Abstracts Archive - Page 691 of 2425 - ACR Meeting Abstracts

Abstract Number: 0951 • ACR Convergence 2020
The Comparative Effect of Exposure to Various Risk Factors on the Risk of Hyperuricaemia: Diet Has a Weak Causal Effect
Ruth Topless¹, Tanya Major¹, Jose Florez², Joel Hirschhorn³, Murray Cadzow¹, Nicola Dalbeth⁴, Lisa Stamp⁵, Phillip Wilcox¹, Richard Reynolds⁶, Joanne Cole² and Tony Merriman¹, ¹University of Otago, Dunedin, New Zealand, ²Massachusetts General Hospital, Boston, ³Harvard Medical School, Boston, ⁴University of Auckland, Auckland, New Zealand, ⁵University of Otago Christchurch, Christchurch, New Zealand, ⁶University of Alabama Birmingham, Birmingham
Background/Purpose: Prevention of hyperuricaemia (HU) is critical to the prevention of gout. Therefore, understanding the causal relationships and relative contributions of various risk factors to…
Abstract Number: 0957 • ACR Convergence 2020
Mitochondrial ROS as a Regulator of Calcinosis in Juvenile Dermatomyositis
Bhargavi Duvvuri¹, Lauren Pachman², Richard Moore¹, Stephen Doty³ and Christian Lood¹, ¹University of Washington, Seattle, WA, ²Department of Pediatrics, Northwestern University Feinberg School of Medicine; The Ann and Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Rheumatology; The CureJM Center of Excellence in Juvenile Myositis Research and Care, The Stanley Manne Children's Research Center of Chicago, Lake Forest, IL, ³The Hospital for Special Surgery, New York
Background/Purpose: Calcinosis, the accumulation of calcium crystals in soft tissues, is often a locus of infection and a debilitating manifestation of chronic juvenile dermatomyositis (JDM),…
Abstract Number: 0956 • ACR Convergence 2020
An IL-18-Containing Five-Gene Signature Distinguishes Histologically Identical Dermatomyositis and Lupus Erythematosus Skin Lesions
Alex Tsoi¹, Mehrnaz Gharaee-Kermani², Celine Berthier¹, Tori Nault³, Grace Hile², Shannon Estadt⁴, Matthew Patrick¹, Rachael Wasikowski¹, Allison Billi¹, Lori Lowe¹, Tamra Reed¹, Johann Gudjonsson⁵ and J. Michelle Kahlenberg⁶, ¹University of Michigan, Ann Arbor, ²University of Michigan, Ann Arbor, MI, ³University of Michigan, Canton, MI, ⁴University of Michigan, Ypsilanti, MI, ⁵University of Michigan, Ann ArborUniversity of Michigan, ⁶Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Skin lesions in dermatomyositis (DM) patients are common, frequently refractory, and have prognostic significance. Histologically, DM lesions appear similar to cutaneous lupus erythematosus (CLE)…
Abstract Number: 0962 • ACR Convergence 2020
Efficacy of Clomipramine for Chronic Lumbar Radicular Pain a Randomized Clinical Trial
Saloua Afilal¹, Safaa Fellous¹, Ilham Aachari¹, Redouane Abouqal², Ihsane Hmamouchi³, Nada Alami¹, Latifa Tahiri¹, Hanan Rkain¹, Najia Hajjaj-Hassouni⁴ and Fadoua Allali¹, ¹Rheumatology B Department, El Ayachi Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco., Rabat, Morocco, ²Laboratory of Biostatistics, Clinical Research and Epidemiology (LBRCE), Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco., Rabat, Morocco, ³Temara Hospital, Laboratory of Biostatistics, Clinical Research and Epidemiology (LBRCE), Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco, Rabat, Morocco, ⁴Health Sciences College, International University of Rabat (UIR), Rabat, Morocco
Background/Purpose: Lumbar radicular pain is the most common chronic neuropathic pain syndrome. Antidepressants are highly recommended for neuropathic pain, but there is no evidence for…
Abstract Number: 0964 • ACR Convergence 2020
Is Meniscal Status in the Anterior Cruciate Ligament Injured Knee Associated with Change in Bone Surface Area? An Exploratory Analysis of Data from the KANON Trial
Barbara Snoeker¹, Aleksandra Turkiewicz¹, Mike Bowes², Frank Roemer³, Stefan Lohmander¹, Richard Frobell¹ and Martin Englund¹, ¹Lund University, Lund, Sweden, ²Imorphics Ltd, Manchester, United Kingdom, ³Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Bone shape changes, which may be an important feature of osteoarthritis (OA) development, have been observed to occur early in the knee after anterior…
Abstract Number: 0959 • ACR Convergence 2020
Altered Gut Microbiome in Dermatomyositis
Sangmee Bae¹, Tien Dong², Venu Lagishetty³, William Katzka⁴, Jonathan Jacobs³ and Christina Charles-Schoeman⁵, ¹University of California Los Angeles, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, ³University of California, Los Angeles, Los Angeles, ⁴UCLA, Los Angeles, ⁵University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Dermatomyositis (DM) is an autoimmune myopathy associated with marked microvascular dysfunction and high morbidity and mortality. The gut microbiome has been implicated in the…
Abstract Number: 0954 • ACR Convergence 2020
Dual-energy CT Predicts Mortality in Gout Patients: A 3-year Follow-up Cohort Study
Anne Marty-Ané¹, Laurène Norberciak², Jean--Francois Budzik³ and Tristan Pascart², ¹GHICL, Lille, France, ²GHICL, Lomme, France, ³University of Lille, Lille, France
Background/Purpose: Cardiovascular events, chronic kidney disease and increased mortality are common in gout patients but what links them remains unclear. Tophaceous gout in particular is…
Abstract Number: 0967 • ACR Convergence 2020
Absence of Thy1 Associated with Severe Bone Loss in the TNF-transgenic (TNF-Tg) Mice Arthritis Model
Ananta Paine¹, Maria de la Luz Garcia-Hernandez², Marc Nuzzo³, Stacey Duemmel³, Benjamin Korman¹ and Christopher Ritchlin¹, ¹Department of Medicine, University of Rochester Medical Center, Rochester, NY, ²Department of Medicine, University of Rochester Medical Center, West Henrietta, NY, ³Department of Medicine, University of Rochester Medical Center, Rochester
Background/Purpose: Thy1 (CD90) is a glycosylated, glycophosphatidylinositol (GPI)-anchored membrane protein noted to be expressed on many cells including T lymphocytes, stem cells, osteoblasts and fibroblasts.…
Abstract Number: 0970 • ACR Convergence 2020
Oxylipins Profiles During the Earliest Phases of Rheumatoid Arthritis: Associations with Clinical Stage and Treatment Outcomes
Roxana Coras¹, Javier Rodríguez-Carrio², Mercedes Alperi-López³, Patricia López⁴, Catalina Ulloa⁵, Francisco J Ballina-García³, Aaron M Armando⁶, Oswald Quehenberger¹, Monica Guma⁷ and Ana Suárez⁴, ¹University of California San Diego, La Jolla, CA, ²Department of Functional Biology, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain/Bone and Mineral Research Unit, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Spain, Oviedo, ³Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, Oviedo, ⁴Department of Functional Biology, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain, Oviedo, ⁵Bone and Mineral Research Unit, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Spain, Oviedo, ⁶Department of Pharmacology, School of Medicine, University of California, San Diego, USA, San Diego, ⁷Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Altered eicosanoids have been linked to rheumatoid arthritis (RA), suggesting an enhanced metabolization. Eicosanoid metabolism forms a complex network, involving different pathways and mediators,…
Abstract Number: 0971 • ACR Convergence 2020
Single-cell Profiling of Synovial Stromal Cells Reveals an Angiocrine Endothelium in Rheumatoid Arthritis
Kevin Wei¹, Ilya Korsunsky², Jennifer Marshall³, Gerald Watts⁴, Triin Major³, Zhu Zhu⁴, Yuhong Li⁵, Christopher Buckley⁶, Soumya Raychaudhuri⁷ and Michael Brenner¹, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom, ⁴Brigam and Women's Hospital, Boston, ⁵Brigham and Women's Hospital, Boston, ⁶University of Birmingham, Birmingham, United Kingdom, ⁷Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Vascular endothelial cells that provide the structure for blood vessels have traditionally been perceived as passive, structural units that provide blood flow. We recently…
Abstract Number: 0966 • ACR Convergence 2020
Decoupling Inflammation and Bone Loss in Rheumatoid Arthritis via Schnurri-3
Zheni Stavre¹, JungMin Kim², Jae-Hyuck Shim² and Ellen Gravallese³, ¹University of Massachusetts Medical School-Rheumatology Division, Worcester, MA, ²University of Massachusetts Medical School, Worcester, MA, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to local and systemic bone loss. TNF is a key mediator of bone loss,…
Abstract Number: 0977 • ACR Convergence 2020
Expanded T Peripheral Helper Cells and Increased Pathologic B Cell Lung Infiltration in Pristane-induced Murine Lupus in the Absence of BCL6+ Tfh Cells
Runci Wang¹, Pui Lee², Peter Nigrovic³ and Deepak Rao¹, ¹Brigham and Women's Hospital, Boston, MA, ²1.Boston Children's Hospital;2.Brigham and Women's Hospital;3.Harvard Medical School, Newton, MA, ³Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston
Background/Purpose: PD-1hi CXCR5- T peripheral helper (Tph) cells are highly expanded in RA and SLE patients. Like T follicular helper (Tfh) cells, human Tph cells…
Abstract Number: 0974 • ACR Convergence 2020
Role of NR4A Nuclear Receptor Family in RA Synovial Ectopic Lymphoid Neogenesis Revealed by Single Cell Profiling
Nida Meednu¹, Fan Zhang², Katherine Escalera-Rivera¹, Elisa Corsiero³, Edoardo Prediletto³, Michele Bombardieri⁴, Edward DiCarlo⁵, Dana Orange⁶, Susan Goodman⁷, Laura Donlin⁸, Soumya Raychaudhuri², Costantino Pitzalis⁴, Andrew McDavid¹ and Jennifer Anolik¹, ¹University of Rochester Medical center, Rochester, NY, ²Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ³Queen Mary University of London, London, England, United Kingdom, ⁴Queen Mary University of London, London, United Kingdom, ⁵Hospital for Special Surgery, New York, ⁶Rockefeller University, New York, ⁷Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁸Hospital for Special Surgery, Weill Cornell Medicine, New York
Background/Purpose: Ectopic lymphoid structures (ELS) have been observed in synovial tissue of rheumatoid arthritis (RA) patients but their functional relevance in the disease remains unclear.…
Abstract Number: 0969 • ACR Convergence 2020
Investigating Murine Joint-Draining Lymphatics: Lineage Tracing and Single Cell RNA Sequencing Reveal Evidence That Popliteal Lymphatic Muscle Cells and Their Progenitors Represent Distinct Cell Types Divergent from Striated and Vascular Muscle Cells
H. Mark Kenney¹, Richard Bell², Elysia Masters¹, Lianping Xing¹, Christopher Ritchlin³ and Edward Schwarz¹, ¹University of Rochester Medical Center, Rochester, ²Hospital for Special Surgery, New York, ³Department of Medicine, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Previous studies demonstrated that tumor necrosis factor transgenic (TNF-Tg) mice with inflammatory arthritis have damaged lymphatic muscle cells (LMCs) and eventual loss of popliteal…
Abstract Number: 0861 • ACR Convergence 2020
Hydroxychloroquine Use Is Associated with Diminished Type I Interferon-related Pathways in Systemic Lupus Erythematosus Patients
Samantha Slight-Webb¹, Kevin Thomas¹, Rufei Lu¹, Susan Macwana¹, Joan Merrill¹, Cristina Arriens¹, Eliza Chakravarty¹, Teresa Aberle¹, Holden Maecker², Paul Utz³, Joel Guthridge¹ and Judith James⁴, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, ³Stanford University School of Medicine, Stanford, CA, ⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK
Background/Purpose: Hydroxychloroquine (HCQ) has been used for decades to treat systemic lupus erythematosus (SLE) and is associated with decreased lupus flares and damage. However, despite…

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