Abstracts Archive - Page 463 of 2607 - ACR Meeting Abstracts

Abstract Number: 2367 • ACR Convergence 2023
Characterization of the SFRP4+ PRG4+ Fibroblast Subpopulation in the Dermis of Healthy Skin and Its Relationship to SFRP4+ PRG4- Myofibroblasts in the Skin of Patients with Systemic Sclerosis
Banafsheh Nazari¹, Tracy Tabib² and Robert Lafyatis², ¹University of Pittsburgh, Atlanta, GA, ²University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic sclerosis (SSc) is a debilitating autoimmune disease characterized by extensive fibrosis affecting multiple organs. The fibrosis arises from the excessive production of collagen…
Abstract Number: 2385 • ACR Convergence 2023
Risk of Major Adverse Cardiovascular Events in ANCA-associated Vasculitis
Jon Idoate¹, Morgane Mourguet¹, Thomas Villeneuve¹, Grégoire Prevot¹, Laurent Guilleminault², Ribes David¹, Stan Faguer¹, Antoine Huart¹, Dominique Chauveau¹, Laurent Alric¹, Martin Michaud¹, Laurent Sailler¹, Sébastien De Almeida Chavez¹, Emmanuelle Mouchon¹, Olivier Lairez¹ and Gregory Pugnet³, ¹CHU Toulouse, Toulouse, France, ²Department of respiratory and allergic diseases, Toulouse University Hospital Center, Toulouse, France, ³CHU Toulouse Rangueil Service de Medecine Interne et Immunologie Clinique, Toulouse, France
Background/Purpose: The aim of this study was to investigate the risk of major adverse cardiovascular events (MACE) in patients with ANCA-associated vasculitis (AAV). Methods: We…
Abstract Number: 2386 • ACR Convergence 2023
Impact of ANCA Specificity on Risk of Major Adverse Cardiovascular Events in ANCA-associated Vasculitis
Jon Idoate¹, Morgane Mourguet¹, Ribes David¹, Stan Faguer¹, Antoine Huart¹, Dominique Chauveau¹, Thomas Villeneuve¹, Grégoire Prevot¹, Laurent Guilleminault², Emmanuelle Mouchon¹, Laurent Balardy¹, Laurent Sailler¹, Sébastien De Almeida Chavez¹, Laurent Alric¹, Martin Michaud¹, Olivier Lairez¹ and Gregory Pugnet³, ¹CHU Toulouse, Toulouse, France, ²Department of respiratory and allergic diseases, Toulouse University Hospital Center, Toulouse, France, ³CHU Toulouse Rangueil Service de Medecine Interne et Immunologie Clinique, Toulouse, France
Background/Purpose: The aim of this study was to investigate the relationship between ANCA specificity and the risk of major adverse cardiovascular events (MACE) in patients…
Abstract Number: 2381 • ACR Convergence 2023
ANCA-associated Vasculitis and Renal Disease in a Multidisciplinary Outpatient Clinic in Northern Spain
Salma Al Fazazi¹, Fabricio Benavides², Vanesa Calvo Río³, maria rodriguez Vidriales², clara escagedo Cagigas², monica renuncio garcia², luis martin penagos⁴ and Ricardo Blanco⁵, ¹Hospital Universitario Puerta Del Mar, Cádiz, Spain, ²Hospital Universitario Marqués de Valdecilla, Santander, Spain, ³Valdecilla Hospital, Santander, Spain, ⁴Division of Nephrology, Immunopathology Group, Hospital Universitario Marqués de Valdecilla-DIVAL, Santander, Spain, ⁵Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
Background/Purpose: The severity of clinical features and outcomes in previous series of patients reported with renal disease related to ANCA-associated vasculitis (AAV) vary greatly, probably…
Abstract Number: 2384 • ACR Convergence 2023
Major Cardiovascular Adverse Events in Patients with ANCA Vasculitis Compared with Hypertension Control Group
Lisa Rosenberg¹, Larabe Farrukh¹, Simrin Kooner¹, Moiz Ehtesham¹, Sumbal Wajid¹, Ruben Peredo-Wende² and Shannon Murawski¹, ¹Albany Medical Center, Albany, NY, ²Stratton VA Medical Center, Albany, NY
Background/Purpose: Vascular damage from inflammation in ANCA vasculitis leads to a sustained procoagulant state causing accelerated atherosclerosis. A population-based cohort study found that the risk…
Abstract Number: 2329 • ACR Convergence 2023
AMTX-100, a Nuclear Transport Inhibitor, Attenuates Inflammatory Cytokine Production in vitro and Following UV Mediated Skin Inflammation in a Mouse Model of Cutaneous Lupus Erythematosus in vivo
Xizhang Sun¹, Jie An¹, Ting Wang¹, Arpit Rathee¹, Vernon Alvarez², Matthew Gonda³, Christian Lood¹ and Keith Elkon¹, ¹University of Washington, Seattle, WA, ²Amytrx Therapeutics Inc., Nashville, TN, ³Amytrx Therapeutics, Nashville, TN
Background/Purpose: Inflammatory stimuli induce transcription factors (TFs) such as NF-kB and interferon regulatory factors (IRFs). TFs are transported from cytosol to nucleus to activate genes…
Abstract Number: 2370 • ACR Convergence 2023
C5 as a Genetic Marker for Discriminating Between IgA Vasculitis and IgA Nephropathy?
JOAO CARLOS BATISTA LIZ¹, Vanesa Calvo Río², María Sebastián Mora-Gil¹, Belén Sevilla-Pérez³, María Teresa Leonardo⁴, Ana Peñalba⁴, María Jesús Cabero⁴, Javier Narvaez⁵, luis martin penagos⁶, Emilio Rodrigo⁶, Lara Belmar-Vega⁶, Cristina Gomez-Fernandez⁷, Luis Caminal-Montero⁸, Paz Collado⁹, Antonio Fernandez-Nebro¹⁰, gisela Díaz-Cordovés¹¹, Maryia Nikitsina¹², Esther Vicente Rabaneda¹³, secundino Cigarrán¹⁴, jesús Calviño¹⁵, carmen cobelo¹⁵, Manuel León Luque¹⁶, Esteban Rubio¹⁶, Juan María Blanco-Madrigal¹⁷, Eva Galindez-Agirregoikoa¹⁸, Santos Castañeda¹⁹, Ricardo Blanco²⁰, Verónica Pulito-Cueto¹ and Raquel López-Mejías¹, ¹Rheumatology Department, Immunopathology Group, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain, ²Valdecilla Hospital, Santander, Spain, ³Division of Pediatrics, Hospital Universitario San Cecilio, Granada, Spain, ⁴Division of Pediatrics, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁵Hospital Universitario de Bellvitge, Barcelona, Spain, ⁶Division of Nephrology, Immunopathology Group, Hospital Universitario Marqués de Valdecilla-DIVAL, Santander, Spain, ⁷Division of Dermatology,Immunopathology Group, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain, ⁸Internal Medicine Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain, ⁹Division of Rheumatology, Hospital Universitario Severo Ochoa, Madrid, Spain, ¹⁰Hospital Regional Universitario de Málaga, Malaga, Spain, ¹¹Division of Rheumatology, Hospital Regional Universitario Carlos Haya, Málaga, Spain, ¹²Division of Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain, ¹³Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain, ¹⁴Division of Nephrology, Hospital da Costa Burela, Lugo, Spain, ¹⁵Division of Nephrology, Hospital Universitario Lucus Augusti, Lugo, Spain, ¹⁶Division of Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ¹⁷Division of Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain, ¹⁸Basurto University Hospital, Bilbao, Spain, ¹⁹Hospital Universitario de la Princesa, Madrid, Spain, ²⁰Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
Background/Purpose: Immunoglobulin-A vasculitis (IgAV) and IgA nephropathy (IgAN) are inflammatory conditions that share pathophysiological mechanisms1,2. Similar features are also described between IgAV nephritis (IgAVN) and…
Abstract Number: 2335 • ACR Convergence 2023
Defining a Basket Population for ANA+ Arthritis Trials
Jack Arnold¹, Md Yuzaiful Md Yusof¹, Lucy Carter², Zoe Wigston¹ and Ed Vital¹, ¹University of Leeds, Leeds, United Kingdom, ²University of Leeds, Hartlepool, United Kingdom
Background/Purpose: Musculoskeletal (MSK) manifestations are common in systemic lupus erythematosus (SLE) and other ANA-associated rheumatic musculoskeletal diseases (ANA-RMDs). Presently clinical trials recruit patients from individual…
Abstract Number: 2379 • ACR Convergence 2023
A Real-World Descriptive Study of Renal Outcomes Among Patients with ANCA-Associated Vasculitis Initiating Remission Induction Therapy
Sam Oh¹, Sushmitha Inguva², Pallavi Rane² and Brian Tumminello³, ¹Amgen, Inc., South San Francisco, CA, ²Amgen, Inc., Thousand Oaks, CA, ³Amgen, Inc., San Juan Capistrano, CA
Background/Purpose: ANCA-associated vasculitis (AAV) is a group of rare autoimmune diseases characterized by inflammation and necrosis of small- to medium-sized blood vessels, commonly affecting the…
Abstract Number: 2391 • ACR Convergence 2023
Epidemiology and Predictors of Relapse in Giant Cell Arteritis: Results of the ARTESER Register
Javier Narvaez¹, Jesús Sanchez-Costa², Iñigo Hernández-Rodríguez³, Rafael Benito Melero-Gonzalez⁴, Eugenio De Miguel⁵, Irene Monjo⁶, Maite silva díaz⁷, LUCIA SILVA FERNANDEZ⁸, Joaquin Maria Belzunegui Otano⁹, Jesus Alejandro Valero-Jaimes¹⁰, Clara Moriano Morales¹¹, Ismael González¹², Julio Sanchez Martin¹³, Tomas Almorza Hidalgo¹⁴, Judit Lluch¹⁵, Eva Galindez-Agirregoikoa¹⁶, Itziar Calvo-Zorrilla¹⁶, Vicente Aldasoro¹⁷, Javier Mendizabal¹⁸, LYDIA ABASOLO¹⁹, PIA LOIS²⁰, Javier Loricera¹³, Noemi Garrido-Puñal²¹, ALBERTO MARIANO RUIZ ROMAN²², Santos Castañeda²³, Cristina Valero²³, Patricia Moya Albarado²⁴, Hector Corominas²⁵, Maria J. García-Villanueva²⁶, Carmen Larena²⁷, Paula V. Estrada-Alarcón²⁸, Vanessa Navarro²⁹, Carles Galisteo³⁰, Anne Riveros-Frutos³¹, Francisco Miguel Ortiz Sanjuan³², Selene Labrada-Arrabal³³, María Alcalde³⁴, Clara Molina Almela³⁵, Carlos Garcia Porrua³⁶, Maria García-González³⁷, Margarida Rocha³⁸, Antonio Juan Mas³⁹, Miguel A Gonzalez-Gay⁴⁰ and Ricardo Blanco⁴¹, ¹Hospital Universitario de Bellvitge, Barcelona, Spain, ²Unidad de Investigación de la Sociedad Española de Reumatología, Madrid, Spain, ³Hospital do Meixoeiro. Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ⁴CHU Vigo, O Carballino, Spain, ⁵Hospital Universitario La Paz, Madrid, Spain, ⁶University Hospital La Paz, Madrid, Spain, ⁷Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC)., A Coruña, Spain, ⁸Complejo Hospitalario Universitario de la Coruña, Pontevedra, Spain, ⁹University Hospital Donostia, Donostia-San Sebasti, Spain, ¹⁰Hospital Bidasoa, Irún, Spain, ¹¹Rheumatology, Hospital Universitario de León, León, Spain, ¹²Hospital Universitario de León, León, Spain, ¹³Hospital Universitario Marqués de Valdecilla, Santander, Spain, ¹⁴Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁵Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ¹⁶Basurto University Hospital, Bilbao, Spain, ¹⁷Hospital Universitario de Navarra, Pamplona, Spain, ¹⁸Complejo Hospitalario de Navarra, Pamplona, Spain, ¹⁹Hospital Clínico San Carlos, Madrid, Spain, ²⁰Hospital Clinico San Carlos, Madrid, Spain, ²¹Hospital Universitario Virgen del Rocío, Sevilla, Spain, ²²Department of Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ²³Hospital Universitario de la Princesa, Madrid, Spain, ²⁴Hospital Universitario de Sant Pau, Barcelona, Spain, ²⁵Hospital Universitario Sant Pau, Rheumatology, Barcelona, Spain, ²⁶Hospital Ramón y Cajal, Madrid, Spain, ²⁷Hospital Universitario Ramon y Cajal, Madrid, Spain, ²⁸Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, ²⁹Hospital de Sant Joan Despí – Moises Broggi, Barcelona, Spain, ³⁰Hospital Universitario Parc Taulí, Sabadell, Spain, ³¹Hospital Universitario Germans Trias i Pujol, Barcelona, Spain, ³²Hospital Universitario y Politecnico La Fe, Valencia, Spain, ³³Hospital del Mar, Barcelona, Spain, ³⁴Hospital Severo Ochoa, Madrid, Spain, ³⁵Hospital General de Valencia, Valencia, Spain, ³⁶Hospital Universitario Lucus Augusti, Lugo, Spain, ³⁷Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ³⁸Osakidetza, Bilbo, Spain, ³⁹Hospital Universitario Son Llàtzer, Mallorca, Spain, ⁴⁰IDIVAL and School of Medicine, UC, Santander; Department of Rheumatology, IIS-Fundación Jiménez Díaz, Madrid, Santander, Spain, ⁴¹Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
Background/Purpose: The relapse rate of treated patients with giant cell arteritis (GCA) varied widely in observational series and randomized controlled trials. This study aimed to…
Abstract Number: 2390 • ACR Convergence 2023
Characterization of Senescent Cells in Temporal Arteries of Patients with Giant Cell Arteritis Reveal an Inflammatory Phenotype and Strong Dependence from IL-6
Dimitrios Veroutis¹, Ourania D Argryropouou¹, Andreas Goules², Konstantinos Kambas³, Dimitris Anastasios Palamidas¹, Konstantinos Evangelou¹, Sophia Havaki¹, Aikaterini Polyzou¹, Evangelia Xingi³, Elli Karatza⁴, Kyriaki Boki⁵, alberto cavazza⁶, Christos Kittas¹, Dimitris Thanos⁷, caterina Ricordi⁶, chiara marvisi⁶, Francesco Muratore⁸, Elena Galli⁶, Stefania Croci⁶, Carlo Salvarani⁹, Vassilis G Gorgoulis¹ and Athanasios Tzioufas², ¹National and Kapodistrian University of Athens, Athens, Greece, ²Dept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ³Hellenic Pasteur Institute, Athens, Greece, ⁴Laikon General Hospital, Athens, Greece, ⁵Sismanoglion Hospital, Athens, Greece, ⁶Azienda Unità Sanitaria Locale-IRCCS Di Reggio Emilia, Reggio Emilia, Italy, ⁷Biomedical Research Foundation of the Academy of Athens, Athens, Greece, ⁸IRCCS di Reggio Emilia, Reggio Emilia, Italy, ⁹Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy
Background/Purpose: Age is the strongest risk factor of giant cell arteritis (GCA), implying a possible pathogenetic role of cellular senescence. So far, no studies have…
Abstract Number: 2346 • ACR Convergence 2023
SLE Medication Usage and Organ Damage Among Adult SLE Patients with SLE Treated with Belimumab (BEL): Pooled Data from Three Open-Label Extension Studies over 11+ Years
Zahi Touma¹, Cristina Arriens², Christine Henning³, Angela Carroll³, Paula Curtis⁴, Roger A. Levy⁵ and William Stohl⁶, ¹University of Toronto, Toronto, ON, Canada, ²Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, Department of Arthritis & Clinical Immunology, Oklahoma City, OK, ³GlaxoSmithKline, US Medical Affairs, Durham, NC, ⁴GlaxoSmithKline, R&D Biostatistics, Brentford, United Kingdom, ⁵GlaxoSmithKline, Global Medical Affairs, Collegeville, PA, ⁶University of Southern California Keck School of Medicine, Division of Rheumatology, Los Angeles, CA
Background/Purpose: A key treatment goal for patients (pts) with SLE is to reduce use of CS, due to their association with organ damage.1 BEL is…
Abstract Number: 2353 • ACR Convergence 2023
Role of Insulin-like Growth Factor Binding Protein-7 (IGFBP7) in Pulmonary Hypertension Pathogenesis and as a Biomarker Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)
Ye Jin Jeong¹, Soumyaroop Bhattacharya¹, Maria de la Luz Garcia-Hernandez², Javier Rangel-Moreno¹, Qingfu Xu³ and Benjamin Korman¹, ¹University of Rochester, Rochester, NY, ²University of Rochester, West Henrietta, NY, ³CanSino Biologic Inc., Tianjin, China
Background/Purpose: Systemic sclerosis (SSc, scleroderma) is an autoimmune connective tissue disease that causes autoimmunity, vascular dysfunction, and fibrosis of the skin, lungs, and other organs.…
Abstract Number: 2348 • ACR Convergence 2023
Incidence of Infections Among Adult Patients with SLE Treated with Belimumab (BEL): Pooled Data from Three Open-Label Extension Studies over 11+ Years
Jinoos Yazdany¹, Kenji Oku², Luciana Seguro³, Paula Curtis⁴, Yoshifumi Inagaki⁵, Roger A. Levy⁶ and Andrea Doria⁷, ¹University of California, General Department of Medicine, Division of Rheumatology, San Francisco, CA, ²Kitasato University School of Medicine, Department of Rheumatology and Infectious Diseases, Kanagawa, Japan, ³Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Rheumatology Division, Universidade de Sao Paulo, São Paulo, Brazil, ⁴GlaxoSmithKline, R&D Biostatistics, Brentford, United Kingdom, ⁵GlaxoSmithKline, Global Medical Affairs, Brentford, United Kingdom, ⁶GlaxoSmithKline, Global Medical Affairs, Collegeville, PA, ⁷University of Padova, Rheumatology Unit, Department of Medicine, Padova, Italy
Background/Purpose: BEL-treated patients (pts) in clinical trials and long-term extension (LTE) studies1-7 experienced comparable incidence of infections versus those treated with standard therapy (ST) alone…
Abstract Number: 1886 • ACR Convergence 2023
Costotransverse Joint Ankylosis and Association with Syndesmophyte Progression in Patients with Radiographic Axial Spondyloarthritis
Hong Ki Min¹, Se Hee Kim², Hae-Rim Kim³, Sang-Heon Lee¹ and Sang-Hoon Lee², ¹Konkuk University School of Medicine, Seoul, South Korea, ²Kyung Hee University Hospital at Gangdong, Seoul, South Korea, ³Rheumatology, Konkuk University Medical Center, Seoul, South Korea
Background/Purpose: Costotransverse joint ankylosis in radiographic axial spondyloarthritis (r-axSpA) patients was measured. Furthermore, the association between syndesmophyte progression assessed by CT syndesmophyte score (CTSS) and…

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