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  • Abstract Number: 2116 • ACR Convergence 2022

    Assessment of the Ultrasound and Clinical Response to Apremilast Using a Joint-periarticular-nail Ultrasound Index and Clinical Evaluation in Patients with Active Psoriatic Arthritis

    Juan Josè de Agustin1, Gustavo Añez1, delia reina2, Sergi Heredia3, Felipe Julio Ramirez Garcia4, Andrea Cuervo5, Jesus Rodriguez6, Carmen Moragues6, Patricia Moya7, Mireia Moreno8, Marta Arévalo8, Manel Pujol9, Georgina Salvador9, Noemi Busquets10, andres Ponce10, Ana Maria Laiz Alonso7 and MAria Pascual Pastor11, 1Vall D'hebron University Hospital, Barcelona, Spain, 2Complex Hospitalari Moisès Broggi, Sant Joan Despí, Catalonia, Spain, 3Complex Hospitalari Moisès Broggi, Sant Joan Despi, Catalonia, Spain, 4Hospital Clínic, Barcelona, Spain, 5Hospital Clínico y Provincial de Barcelona, Barcelona, Spain, 6Hospital Bellvitge, Hospitalet de Llobregat, Spain, 7Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 8Parc Tauli Hospital Universitari, Sabadell, Catalonia, Spain, 9Hospital Universitario MútuaTerrassa, Terrassa, Spain, 10Hospital General de Granollers, Granollers, Spain, 11Hospital Universitari Vall d'Hebron, Barcelona, Spain

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory disease involving joint and enthesis disease. Ultrasound (US) has demonstrated its useful tool for the diagnosis of…
  • Abstract Number: 2112 • ACR Convergence 2022

    Stringent Disease Activity Control at 2 Years Across Psoriatic Arthritis Domains Irrespective of Baseline Characteristics in Patients Treated with Guselkumab: Post Hoc Analysis of a Phase 3, Randomized, Double-blind, Placebo-controlled Study

    Christopher Ritchlin1, Philip J Mease2, Wolf-Henning Boehncke3, John Tesser4, Soumya Chakravarty5, Emmanouil Rampakakis6, May Shawi7, Elena Schiopu8, Joseph Merola9, Iain B McInnes10 and Atul Deodhar11, 1Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, 2Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 3Deptartment of Dermatology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland, 4Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, 5Janssen Scientific Affairs, LLC; Drexel University College of Medicine, Villanova, PA, 6McGill University, Department of Pediatrics and JSS Medical Research, Montréal, QC, Canada, 7Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 8Michigan Medicine Rheumatology Clinic – Taubman Center, Ann Arbor, MI, 9Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 10Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom, 11Oregon Health & Science University, Portland, OR, USA, Portland, OR

    Background/Purpose: Guselkumab (GUS) is associated with robust and sustained improvement in PsA signs and symptoms in subgroups of patients (pts) pooled from the phase 3…
  • Abstract Number: 2123 • ACR Convergence 2022

    Hierarchical Ranking of Biologic Disease-Modifying Antirheumatic Drugs and Targeted Systemic Therapies for Psoriatic Arthritis: A Network Meta-analysis

    Jesus Diaz1, Guillermo Quiceno2 and Adela Castro3, 1Hamilton Medical Center, Chattanooga, TN, 2UT Southwestern Medical Center, Dallas, TX, 3Hamilton Physician Group-Specialty Care, Dalton, GA

    Background/Purpose: There are an increasing number of biological and targeted DMARDs in PsA. However, challenges around treatment selection remain, given the few head-to-head studies directly…
  • Abstract Number: 2125 • ACR Convergence 2022

    Effects of Treatment with Risankizumab on Minimal Disease Activity and Disease Activity in Psoriatic Arthritis: An Analysis of the KEEPsAKE-1 and -2 Trials

    Joseph Merola1, Iain B McInnes2, Arthur Kavanaugh3, Peter Nash4, Zhenyi Xue5, Vassilis Stakias6, Ann Eldred7, Sandra Ciecinski8, Kevin Douglas6 and Laura Coates9, 1Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 2Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom, 3University of California San Diego, La Jolla, CA, 4School of Medicine, Griffith University, Sunshine Coast, Australia, 5AbbVie, Inc., Wilmington, DE, 6AbbVie, Inc., North Chicago, IL, 7AbbVie, Inc., Lake Bluff, IL, 8AbbVie, Inc., Mettawa, IL, 9Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, England, United Kingdom

    Background/Purpose: Risankizumab (RZB) is a monoclonal antibody that specifically inhibits interleukin 23.Methods: KEEPsAKE-1 and -2, double-blind, phase 3 trials, evaluated the efficacy of RZB versus…
  • Abstract Number: 2122 • ACR Convergence 2022

    Bimekizumab Treatment Improves Health-Related Quality of Life in Biologic DMARD-Naïve and TNFi-IR Patients with Active PsA: Pooled 16-Week Results from Two Phase 3 Randomized, Placebo-Controlled Studies

    Dafna Gladman1, Lars Erik2, Diamant Thaci3, Paolo Gisondi4, Laure Gossec5, M. Elaine Husni6, Alice Gottlieb7, Hiroaki Dobashi8, Barbara Ink9, Deepak Assudani9, Rajan Bajracharya9, Jason Coarse10, Jérémy Lambert11 and William Tillett12, 1Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada, 2Bispebjerg-Frederiksberg Hospital, Vedbæk, Denmark, 3Institute and Comprehensive Center for Inflammation Medicine, University Hospital of Lübeck, Lübeck, Germany, 4Dermatology and Venereology, Department of Medicine, Università di Verona, Verona, Italy, Verona, 5Sorbonne Université, Paris, France, 6Cleveland Clinic, Cleveland, OH, 7Department of Dermatology, The Icahn School of Medicine at Mount Sinai, New York, NY, 8Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Japan, 9UCB Pharma, Slough, United Kingdom, 10UCB Pharma, Raleigh, NC, USA, Raleigh, NC, 11UCB Pharma, Colombes, France, Irigny, France, 12Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom

    Background/Purpose: PsA imparts a substantial burden on patient health-related quality of life (HRQoL).1 Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition…
  • Abstract Number: 2124 • ACR Convergence 2022

    Immunological Differences Between PsA Patients Who Are Tumor Necrosis Factor Inhibitor-Naïve and Who Have Inadequate Response to Tumor Necrosis Factor Inhibitors

    Stefan Siebert1, Laura Coates2, Georg Schett3, Siba P. Raychaudhuri4, Warner Chen5, Sheng Gao5, Soumya Chakravarty6, May Shawi7, Frederic Lavie8, Elke Theander9, Marlies Neuhold10, Alexa Kollmeier11, Xie L Xu12, Proton Rahman13, Philip J Mease14 and Atul Deodhar15, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, 2Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, England, United Kingdom, 3Universitätsklinikum Erlangen, Erlangen, Germany, 4Rheumatology, Allergy, and Clinical Immunology, University of California Davis, School of Medicine, Sacramento, CA, 5Janssen Research and Development, LLC, Spring House, PA, 6Janssen Scientific Affairs, LLC; Drexel University College of Medicine, Villanova, PA, 7Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 8The Janssen Pharmaceutical Companies of Johnson & Johnson, Paris, France, Paris, France, 9Janssen Cilag, Lund, Sweden, 10Janssen, Zug, Switzerland, 11Janssen-Cilag, Research & Development, LLC, San Diego, CA, 12Janssen Research & Development, LLC, San Diego, CA, USA, San Marcos, CA, 13Memorial University, St. John's, NL, Canada, 14Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 15Oregon Health & Science University, Portland, OR, USA, Portland, OR

    Background/Purpose: A better understanding of the immunological differences between psoriatic arthritis (PsA) patients (pts) who are tumor necrosis factor inhibitor (TNFi)-naïve and who have inadequate…
  • Abstract Number: 2135 • ACR Convergence 2022

    Evaluation of Candidate Protein Biomarkers to Predict Treatment Response in Patients with Psoriatic Arthritis

    James C Waddington1, Ruoyi Zhou1, Orla Coleman1, Bruna Wundervald2, Andrew Parnell3, Vinod Chandran4, Lara Fallon5, Douglass Chapman6, Remy Pollock7, Shibing Deng8, Oliver FitzGerald9, Stephen R Pennington10 and Philip J Mease11, 1Atturos, Dublin, Ireland, 2Atturos/Hamilton Institute, Maynooth University, Dublin, Ireland, 3Hamilton Institute, Maynooth University, Kildare, Ireland, 4Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 5Pfizer Inc, Montréal, QC, Canada, 6Pfizer Inc, New York, NY, 7Pfizer Canada ULC, Kirkland QC, Canada, 8Pfizer Inc, Waterford, MI, 9Conway Institute, University College Dublin, Dublin, Ireland, 10Atturos/Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland, 11Swedish Medical Center/Providence St. Joseph Health, Seattle, WA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of PsA.1,2 Using two mass spectrometry (MS)-based proteomic approaches (targeted multiple reaction monitoring [MRM]…
  • Abstract Number: 2131 • ACR Convergence 2022

    Minimal Disease Activity Response Patterns in Bio-Naïve Patients Treated with Guselkumab: A Machine Learning Analysis

    Alen Zabotti1, Sarah Ohrndorf2, William Tillett3, Marlies Neuhold4, Michel van Speybroeck5, Elke Theander6, Christine Contré7, Mohamed Sharaf8, May Shawi9, Michelle Perate10, Alexa Kollmeier11 and Pascal Richette12, 1Department of Medical and Biological Sciences, Rheumatology Unit, University of Udine, Udine, Italy, 2Charité Universitätsmedizin Berlin, Berlin, Germany, 3Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 4Takeda Europe & Canada Business Unit (EUCAN) Medical Affairs, Zurich, Switzerland; formerly at Janssen Scientific Affairs, LLC, Zug, Switzerland, 5Janssen Pharmaceutica, Beerse, Belgium, 6Janssen Cilag, Lund, Sweden, 7Formerly at Janssen Scientific Affairs, LLC, Issy-les-Moulineaux, France, Issy-les-Moulineaux, France, 8Johnson & Johnson, Middle East FZ LLC, Dubai, United Arab Emirates, 9Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 10Janssen Scientific Affairs, LLC, Horsham, PA, 11Janssen-Cilag, Research & Development, LLC, San Diego, CA, 12Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France

    Background/Purpose: Guselkumab (GUS), a human monoclonal antibody targeting the interleukin-23p19 subunit, demonstrated joint and skin efficacy in patients with active psoriatic arthritis (PsA) in the…
  • Abstract Number: 2070 • ACR Convergence 2022

    Health-Related Quality of Life Across the Spectrum of Connective Tissue Diseases: A Latent Profile Analysis

    Sarah Dyball1, John Reynolds2, Hector Chinoy3, Ariane Herrick1, Sahena Haque4, Ellen Bruce5, Sophia Naz6, Ben Parker7 and Ian N. Bruce8, 1The University of Manchester, Manchester, United Kingdom, 2University of Birmingham, Birmingham, United Kingdom, 3The University of Manchester, Sale, United Kingdom, 4Manchester Foundation Trust, Manchester, United Kingdom, 5Kellgren Centre for Rheumatology, Manchester, United Kingdom, 6Pennine Acute Hospitals NHS Trust, Manchester, United Kingdom, 7Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 8Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Poor health-related quality of life (HR-QoL) is well recognised within patients with connective tissue diseases (CTD). We hypothesised that subgroups of patients across the…
  • Abstract Number: 2127 • ACR Convergence 2022

    Guselkumab Provides Continued Improvement in Key Domains of Psoriatic Arthritis Through 2 Years

    Laura Coates1, Laure Gossec2, Christine Contré3, May Shawi4, Emmanouil Rampakakis5, Natalie Shiff6, Alexa Kollmeier7, Xie L Xu8, Peter Nash9, Philip J Mease10 and Philip Helliwell11, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, England, United Kingdom, 2Sorbonne Université, Paris, France, 3Formerly at Janssen Scientific Affairs, LLC, Issy-les-Moulineaux, France, Issy-les-Moulineaux, France, 4Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 5McGill University, Department of Pediatrics and JSS Medical Research, Montréal, QC, Canada, 6Janssen Scientific Affairs, LLC; Community Health and Epidemiology, University of Saskatchewan, Philadelphia, PA, 7Janssen-Cilag, Research & Development, LLC, San Diego, CA, 8Janssen Research & Development, LLC, San Diego, CA, USA, San Marcos, CA, 9School of Medicine, Griffith University, Sunshine Coast, Australia, 10Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 11Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Recent guidelines from the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) recommend that psoriatic arthritis (PsA) therapy achieve lowest possible…
  • Abstract Number: 2136 • ACR Convergence 2022

    Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 Inhibitor, in a Phase 2 Trial in Psoriatic Arthritis: Achievement of Minimal Disease Activity and Its Components

    Arthur Kavanaugh1, Laura Coates2, Joseph Merola3, Philip J Mease4, Miroslawa Nowak5, Subhashis Banerjee5, Lauren Hippeli5 and Tom Lehman5, 1University of California San Diego, La Jolla, CA, 2Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, England, United Kingdom, 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 5Bristol Myers Squibb, Princeton, NJ

    Background/Purpose: Tyrosine kinase 2 (TYK2) is an intracellular kinase in the Janus kinase (JAK) family that mediates the signaling of multiple cytokines, including those central…
  • Abstract Number: 2141 • ACR Convergence 2022

    How Well Does Ultrasound-assessed Synovitis in Reduced Joint Sets Predict the Response to Secukinumab in Patients with Active Psoriatic Arthritis and Inadequate Response to Conventional DMARDs? – Exploratory Results from a Phase 3b Study

    Maria-Antonietta D'Agostino1, Philip G Conaghan2, Corine Gaillez3, Esperanza Naredo4, Peter mandl5, Philippe Carron6, Ladislav Šenolt7, Javier Eduardo Rosa8, Alejandra Lopez Rdz9, Punit Goyanka10, Braja Gopal Sahoo10, Weibin Bao11, Georg Schett12 and Maarten Boers13, 1Catholic University of Sacred Heart, Roma, Italy, 2University of Leeds, Leeds, United Kingdom, 3Novartis Pharma AG, Basel, Switzerland, 4Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain, 5Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria, 6Ghent University Hospital, Ghent, Belgium, 7Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 8Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 9Dermatológico Country, PSOAPS Psoriasis Clinical and Research Centre, Guadalajara, Mexico, 10Novartis Healthcare Pvt Ltd, Hyderabad, India, 11Novartis Pharmaceuticals Corporation, East Hanover, NJ, 12Universitätsklinikum Erlangen, Erlangen, Germany, 13Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands

    Background/Purpose: Power Doppler ultrasound (PDUS) allows the visualization of morphological and inflammatory changes of the synovium. The ULTIMATE study (NCT02662985) was the first large, randomized,…
  • Abstract Number: 2140 • ACR Convergence 2022

    Exposure-Adjusted Incidence Rate for Adverse Events of Special Interest in Patients with Psoriatic Arthritis Treated with Apremilast

    Philip J Mease1, Dafna Gladman2, Georg Schett3, Maria Paris4, Sue Cheng5, Sven Richter5, Lichen Teng5 and Arthur Kavanaugh6, 1Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 2Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada, 3Universitätsklinikum Erlangen, Erlangen, Germany, 4Amgen Inc., Westfield, NJ, 5Amgen, Inc., Thousand Oaks, CA, 6University of California San Diego, La Jolla, CA

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic systemic inflammatory musculoskeletal disease. The potential relationship between PsA therapies and specific safety events such as major adverse…
  • Abstract Number: 2130 • ACR Convergence 2022

    Apremilast in Bio-Naïve Patients with Early Psoriatic Arthritis: A National, Real-Life, Multicenter, Non-Interventional, Prospective, 52-week Cohort Study

    Petros P. Sfikakis1, Dimitrios Vassilopoulos2, Gkikas Katsifis3, Georgios Vosvotekas4, Theodoros Dimitroulas5, Argyro Repa6, Grigorios Sakellariou7, THEODORA SIMOPOULOU8, Athanasios Georgountzos9, Andreas Bounas10, Panagiotis Georgiou11, Evangelia Mole12, Evangelia Kataxaki13, Stamatis Nick Liossis14, Evangelos Theodorou15, Christina Antoniadou16, EVANGELOS THEOTIKOS17, PANAYIOTIS VLACHOYIANNOPOULOS18, THEODORA MARKATSELI19, Angeliki Kekki20, NIKOLAOS ANTONAKOPOULOS21 and Dimitrios Boumpas22, 1Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece, 2Clinical Immunology-Rheumatology Unit, 2nd Department of Internal Medicine and Laboratory, National and Kapodistrian University of Athens, School of Medicine, Hippokration General Hospital, Athens, Greece, 3Naval Hospital of Athens, Athens, Greece, 4Euromedica General Clinic of Thessaloniki, Thessaloniki, Greece, Thessaloniki, Greece, 54th Department of Internal medicine, Hippokration Hospital, School of medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, Thessaloniki, Greece, 6Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Crete, Greece, 7Department of Rheumatology, 424 General Army Hospital, Thessaloniki, Greece, Thessaloniki, Greece, 8Clinic of Rheumatology and Clinical Immunology, University Hospital of Larissa, Larissa, Greece, Larissa, Larisa, Greece, 9General Hospital of Athens G. Gennimatas, Athens, Greece, 10Olympion private General Clinic of Patras, Patras, Greece;, Patra, Akhaia, Greece, 11Rheumatology Unit, Agios Andreas Hospital, Patras, Greece, PATRA, Akhaia, Greece, 12Department of Rheumatology, KAT General Hospital of Attica, Athens, Greece, 13Rheumatology Unit, Thriasio General Hospital of Elefsina, Magoula, Greece, 14Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Patras, Greece, Patras, Akhaia, Greece, 15Rheumatology Clinic 251 Hellenic Air Force Hospital, Athens, Greece, 16First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece, 17Rheumatology Department, Asklepieion Voulas General Hospital, Athens, Greece, 18Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece, 19Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, 20Genesis Pharma SA, Halandri, Greece, 21Genesis Pharma SA, Chalandri, Greece, 224th Department of Internal Medicine, "Attikon" University Hospital, Athens, Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Background/Purpose: Apremilast is a targeted synthetic disease-modifying anti-rheumatic drug (tsDMARD) approved for psoriatic arthritis (PsA). Few clinical studies assessing treatment regimens in PsA have focused…
  • Abstract Number: 1810 • ACR Convergence 2022

    Frequency and Patterns of Opioid Use in the Management of Gout: A Population-Based Study

    Tuhina Neogi1, Martin Englund2, Aleksandra Turkiewicz2 and Ali Kiadaliri2, 1Boston University School of Medicine, Boston, MA, 2Lund University, Lund, Sweden

    Background/Purpose: Treatment guidelines for management of gout do not recommend opioids. We evaluated the frequency of opioid prescriptions in those with gout compared with the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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