Abstracts Archive - Page 785 of 2425 - ACR Meeting Abstracts

Abstract Number: 1955 • ACR Convergence 2020
High-throughput Identification of Functional Regulatory SNPs Associated with Systemic Lupus Erythematosus
Qiang Wang¹, Marta Martínez², Matthew Weirauch³ and Peter Nigrovic⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, ⁴Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston
Background/Purpose: Systemic lupus erythematosus (SLE) is a disease involves the complex interplay of many genes, reflected in more than one hundred loci linked with disease…
Abstract Number: 1956 • ACR Convergence 2020
Dysregulated Expression of the Long Non-coding RNA, LINC01871, Implicated in Sjögren’s Syndrome Pathogenesis
Michelle Joachims¹, Bhuwan Khatri¹, Kandice Tessneer², Anna Stolarczyk¹, Graham Wiley¹, Astrid Rasmussen¹, Joel Guthridge¹, Judith James³, R. Scofield¹, Kathy Sivils¹, Indra Adrianto⁴ and Christopher Lessard¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, ⁴Henry Ford Health System, Detroit, MI
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammatory destruction of the exocrine glands. Long non-coding RNAs (lncRNAs) are a functionally diverse class…
Abstract Number: 1957 • ACR Convergence 2020
A Single Cell Stromal Atlas Identifies Conserved Fibroblast Phenotypes Expanded in the Inflamed Synovium, Lung, Intestine, and Salivary Gland
Ilya Korsunsky¹, Kevin Wei², Mathilde Pohin³, Edy Kim⁴, Jason Turner⁵, Saba Nayar⁶, Benjamin Fisher⁷, Karim Raza⁸, Matthias Friedrich⁹, Jennifer Marshall⁵, Adam Croft⁵, Mark Coles¹⁰, Andreas Frei¹¹, Andrew Filer¹², Francesca Barone⁵, Kara Lassen¹¹, Fiona Powrie¹⁰, Christopher Buckley¹³, Michael Brenner² and Soumya Raychaudhuri¹⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, Oxford, United Kingdom, ⁴Brigham and Women’s Hospital, Division of Pulmonary and Critical Care Medicine, Boston, MA, ⁵Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom, ⁶Institute for Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁷University Hospitals Birmingham NHS Foundation Trust-Birmingham, Birmingham, United Kingdom, ⁸Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom, ⁹Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom, ¹⁰Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ¹¹Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland, ¹²Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ¹³University of Birmingham, Birmingham, United Kingdom, ¹⁴Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Pro-inflammatory fibroblasts have been independently implicated in the pathogenesis of rheumatoid arthritis (RA), inflammatory bowel disease (IBD), interstitial lung disease (ILD), and Sjogren’s syndrome…
Abstract Number: 1958 • ACR Convergence 2020
Patterns and Impact of Long-term Glucocorticoid Use on RA Patients at Risk for Major Adverse Cardiac Events
Beth Wallace¹, Yuqing Gao², Punyasha Roul³, Bryant England³, Ted Mikuls³, Shirley Cohen-Mekelburg⁴, Daniel Clauw⁵, Rodney Hayward¹ and Akbar Waljee¹, ¹Michigan Medicine, VA Ann Arbor Healthcare System Center for Clinical Management Research, Ann Arbor, MI, ²VA Ann Arbor Healthcare System, Center for Clinical Management Research, Ann Arbor, MI, ³University of Nebraska Medical Center, Omaha, NE, ⁴Michigan Medicine/VA Ann Arbor Healthcare System Center for Clinical Management Research, Ann Arbor, MI, ⁵Michigan Medicine, Ann Arbor, MI
Background/Purpose: One-quarter to one-third of RA patients use long-term glucocorticoids (GCs) despite their known, dose-dependent association with increased risk of major adverse cardiovascular (CV) events…
Abstract Number: 1959 • ACR Convergence 2020
Epidemiology of Hospitalizations and Associated Mortality in Vasculitis: A National Study
Jasvinder Singh¹ and John Cleveland¹, ¹University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: To assess whether comorbid diseases frequently associated with primary hospitalizations for non-vasculitis causes in people with vasculitis are changing over time in people with…
Abstract Number: 1960 • ACR Convergence 2020
Cost-effectiveness of Surgical and Non-Surgical Weight Loss Programs for Morbidly Obese Patients with Knee Osteoarthritis
Valia Leifer¹, Jeffrey Katz², Faith Selzer³, Tuhina Neogi⁴, Jamie Collins⁵ and Elena Losina², ¹The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, ²Harvard Medical School / The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA, ³The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Amesbury, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA
Background/Purpose: Growing numbers of knee osteoarthritis (KOA) patients are morbidly obese (BMI ≥ 35 kg/m2). Evolving evidence suggests weight reduction may delay the structural progression…
Abstract Number: 1961 • ACR Convergence 2020
Decreased Visits in RISE Practices Due to the SARS-CoV-2 Global Pandemic
Jing Li¹, Sarah Ringold², Jeffrey R Curtis³, Kaleb Michaud⁴, Tracy Johansson⁵, Jinoos Yazdany⁶ and Gabriela Schmajuk⁷, ¹University of California, San Francisco, San Francisco, CA, ²Seattle Children's, Seattle, WA, ³Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵Adult / ACR Test Training Program #4, Atlanta, GA, ⁶UCSF, San Francisco, CA, ⁷University of California, San Francisco, Atherton, CA
Background/Purpose: The SARS-CoV-2 global pandemic has resulted in major disruptions to medical care, including rheumatology. We aimed to understand the changes in clinical visit counts…
Abstract Number: 1962 • ACR Convergence 2020
Utilization of Telehealth Among Patients with Rheumatic Diseases in the Early Months of the COVID-19 Pandemic
Kristin Wipfler¹, Yomei Shaw², Teresa Simon³, Adam Cornish¹, Patricia Katz⁴ and Kaleb Michaud⁵, ¹FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ²FORWARD, The National Databank for Rheumatic Diseases, East Lansing, MI, ³Bristol-Myers Squibb Company (at time of analysis), Princeton, NJ, ⁴University of California, San Francisco, Novato, CA, ⁵University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Many health care providers replaced in-person clinical visits with telehealth visits or expanded their telehealth offerings due to the COVID-19 pandemic. We sought to…
Abstract Number: 1963 • ACR Convergence 2020
Variation in Quality of Care Among Patient Sociodemographic Groups in RISE Practices
Zara Izadi¹, Gabriela Schmajuk² and Jinoos Yazdany³, ¹University of California San Francisco, San Francisco, CA, ²University of California, San Francisco, Atherton, CA, ³University of California, San Francisco, San Francisco, CA
Background/Purpose: Previous studies have shown that sociodemographic factors are associated with quality of care. Using the Rheumatology Informatics System for Effectiveness (RISE) registry, we assessed…
Abstract Number: 1964 • ACR Convergence 2020
Engaging Patients in the Development of a Quality Measure of Functional Status to Improve Care Among Patients with Rheumatoid Arthritis
Sarah Hopkins Gillespie¹, Liana Fraenkel², Lisa Suter³, Gabriela Schmajuk⁴, Patricia Katz⁵, Alex Limanni⁶ and Alexis Ogdie¹, ¹University of Pennsylvania, Philadelphia, PA, ²Yale School of Medicine; West Haven VA; Berkshire Medical Center, Lenox, MA, ³Yale School of Medicine, New Haven, CT, ⁴University of California, San Francisco, Atherton, CA, ⁵University of California, San Francisco, Novato, CA, ⁶n/a, Dallas, TX
Background/Purpose: The ACR Quality of Care committee is working to develop a quality measure to reflect functional assessment in rheumatoid arthritis (RA). One proposed approach…
Abstract Number: 1965 • ACR Convergence 2020
Reducing Delays for Biologic Medication Approval in Outpatient Rheumatology
Josh Waytz¹, Dahlia Sultan¹ and Veena Patel², ¹University of Chicago, Chicago, IL, ²Dell Medical School - UT Health Austin, Austin, TX
Background/Purpose: Biologic medications are commonly used for numerous rheumatologic conditions. A significant proportion of these medications are denied for non-medical reasons by insurance companies causing…
Abstract Number: 1966 • ACR Convergence 2020
Improving Value Concordant Care Through Increased Use of Subcutaneous Methotrexate in Rheumatoid Arthritis
Jason Bankert¹, Jonida Cote², Joseph Chronowski¹ and Eric Newman¹, ¹Geisinger Medical Center, Danville, PA, ²Geisinger Medical Center, Danvile, PA
Background/Purpose: Rheumatoid Arthritis (RA) is an expensive disease which untreated can lead to disability and socioeconomic burden. This high cost of treatment impacts the use…
Abstract Number: 1967 • ACR Convergence 2020
Combating Rheumatologist Burnout: Use of Protocol Driven Medication Refill by Pharmacists
Eva Rottmann¹, Jonida Cote², Swana Thomas³, Dante Grassi¹, Joseph Chronowski¹, Lisa L. Schroeder¹, David Pugliese⁴ and Eric Newman¹, ¹Geisinger Medical Center, Danville, PA, ²Geisinger Medical Center, Danvile, PA, ³Geisinger Medical Center, Wilkes-Barre, PA, ⁴Geisinger Health System, Wilkes Barre, PA
Background/Purpose: Increased electronic health record (EHR) administrative workload is a great source of physician dissatisfaction. We embedded pharmacists into our Rheumatology team in 2019. This…
Abstract Number: 1968 • ACR Convergence 2020
Cathepsin S Gene Expression Measured in the Peripheral Blood of Osteoarthritic Patients Prior to Surgery as a Biomarker of Post-operative Pain Development
Elena Tchetina¹, Kseniya Glemba¹, Galina Markova¹, Maksim Makarov¹ and Aleksandr Lila¹, ¹Nasonova Research Institute of Rheumatology, Moscow, Russia
Background/Purpose: Osteoarthritis (OA) is a chronic rheumatic disease, which involves pain, limited inflammation, and local destruction of the knee joint. OA pain is a major…
Abstract Number: 1969 • ACR Convergence 2020
The Dynamics of Macrophage Sub-Populations in the Inflammatory Phase Following Joint Trauma
Samuel Hamilton¹, Anna Montgomery¹, Niamh Fahy², Maximilian Mayr¹, Shang-Yang Chen¹, Gaurav Gadhvi¹, Yvonne Bastiaansen-Jenniskens² and Deborah Winter³, ¹Northwestern University, Chicago, IL, ²Erasmus MC, Rotterdam, Netherlands, ³Northwestern University Division of Rheumatology, Chicago, IL
Background/Purpose: Macrophages fulfill critical functions in maintaining tissue homeostasis in steady-state, as well as in inflammation and immune response. In the joint synovium, we have…

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