Abstracts Archive - Page 773 of 2607 - ACR Meeting Abstracts

Abstract Number: 1018 • ACR Convergence 2021
Joint-Draining Popliteal Lymphatic Vessels Exhibit Lymphatic Muscle Cell Dysfunction in TNF-Tg Mice with Inflammatory Arthritis
H. Mark Kenney¹, Yue Peng¹, Karen de Mesy Bentley¹, Chad Galloway¹, Homaira Rahimi², Lianping Xing³, Christopher Ritchlin⁴ and Edward Schwarz², ¹University of Rochester Medical Center, Rochester, NY, ²University of Rochester, Rochester, NY, ³University of Rochester Medical Center, Webster, NY, ⁴Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Lymphatic dysfunction is a factor in the onset and progression of rheumatoid arthritis (RA) (1). Our prior studies demonstrated reduced lymphatic clearance in the…
Abstract Number: 1019 • ACR Convergence 2021
Cigarette Smoking Induces Post-translational Protein Modifications in Both in Vitro and in Vivo Models of Rheumatoid Arthritis-associated Interstitial Lung Disease
Alyssa Gregory¹, Corrine Kliment¹, Geoffrey Thiele², Michael Duryee², Ted Mikuls², Bryant England², Jill Poole² and Dana Ascherman³, ¹University of Pittsburgh School of Medicine, Pittsburgh, PA, ²University of Nebraska Medical Center, Omaha, NE, ³University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Cigarette smoking has been epidemiologically linked to the development of ACPA+ rheumatoid arthritis (RA) and, by extension, RA-associated interstitial lung disease (RA-ILD). Providing strong…
Abstract Number: 1020 • ACR Convergence 2021
Enhancing Endothelial Cell Barrier Function via Sphingosine -1 Phosphate Receptor 1 (S1PR1) – a Novel Treatment for Experimental Arthritis
Nathalie Burg, Ryan Malpass, Carl Blobel and Jane Salmon, Hospital for Special Surgery, New York, NY
Background/Purpose: S1PR1 signaling plays critical roles in EC barrier function and vascular health, but until now, research on S1PR1 modulation in autoimmune rheumatic disease has…
Abstract Number: 1021 • ACR Convergence 2021
Organic Dust Exposure Induces Post-translational Protein Modifications and a HLA-DR4-dependent Pro-inflammatory Lung Phenotype in a Murine Model of Interstitial Lung Disease
Jill Poole¹, Ted Mikuls¹, Amy Nelson¹, Rohit Gaurav¹, Michael Duryee¹, Geoffrey Thiele¹, Bryant England¹ and Dana Ascherman², ¹University of Nebraska Medical Center, Omaha, NE, ²University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Environmental and occupational exposures have been epidemiologically linked to the development of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Previous investigation and modeling have also…
Abstract Number: 1022 • ACR Convergence 2021
Incidence of Antisynthetase Syndrome and Risk of Malignancy in a Population-based Cohort (1998-2019)
Caitrin Coffey¹, Li Wang¹, Stephanie Duong¹, Cassondra Hulshizer¹, Cynthia Crowson², Jay Ryu¹ and Floranne Ernste¹, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Eyota, MN
Background/Purpose: The antisynthetase syndrome (ASSD) is a distinct subgroup of the idiopathic inflammatory myopathies characterized by myositis, interstitial lung disease, inflammatory arthritis, Raynaud’s phenomenon and…
Abstract Number: 1023 • ACR Convergence 2021
Racial and Ethnic Distribution of Rheumatic Diseases in Health Systems of the National Patient-Centered Clinical Research Network
William Nowell¹, Edward L. Barnes², Nupur Parikh¹, Shilpa Venkatachalam¹, Michael Kappelman², Jeffrey Curtis³, Peter Merkel⁴, Dianne Shaw⁵, Kalen Young⁵ and Michael George⁴, ¹Global Healthy Living Foundation, Upper Nyack, NY, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Vasculitis Foundation, Kansas City, MO
Background/Purpose: Ensuring adequate representation of racial/ethnic minorities in research necessitates understanding the prevalence of rheumatic and musculoskeletal diseases in these populations. We sought to evaluate…
Abstract Number: 1024 • ACR Convergence 2021
Medical Care Seeking Is Frequent and Associated with Overuse of Low-Value Care for Low Back Pain in Portugal: Results from a Nationwide Population-Based Study
Luís Antunes Gomes¹, Eduardo Brazete Cruz², Ana Rita Henriques¹, Jaime Branco³, Helena Canhão⁴ and Ana Maria Rodrigues³, ¹EpiDoC Unit, Comprehensive Health Research Centre (CHRC), Lisbon, Portugal, ²Comprehensive Health Research Centre (CHRC), Setubal, Portugal, ³EpiDoC Unit, CEDOC, Nova Medical School, Comprehensive Health Research Centre (CHRC), Lisbon, Portugal, ⁴EpiDoC Unit, Comprehensive Health Research Centre (CHRC), Lisboa, Portugal
Background/Purpose: Low back pain (LBP) constitutes an important cause of disability and morbidity in general population. Appropriate care for LBP includes non-pharmacological interventions based on…
Abstract Number: 1025 • ACR Convergence 2021
Survival of Patients with Idiopathic Inflammatory Myopathy in Slovenia
Alojzija Hocevar¹, Andrej Virscek², Monika Krosel¹, Matija Tomšič³ and Ziga Rotar³, ¹UKC Ljubjana, Ljubjana, Slovenia, ²Statistical Office of the Republic of Slovenia, Ljubljana, Slovenia, ³Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of rare systemic diseases associated with significant morbidity and mortality. The aim of our study was to…
Abstract Number: 1026 • ACR Convergence 2021
Factors Impacting Likelihood of Discontinuing Immunosuppression in Adult Dermatomyositis: A Single-Center Study
Sung Kyung Cho¹, Lorinda Chung² and David Fiorentino³, ¹University of Texas Southwestern, Dallas, TX, ²Stanford University, Palo Alto, CA, ³Stanford University, Redwood City, CA
Background/Purpose: Dermatomyositis (DM) is a chronic idiopathic inflammatory myopathy with variable clinical course, but little is known regarding factors associated with remission of disease. We…
Abstract Number: 1027 • ACR Convergence 2021
Epidemiology of Latent Tuberculosis Infection in Patients with Rheumatic Immune-mediated Diseases: Single University Study of 1117 Patients
David Martinez-Lopez¹, Joy Osorio-Chávez¹, Carmen Álvarez-Reguera¹, Virginia Portilla², Miguel Ángel gonzalez-Gay³ and Ricardo Blanco⁴, ¹Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ³Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla; School of Medicine, Universidad de Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ⁴Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
Background/Purpose: Background: Patients with rheumatologic immune-mediated diseases (R-IMID) with Latent tuberculosis infection (LTBI) requiring biologic therapy (BT) are at an increased risk of active tuberculosis…
Abstract Number: 1028 • ACR Convergence 2021
Knee Osteoarthritis and Mortality: The Osteoarthritic Initiative
Jane Cauley¹, Michael Nevitt², Kai Sun³, Jason Maeda³, C. Kent Kwoh⁴, Leena Sharma⁵, Rebecca Jackson⁶, Susan Rubin³ and Marc Hochberg⁷, ¹University of Pittsburgh Graduate School of Public Health, Pittsbugh, PA, ²University of California San Francisco, Orinda, CA, ³University of California San Francisco, San Francisco, CA, ⁴University of Arizona College of Medicine, Tuscon, AZ, ⁵Northwestern University, Chicago, IL, ⁶Ohio State University, Columbus, OH, ⁷University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: A recent international individual participant data (IPD) meta-analysis (n=10,723) reported a 35-37% increased mortality risk among individuals with painful knees (no radiographic OA) and…
Abstract Number: 1029 • ACR Convergence 2021
Evaluation of the EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus in a Population-Based Registry
Allison Guttmann¹, Brendan Denvir¹, Jill Buyon², Martin Aringer³, H. Michael Belmont², Sara Sahl⁴, Jane Salmon⁵, Anca Askanase⁶, Joan Bathon⁷, Laura Geraldino⁸, Yousaf Ali⁹, Ellen Ginzler¹⁰, Chaim Putterman¹¹, Caroline Gordon¹², Charles Helmick¹³, Hilary Parton¹⁴ and Peter Izmirly¹, ¹New York University School of Medicine, New York, NY, ²NYU School of Medicine, New York, NY, ³Rheumatology, Medicine III, University Medical Center & Faculty of Medicine, TU Dresden, Dresden, Germany, ⁴UCLA-Harbor, Los Angeles, CA, ⁵Hospital for Special Surgery, New York, NY, ⁶Columbia University Medical Center, New York, NY, ⁷Columbia University, New York, NY, ⁸New York Presbyterian Hospital - Columbia Campus, New York, NY, ⁹Icahn School of Medicine at Mount Sinai, New York, NY, ¹⁰SUNY Downstate Health Sciences University, Brooklyn, NY, ¹¹Albert Einstein College of Medicine, Bronx, NY, ¹²Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ¹³Centers for Disease Control and Prevention, Atlanta, GA, ¹⁴New York City Department of Health and Mental Hygiene, Long Island City, NY
Background/Purpose: The Manhattan Lupus Surveillance Program (MLSP) is a multi-racial/ethnic population-based registry with the primary goal to determine the prevalence and incidence of Systemic Lupus…
Abstract Number: 1030 • ACR Convergence 2021
Critical Illness in Modern Rheumatology: Analysis of Admissions to Australian and New Zealand ICUs
Robyn Lambert¹, Shailesh Bihari², Mihir Wechalekar³, David Pilcher⁴ and Eliza Pontifex², ¹Flinders University, South Australia, Adelaide, Australia, ²Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, Australia, ³Flinders Medical Centre, Southern Adelaide Local Health Network, Bedford Park, Australia, ⁴Alfred Health, Melbourne, Australia
Background/Purpose: Patients with systemic rheumatic diseases (SRD) have an increased risk of admission to the Intensive Care Unit (ICU) relative to the general population, secondary…
Abstract Number: 1031 • ACR Convergence 2021
Clinical and Humanistic Burden of Dermatomyositis and Polymyositis in the United States: A Systematic Literature Review
Swamy Venuturupalli¹, Namita Goyal², Nathalie Fortune³, Richard Leff⁴, Konrad Pisarczyk⁵, Izabela Aleksanderek⁶, Kiruthi Palaniswamy⁷ and Noreen Henig⁸, ¹Cedars-Sinai Medical Center, Beverly Hills, CA, ²University of California Irvine, Irvine, CA, ³Attune Health, Beverly Hills, CA, ⁴Richard L Leff MD LLC, Chadds Ford, PA, ⁵Maple Health Group, Krakow, Poland, ⁶Maple Health Group, Toronto, ON, Canada, ⁷Kezar Life Sciences, Los Angeles, CA, ⁸Kezar Life Sciences, Inc, Foster City, CA
Background/Purpose: Dermatomyositis (DM) and polymyositis (PM) are rare heterogenous systemic autoimmune disorders of the skin, muscles, and other organs that may have a devastating impact…
Abstract Number: 1032 • ACR Convergence 2021
Causes of Death Among Populations with Systemic Lupus Erythematosus by Race and Ethnicity
Tiffany Taylor¹, Christine Anastasiou¹, Stephanie Rush¹, Laura Trupin², Maria Dall'Era³, Patricia Katz¹, Kamil Barbour⁴, Jinoos Yazdany¹ and Milena Gianfrancesco¹, ¹University of California San Francisco, San Francisco, CA, ²UC San Francisco, San Francisco, CA, ³University of California San Francisco, Corte Madera, CA, ⁴Centers for Disease Control, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with manifestations that vary widely in severity. Data indicate that minority populations are at higher…

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