Abstracts Archive - Page 605 of 2425 - ACR Meeting Abstracts

Abstract Number: 1566 • ACR Convergence 2021
Hyperuricemia Is Associated with Vascular Endothelial Dysfunction – the Impact of Hyperuricemia on Flow Mediated and Nitroglycerin Mediated Dilatation of the Brachial Artery
Rachael Flood, Colm Kirby, David Kane and Ronan Mullan, Tallaght University Hospital, Dublin, Ireland
Background/Purpose: Vascular endothelial cells line the entire circulatory system, these cells have very distinct and unique functions that are paramount to vascular biology. Hyperuricemia has…
Abstract Number: 1571 • ACR Convergence 2021
Elevated Lactate, Procalcitonin Levels and SIRS (Systemic Inflammatory Response Syndrome) in a Subset of Patients with Gout
Christopher Podgorski¹, Paula Skarda² and Elie Gertner³, ¹Department of Medicine, University of Minnesota Medical School, Saint Paul, MN, ²Department of Medicine, Regions Hospital, University of Minnesota Medical School, Saint Paul, MN, ³Section of Rheumatology, Regions Hospital and Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: The intense inflammatory cascade of acute gouty inflammation makes it difficult to differentiate clinically between acute gouty inflammation and sepsis, particularly since they can…
Abstract Number: 1570 • ACR Convergence 2021
AR882, a Novel Uricosuric Agent, Exhibited Favorable Pharmacokinetic Profile and Balanced Excretion and Metabolic Pathways in a Human AME Study
Rongzi Yan¹, zancong shen², Elizabeth Polvent³, vijay hingorani⁴, Shunqi Yan⁵ and Litain Yeh⁶, ¹Arthrosi Therapeutics, Inc, Irvine, CA, ²Arthrosi Therapeutics, Inc., San Diego, CA, ³Arthrosi Therapeutics, Inc., Roseville, CA, ⁴Vanguard Healthsciences, Inc., San Diego, CA, ⁵Arthrosi Therapeutics, Inc., Laguna Hills, CA, ⁶Arthrosi Therapeutics, Inc., Irvine, CA
Background/Purpose: AR882, a novel uric acid transporter 1 (URAT1) inhibitor is being developed for the treatment of gout with hyperuricemia. In Phase 1 and Phase…
Abstract Number: 1572 • ACR Convergence 2021
Ultrasound Signs of Gout in a Population with Asymptomatic Hyperuricemia
Bilal Bengana¹, Aicha Ladjouze², Nabil Baramtane Raaf³, Chaffa Aimeur⁴, Soraya Ayoub⁵, Abdenour Boukabous⁶ and Salima Lefkir-Tafiani⁷, ¹University Hospital of Beni Messous Algiers - Rheumatology Department, Algiers, Algeria, ²Specialized hospital establishment of Benaknoune, Rheumatology, Algiers, Algeria, ³Hospital of Bitraria, Biochemistry, El Biar, Algiers, Algeria, ⁴University hospital of Mustapha Bacha, Radiology, Sidi Mhamed, Algiers, Algeria, ⁵University hospital of Beni Messous, Internal Medicine, BeniMessous, Algiers, Algeria, ⁶University Hospital of Beni Messous Algiers- Rheumatology Department, Algiers, Algeria, ⁷University Hospital of Beni Messous Algiers - Rheumatology Department, Benimessous, Algeria
Background/Purpose: Hyperuricemia is a common biological abnormality, often clinically asymptomatic. However, it can announce a gout and be linked to many diseases such as metabolic…
Abstract Number: 1569 • ACR Convergence 2021
Effect of Elevated Serum Urate on Kidney Function: Analysis of a Randomized Controlled Trial of Inosine Supplementation
Nicola Dalbeth¹, Borislav Mihov¹, Angela Stewart¹, Gregory Gamble¹, Tony Merriman², David Mount³, Lisa Stamp⁴, Ian Reid¹ and Anne Horne¹, ¹University of Auckland, Auckland, New Zealand, ²University of Alabama at Birmingham, Dunedin, New Zealand, ³Brigham and Women's Hospital, Boston, MA, ⁴University of Otago, Christchurch, Christchurch, New Zealand
Background/Purpose: Observational studies have reported that serum urate associates with development and progression of kidney disease. However, it is uncertain whether elevated serum urate directly…
Abstract Number: 1551 • ACR Convergence 2021
Generation of Autoantibodies and Their Association with Rheumatic Disease Flares in Adult Patients with Autoimmune Inflammatory Rheumatic Diseases and General Adult Population Following BNT162b2 mRNA Covid-19 Vaccination
Tal Gazitt¹, Joy Feld², Amir Haddad³, Muna Elias⁴, Nizar Hijazi⁴, Nili Stein⁴, Victoria Furer⁵, Tali Eviatar⁶, Hagit Peleg⁷, Ori Elkayam⁸ and Devy Zisman⁴, ¹Carmel Hospital, Haifa, Israel, ²Carmel and Zvulun Medical Centre, Haifa, Israel, ³Carmel Medical Centre, Haifa, Israel, ⁴Carmel Medical Center, Haifa, Israel, ⁵Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁶Tel Aviv Sourasky Medical Center, Givataim, Israel, ⁷Hadassah Medical Center, Jerusalem, Israel, ⁸Tel Aviv Medical Center, Tel Aviv, Israel
Background/Purpose: The rapid spread of the COVID-19 pandemic has created the need for mass vaccination of patients with autoimmune rheumatic disease (AIIRD) despite the lack…
Abstract Number: 1576 • ACR Convergence 2021
Development of a Plain Radiographic Scoring System for New Bone Formation in Gout
Chang-Nam Son¹, Ken Cai², John Ferrier³, Yun-Jung Tsai³, Thomas Bardin⁴, Anthony Doyle⁵ and Nicola Dalbeth⁵, ¹Keimyung University School of Medicine, Daegu, Republic of Korea, ²University of Auckland, Sydney, Australia, ³Department of Radiology, Auckland District Health Board, Auckland, New Zealand, ⁴Hôpital Lariboisiere, Paris, France, ⁵University of Auckland, Auckland, New Zealand
Background/Purpose: Features of new bone formation (NBF) such as sclerosis and spurs are common on plain radiography in tophaceous gout. While a plain radiographic damage…
Abstract Number: 1580 • ACR Convergence 2021
Whole Blood Gene Expression and eQTL Analysis Implicate GGT7 and FADS2 in Gout Pathogenesis
Richard Reynolds¹, Riku Takei¹, Jeffrey Edberg¹, Nicholas Sumpter¹, Tony Merriman² and Megan Leask¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Dunedin, New Zealand
Background/Purpose: Gene expression studies of whole blood represent a powerful approach for understanding the pathogenesis of gout because differentially expressed transcripts may reflect the activation…
Abstract Number: 1582 • ACR Convergence 2021
Diagnostic Accuracy and Reliability of Conventional Radiography of the Knee in Calcium Pyrophosphate Deposition Disease by Using New Definitions: An Ancillary Study of the OMERACT Ultrasound – CPPD Group
Silvia Sirotti¹, Fabio Becce², Luca Maria Sconfienza³, Carlos Pineda⁴, Marwin Gutierrez⁵, Teodora Serban⁶, Daryl MacCarter⁷, Antonella Adinolfi⁸, Anna Scanu⁹, Carlo Alberto Scire¹⁰, Ingrid Moller¹¹, Esperanza Naredo¹², Piercarlo Sarzi-Puttini¹³, Abhishek Abhishek¹⁴, Hyon K. Choi¹⁵, Nicola Dalbeth¹⁶, Sara Tedeschi¹⁷, Maria-Antonietta D'Agostino¹⁸, Nemanja Damjanov¹⁹, Helen Keen²⁰, Lene Terslev²¹, Annamaria Iagnocco²² and Georgios Filippou²³, ¹Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy, ²Lausanne University Hospital, Lausanne, Switzerland, ³Department of Biomedical Sciences for Health, Università Degli Studi di Milano, Milan, Italy, ⁴Instituto Nacional de Rehabilitacion, Mexico City, Federal District, Mexico, ⁵Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitacion, Mexico City, Mexico, ⁶Ospedale La Colletta, ASL3 Genovese, Genoa, Italy, ⁷Rheumatology Department, North Valley Hospital, Whitefish, MT, ⁸Rheumatology Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy, ⁹Department of Medicine-DIMED, Rheumatology Unit, University of Padova, Padoa, Italy, ¹⁰SIR Epidemiology, Research Unit, Pavia, Italy, ¹¹University of Barcelona, Barcelona, Spain, ¹²Department of Rheumatology and Joint and Bone Research Unit, Hospital Fundación Jiménez Díaz and Autónoma University, Madrid, Spain, ¹³Rheumatology Department, Luigi Sacco University Hospital, Milano, Italy, ¹⁴University of Nottingham, Nottingham, United Kingdom, ¹⁵Massachusetts General Hospital, Lexington, MA, ¹⁶University of Auckland, Auckland, New Zealand, ¹⁷Brigham and Women's Hospital, Boston, MA, ¹⁸Rheumatology Department, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy, ¹⁹University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade, Serbia, ²⁰University of Western Australia, Daglish, Australia, ²¹Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University, Glostrup, Denmark, ²²University of Turin, Roma, Italy, ²³Rheumatology Department, Luigi Sacco University Hospital, Siena, Italy
Background/Purpose: Conventional Radiography (CR) has been widely used in Calcium Pyrophosphate Deposition Disease (CPPD) and is considered an important tool for the diagnosis. However, there…
Abstract Number: 1581 • ACR Convergence 2021
Genetic Effects on the Transition from Hyperuricemia to Gout
Nicholas Sumpter¹, Riku Takei¹, Richard Reynolds¹ and Tony Merriman², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Dunedin, New Zealand
Background/Purpose: There is clear evidence of genetic control of hyperuricemia resulting in increased gout risk, however genetic control of the transition from hyperuricemia to gout…
Abstract Number: 1575 • ACR Convergence 2021
Urate Crystals Regulate a Distinct JNK-Dependent Metabolic and Inflammatory Response
Anyan Cheng¹, Isidoro Cobo¹, Jessica Murillo Saich¹, Roxana Coras², Alyssa Torres³, Addison Lana¹, Johannes Schlachetzki¹, Ru Liu Bryan⁴, Robert Terkeltaub⁵, Elsa Sanchez-Lopez³, Christopher Glass¹ and Monica Guma⁶, ¹University of California San Diego, La Jolla, CA, ²University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, ³University of California San Diego, San Diego, CA, ⁴University of California San Diego and VASDHS, San Diego, CA, ⁵VA/UCSD, San Diego, CA, ⁶University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Although metabolic reprograming and its regulation in macrophages after TLR activation is well established, little is known about the regulation and the role of…
Abstract Number: 1583 • ACR Convergence 2021
Creation of an Ultrasonographic Scoring System for CPPD Extent: Results from a Delphi Process by the OMERACT US Working Group – CPPD Subgroup
Silvia Sirotti¹, Antonella Adinolfi², Fabio Becce³, Tomas Cazenave⁴, Sara Nysom Christiansen⁵, Edoardo Cipolletta⁶, Andrea Delle Sedie⁷, Mario Enrique Diaz Cortes⁸, Fabiana Figus⁹, Emilio Filippucci¹⁰, Peter Mandl¹¹, Daryl MacCarter¹², Ingrid Moller¹³, Mohamed Mortada¹⁴, Gael Mouterde¹⁵, Maria Esperanza Naredo Sanchez¹⁶, Carlos Pineda¹⁷, Francesco Porta¹⁸, Wolfgang Schmidt¹⁹, Teodora Serban²⁰, Lene Terslev²¹, Florentin Vreju²², Richard Wakefield²³, Pascal Zufferey²⁴, Piercarlo Sarzi-Puttini²⁵, Maria-Antonietta D'Agostino²⁶, Nemanja Damjanov²⁷, Annamaria Iagnocco²⁸, Helen Keen²⁹ and Georgios Filippou³⁰, ¹Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy, ²Rheumatology Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy, ³Lausanne University Hospital, Lausanne, Switzerland, ⁴Instituto de Rehabilitación Psicofisica, Buenos Aires, Argentina, Buenos Aires, Argentina, ⁵Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁶Polytechnic University of Marche, Jesi, Italy, ⁷University of Pisa, Pisa, Italy, ⁸Rheumatology Unit, University Hospital Fundación Santa Fe de Bogota, Bogotà, Colombia, ⁹University of Torino, Torino, Italy, ¹⁰Rheumatology Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Jesi, Italy, ¹¹Medical University of Vienna, Vienna, Austria, ¹²Rheumatology Department, North Valley Hospital, Whitefish, MT, ¹³University of Barcelona, Barcelona, Spain, ¹⁴Zagazig University, Zagazig, Egypt, ¹⁵Rheumatology department, CHU Montpellier, Montpellier, France, ¹⁶Department of rheumatology, Joint and Bone research Unit, Hospital Universitario Fundación Jiménez díaz and Autónoma University, Madrid, Spain, ¹⁷Instituto Nacional de Rehabilitacion, Mexico City, Federal District, Mexico, ¹⁸INS, Institute of Neurosciences, Florence, Italy, ¹⁹Immanuel Krankenhaus Berlin, Berlin, Germany, ²⁰ASL 3 Genovese, Genova, Italy, ²¹Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University, Glostrup, Denmark, ²²Rheumatology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania, ²³Rheumatology, Leeds University, Leeds, United Kingdom, ²⁴Rheumatology Department, University of Lausanne, CHUV, Lausanne, Switzerland, ²⁵L.Sacco University Hospital, Milano, Italy, ²⁶Rheumatology Department, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy, ²⁷University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade, Serbia, ²⁸University of Turin, Roma, Italy, ²⁹University of Western Australia, Daglish, Australia, ³⁰Rheumatology Department, Luigi Sacco University Hospital, Siena, Italy
Background/Purpose: Ultrasound (US) has proven to be an excellent technique for detecting Calcium Pyrophosphate (CPP) deposits, however there are no grading systems that allow for…
Abstract Number: 1574 • ACR Convergence 2021
Comparison of Urate Quantification in Gout and Asymptomatic Hyperuricemia by Ultrasound and Dual Energy Computed Tomography
Rachael Flood¹, Aamir Saeed², Kate Harrington¹, Conor Shortt¹, Ronan Mullan¹ and David Kane¹, ¹Tallaght University Hospital, Dublin, Ireland, ²Worcestershire Acute Hospitals NHS Trust., Worcester, United Kingdom
Background/Purpose: The diagnostic gold standard for gout remains aspiration and identification of monosodium urate (MSU) crystals under polarised light microscopy. Joint aspiration is invasive and…
Abstract Number: 1550 • ACR Convergence 2021
Flares and Side Effects After COVID-19 Vaccination in Patients with Rheumatic Diseases
Anna Carbone, Gentiana Vukatana, Enrica Vandelli, Marica Trevisani, Elisa Rossi, Rita Mulè and Marco Fusconi, Rheumatology Unit, Azienda Ospedaliero-Universitaria Bologna, Bologna, Italy
Background/Purpose: There is increasing interest in the safety of COVID-19 vaccination in patients with underlying chronic conditions. We investigated the rates of side effects and/or…
Abstract Number: 1592 • ACR Convergence 2021
ACT for Lupus: Pilot Study of a Novel Acceptance and Commitment Therapy (ACT) Online Program to Support Patients with Lupus During the COVID-19 Pandemic
Tessa Englund¹, Saira Sheikh², Becki Cleveland¹, Emily McCormick¹, Crystal Schiller³ and Teresa Dickson¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, ²University of North Carolina Thurston Arthritis Research Center, and Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic disease associated with significant symptom burden, including fatigue, anxiety, depression, pain, and negative impacts on health-related quality…

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