Abstracts Archive - Page 742 of 2607 - ACR Meeting Abstracts

Abstract Number: 0553 • ACR Convergence 2021
IgG from Systemic Sclerosis Patients Induce a Profibrosing and Serotype-dependent Phenotype in Normal Dermal Fibroblast: A Multi-omics Study
Aurélien Chepy¹, Solange Vivier², Fabrice Bray³, Martin Figeac⁴, Jean-Pascal Meneboo⁴, Camille Ternynck⁵, Lucile Guilbert², Manel Jendoubi², Christian Rolando³, David Launay¹, Sylvain Dubucquoi⁶, Guillemette Marot⁵ and Vincent Sobanski¹, ¹Univ. Lille, Inserm, CHU Lille, Service de Médecine Interne, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France, Lille, France, ²Univ. Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F59000 Lille, France, Lille, France, ³Univ. Lille, CNRS, USR 3290 - MSAP - Miniaturisation pour la Synthèse, l'Analyse et la Protéomique, F-59000 Lille, France, Lille, France, ⁴Université de Lille, Functional Genomics Platform, Lille, France., Lille, France, ⁵ULR 2694 – METRICS : évaluation des technologies de santé et des pratiques médicales, université de Lille, CHU de Lille, 59000 Lille, France, Lille, France, ⁶Univ. Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F59000 Lille, France, Lille
Background/Purpose: Antinuclear antibodies are frequent in systemic sclerosis (SSc). While recognized as potent biomarkers, their pathogenic role is much more debated. This study explored the…
Abstract Number: 0554 • ACR Convergence 2021
Reverse Signaling Through PD-L1 Plays a Central Role in Extracellular Matrix Protein Secretion from Cutaneous Myofibroblasts in Systemic Sclerosis
Maithri Aspari¹, Stinne Greisen¹, Malene Hvid¹, Klaus Sondergaard², Voon Ong³, Christopher Denton⁴, David Abraham⁵ and Bent Deleuran¹, ¹Aarhus University, Aarhus, Denmark, ²Aarhus University Hospital, Aarhus, Denmark, ³University College London Medical School Royal Free Campus, London, United Kingdom, ⁴University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, ⁵University College London, London, United Kingdom
Background/Purpose: The PD-1/PD-L1 pathway has been implicated in Systemic Sclerosis (dSSc). This disease is dominated by increased extracellular matrix deposition initiated by myofibroblasts. We therefore…
Abstract Number: 0555 • ACR Convergence 2021
Pathway-Driven Drug Repositioning in Systemic Sclerosis from Omics Data
Dillon Popovich¹, Tamar Abel¹, Noelle Kosarek², Monica Espinoza³, Rezvan Parvizi⁴, Jonathan Garlick⁵ and Michael Whitfield⁴, ¹Geisel School of Medicine, West Lebanon, NH, ²Dartmouth Geisel School of Medicine, Hartford, VT, ³Geisel School of Medicine, Hanover, NH, ⁴Geisel School of Medicine, Lebanon, NH, ⁵Tufts University School of Dental Medicine, Boston, MA
Background/Purpose: Omic analyses of systemic sclerosis (SSc) skin biopsy datasets identified distinct sets of patients that respond differently to treatment. The goal of this study…
Abstract Number: 0556 • ACR Convergence 2021
Investigating the Heterogeneity of Skin Macrophages in Systemic Scleroderma
Hadijat Makinde¹, Salina Dominguez¹, Monique Hinchcliff², Deborah Winter³ and Harris Perlman¹, ¹Northwestern University, Chicago, IL, ²Yale School of Medicine, Westport, CT, ³Northwestern University Division of Rheumatology, Chicago, IL
Background/Purpose: The etiology and pathogenesis of systemic sclerosis (SSc) are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes…
Abstract Number: 0557 • ACR Convergence 2021
The Beta Secretase BACE1 Induces Systemic Sclerosis (SSc) Fibroblast Activation Through the Regulation of the Pro-Fibrotic Notch Signalling Pathway
Christopher Wasson¹, Eva Clavane², Rebecca Ross¹, Paul Meakin² and Francesco Del Galdo³, ¹LIRMM University of Leeds, Leeds, United Kingdom, ²LICAMM University of Leeds, Leeds, United Kingdom, ³University of Leeds, Leeds, United Kingdom
Background/Purpose: Extensive work in the Alzheimer’s field has shown BACE1 plays an important role in amyloid beta processing. Additionally, there is evidence showing BACE1 regulating…
Abstract Number: 0558 • ACR Convergence 2021
The Systemic Sclerosis (SSc) Risk Gene A20 (TNFAIP3) and Its Repressor DREAM Determine Susceptibility to Fibrosis
Swarna Bale¹, Wenxia Wang², Roberta G Marangoni³, Erica Herzog⁴, Bettina C Schock⁵, Swati Bhattacharyya¹ and Varga John¹, ¹University of Michigan, Ann Arbor, MI, ²Northwestern University, Chicago, IL, ³University of Rochester, Rochester, NY, ⁴Yale University School of Medicine, New Haven, CT, ⁵Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom
Background/Purpose: The ubiquitin-editing enzyme A20, encoded by TNFAIP3, is genetically implicated in autoimmune and inflammatory diseases. A20 plays a pivotal role in regulating inflammatory cellular…
Abstract Number: 0559 • ACR Convergence 2021
Targeting NNMT as a Novel Metabolic Approach to Treat Systemic Sclerosis
M.Asif Amin¹, Bo Shi², Pei-Suen Tsou¹, Swarna Bale¹, Phillip Campbell¹, Mikel Gurrea-Rubio¹, Mark Eckert³, Ernst Lengyel³, Johann Gudjonsson⁴ and Varga John¹, ¹University of Michigan, Ann Arbor, MI, ²Nothwestern university, Chicago, IL, ³University of chicago, Chicago, IL, ⁴Department of Dermatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Fibrosis, the hallmark of systemic sclerosis (SSc), is associated with metabolic and epigenetic alterations that are incompletely characterized. Our laboratory had previously implicated dysregulated…
Abstract Number: 0560 • ACR Convergence 2021
Effectiveness, Safety, Quality of Life and Patient Satisfaction with Tofacitinib Treatment in Adult Patients with Rheumatoid Arthritis Under Routine Clinical Care: Second Interim Analysis of a German Non-Interventional, Prospective, Multi-Center Study
Klaus Krüger¹, Frank Behrens², Ulrich Prothmann³, Thilo Klopsch⁴, Lisa Blindzellner⁵, Olaf Behmer⁵, Jürgen Jobst⁵, Pascal Klaus⁵, Thomas Meng⁵ and Peter-Andreas Löschmann⁵, ¹Rheumatological Practice Center, Munich, Germany, ²CIRI/Rheumatology & Fraunhofer IME, Research Division Translational Medicine & Pharmacology, Goethe University Hospital, Frankfurt, Germany, ³Knappschaftsklinikum Saar, Püttlingen, Germany, ⁴Rheumatological Practice, Neubrandenburg, Germany, ⁵Pfizer Pharma GmbH, Berlin, Germany
Background/Purpose: Tofacitinib is a Janus kinase inhibitor, which is orally applied and is approved for rheumatoid arthritis among other indications. ESCALATE-RA is the first prospective,…
Abstract Number: 0561 • ACR Convergence 2021
Enhancing the Identification of Rheumatoid Arthritis-Associated Interstitial Lung Disease in Electronic Health Records Through Text Mining of Computerized Tomography Reports
Brent Luedders¹, Brendan Cope², Matt Devries², W. Scott Campbell², James Campbell², Ted Mikuls³, Jeffrey Curtis⁴, Daniel Hershberger³ and Bryant England³, ¹University of Nebraska Medical Center, Omaha, NE, United Kingdom, ²University of Nebraska Medical Center, Omaha, ³University of Nebraska Medical Center, Omaha, NE, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Interstitial lung disease (ILD) is an extraarticular manifestation of RA that leads to increased morbidity and mortality. Algorithms incorporating multiple diagnostic and procedure codes…
Abstract Number: 0562 • ACR Convergence 2021
Inpatient Epidemiology and Resource Utilization of Ankylosing Spondylitis: National Inpatient Sample 2018
Patompong Ungprasert¹, Thanat Chaikijurajai², Karn Wijarnpreecha³ and Paul Kroner³, ¹Cleveland Clinic, Cleveland Heights, OH, ²Cleveland Clinic, Cleveland, OH, ³Mayo Clinic Florida, Jacksonville, FL
Background/Purpose: Little is known about inpatient epidemiology, economic burden and resource utilization of patients with ankylosing spondylitis (AS). The current study aims to describe those…
Abstract Number: 0563 • ACR Convergence 2021
Validating the FRAX Score in a US Population-Based Study of Patients with Rheumatoid Arthritis
Madeline Peterson¹, Cynthia Crowson², Elena Myasoedova¹, Shreyasee Amin¹, John Davis¹, Sara Achenbach¹, Sundeep Kholsa¹ and Elizabeth Atkinson¹, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Eyota, MN
Background/Purpose: The FRAX tool, launched by the World Health Organization Collaborating Centre at the University of Sheffield in 2008 (https://www.sheffield.ac.uk/FRAX/), is widely used to quickly…
Abstract Number: 0564 • ACR Convergence 2021
Associations of Sinusitis, Pharyngitis, and Respiratory Tract Disease Burden with Incident Rheumatoid Arthritis
Vanessa Kronzer¹, Weixing Huang², Alessandra Zaccardelli², Cynthia Crowson³, John Davis¹, Robert Vassallo¹, Tracy Doyle⁴, Elena Losina² and Jeffrey Sparks², ¹Mayo Clinic, Rochester, MN, ²Brigham and Women's Hospital, Boston, MA, ³Mayo Clinic, Eyota, MN, ⁴Brigham and Women's Hospital, West Roxbury, MA
Background/Purpose: Increasing evidence implicates respiratory mucosa in the pathogenesis of rheumatoid arthritis (RA). However, individual respiratory tract diseases, especially of the upper airways, sinuses, and…
Abstract Number: 0565 • ACR Convergence 2021
Increased Risk for Inflammatory Arthritis in Veterans with Depression or Anxiety
Brian Breviu¹, Shaobo Pei¹, Matthew Kirkpatrick², Bingjian Feng¹ and Jessica Walsh³, ¹Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, ²University of Utah, Salt Lake City, UT, ³Salt Lake City Veteran Affairs Medical Center (VAMC)/University of Utah Hospital, Salt Lake City, UT
Background/Purpose: Depression and anxiety are common in patients with inflammatory arthritis (IA), and have been reported as risk factors for various inflammatory diseases. The study…
Abstract Number: 0566 • ACR Convergence 2021
Natural Language Processing of Electronic Health Record Notes Captures Forced Vital Capacity in Rheumatoid Arthritis-Associated Interstitial Lung Disease
Punyasha Roul¹, Yangyuna Yang¹, Daniel Hershberger¹, Ted Mikuls¹, Jorge Rojas², Jeffrey Curtis³, Joshua Baker⁴, Brian Sauer⁵ and Bryant England¹, ¹University of Nebraska Medical Center, Omaha, NE, ²VA Puget Sound, Seattle, WA, ³Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Pennsylvania, Philadelphia, PA, ⁵University of Utah, Salt Lake City, UT
Background/Purpose: Rheumatoid arthritis-interstitial lung disease (RA-ILD) has a poor long-term prognosis, including premature mortality. Longitudinal monitoring of patients in clinical and clinical trial settings includes…
Abstract Number: 0567 • ACR Convergence 2021
Determinants of Health-Related Quality of Life in Spondyloarthritis and Comparison with Chronic Low Back Pain – Results from a Nation-Wide Study
Helena Santos¹, Ana Rita Henriques², Ana Maria Rodrigues³, Jaime Branco³ and Helena Canhao³, ¹Portuguese Institute of Rheumatology, Lisbon, Portugal, ²EpiDoC Unit, Comprehensive Health Research Centre (CHRC), Lisbon, Portugal, ³EpiDoC Unit, CEDOC, NOVA Medical School, Comprehensive Health Research Centre (CHRC), Lisbon, Portugal
Background/Purpose: Spondyloarthritis (SpA) causes pain, fatigue, stiffness, loss of physical function and impaired health-related quality of life (HRQoL).This study aims to: 1) to compare HRQoL…

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