Abstracts Archive - Page 584 of 2425 - ACR Meeting Abstracts

Abstract Number: 0479 • ACR Convergence 2021
A Novel Semi-automated Classifier of Radiographic Hip Osteoarthritis on DXA Scans Is Strongly Predictive of Pain, Clinical Diagnosis and Joint Replacement: Findings from 40,000 Participants in UK Biobank
Benjamin Faber¹, Raja Ebsim², Fiona Saunders³, Monika Frysz¹, Claudia Lindner², Jennifer Gregory³, Richard Aspden³, Nicholas Harvey⁴, George Davey Smith¹, Timothy Cootes² and Jon Tobias¹, ¹University of Bristol, Bristol, United Kingdom, ²University of Manchester, Manchester, United Kingdom, ³University of Aberdeen, Aberdeen, United Kingdom, ⁴University of Southampton, Southampton, United Kingdom
Background/Purpose: Radiographic hip osteoarthritis (rHOA) is traditionally defined on hip or pelvic radiographs, using subjective methods such as Kellgren-Lawrence scoring. Associations between subjective rHOA measures…
Abstract Number: 0478 • ACR Convergence 2021
Identification of Clinical Phenotypes of Hand Osteoarthritis Using Hierarchical Clustering Method
Marie Binvignat¹, Gabriel Pires¹, Nicolas Tchitchek¹, Alice Courties², Felicie Costantino³, David Klatzmann¹, Bernard Combe⁴, Maxime Dougados⁵, Pascal Richette⁶, Encarnita Mariotti-Ferrandiz¹, Francis Berenbaum⁷ and Jeremie Sellam⁸, ¹Sorbonne Universite, Paris, France, ²Service de Rhumatologie, AP-HP Hopital Saint-Antoine, Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine, Paris, France, ³Inserm, Boulogne Billancourt, France, ⁴CHU Montpellier Montpellier University, Montpellier, France, ⁵Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France, ⁶Lariboisiere Hospital, Paris, France, ⁷Sorbonne Universit - hopital Saint-Antoine, Paris, France, ⁸INSERM UMRS_938, Sorbonne Université, St-Antoine Hospital, Paris, France, Paris, France
Background/Purpose: Hand osteoarthritis (OA) is an heterogenous disease in terms of risk factors, localization and severity. This heterogeneity also applies to the clinical presentation and…
Abstract Number: 0477 • ACR Convergence 2021
TNX-102 SL (Sublingual Cyclobenzaprine) for the Treatment of Fibromyalgia in the RELIEF Study: Positive Results of a Phase 3 Randomized, Double-Blind, Placebo-Controlled Multicenter Efficacy and Safety Trial
Gregory Sullivan¹, Mary Kelley², Annabelle Iserson¹, Perry Peters², Ashild Peters², Candace Flint¹, Judy Gendreau³, Herb Harris¹, Ben Vaughn⁴ and Seth Lederman⁵, ¹Tonix Pharmaceuticals, Inc., Chatham, NJ, ²Tonix Pharmaceuticals, Inc., San Diego, CA, ³Gendreau Consulting, LLC, Poway, CA, ⁴Rho, Inc., Cary, NC, ⁵Tonix Pharmaceuticals, Inc., South Dartmouth, MA
Background/Purpose: Fibromyalgia (FM) is characterized by chronic widespread pain, fatigue, and nonrestorative sleep, a symptom constellation suggestive of a pathological disturbance in central pain processing…
Abstract Number: 0472 • ACR Convergence 2021
An Atlas of Human and Mouse Intrarenal Immune Cells in Lupus Nephritis Reveals Homologous Immune Populations Across Common Mouse Strains and Species
Paul Hoover¹, Michael Peters², David Lieb², Runci Wang³, Garett Dunlap⁴, Deepak Rao¹, Nir Hacohen² and Anne Davidson⁵, ¹Brigham and Women's Hospital, Boston, MA, ²Broad Institute, Cambridge, MA, ³Brigham and Women’s Hospital, Boston, MA, ⁴Harvard University, Somerville, MA, ⁵Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: We discovered 21 immune cell-types in lupus nephritis kidney biopsies as part of the Accelerating Medicines Partnership (AMP) consortium. These immune cells are the…
Abstract Number: 0483 • ACR Convergence 2021
Frequent Use of Prescription Oral NSAIDs Among People with Knee or Hip Osteoarthritis Despite Contraindications to or Precautions with NSAIDs
Tuhina Neogi¹, Andrea Dell'isola², Martin Englund² and Aleksandra Turkiewicz², ¹Boston University School of Medicine, Boston, MA, ²Lund University, Lund, Sweden
Background/Purpose: Oral NSAIDs are recommended for OA management. However, many patients with OA have contraindications to NSAIDs or have comorbidities that warrant precaution. Because few…
Abstract Number: 0482 • ACR Convergence 2021
Metformin Use Reduces the Risk of Developing Osteoarthritis: A Propensity Score Matching Study
Khushboo Sheth¹, Di Lu², Rong Lu², William Robinson³ and Matthew Baker⁴, ¹Stanford University/VA Palo Alto, Atherton, CA, ²Stanford University, Stanford, ³Stanford University, Palo Alto, CA, ⁴Stanford University, Menlo Park, CA
Background/Purpose: Preclinical and observational data suggest a protective effect of metformin against developing osteoarthritis (OA).1,2 In this retrospective cohort study, we evaluated the time to…
Abstract Number: 0480 • ACR Convergence 2021
Signs of Regression to the Mean in Observational Data from a Nation-Wide Exercise and Education Intervention for Osteoarthritis
Martin Englund¹, Dorte Grønne², Ewa Roos², Søren Skou² and Aleksandra Turkiewicz¹, ¹Lund University, Lund, Sweden, ²University of Southern Denmark, Odense, Denmark
Background/Purpose: Patients who enroll in interventions are likely to do so when they experience a flare-up in symptoms. This may create issues in interpretation of…
Abstract Number: 0484 • ACR Convergence 2021
RheumMadness: Creating an Online Community of Inquiry
David Leverenz¹, Akrithi Udupa², Didem Saygin³, Guy Katz⁴, Christopher Witt², Lisa Criscione-Schreiber⁵ and Matthew Sparks⁵, ¹Duke University, Durham, NC, ²Duke University Hospital, Durham, NC, ³University of Chicago, Chicago, IL, ⁴Massachusetts General Hospital, Boston, MA, ⁵Duke University School of Medicine, Durham, NC
Background/Purpose: RheumMadness is an online collaborative learning experience in which rheumatology concepts compete as teams in a tournament. The Community of Inquiry (CoI) framework describes…
Abstract Number: 0486 • ACR Convergence 2021
A Practical Approach to Competency-based Evaluations and Milestone Mapping for Adult Rheumatology Fellowship Programs
Grant hughes¹, Sarah Chung¹, Elizabeth Wahl², Jenna Thomason¹, Bernard Ng³, Ingeborg Sacksen⁴ and Alison Bays¹, ¹University of Washington, Seattle, WA, ²VA Puget Sound Healthcare System, Seattle, WA, ³Rheumatology Section, VA Puget Sound HCS, University of Washington, Seattle, WA, ⁴University of Washington, Bellingham, WA
Background/Purpose: The American College of Rheumatology has developed 14 Entrustable Professional Activities (EPAs) for Adult Rheumatology that define broad clinical competency goals for fellowship. At…
Abstract Number: 0485 • ACR Convergence 2021
The Impact of COVID-19 on Rheumatology Trainee Health and Wellbeing: Results from the COVID-19 Global Rheumatology Alliance Trainee Survey
Kristen Young¹, Su-Ann Yeoh², Michael Putman³, Sebastian Sattui⁴, Richard Conway⁵, Elizabeth Graef⁶, Adam Killian⁷, Maximilian Konig⁸, Jeffrey Sparks⁹, Manuel Ugarte-Gil¹⁰, Laura Upton¹¹, Francis Berenbaum¹², Suleman Bhana¹³, Jonathan Hausmann¹⁴, Pedro Machado¹⁵, Philip Robinson¹⁶, Emily Sirotich¹⁷, Paul Sufka¹⁸, Jinoos Yazdany¹⁹, Jean Liew²⁰, Rebecca Grainger²¹, Zachary Wallace²² and Aruni Jayatilleke²³, ¹University of Texas Southwestern Medical Center, Dallas, TX, ²University College London, London, United Kingdom, ³Medical College of Wisconsin, Brookfield, WI, ⁴Hospital for Special Surgery, New York, NY, ⁵St. James's University Hospital, Dublin, Ireland, ⁶Emerson Hospital, Concord, MA, ⁷George Washington University, Washington, DC, ⁸The Johns Hopkins University School of Medicine, Baltimore, MD, ⁹Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ¹⁰Hospital Guillermo Almenara Irigoyen, Essalud/Universidad Científica del Sur, Lima, Peru, ¹¹Georgetown University School of Medicine, Melbourne, FL, ¹²Sorbonne Universit - hopital Saint-Antoine, Paris, France, ¹³Crystal Run Health, Montvale, NJ, ¹⁴Boston Children's Hospital / Beth Israel Deaconess Medical Center, Cambridge, MA, ¹⁵Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, ¹⁶University of Queensland School of Clinical Medicine, Brisbane, Queensland, Australia, Herston, Australia, ¹⁷McMaster University, Hamilton, ON, Canada, ¹⁸HealthPartners, Eagan, MN, ¹⁹University of California San Francisco, San Francisco, CA, ²⁰Boston University, Boston, MA, ²¹University of Otago, Wellington, New Zealand, ²²Massachusetts General Hospital, Newton, MA, ²³Temple University, Philadelphia, PA
Background/Purpose: The COVID-19 pandemic has disrupted healthcare delivery and education of physicians, including rheumatology trainees. Our objective was to assess the impact of the COVID-19…
Abstract Number: 0481 • ACR Convergence 2021
The Day-to-day Variability of Pain and the Relationship with Physical Activity in People with Knee Osteoarthritis: A Longitudinal, Observational Feasibility Study
Arani Vivekanantham¹, David Selby², Mark Lunt², Terence O’Neill² and Will Dixon², ¹University of Oxford, Oxford, United Kingdom, ²University of Manchester, Manchester, United Kingdom
Background/Purpose: Pain is a cardinal symptom in people with knee osteoarthritis (OA). However, pain in knee OA is often infrequently measured both in clinical practice…
Abstract Number: 0475 • ACR Convergence 2021
Quantitative Analysis of Gender and Racial Disparities in Randomized Controlled Trials of Fibromyalgia
Rami Diab¹, Ali Malik², Mahmoud Al Rifai³ and Dennis Ang⁴, ¹Wake Forest Baptist Health/Wake Forest School of Medicine, Winston-Salem, NC, ²Wake Forest Baptist Health / Wake Forest School of Medicine, Winston-Salem, NC, ³Baylor College of Medicine, Houston, TX, ⁴Wake Forest School of Medicine, Winston-Salem, NC
Background/Purpose: Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, mood disorders, fatigue, and cognitive and sleep disturbance. Mainstay treatments include tricyclic antidepressants,…
Abstract Number: 0456 • ACR Convergence 2021
Functional Connectivity, Enhanced Blood-Brain Barrier Leakage and Cognitive Impairment in Systemic Lupus Erythematosus
John Hanly¹, Jason Robertson¹, Lyna Kamintsky¹, Alon Friedman¹, Steven Beyea¹, John Fisk¹, Antonina Omisade¹, Cindy Calkin¹, Tim Bardouille¹, Chris Bowen¹, Alexandra Legge¹, Arnold Mitnitski², Kara Matheson² and Javeria Hashmi¹, ¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
Background/Purpose: Cognitive impairment is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. We have previously…
Abstract Number: 0427 • ACR Convergence 2021
Increased Risk of Severe Infections and Mortality in Patients with Newly Diagnosed Anti-neutrophil Cytoplasmic Antibody–associated Vasculitis: A Population-based Study
Kai Zhao¹, Hui Xie², John Esdaile³ and J. Antonio Avina-Zubieta², ¹Simon Fraser University, Coquitlam, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Arthritis Research Canada, Vancouver, BC, Canada
Background/Purpose: Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are a group of multisystem inflammatory diseases of the small blood vessels. Infections are serious complications in AAV…
Abstract Number: 0364 • ACR Convergence 2021
Dose Tapering of TNF Inhibitors in Patients with Axial Spondyloarthritis in Routine Care – 2-year Clinical and MRI Outcomes and Predictors of Successful Tapering
Marie Wetterslev¹, Stylianos Georgiadis², Inge Juul Sørensen³, Susanne Juhl Pedersen², Sara Nysom Christiansen⁴, Merete Lund Hetland¹, Cecilie Heegaard Brahe², Mads Bakkegaard⁵, Anne Duer⁶, Mikael Boesen⁷, Kasper Kjærulf Gosvig⁸, Jakob Møllenbach Møller⁸, Niels Steen Krogh⁹, Bente Jensen⁵, Ole Rintek Madsen⁵, Jan Christensen⁵, Annette Hansen⁵, Jesper Nørregaard⁵, Henrik Røgind⁵ and Mikkel Ostergaard¹⁰, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, ²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, ³Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁴Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁵Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, ⁶Department of Radiology, Rigshospitalet, Glostrup, Copenhagen, Denmark, ⁷Department of Radiology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ⁸Department of Radiology, Herlev and Gentofte Hospital, Copenhagen, Denmark, ⁹ZiteLab ApS, Copenhagen, Denmark, Frederiksberg, Denmark, ¹⁰Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark
Background/Purpose: In a 2-year follow-up study of patients with axial spondyloarthritis (axSpA) in clinical remission who tapered Tumor Necrosis Factor inhibitor (TNFi) treatment according to…

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