase (AMPK) in Mice
Jun Li¹, Yun Wang², Di Chen³ and Ru Liu Bryan⁴, ¹Rush University Medical Center, Chicago, IL, ²Valo Health, Lexington, MA, ³Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (People's Republic), ⁴University of California San Diego and VASDHS, San Diego, CA
Background/Purpose: AMP-activated protein kinase (AMPK), a master regulator of energy balance and metabolism, is implicated to play an important role in cartilage homeostasis. Berberine is…
Abstract Number: 1472 • ACR Convergence 2021
Characterization and Function of Tumor Necrosis Factor α and Interleukin-6–Induced Osteoclasts in Rheumatoid Arthritis
Kazuhiro Yokota¹, Kojiro Sato², Yoshimi Aizaki³, Shinya Tanaka⁴, Miyoko Sekikawa⁴, Noritsune Kozu⁵, Yuho Kadono⁴, Hiromi Oda⁶ and Toshihide Mimura⁷, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Jichi Medical University, Tochigi, Japan, ³Saitama Medical University, Saitama, Japan, ⁴Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan, ⁵Kozu Orthopaedic Clinic, Chiba, Japan, ⁶Department of Orthopaedic Surgery, National Hospital Organization Ibusuki Medical Center, Kagoshima, Japan, ⁷Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama, Japan
Background/Purpose: We have previously reported that stimulation of mouse bone marrow–derived macrophages with a combination of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) induces…
Abstract Number: 1473 • ACR Convergence 2021
Chaperone-mediated Autophagy Is a Hallmark of Joint Damage in Osteoarthritic Patients
Irene Lorenzo-Gómez¹, Uxía Nogueira-Recalde¹, Natividad Oreiro², José A. pinto³, Francisco Blanco-García⁴ and Beatriz Caramés¹, ¹Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ³Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain, ⁴Unidad de Proteómica. Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). C/ As Xubias de Arriba 84, 15006, A Coruña, España.Universidade da Coruña (UDC), Grupo de Investigación de Reumatología y Salud (GIR-S). Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, Campus de Oza, 15008, A Coruña, España., A Coruña, Spain
Background/Purpose: In osteoarthritis (OA), defects in Autophagy are evident and precede joint damage. Therefore, identifying hallmarks associated with specific autophagy subtypes could shed light to…
Abstract Number: 1474 • ACR Convergence 2021
Automatic Detection of Bone Marrow Lesions from Knee MRI Data from the OAI Study
Shen Liu¹, Xiaoxiao Sun¹, Frank Roemer², Erin Ashbeck³, Edward Bedrick¹, Zong-Ming Li¹, Ali Guermazi⁴ and Kent Kwoh¹, ¹University of Arizona, Tucson, AZ, ²Friedrich-Alexander University Erlangen-Nurnberg, Erlangen, Germany, ³University of Arizona Arthritis Center, Tucson, AZ, ⁴Boston University, Boston, MA
Background/Purpose: Subchondral bone marrow lesions (BMLs) are associated with symptoms and structural progression of knee OA. BMLs are characterized by diffuse hyperintensity on fat suppressed…
Abstract Number: 1475 • ACR Convergence 2021
Long Term Compressive Loading Modulates the Extracellular Matrix Response to Growth Factors in Bovine Cartilage Explants
Frederik Gillesberg¹, Amalie Engstrøm¹, Morten Karsdal², Anne-Christine Bay-Jensen³ and Christian S Thudium³, ¹University of Copenhagen, Herlev, Denmark, ²Nordic Bioscience, Herlev, ³Nordic Bioscience, Herlev, Denmark
Background/Purpose: Mechanical loading of cartilage is an essential part of the function and maintenance of the joint. Despite the apparent importance of continuous mechanical loading,…
Abstract Number: 1476 • ACR Convergence 2021
Metabolic Reprogramming: Inhibiting Osteoarthritis-induced Expression of the Pyruvate Dehydrogenase Kinase Preserves Mitochondrial Respiration
Alexandra Damerau¹, Marieluise Kirchner², Moritz Pfeiffenberger¹, Duc Ha Do Nguyen¹, Yannick Palmowski¹, Benjamin Bartek¹, Tazio Maleitzke¹, Sebastian Hardt¹, Tobias Winkler¹, Frank Buttgereit³ and Timo Gaber¹, ¹Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ²Berlin Institute of Health and Max-Delbrück-Centrum for Molecular Medicine, Berlin, Germany, ³Charité – Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Osteoarthritis (OA) is the most common degenerative joint disease worldwide, traditionally classified as non-inflammatory. Recently, attention has been drawn to the importance of synovitis…
Abstract Number: 1477 • ACR Convergence 2021
Circulating MicroRNAs in Hand Osteoarthritis
Aneta Pekacova¹, Jiri Baloun¹, Olga Sleglova¹, Jiri Vencovsky¹, Karel Pavelka², Ladislav Senolt² and Olga Ruzickova¹, ¹Institute of Rheumatology, Prague, Czech Republic, ²Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Background/Purpose: microRNAs (miRNAs) are small non-coding RNAs that can ignite the degradation of mRNAs or inhibit the protein translation and are therefore essential for several…
Abstract Number: 1478 • ACR Convergence 2021
An Orphan Receptor and Osteoarthritis: Mouse Gpr34 Expression in Dorsal Root Ganglia After Partial Meniscectomy
David Thomas¹, Terese Geraghty², Alia Obeidat², Jun Li², Rachel Miller² and Anne-Marie Malfait³, ¹University of Minnesota Internal Medicine Residency, St. Paul, MN, ²Rush University Medical Center, Chicago, IL, ³Rush University, Chicago, IL
Background/Purpose: Osteoarthritis (OA) is one of the leading causes of musculoskeletal pain and disability. Worldwide, an estimated 303 million patients have clinically diagnosed OA, with…
Abstract Number: 1479 • ACR Convergence 2021
CD14, a Toll-like Receptor Co-Factor, Influences Osteoclast Differentiation and Activity, but Does Not Alter Osteoblastic Potential of Bone-Marrow Precursors in Mice
Jerahme Martinez, Vu Nguyen, Cheng Zhou, George Dodge and Carla Scanzello, University of Pennsylvania, philadelphia, PA
Background/Purpose: Changes in subchondral bone structure (SCB) occur in osteoarthritis (OA), and are visible by imaging as subchondral sclerosis on radiographs, and bone marrow lesions…
Abstract Number: 1480 • ACR Convergence 2021
LncRNA XIST Alters the Balance of Peripheral Blood Immune Cells in Systemic Lupus Erythematosus by Regulating the miR-17-92/OFLM4 and CEACAM8 Axis
Qi Cheng, Mo Chen, xin Chen, peiyu zhang, huaxiang wu and yan du, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (People's Republic)
Background/Purpose: X-inactive-specific transcript (XIST) has been shown to silence linked genes on the X chromosome that may be related to the pathogenesis of systemic lupus…
Abstract Number: 1481 • ACR Convergence 2021
Malondialdehyde-acetaldehyde Antibodies Occur in Systemic Lupus Erythematosus and Associate Specifically with Neuropsychiatric Involvement
Rory Monahan, Michelle van Beukel, Nicole Borggreven, Margreet Kloppenburg, Tom WJ Huizinga, Gerda Steup-Beekman and Leendert Trouw, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease characterized by a global loss of self-tolerance. Although autoantibodies are an important hallmark of SLE,…
Abstract Number: 1482 • ACR Convergence 2021
LN Urinary Proteomics Reveals Common Biological Pathways Identified by Distinct Disease Measures
Paul Newcombe¹, Madhu Ramaswamy², Dominic Sinibaldi², Catharina Lindholm³, Frederick Jones¹, Ahmad Akhgar², Philip Brohawn², Raj Tummala² and Wendy White², ¹BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, ²BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, ³BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
Background/Purpose: LN is a severe consequence of SLE and there is a huge unmet need for discovery of urine protein biomarkers that provide non-invasive surrogates…

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