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  • Abstract Number: 1039 • ACR Convergence 2022

    Differential Retention of Adalimumab and Etanercept Biosimilars Compared to Originator Treatments: Results of a Retrospective French Multicentre Study

    Guillaume LARID1, Guy Baudens2, Alexis DANDURAND1, Pascal COQUERELLE3, Vincent Goeb4, Marie-Hélène Guyot5, Laurent Marguerie6, Frédéric MAURY7, Viellard Eric8, Eric Houvenagel9, Jean Hugues SALMON10, René-Marc Flipo11 and elisabeth gervais1, 1CHU Poitiers, Poitiers, France, 2Private practice, Valenciennes, France, 3CH Béthune, Béthune, France, 4CHU Amiens, Amiens, France, 5Private practice, Roubaix, France, 6Institut Calot, Berck-Sur-Mer, France, 7Private practice, Béthune, France, 8Private practice, St. Malo, France, 9Groupement Hospitalier de l'Institut Catholique de Lille, Lomme, France, 10Reims University Hospital, Reims, France, 11CHU Lille, Boulogne-Billancourt, France

    Background/Purpose: Studies have demonstrated equivalence in term of efficacy and safety of biosimilars (bsDMARDs) compared to the originals treatments (boDMARDs) and in switching situation. Less…
  • Abstract Number: 1038 • ACR Convergence 2022

    Genetic and Molecular Distinctions Between Axial Psoriatic Arthritis and Ankylosing Spondylitis

    Arthur Kavanaugh1, Xenofon Baraliakos2, Sheng Gao3, Warner Chen3, Kristen Sweet3, Soumya Chakravarty4, Qingxuan Song3, May Shawi5, Frank Behrens6 and Proton Rahman7, 1University of California San Diego, San Diego, CA, USA, San Diego, CA, 2Rheumazentrum Ruhrgebiet Herne, Herne, Germany, 3Janssen Research and Development, LLC, Spring House, PA, 4Janssen Scientific Affairs, LLC; Drexel University College of Medicine, Villanova, PA, 5Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 6Rheumatology University Hospital & Fraunhofer Institute Translational Medicine and Pharmacology, Goethe-University Frankfurt, Frankfurt Am Main, Germany, 7Memorial University, St. John's, NL, Canada

    Background/Purpose: Despite overlapping symptoms, axial psoriatic arthritis (axPsA) and ankylosing spondylitis (AS) may be distinct disorders with differing clinical manifestations, genetic associations, and radiographic findings.1…
  • Abstract Number: 1037 • ACR Convergence 2022

    Performance of BASDAI vs. ASDAS in Evaluating Axial Involvement in Patients with PsA Treated with Guselkumab: Pooled Analysis of Two Phase 3 Studies

    Xenofon Baraliakos1, Dafna Gladman2, Soumya Chakravarty3, Cinty Gong4, May Shawi5, Emmanouil Rampakakis6, Kishimoto Mitsumasa7, Enrique R Soriano8 and Philip J Mease9, 1Rheumazentrum Ruhrgebiet Herne, Herne, Germany, 2Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada, 3Janssen Scientific Affairs, LLC; Drexel University College of Medicine, Villanova, PA, 4Janssen Scientific Affairs, LLC, Horsham, PA, 5Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 6McGill University, Department of Pediatrics and JSS Medical Research, Montréal, QC, Canada, 7Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, 8Rheumatology Unit and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 9Swedish Medical Center/Providence St. Joseph Health, Seattle, WA

    Background/Purpose: Although the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is used to assess the activity of axial disease in patients (pts) with PsA, only…
  • Abstract Number: 1042 • ACR Convergence 2022

    Long-term Safety of Ixekizumab in Adult Patients with Psoriasis, Psoriatic Arthritis, and Axial Spondyloarthritis

    Atul Deodhar1, Andrew Blauvelt2, Sergio Schwartzman3, Carlo Salvarani4, Meghan Feely5, Andris Kronbergs5, Nadia Eberhart6, Danting Zhu5, Elsa Mevel5, Thorsten Holzkämper5, Eswar Krishnan7, Mark Lebwohl8, Proton Rahman9 and Helena Marzo-Ortega10, 1Oregon Health & Science University, Portland, OR, USA, Portland, OR, 2Oregon Medical Research Center, Portland, OR, USA, Portland, OR, 372nd Street Medical Associates, Scarsdale, NY, 4University of Reggio Emilia, Reggio Emilia, Italy, 5Eli Lilly and Company, Indianapolis, IN, 6Eli Lilly and Company, Vienna, Austria, 7Eli Lilly and Company, Carmel, IN, 8Icahn School of Medicine at Mount Sinai, New York, NY, 9Memorial University, St. John's, NL, Canada, 10Leeds Teaching Hospitals Trust and University of Leeds, Leeds, United Kingdom

    Background/Purpose: Ixekizumab (IXE) is a high-affinity, monoclonal antibody targeting IL-17A and is approved for the treatment of psoriasis (PsO), psoriatic arthritis (PsA), ankylosing spondylitis (AS),…
  • Abstract Number: 1045 • ACR Convergence 2022

    Quantification of the Enthesic Response to Biological Therapies in Patients with Spondyloarthritis by Computer Analysis of Ultrasound Images

    Marina Tortosa Cabanas, CARLOS ANTONIO GUILLEN ASTETE and Africa Andreu Suarez, Ramon y Cajal University Hospital, Madrid, Spain

    Background/Purpose: Enthesitis is the base of the pathophysiology of spondyloarthritis. Recently, our research group has shown that computer analysis of static images can be used…
  • Abstract Number: 1044 • ACR Convergence 2022

    Combined Biological or Targeted Therapy in Spondyloarthritis: Experience from a Multicenter Case Series in Spain

    cristina Valero-Martinez1, Judith Font Urguelles2, Meritxell Sallés3, BEATRIZ E. JOVEN4, Felipe Julio Ramirez Garcia5, Xavier Juanola6, Raquel Almodóvar7, ana Laiz8, Mireia Moreno9, Manel Pujol10, Luis Sala-Icardo11, Santos Castañeda12 and Rosario Garcia-Vicuña1, 1Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 2Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 3Althaia Xarxa Assistencial Universitària, Manresa, Spain, 4Hospital Universitario 12 de Octubre, Madrid, Spain, 5Hospital Clínic, Barcelona, Spain, 6Hospital Universitari Bellvitge, Hospitalet de Llobregat, Barcelona, Spain, 7Hospital Universitario Fundación Alcorcón, Madrid, Spain, 8Unitat Territorial de Reumatologia Sant Pau-Dos de Maig, Barcelona, Spain, 9Hospital Universitari Parc Taulí, Sabadell, Spain, 10Hospital Universitario MútuaTerrassa, Terrassa, Spain, 11Hospital Universitario de Torrejón de Ardoz, Madrid, Spain, 12Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain

    Background/Purpose: Combined biological or targeted therapy (CBTT) is rarely considered in clinical practice due to contraindication in guidelines, potential safety concerns and high costs. However,…
  • Abstract Number: 1041 • ACR Convergence 2022

    Tofacitinib in Refractory Uveitis – an Observational Study

    Nikhil Gupta1 and Deepankur Mahajan2, 1Centre for Arthritis and Rheumatological diseases in Delhi, New Delhi, India, 2Mahajan Eye Centre, New Delhi, India

    Background/Purpose: To evaluate the effect of generic tofacitinib in refractory uveitis patients.Methods: It was a prospective observational study of 23 patients of refractory anterior uveitis.…
  • Abstract Number: 1023 • ACR Convergence 2022

    Are We Treating-to-target in Spondyloarthritis (SpA)? A Cross Sectional Analysis from the Asia Pacific League of Associations for Rheumatology (APLAR) SpA Registry

    Isaac Cheng1, Ying Ying Leung2, Ho SO1, Praveena Chiowchanwisawakit3, Stanley Angkodjojo4, Muhammad Saeed5, Kichul Shin6, Han Joo Baek7, Mohit Goyal8, Muhammad Haroon9, Eman Satti10, Nallasivan Subramanian11, Fariz Yahya12, Soosan Soroosh13, ASAL ADNAN RIDHA14, Ho Yin Chung15, James Cheng-Chung WEI16, Kishimoto Mitsumasa17 and Lai-shan Tam1, 1The Chinese University of Hong Kong, Hong Kong, China, 2Rheumatology Department, Singapore General Hospital, Singapore, Singapore, 3Mahidol University, Bangkok, Thailand, 4Sengkang General Hospital / Singhealth, Singapore, Singapore, 5Central Park Medical College, Lahore, Pakistan, 6Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, Republic of Korea, 7Gachon University College of Medicine, Inchon, Republic of Korea, 8CARE Pain & Arthritis Centre, Udaipur, India, 9Doctor, Tralee, Ireland, 10Hamad Medical Corporation, Doha, Qatar, 11Velammal Medical College Hospital, Velammal, India, 12University of Malaya, Kuala Lumpur, Malaysia, 13Army University for Medical School, Tehran, Iran, 14Baghdad Teaching Hospital, Baghdad, Iraq, 15Chiron Medical, Hong Kong, Hong Kong, 16Chung Shan Medical University Hospital, Taichung, Taiwan, 17Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan

    Background/Purpose: Data on the extent to which internationally agreed treat-to-target (T2T) recommendations were applied in clinical practice in patients with SpA across the Asia-Pacific region…
  • Abstract Number: 1002 • ACR Convergence 2022

    Investigation of Pharmacodynamic Biomarkers in a Phase 2b Study in Patients with Moderate to Severe SLE Treated with the S1P1 Receptor Modulator Cenerimod

    Daniel Strasser1, clélia Cahuzac2, peter Cornelisse2, Ouali Berkani2, Peter Groenen2 and Mark Murphy2, 1Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland, 2Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland

    Background/Purpose: Sphingosine-1-phosphate (S1P) regulates lymphocyte egress from lymphoid organs into circulation. In a SLE proof-of-concept study, cenerimod—a potent, selective S1P1 receptor modulator—reduced circulating antibody-secreting cells…
  • Abstract Number: 1049 • ACR Convergence 2022

    Risk Stratification of Patients with Systemic Sclerosis-associated Pulmonary Arterial Hypertension in EUSTAR Using the Current and New Proposed Criteria

    Hilde Jenssen Bjørkekjær1, cosimo bruni2, PATRICIA E CARREIRA3, Paolo Airò4, CARMEN PILAR SIMEON5, Marie-Elise Truchetet6, Alessandro Giollo7, Alexandra Balbir-Gurman8, Mickaël MARTIN9, Chris Denton10, Armando Gabrielli11, Håvard Fretheim12, Imon Barua12, Helle Bitter13, Øyvind Midtvedt12, Kaspar Broch14, Arne Andreassen12, Yoshiya Tanaka15, Gabriela Riemekasten16, Ulf Müller-Ladner17, Marco Matucci-Cerinic2, Ivan Castellvi18, Elise Siegert19, Eric Hachulla20, Oliver Distler21 and Anna-Maria Hoffmann-Vold12, 1Department of Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, Kristiansand, Norway, 2University of Florence, Florence, Italy, 3HOSPITAL 12 DE OCTUBRE, Madrid, Spain, 4Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, Brescia, Italy, 5Hospital Vall D'Hebron, Barcelona, Spain, 6CHU de Bordeaux, Bordeaux, France, 7Rheumatology Section, Department of Medicine, University of Verona, Italy, Verona, Italy, 8Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel, 9Poitiers's Universatory Hospital, Department of Internal Medicine, Poitiers, France, Mignaloux-Beauvoir, France, 10University College London, London, United Kingdom, 11Università Politecnica delle Marche, Ancona, Italy, 12Oslo University Hospital, Oslo, Norway, 13Sorlandet sykehus, Kristiansand, Norway, 14Oslo University Hospital, Rikshospitalet, Department of Cardiology, Oslo, Norway, Oslo, Norway, 15University of Occupational and Environmental Health, Kitakyusyu Fukuoka, Japan, 16University Clinic Schleswit-Holstein (UKSH), Luebeck, Germany, 17JLU Campus KK, Bad Nauheim, Germany, 18Hospital Universitari de la Santa Creu i Sant Pau, Vilafranca del Pened, Spain, 19Charité Hospital, Berlin, Germany, 20University of Lille, LILLE, France, 21Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a major clinical challenge in systemic sclerosis (SSc). A new definition for precapillary PH is proposed. Risk stratification is…
  • Abstract Number: 1047 • ACR Convergence 2022

    A Novel Prediction Tool for Progression of Systemic Sclerosis-Interstitial Lung Disease Despite Treatment with Immunosuppression

    Elizabeth Volkmann1, Holly Wilhalme1, Grace Kim1, Jonathan Goldin1, Shervin Assassi2, Masataka Kuwana3, Donald Tashkin1 and Michael roth1, 1University of California Los Angeles, Los Angeles, CA, 2McGovern Medical School, University of Texas, Houston, TX, 3Nippon Medical School Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: Systemic sclerosis-interstitial lung disease (SSc-ILD) is the leading cause of SSc-related death. While some patients respond favorably to treatment with immunosuppression, a subset of…
  • Abstract Number: 1053 • ACR Convergence 2022

    The Collaborative National Quality and Efficacy Registry for Scleroderma: Association of Resource Utilization and Gastrointestinal Tract Symptoms in Early Disease

    Sarah Luebker1, Tracy Frech1, Shervin Assassi2, Jessica Gordon3, Elana Bernstein4, Virginia Steen5, Laura Hummers6, Ami Shah7, Carrie Richardson8, Dinesh Khanna9, Flavia Castelino10, Lorinda Chung11, Faye Hant12, Vicki Shanmugam13, John VanBuren14, Jessica Alvey14, Monica Harding14, Luke Evnin15 and Nora Sandorfi16, 1Vanderbilt University Medical Center, Nashville, TN, 2McGovern Medical School, University of Texas, Houston, TX, 3Hospital for Special Surgery, New York, NY, 4Columbia University, New York, NY, 5Georgetown University School of Medicine, Washington, DC, 6Johns Hopkins Univerisity, Baltimore, MD, 7Johns Hopkins Rheumatology, Baltimore, MD, 8Northwestern University, Chicago, IL, 9Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI, 10Massachusetts General Hospital, Boston, MA, 11Stanford University, Stanford, CA, 12Medical University of South Carolina, Charleston, SC, 13George Washington University, Washington, DC, 14University of Utah, Salt Lake City, UT, 15Scleroderma Research Foundation, Brisbane, CA, 16University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Health costs and resource utilization are important in chronic disease management. Systemic sclerosis (SSc) is a multi-organ system disease with outcomes that are often…
  • Abstract Number: 1052 • ACR Convergence 2022

    Short-term Safety of COVID-19 Vaccination in Systemic Sclerosis Patients: Report from a Global Patient-Reported E-survey

    Darpan Thakare1, Naveen R1, John Pauling2, Sakir Ahmed3, Chris Wincup4, Nicolletta Del Papa5, Gianluca Sambataro6, Fabiola Atzeni7, Marcello Govoni8, SIMONE PARISI9, Elena Bartoloni Bocci10, Gian Domenico Sebastiani11, Enrico Fusaro12, Marco Sebastiani13, Luca Quartuccio14, Franco Franceschini15, Pier Paolo Sainaghi16, Giovanni Orsolini17, Rossella De Angelis18, Maria Giovanna Danielli19, Vincenzo Venerito20, Parikshit Sen21, Minchul Kim22, Abraham Edgar Gracia-Ramos23, Akira Yoshida24, James B. Lilleker25, Vishwesh Agarwal26, Sinan Kardes27, Jessica Day28, Marcin Milchert29, Mrudula Joshi30, Tamer A Gheita31, Babur Salim32, Ioannis Parodis33, Albert Selva O’Callaghan34, Elena Nikiphorou35, Tulika Chatterjee22, Ai Lyn Tan36, Arvind Nune37, Lorenzo Cavagna38, Samuel Shinjo39, Nelly Ziade40, Johannes Knitza41, Hector Chinoy42, Oliver Distler43, Masataka Kuwana44, Rohit Aggarwal45, Latika Gupta46, Vikas Agarwal1 and Ashima Makol47, 1Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2North Bristol NHS Trust, Bristol, United Kingdom, 3Kalinga Institute of Medical Sciences, Bhubaneswar, India, 4Rayne Institute, University College London, London, United Kingdom, 5Unità operativa complessa (UOC) Day Hospital Reumatologia via Gaetano Pini 9, Centro Specialistico Ortopedico Traumatologico, Gaetano Pini-CTO,, Milano, 6Medico Immunologia e reumatologia presso, Artoreuma S.R.L., Cors S, Mascalucia, 7Rheumatology Unit, University of Messina, Messina, Italy, 8S. Anna Hospital and University of Ferrara, Ferrara, Italy, 9Italian Society for Rheumatology, Turin, Italy, 10Rheumatology Unit. Department of Medicine, Perugia, Perugia, Italy, 11U.O.C. Reumatologia, Ospedale San Camillo-Forlanini,, Roma, 12Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy, 13Azienda Policlinico di Modena, Modena, Italy, 14Department of Medicine (DAME), ASUFC, University of Udine, Udine, 15Department of Clinical and Experimental Sciences, ASST Spedali Civili and University of Brescia, Brescia, Italy, 16IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, Novara, Italy, 17Department of Medicine, Rheumatology Unit, University of Verona, Verona, Verona, 18Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Marche, Italy, 19Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle, Marche, Italy, 20Department of Emergency and Organ Transplantations-Rheumatology Unit, University of Bari "Aldo Moro", Bari, Italy, 21Maulana Azad Medical College, New Delhi, India, 22University of Illinois College of Medicine Peoria, Peoria, IL, 23Instituto Mexicano del Seguro Social, Ciudad de México, Mexico, 24Nippon Medical School Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan, 25The University of Manchester, Manchester, United Kingdom, 26Mahatma Gandhi Missions Medical College, Lucknow, India, 27Istanbul University, Istanbul, Turkey, 28Walter and Eliza Hall Institute, Melbourne, Australia, 29Pomeranian Medical University in Szczecin, Szczecin, Poland, 30Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India, 31Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, 32Fauji foundation hospital Rawalpindi, Rawalpindi, Pakistan, 33Karolinska Institutet, Stockholm, Sweden, 34Hospital Universitari Vall d'Hebron, Barcelona, Spain, 35Leiden University Medical Center & King's College London, London, United Kingdom, 36University of Leeds, Leeds, United Kingdom, 37Southport and Ormskirk Hospital NHS Trust, Southport, United Kingdom, 38Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Pavia, Italy, 39Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil, 40Saint-Joseph University, Beirut, Lebanon, 41Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 42The University of Manchester, Sale, United Kingdom, 43Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 44Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 45Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 46Royal Wolverhampton Trust, Wolverhampton/University of Manchester, United Kingdom, 47Mayo Clinic, Rochester, MN, Rochester, MN

    Background/Purpose: Dedicated data on COVID-19 vaccine-related adverse events (ADEs) in patients with systemic sclerosis (SSc) is limited. Therefore, we aimed to compare all patient-reported ADEs…
  • Abstract Number: 1048 • ACR Convergence 2022

    Nailfold Capillaroscopy and Candidate Biomarker Levels in Systemic Sclerosis-associated Pulmonary Hypertension, Profiling of Non-invasive Markers: A Cross Sectional Study

    Jacqueline Lemmers1, Arjan van Caam2, Brigit Kersten2, Els Ende, van den2, Hanneke KNAAPEN2, Arie Dijk, van2, Wanda Hagmolen of ten Have2, Frank van den Hoogen2, Hans Koenen2, Sander van Leuven3, wynand Alkema4, Ruben Smeets2 and Madelon Vonk5, 1Radboud University Medical Centre Nijmegen, Nijmegen, Netherlands, 2Radboudumc, Nijmegen, Netherlands, 3Radboud University, Nijmegen, Netherlands, 4Hanze University, Groningen the Netherlands, Dept. Data Science for Life Sciences & Health, Groningen, Netherlands, 5Department of Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands

    Background/Purpose: Pulmonary hypertension (PH) is one of the leading causes of death in Systemic Sclerosis (SSc). Early detection and treatment of PH in SSc is…
  • Abstract Number: 1055 • ACR Convergence 2022

    Associations of Potential Risk Factors with Severe Outcomes in Scleroderma Renal Crisis: Results from a Single Center Study

    Alex Luta1, Saloni Godbole1 and Virginia Steen2, 1Medstar Georgetown University Hospital, Washington, DC, 2Georgetown University School of Medicine, Washington, DC

    Background/Purpose: Scleroderma Renal Crisis (SRC) is a severe and life-threatening complication of Systemic Sclerosis (SSc). Given the rare nature of SSc, it is challenging to…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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