Abstracts Archive - Page 721 of 2425 - ACR Meeting Abstracts

Abstract Number: 1407 • ACR Convergence 2020
Resolvin D5 Modulates Th17/Treg Cell Differentiation and Suppresses Osteoclastogenesis
Hirotaka Yamada¹, Jun Saegusa², Sho Sendo³, Yo Ueda⁴, Takaichi Okano¹, Yoshikazu Fujikawa⁵, Yuzuru Yamamoto⁶, Takumi Nagamoto¹, Yoshihide Ichise¹, Ikuko Naka¹, Kengo Akashi⁷, Akira Onishi⁷, Masakazu Shinohara¹ and Akio Morinobu⁷, ¹Kobe University, Kobe, Japan, ²Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan, ³Kobe University, Kobe, ⁴Kobe UniversityRheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan, ⁵Kobe University, Kobe city, Japan, ⁶Kobe University, Kobe-city, Japan, ⁷Rheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan
Background/Purpose: Over the last two decades, it has become increasingly clear that resolution of acute inflammation is not a passive process, but requires active modulation.…
Abstract Number: 1406 • ACR Convergence 2020
LAG-3+ T Cells Are Diminished in Active Psoriatic Arthritis Patients and Their Restoration in Vitro Is Mediated by TNF Inhibitors
Smadar Gertel¹, Ari Polachek², Victoria Furer³, David Levartovsky³ and Ori Elkayam⁴, ¹Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, ²Tel Aviv Sourasky Medical Center, Petah-Tikva, Israel, ³Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁴Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel
Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis. Aberrant T cell regulation has been implicated in the process of inflammation in…
Abstract Number: 1412 • ACR Convergence 2020
A T Cell Intrinsic Role for Nod2 in Suppression of Th17-Mediated Experimental Arthritis and Uveitis: Implications for Blau Syndrome
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Sydney Lashley², Luke Uebelhoer³, Christina Lancioni³, Richard Vehe⁴, Bryce Binstadt⁴, Rachel Caspi⁵ and Holly Rosenzweig¹, ¹Oregon Health & Science University and VA Portland Health Care System, Portland, OR, ²VA Portland Health Care System, Portland, OR, ³Oregon Health & Science University, Portland, ⁴University of Minnesota, Minneapolis, MN, ⁵NIH, Bethesda, MD
Background/Purpose: Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause Blau syndrome, an inflammatory disorder characterized by uveitis, dermatitis, and polyarthritis. The antimicrobial functions of NOD2 are…
Abstract Number: 1414 • ACR Convergence 2020
Highly Polyfunctional Metabolically Altered Pathogenic T Cells Accumulate in the Synovial Tissue of RA Patients and Arthralgia Subject but Not Healthy Control Synovial Tissue
Achilleas Floudas¹, Barry Moran², Nuno Neto³, Michael Monaghan⁴, Vinod Krishna⁵, Sunil Nagpal⁶, Phil Gallagher⁷, Conor Hurson⁸, Douglas Veale⁹ and Ursula Fearon¹⁰, ¹Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Dublin, Ireland, ²Trinity Biomedical Sciences Institute, Dublin, Ireland, ³Department of Mechanical and Manufacturing Engineering, Dublin, Dublin, Ireland, ⁴Department of Mechanical and Manufacturing Engineering, Dublin, Ireland, ⁵Janssen R&D, Spring House, PA, ⁶Janssen Research & Development, Collegeville, PA, ⁷St Vincents University Hospital, UCD, Dublin, Ireland, ⁸St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, ⁹EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, ¹⁰Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland
Background/Purpose: Effective treatment of Rheumatoid arthritis (RA) patients is achievable within a short window of opportunity following diagnosis. Identification of pathogenic immune mechanisms at a…
Abstract Number: 1409 • ACR Convergence 2020
Lack of Conventional Acinar Cells in the Salivary Gland Following Anti PD-L1 and anti-PD-1 Immune Checkpoint Inhibitor Therapy
Sarah Pringle¹, Bert van der Vegt¹, Xiaoyan Wang¹, Nico van Bakelen¹, Arjan Vissink¹, Frans Kroese² and Hendrika Bootsma², ¹UMCG, Groningen, ²University Medical Centre Groningen, Groningen, Netherlands
Background/Purpose: Salivary glands (SGs) can be damaged by immune checkpoint inhibitor (ICI) therapy. In patients with ICI-induced SG dysfunction, 60% progress to fulfill the ACR-EULAR…
Abstract Number: 1404 • ACR Convergence 2020
Investigating the Dermatomyositis Skin Inflammatory Infiltrate Using Image Mass Cytometry
Jay Patel¹, Spandana Maddukuri², Yubin Li³, Christina Bax⁴ and Victoria Werth³, ¹University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, ²University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Montville, NJ, ³University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, ⁴University of Pennsylvania, Department of Dermatology, Philadelphia
Background/Purpose: Dermatomyositis (DM) is a systemic autoimmune disease affecting the skin and muscles, among other organs. The inflammatory infiltrate in skin has not been fully…
Abstract Number: 1417 • ACR Convergence 2020
Risk of Relapse of ANCA-associated Vasculitis in Patients of 75 Years and Older: A Retrospective Study
Sara Thietart¹, Guillaume Beinse², Perrine Smets³, Alexandre Karras⁴, Carole Philipponnet⁵, Jean-François Augusto⁶, Khalil El Karoui⁷, Rafik Mesbah⁸, Dimitri Titeca Beauport⁹, Mohamed Hamidou¹⁰, Pierre-Louis Carron¹¹, Julien Campagne¹², Karim Sacre¹³, Pascal Cohen¹, Eric Liozon¹⁴, Claire Blanchard-Delaunay¹⁵, Alex Kostianovsky¹⁶, Christian Pagnoux¹⁷, Luc Mouthon¹, Loïc Guillevin¹⁸, Benjamin Terrier¹ and Xavier Puéchal for the French Vasculitis Study Group¹, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France, ²Inserm UMR 1138, Centre de Recherche des Cordeliers, Paris, France, ³Department of Internal Medicine, Centre Hospitalier Universitaire Clermont-Ferrand Hôpital Gabriel-Montpied, Clermont Ferrand, France, ⁴Department of Nephrology, Hôpital Européen Georges Pompidou, Paris, France, ⁵Department of Nephrology, CHU Clermont-Ferrand, Clermont-Ferrand, Clermont Ferrand, France, ⁶Department of Nephrology-Dialysis-Transplantation, CHU Angers, Angers, France, ⁷Department of Nephrology and Transplantation, Hôpital Universitaire Henri-Mondor, Creteil, France, ⁸Department of Nephrology, CH Boulogne-sur-Mer, Boulogne-Sur-Mer, France, ⁹Department of Nephrology, Amiens University Medical Center, Amiens, France, ¹⁰Department of Internal Medicine, Hôtel-Dieu, CHU Nantes, Nantes, France, ¹¹Department of Nephrology-Dialysis-Transplantation, CHU Grenoble-Alpes, Grenobles, France, ¹²Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, ¹³Département de Médecine Interne, Hôpital Bichat, APHP, Paris, France, ¹⁴Department of Internal Medicine and Clinical Immunology, Limoges University Hospital, Limoges, France, ¹⁵Department of Internal Medicine, CH, Niort, France, ¹⁶Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno", Buenos Aeres, Argentina, ¹⁷Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ¹⁸Department of Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France
Background/Purpose: ANCA-associated vasculitis (AAV) frequently occurs among older patients, with different clinical presentations than the younger. Little is known on the outcome of older patients…
Abstract Number: 1420 • ACR Convergence 2020
Characterization of ANCA-Associated Vasculitis Among African American Patients
Sehris Khawaja¹, Saloni Godbole¹, Maryann Kimoto², Virginia Steen³ and Kaitlin Quinn⁴, ¹Georgetown University, Washington, DC, ²UCLA, Los Angeles, CA, ³Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, ⁴National Institutes of Health, Washington, DC
Background/Purpose: ANCA-associated vasculitis (AAV) comprises a group of disorders characterized by inflammation of small and medium-sized arteries. Prevalence and phenotype of these diseases appear to…
Abstract Number: 1421 • ACR Convergence 2020
Clinical Features, Disease Activity and Prognosis of ANCA-Associated Vasculitis in US African Americans
Luis Palomino¹, Angelo Gaffo², Sebastian Sattui³ and Dongmei Sun², ¹University of Alabama at Birmingham Hospital, Birmingham, AL ²University of Alabama at Birmingham, Birmingham, AL, ³Hospital for Special Surgery, New York, NY
Background/Purpose: ANCA-associated vasculitis (AAV), including Granulomatosis with Polyangiitis (GPA), Eosinophilic Granulomatosis with Polyangiitis (EGPA) and Microscopic Polyangiitis (MPA), affect mostly Caucasians of European descent. Clinical…
Abstract Number: 1416 • ACR Convergence 2020
Effects of the COVID-19 Pandemic on Patients Living with Vasculitis
Shubhasree Banerjee¹, Michael George², Kalen Young³, Shilpa Venkatachalam⁴, Jennifer Gordon⁵, Cristina Burroughs⁶, David Curtis⁷, Marcela Ferrada⁸, Kelly Gavigan⁹, Peter C. Grayson¹⁰, Joyce Kullman¹¹, Jeffrey R Curtis¹², Dianne Shaw³, William Nowell¹³ and Peter Merkel², ¹University of Pennsylvania, Philadelphia, ²University of Pennsylvania, Philadelphia, PA, ³Vasculitis Foundation, Kansas City, ⁴Global Healthy Living Foundation, Upper Nyack, ⁵Temple University, Philadelphia, ⁶University of South Florida, Tampa, ⁷Global Healthy Living Foundation, New York City, ⁸Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁹Global Healthy Living Foundation, Upper Nyack, NY, ¹⁰Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD, ¹¹Vasculitis Foundation, Kansas City, MO, ¹²Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹³Global Healthy Living Foundation, New York City, NY
Background/Purpose: The COVID-19 pandemic has the potential to impact how patients with vasculitis interact with health care systems due to concerns about infections. This study…
Abstract Number: 1427 • ACR Convergence 2020
Anti-IL5 Therapy for Eosinophilic Granulomatosis with Polyangiitis (EGPA) – An 18 Month Follow-up Study as a Steroid Sparing Therapeutic Approach
Allyson Egan¹, Pasupathy Sivasothy², Robin Gore³, Caroline Owen³, Marcos Del Martinez Pero⁴, Rachel Jones⁴, Lisa Willcocks⁴, Rona Smith⁴, Stella Burns⁴ and David Jayne⁵, ¹Vasculitis and Lupus Clinic, Department of Medicine, Addenbrooke's Hospital, Cambridge., London, United Kingdom, ²Vasculitis and Lupus Clinic, Department of Medicine, Addenbrooke's Hospital, Cambridge., Cambridge, England, United Kingdom, ³Department of Respiratory medicine, Addenbrooke's Hospital, Cambridge, Cambridge, United Kingdom, ⁴Vasculitis and Lupus Clinic, Department of Medicine, Addenbrooke's Hospital, Cambridge., Cambridge, ⁵Department of Medicine, Vasculitis and Lupus Research Group, University of Cambridge, Cambridge, UK, Cambridge, United Kingdom
Background/Purpose: EGPA is a small vessel vasculitis characterized by the presence of tissue eosinophilia, necrotizing vasculitis and granulomatous inflammation1. In the randomized, placebo-controlled MIRRA trial…
Abstract Number: 1424 • ACR Convergence 2020
Outcomes of Hospitalizations for Acute Myocardial Infarction in Patients with ANCA Associated Vasculitis from the National Inpatient Sample
Atefeh Vafa¹, Marielys Figueroa Sierra¹, Omid Behnamfar², Hamayon Babary¹, Suraiya Afroz¹ and Yih Chang Lin³, ¹University of South Florida, Tampa, FL, ²University of California San Diego, La Jolla, CA, ³University of South Florida, Morsani College of Medicine, Tampa, FL
Background/Purpose: Several studies in the past have shown significantly increased risks of cardiovascular disease in patients with ANCA associated vasculitis (AAV). This association is thought…
Abstract Number: 1419 • ACR Convergence 2020
Clinical Disease Might Be Divided into Two Phenotypes in ANCA Associated Vasculitis; Results of a Cluster Analysis
Elif Ediboglu¹, Onay Gercik², Emre Bilgin³, Dilek Solmaz⁴, Irfan Ocal⁵, Arzu Saglam⁶, Zeki Soypacacı², Haluk Cinaklı⁵, Sedat Kiraz³, Ömer Karadağ⁷ and Servet Akar², ¹Izmir Katip Celebi University, Izmir, Izmir, Turkey, ²Izmir Katip Celebi University, Izmir, Turkey, ³Hacettepe University, Ankara, Turkey, ⁴Izmir Katip Celebi University, Department of Internal Medicine, Division of Rheumatology, Izmir, TURKEY, Izmir, Turkey, ⁵Izmir Katip Celebi University, Izmir, ⁶Hacettepe University, Ankara, ⁷Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara,, Ankara, Turkey
Background/Purpose: One of the controversial matters in ANCA associated vasculitis is the definition of disease based on clinical characteristics since there is a remarkable overlap…
Abstract Number: 1311 • ACR Convergence 2020
Identification of Clinical Phenotypes in Patients with Axial Spondyloarthritis, Peripheral Spondyloarthritis and Psoriatic Arthritis According to Peripheral Musculoskeletal Manifestations: A Cluster Analysis in the International ASAS-PerSpA Study
Clementina Lopez-Medina¹, Sylvie Chevret², Anna Molto¹, Joachim Sieper³, Mehmet Tuncay Duruöz⁴, Uta Kiltz⁵, Bassel El-Zorkany⁶, Najia Hajjaj-Hassouni⁷, Ruben Burgos-Vargas⁸, Jose Maldonado-Cocco⁹, Nelly Ziade¹⁰, Meghna Gavali¹¹, Victoria Navarro-Compán¹², Shue Fen Luo¹³, Alessandro Biglia¹⁴, Tae-Jong Kim¹⁵, Mitsumasa Kishimoto¹⁶, Fernando Pimentel-Santos¹⁷, Jieruo Gu¹⁸, Laura Muntean¹⁹, Floris van Gaalen²⁰, Pál Géher²¹, Marina Magrey²², Sebastian Ibanez²³, Wilson Bautista-Molano²⁴, Walter Maksymowych²⁵, Pedro M Machado²⁶, Robert Landewé²⁷, Désirée van der Heijde²⁸ and Maxime Dougados²⁹, ¹Rheumatology Department, Cochin Hospital, Paris, Paris, France, ²INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris, Paris, France, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴Marmara University School of Medicine, PMR Department, Rheumatology Division, Istanbul, Turkey, ⁵Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany, ⁶Cairo University, Cairo, Egypt, ⁷Health Sciences College, International University of Rabat (UIR), Rabat, Morocco, ⁸Department of Rheumatology, General Hospital of Mexico, Ciudad de Mexico, Mexico, ⁹Buenos Aires School of Medicine, Buenos Aires, Argentina, ¹⁰Saint-Joseph University, Beirut, Lebanon, Beirut, Lebanon, ¹¹Nizam’s Institute of Medical Sciences, Hyderabad, India, ¹²Hospital Universitario La Paz IdiPaz, Madrid, Pais Vasco, Spain, ¹³Chang Gung Memorial Hospital-Linkou, Taoyuan, Taipei, Taiwan (Republic of China), ¹⁴Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, ¹⁵Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, ¹⁶Department Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, ¹⁷3.CEDOC, NOVA Medical School, Faculdade de Ciências Médicas da Universidade NOVA de Lisboa, Lisboa, Portugal; 7.Hospital Egas Moniz (CHLO) (Rheumatology Department), Lisboa, Portugal, Lisbon, Portugal, ¹⁸Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, guangzhou, China (People's Republic), ¹⁹Rheumatology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, ²⁰Leiden University Medical Center (LUMC), Leiden, Netherlands, ²¹Semmelweis University, Budapest, Budapest, Hungary, ²²Case Western Reserve University School of Medicine, Cleveland, OH, ²³Facultad de Medicina Clínica Alemana – Universidad del Desarrollo, Santiago, Region Metropolitana, Chile, ²⁴University Hospital Fundación Santa Fé de Bogotá and Universidad El Bosque, Bogotá, Colombia, ²⁵University of Alberta, Edmonton, AB, Canada, ²⁶University College London, London, United Kingdom, ²⁷Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ²⁸Leiden University Medical Center, Leiden, Netherlands, ²⁹Department of Rheumatology, Hopital Cochin, Université de Paris, Paris, France
Background/Purpose: Patients with a clinical diagnosis of Spondyloarthritis (SpA) and Psoriatic Arthritis (PsA) may have predominant axial or predominant peripheral symptoms. However, a huge clinical…
Abstract Number: 1186 • ACR Convergence 2020
Red Cell Distribution Width and Absolute Lymphocyte Count Associate with Biomarkers of Inflammation and Subsequent Mortality in Rheumatoid Arthritis
Sofi Damjanovska¹, Lenche Kostadinova², Ibtissam Gad³, Sameena Syed⁴, Alyssa Lange⁵, Corinne Kowal⁶, Carey Shive⁷, Christopher Burant⁸, Brigid Wilson⁹, Taissa Bej⁹, Nora Singer¹⁰, David Canaday⁴, Maya Mattar¹¹, David Zidar⁴ and Donald Anthony¹², ¹Case Western Reserve University/Cleveland VA Medical Center, Cleveland Heights, OH, ²(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Highland Heights, OH, ³Case Western Reserve/ Cleveland VA Medical Center, Cleveland Heights, OH, ⁴Case Western Reserve University/Cleveland VA Medical Center, Cleveland, ⁵Cleveland VA Medical Center, Cleveland, ⁶Case western reserve university/Cleveland VA Medical Center, ohio, ⁷(2) Department of Pathology, Case Western Reserve University, ohio, ⁸Case Western Reserve University, Cleveland, ⁹Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, ¹⁰The MetroHealth System, Case Western Reserve University School of Medicine, Cleveland, OH, ¹¹Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH, ¹²Case Western Reserve University/Cleveland VA Medical Center/MetroHealth Medical Center, Cleveland, OH
Background/Purpose: Peripheral blood red cell distribution width (RDW) and absolute lymphocyte count (ALC) are associated with aging, cardiovascular disease (CVD), and mortality in the general…

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