Abstracts Archive - Page 575 of 2425 - ACR Meeting Abstracts

Abstract Number: 0344 • ACR Convergence 2021
Anti-gAChR Antibody as a Novel Biomarker for Lupus Enteritis in Systemic Lupus Erythematosus
Kuniyuki Aso¹, Michihito Kono¹, Keita Ninagawa¹, Nobuya Abe¹, Yuichiro Fujieda¹, Masaru Kato¹, Olga Amengual¹, Kenji Oku¹ and Tatsuya Atsumi², ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Hokkaido University, Sapporo, Japan
Background/Purpose: Anti-ganglionic nicotinic acetylcholine receptor (gAChR) antibody (Ab) is associated with widespread autonomic dysfunction in autoimmune autonomic ganglionopathy. Although it is also detected in several…
Abstract Number: 0343 • ACR Convergence 2021
Overview of the Childhood Systemic Lupus Erythematosus (cSLE) Cohort in the CARRA Registry
Christine Bacha¹, Anne Dennos², Andrea Knight³, Laura Schanberg⁴, Mary Beth Son⁵, Emily von Scheven⁶, Shahla Amin⁷, Charles Helmick⁸ and Aimee Hersh⁹, ¹Nationwide Children's Hospital, Grandview Heights, OH, ²Duke University, Durham, NC, ³Hospital for Sick Children, Toronto, ON, Canada, ⁴Duke University Medical Center, Durham, NC, ⁵Boston Children's Hospital, Brookline, MA, ⁶University of California San Francisco, San Francisco, CA, ⁷CARRA, Durham, NC, ⁸Centers for Disease Control and Prevention, Atlanta, GA, ⁹University of Utah, Salt Lake City, UT
Background/Purpose: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry is a multi-center, observational registry that collects demographic, clinical, and provider- and patient-reported data from…
Abstract Number: 0342 • ACR Convergence 2021
RAIL Distinguishes Responder and Non-Responder in Pediatric Lupus Nephritis
Ellen Cody¹, Scott Wenderfer², Qing Ma¹, Angela Merritt¹, Prasad Devarajan¹ and Hermine Brunner¹, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Baylor College of Medicine, Houston, TX
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a diagnostic and therapeutic challenge, particularly lupus nephritis (LN). We described a composite score, the Renal Activity Index for…
Abstract Number: 0337 • ACR Convergence 2021
Rarity of Pneumocystis Jirovecii Pneumonia in Patients with Systemic Lupus Erythematosus Using a Real-world, Electronic Health Record
Ben Boone and April Barnado, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Infection is the leading cause of mortality and one of the most common causes of hospitalization in patients with systemic lupus erythematosus (SLE). Pneumocystis…
Abstract Number: 0348 • ACR Convergence 2021
The New EULAR/ ACR 2019 SLE Classification Criteria: A Predictor of Long-term Outcomes
Laura Whittall-Garcia¹, Dafna Gladman², Murray Urowitz³, Jiandong Su⁴, Zahi Touma⁵ and Sindhu Johnson⁶, ¹University of Toronto, University Health Network, Toronto, ON, Canada, ²Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Lupus Clinic, Toronto, ON, Canada, ⁴University Health Network, Toronto, ON, Canada, ⁵University of Toronto, Mississauga, ON, Canada, ⁶University of Toronto, Toronto, ON, Canada
Background/Purpose: We recently demonstrated that a EULAR/ACR classification Criteria score ≥ 20 predicts a higher disease activity throughout the first 5 years after diagnosis. Given…
Abstract Number: 0347 • ACR Convergence 2021
Longitudinal ANA Titers in SLE and ANA+ Controls
Emily Littlejohn¹, Lingxuan Kong², Kelly Speth², Lu Wang² and Emily Somers², ¹Cleveland Clinic, Cleveland, OH, ²University of Michigan, Ann Arbor, MI
Background/Purpose: Antinuclear or anticellular antibodies (ANAs), are a hallmark of systemic lupus erythematosus (SLE). ANAs are also a marker of subclinical autoimmunity, with ~13% of…
Abstract Number: 0345 • ACR Convergence 2021
Anti-MPP-1 Autoantibodies in Systemic Lupus Erythematosus: A Potential Biomarker for Neuropsychiatric Manifestations
Eugene Krustev¹, Katherine Buhler¹, Francesca Cardwell², Marvin Fritzler¹, Ann Clarke¹ and May Choi³, ¹University of Calgary, Calgary, AB, Canada, ²University of Waterloo, Burlington, ON, Canada, ³Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada
Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) can involve the central (CNS) and peripheral nervous system (PNS). Several autoantibodies have been associated with CNS NPSLE including…
Abstract Number: 0349 • ACR Convergence 2021
Performance of the 2019 EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus in a Predominantly African American Cohort
Jessica English¹, Dulaney Wilson², Gary Gilkeson², Jim Oates² and Diane Kamen², ¹Medical University of South Carolina, Johns Island, SC, ²Medical University of South Carolina, Charleston, SC
Background/Purpose: Classification criteria for systemic lupus erythematosus (SLE) were recently published by the European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR) to…
Abstract Number: 0351 • ACR Convergence 2021
Gene Signature Fingerprints Divide SLE Patients in Subgroups with Similar Biological Disease Profiles: A Multicenter Longitudinal Study
Javad Wahadat¹, Dieneke Schonenberg-Meinema², Cornelia van Helden-Meeuwsen¹, Sander van Tilburg¹, Noortje Groot³, Ellen Schatorjé⁴, Esther Hoppenreijs⁴, Petra Hissink Muller⁵, Danielle Brinkman⁶, Denis Dvorak⁷, Marleen Verkaaik³, Katerina Bouchalova⁸, Merlijn van den Berg², Sylvia Kamphuis⁹ and Marjan Versnel¹, ¹Erasmus University Medical Center, Rotterdam, Netherlands, ²Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, Netherlands, ³Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, Netherlands, ⁴Amalia Children's Hospital, Nijmegen, Netherlands, ⁵Willem Alexander Children’s Hospital, Leiden University Medical Center, Leiden, Netherlands, ⁶Willem Alexander Children’s Hospital, Leiden University Medical Center, Leiderdorp, Netherlands, ⁷Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic, ⁸Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czech Republic, ⁹Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Clinical phenotyping and predicting treatment responses in Systemic Lupus Erythematosus (SLE) patients is challenging. Extensive blood transcriptional profiling has identified various gene modules that…
Abstract Number: 0350 • ACR Convergence 2021
EPI-SIGN: Epigenetic SLE Indicators of Glomerular Nephritis
Ashira Blazer¹, Olusola Ayanlowo², Will Liao³, Dzifa Dey⁴, Jasmin Divers⁵, Uyiekpen Ima-Edomwonyin⁶, Hakeem Olaosebikan⁷, Cristina Lanata⁸, Girish Nadkarni⁹, Jill Buyon¹, Peter Izmirly¹⁰ and Timothy Niewold¹¹, ¹NYU School of Medicine, New York, NY, ²College of Medicine University of Lagos, New York, NY, ³New York Genome Center, New York, NY, ⁴University of Ghana, Accra, Ghana, ⁵NYU Langone Hospital - Long Island, Mineola, NY, ⁶Lagos State University Teaching Hospital, Lagos, Nigeria, ⁷Lagos University State Teaching Hospital, Lagos, Nigeria, ⁸University of California San Francisco, Moss Beach, CA, ⁹Icahn School of Medicine at Mount Sinai, New York, NY, ¹⁰New York University School of Medicine, New York, NY, ¹¹Colton Center for Autoimmunity NYU School of Medicine, New York, NY
Background/Purpose: Systemic Lupus Erythematosus (SLE) is more common and severe in those of African Ancestry (AA) who, relative to Europeans, are twice as likely to…
Abstract Number: 0346 • ACR Convergence 2021
The CB-CAPillaryTM Test Kit: A Tool for Point-of-Care Assays to Measure Cell-Bound Complement Activation Products
Joseph Ahearn¹, Susan Manzi¹ and Chau-Ching Liu², ¹Allegheny Health Network, Wexford, PA, ²Allegheny Health Network, Pittsburgh, PA
Background/Purpose: Cell-bound complement activation products (CB-CAPs) have been validated as biomarkers for systemic lupus erythematosus (SLE) diagnosis, monitoring and stratification, and for identification of patients…
Abstract Number: 0340 • ACR Convergence 2021
Urinary L-selectin Predicts Disease Activity and Histological Changes in Lupus Nephritis
Huihua Ding¹, Yiwei Shen¹, Min Dai¹, Chandra Mohan² and Nan Shen³, ¹Shanghai JiaoTong University School of Medicine, Shanghai, China (People's Republic), ²University of Houston, Houston, TX, ³Shanghai Jiang Tong University School of Medicine, Shanghai, China (People's Republic)
Background/Purpose: There remains unmet needs of non-invasive markers of disease activity, damage, prognosis, and treatment response in lupus nephritis patients. Here, we aim to validate…
Abstract Number: 0321 • ACR Convergence 2021
Sequential Administration of Belimumab and Rituximab in Primary Sjögren’s Syndrome Reduces Minor Salivary Gland–Resident B Cells and Delays B-Cell Repopulation in Circulation
André van Maurik¹, David Gardner², Saba Nayar², Charlotte Smith², Kenneth Clark¹, Prafull Mistry¹, Rajesh Punwaney³, David Roth³, Robert Henderson¹, Xavier Mariette⁴ and Francesca Barone², ¹GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom, ²University of Birmingham, College of Medical and Dental Sciences, Birmingham, United Kingdom, ³GlaxoSmithKline, Collegeville, PA, ⁴Université Paris- Saclay, Rheumatology, Paris, France
Background/Purpose: Primary Sjögren’s syndrome (pSS) is characterized by B-cell hyperactivity and elevated serum and saliva B-lymphocyte stimulator (BLyS) levels.1 Sequential administration of belimumab (BEL; anti-BLyS)…
Abstract Number: 0292 • ACR Convergence 2021
Suppressed Paraoxonase-1 Activity and Elevated Oxylipins Associate with the Presence of Small Airways Disease in Patients with Rheumatoid Arthritis
Amir Razmjou¹, Jennifer Wang², Ani Shahbazian², Srinivasa Reddy³ and Christina Charles-Schoeman², ¹University of California Los Angeles Medical Center, Los Angeles, CA, ²Department of Medicine, University of California, Los Angeles, Los Angeles, CA, ³David Geffen School of Meicine, UCLA, Los Angeles, CA
Background/Purpose: Lung disease in patients with rheumatoid arthritis (RA) is common and associates with significantly increased morbidity and mortality. Oxidative stress plays an important role…
Abstract Number: 0229 • ACR Convergence 2021
The Effects of Self-efficacy on Fatigue and Pain Interference in Black Women with Systemic Lupus Erythematosus: The Role of Depression, Age, and Education
Cristina Drenkard¹, Kirk Easley¹, Gaobin Bao¹, Charmayne Dunlop-Thomas¹, Teresa Brady² and S Sam Lim³, ¹Emory University, Atlanta, GA, ²Clarity Consulting and Communications, Atlanta, GA, ³Department of Medicine, Division of Rheumatology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Fatigue and pain are pervasive symptoms that cause escalating distress in patients with SLE, particularly among Black women and other high-risk groups. While these…

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