Abstracts Archive - Page 803 of 2425 - ACR Meeting Abstracts

Abstract Number: 161 • 2020 Pediatric Rheumatology Symposium
Impact of the Month of Birth on the Development of Juvenile Idiopathic Arthritis in the United States
Brandon Estroff ¹, Ishaan Dave ², Talia Gergely ², Lori Ponder ³, Courtney McCracken ² and Sampath Prahalad⁴ for the CARRA investigators, ¹, ²Emory University School of Medicine, Atlanta, ³Emory University, Atlanta, ⁴Emory + Children's Pediatric Institute, Atlanta
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is an autoimmune childhood arthropathy influenced by genetic as well as environmental factors. Several autoimmune disorders have been postulated to…
Abstract Number: 162 • 2020 Pediatric Rheumatology Symposium
Minor Biomarkers in Juvenile Idiopathic Arthritis (JIA)
Terry Moore¹, Austin Dalrymple ², Lance Feller ³ and Paul Tuttle ⁴, ¹ST. LouisUniv12651729, St. Louis, Missouri, ²Saint Louis University School of Medicine, Saint Louis, Missouri, ³Orlando, Florida, ⁴OSMS, Hobart, Wisconsin
Background/Purpose: JIA is a heterogeneous group of patients with varying types of biomarkers detected in a small percentage of patients. More specific biomarkers would help…
Abstract Number: 163 • 2020 Pediatric Rheumatology Symposium
Anti-Dense Fine Speckled (DFS) Autoantibodies in Autoinflammatory Vasculopathies
Asa Laestadius¹, May Choi ¹, Marvin Fritzler ¹, Aurore Fifi-Mah ², Susanne Benseler ³ and Joao Dantas ¹, ¹University of Calgary, Calgary, Canada, ²Calgary, Canada, ³Univeristy of Calgary, Calagry, Canada
Background/Purpose: Autoantibodies to dense fine speckles 70 (DFS70) is now recognized to be more common among apparently healthy individuals compared to patients with ANA-related rheumatic…
Abstract Number: 164 • 2020 Pediatric Rheumatology Symposium
The Juvenile Idiopathic Arthritis-Associated IL2RA and IL6R Haplotypes Contain Enhancers Whose Functions Are Altered by JIA-Associated Genetic Variants
Kaiyu Jiang ¹, Yungki Park ², tao liu ³, Marc Sudman ⁴, Susan Thompson ⁵ and James Jarvis⁶, ¹University at Buffalo, Buffalo, ²University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, ³Roswell Park Cancer Institute, Buffalo, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, ⁵Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati, ⁶University at Buffalo Jacobs School of Medicine, Buffalo
Background/Purpose: The JIA risk haplotypes, like those of other autoimmune diseases, are highly enriched for H3K4me1/H3K27ac histone marks, epigenetic features typically associated with functional enhancers.…
Abstract Number: 165 • 2020 Pediatric Rheumatology Symposium
A Massively Parallel Reporter Assay Screen of Genetic Variants on JIA Haplotypes Reveals Variants Associated with Altered Function of an Intergenic Enhancer in the HLA Class II Locus
Kaiyu Jiang ¹, tao liu ², Ryan Tewhey ³ and James Jarvis⁴, ¹University at Buffalo, Buffalo, ²Roswell Park Cancer Institute, Buffalo, ³Jackson Laboratories, Bar Harbor, ⁴University at Buffalo Jacobs School of Medicine, Buffalo
Background/Purpose: While genome-wide association studies have provided valuable information about genetic risk for juvenile idiopathic arthritis (JIA), we are still unable to determine the actual…
Abstract Number: 166 • 2020 Pediatric Rheumatology Symposium
Resident Memory T Cells in Human RA Synovium Display Restricted TCR Clones
Margaret Chang¹, Anais Levescot ², Nathan Nelson-Maney ³, Rachel Blaustein ⁴, Kellen Winden ¹, Allyn Morris ⁴, Spoorthi Balu ⁴, Alexandra Wactor ⁴, Kevin Wei ⁵, Lauren Henderson ⁶, Rachael Clark ⁴, Deepak Rao ⁴, Robert Fuhlbrigge ⁷ and Peter Nigrovic ⁸, ¹Boston Children's Hospital, Boston, ²Boston, ³, ⁴Brigham and Women's Hospital, Boston, ⁵BWH, Boston, ⁶Boston Children's Hospital, Watertown, Massachusetts, ⁷University of Colorado, Aurora, ⁸Boston Children's Hospital, Boston, Massachusetts
Background/Purpose: Resident memory T cells (TRM) are site-specific memory T cells that take up long-term residence in peripheral tissues and aid in pathogen defense. Dysregulated…
Abstract Number: 167 • 2020 Pediatric Rheumatology Symposium
Lipidomic Profiles of Synovial Fluid from Patients with Oligoarticular Juvenile Idiopathic Arthritis Naïve to Treatment
Melissa Elder ¹, Luciana Paim marques², Akaluck Thatayatikom ¹, John Bowden ², Bianca da SIlva ² and Juan Aristizabal ², ¹University of Florida, Gainesville, ²University of Florida, Gainesville, Florida
Background/Purpose: Metabolomic and lipidomic pathways serve as key sensors and effectors of genetic, epigenetic, and environmental factors that shape the development and function of the…
Abstract Number: 168 • 2020 Pediatric Rheumatology Symposium
Examining the Role of IFN-I and Langerhans Cell ADAM17 in Lupus Photosensitivity
Keila Veiga¹, Noa Schwartz ², William Shipman ¹, Marvin Sandoval ³, Thomas Li ¹, Yurii Chinenov ¹, David Oliver ¹, Ali Jabbari ⁴, James Krueger ⁵, Sarah Taber ¹, Niroshana Anandasabapathy ⁶ and Theresa Lu ¹, ¹Hospital for Special Surgery, New York, ²Albert Einstein College of Medicine/Montefiore Medical Center, New York, ³Weill Cornell Graduate School of Medical Sciences, New York, ⁴University of Iowa, Iowa City, ⁵Rockefeller Center, New York, ⁶Weill Cornell Medicine, New York
Background/Purpose: Photosensitivity resulting in inflammatory skin lesions is a hallmark of cutaneous lupus. Lesions can be disfiguring and have a negative impact on quality of…
Abstract Number: 169 • 2020 Pediatric Rheumatology Symposium
Addressing the Pediatric Rheumatology Workforce Shortage: Is Early Exposure Enough?
Katherine Schultz¹, Theresa Hennard ², Britne Gregg ³, Melissa Klein ⁴, Francis Real ² and Jennifer Huggins ², ¹Cincinnati Childrens Hospital Medical Center, Newport, ²Cincinnati Children's Hospital Medical Center, Cincinnati, ³, ⁴Cincinnati
Background/Purpose: The current demand for pediatric rheumatologists in the United States exceeds supply by 33%, a figure projected to worsen to 61% by 20301. This…
Abstract Number: 170 • 2020 Pediatric Rheumatology Symposium
Clinical Team Perspectives on the Transition from Pediatric to Adult Care for Patients with Childhood-Onset SLE
Nicole Bitencourt¹, Justin Kramer ², Bonnie Bermas ³, Elizabeth Solow ², Tracey Wright ² and Una Makris ², ¹UT Southwestern Medical Center, Dallas, Texas, ²UT Southwestern Medical Center, Dallas, ³UTSouthwestern Medical Center, Dallas
Background/Purpose: The transition from pediatric to adult care for youth with chronic disease is known to be a vulnerable period, with adverse outcomes described for…
Abstract Number: 171 • 2020 Pediatric Rheumatology Symposium
Development and Acceptability of an Adolescent Self-management Program for Juvenile Idiopathic Arthritis
Kelsey Chomistek¹, Cheryl Barnabe ², Katie Birnie ³, Julia Brooks ⁴, Tracey Clancy ⁵, Syeda Farwa Naqvi ⁵, Nadia Luca ⁵, Maggie Mercer ⁴, Maria Santana ⁵, Jennifer Stinson ⁶, Aynsley Wennberg ⁴ and Heinrike Schmeling ⁷, ¹Calgary, Alberta, Canada, ²University of Calgary, Calgary, Alberta, Canada, ³Alberta Children's Hospital, Calgary, Canada, ⁴Alberta Children's Hospital, Calgary, Alberta, Canada, ⁵University of Calgary, Calgary, Canada, ⁶University of Toronto & The Hospital for Sick Children, Toronto, Ontario, Canada, ⁷Alberta Children's Hospital/University of Calgary, Calgary, Alberta, Canada
Background/Purpose: Needs assessments have revealed an urgent need for disease information, self-management skills, and peer support for patients with juvenile idiopathic arthritis (JIA). Our aim…
Abstract Number: 172 • 2020 Pediatric Rheumatology Symposium
Improved Self-efficacy and Knowledge in Pediatric Rheumatology Among General Pediatric Residents Following the Introduction of a Standardized Teaching Series
Elizaveta Limenis¹, Alhanouf Alsaleem ², Herman Tam ³, Piya Lahiry ¹, Kate Neufeld ⁴ and Shirley Tse ⁵, ¹Hospital for Sick Children, Toronto, Canada, ²KFSH&RC, RiYADH, Saudi Arabia, ³The Hospital for Sick Children, Toronto, Canada, ⁴University of Toronto, The Hospital for Sick Children, Toronto, Canada, ⁵SickKids, Toronto, Canada
Background/Purpose: Self-efficacy and knowledge in core pediatric rheumatology (PR) topics are generally low among pediatric residents before their mandatory rotations in PR. The teaching style…
Abstract Number: 173 • 2020 Pediatric Rheumatology Symposium
Impact of a Nutrition-Focused Quality Improvement Intervention on Hospital Readmission Rates in Henoch-Schönlein Purpura with Gastrointestinal Involvement
Maria Pereira¹, Miriah Gillispie-Taylor ², Pooja Patel ³, Michael Nelson ⁴, Ugo Awa ⁴, Monica Bray ⁵, Amanda Brown ⁴, Andrea Ramirez ⁶, MaiLan Nguyen ⁴, Saimun Singla ⁴, Tiphanie Vogel ⁴, Eyal Muscal ⁵, Marietta De Guzman ⁶, Elisabeth Hastings ⁷, Ashleigh Russell ⁷ and Kristina Lakenmacher ⁷, ¹Assistant Professor, Section of Rheumatology, Division of Pediatrics, Baylor College of Medicine, Houston, Texas, ²Levine Children's Hospital, Charlotte, ³Baylor College of Medicine, Houston, Texas, ⁴Baylor College of Medicine, Houston, ⁵Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, Houston, ⁶Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, ⁷Texas Children's Hospital, Houston
Background/Purpose: Henoch-Schönlein Purpura (HScP) is the most common form of vasculitis in children, with gastrointestinal (GI) complaints occurring in more than a third of patients…
Abstract Number: 174 • 2020 Pediatric Rheumatology Symposium
Improving Hospital Discharge Instructions for Pediatric Rheumatology Patients
Laura Ballenger¹, Vidya Sivaraman ², Stephanie Lemle ³ and Kyla Driest ¹, ¹Division of Rheumatology, Nationwide Children's Hospital, Columbus, ²Division of Rheumatology, Nationwide Children's Hospital, Bexley, ³Quality Improvement Services, Nationwide Children's Hospital, Columbus
Background/Purpose: Communication, including clear discharge instructions, is a crucial aspect of the hospital discharge process. Development of standardized discharge templates has been reported to improve…
Abstract Number: 175 • 2020 Pediatric Rheumatology Symposium
Application of Juvenile Idiopathic Arthritis Treatment Guidelines and Factors Associated with Increased Likelihood of Intra-articular Corticosteroid Administration
Erin Balay¹, Jennifer Weiss ², Y. Ingrid Goh ³, Nathan Rubin ⁴ and Danielle Bullock ⁴, ¹University of Minnesota, saint paul, ²Hackensack University Medical Center, Hackensack, ³The Hospital for Sick Children, Toronto, Canada, ⁴University of Minnesota, Minneapolis
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a chronic childhood disease which can result in debilitating arthritis. The 2011 ACR JIA treatment guidelines recommend intra-articular corticosteroid…

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