ACR Meeting Abstracts

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  • Abstract Number: 1924 • ACR Convergence 2022

    Reading the Waves: Identifying Distinct Phenotypes of Multisystem Inflammatory Syndrome in Children During the 2020-2021 COVID-19 Pandemic

    Thomas Renson1, Nils Forkert1, Kimberly Amador1, Paivi Miettunen1, Simon Parsons1, Muhammed Dhalla1, Nicole Johnson2, Nadia Luca2, Heinrike Schmeling1, Rebeka Stevenson1, Marinka Twilt1, Lorraine Hamiwka1 and Susanne Benseler1, 1Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 2University of Calgary, Calgary, AB, Canada

    Background/Purpose: The COVID-19-associated multisystem inflammatory syndrome in children (MIS-C) is characterized by Kawasaki disease (KD)-like mucocutaneous features. The clinical course is often unpredictable. The goals…
  • Abstract Number: 1409 • ACR Convergence 2022

    Impact of a Hybrid Medical Care Model in the Rheumatoid Arthritis Patient-Reported Outcomes: A Non-inferiority Crossover Randomized Study

    Guillermo Guaracha Basañez1, Irazu Contreras-Yáñez2, Vivian Estrada-González2, Lexli Pacheco-Santiago2, Salvador Valverde-Hernández2 and Virginia Pascual Ramos3, 1Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirn", Ciudad de México, Mexico, 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico, 3Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de México, Mexico

    Background/Purpose: Patients and physicians can naturally adopt hybrid healthcare models (HC), that combine face-to-face consultations (FFC) with telemedicine. The study's objective was to compare the…
  • Abstract Number: 1415 • ACR Convergence 2022

    Different Bioactive Lipid Profile Predicts Response to TNF or IL6 Inhibitors in Rheumatoid Arthritis: Result of the CorEvitas CERTAIN Comparative Effectiveness Study

    Mona Alotaibi1, Roxana Coras2, Dimitrios Pappas3, Ted Mikuls4, Joel Kremer5, Geoffrey Thiele6, mohit jain1 and Monica Guma7, 1Department of Medicine, School of Medicine, University of California San Diego, San Diego, CA, 2University of California San Diego, San Diego, CA, 3CorEvitas, LLC, Waltham, MA, 4Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5The Corrona Research Foundation, Delray Beach, FL, 6University of Nebraska Medical Center, Omaha, NE, 7UCSD, La Jolla, CA

    Background/Purpose: Circulating bioactive lipids can provide information about the pathogenesis of specific diseases and potentially help predict therapeutic response. Choosing the right biological therapy earlier…
  • Abstract Number: 1921 • ACR Convergence 2022

    Association Between Knee Osteoarthritis and Health-Related Quality of Life in Persons with Type 2 Diabetes

    Lauren King1, Esther Waugh1, Ian Stanaitis2, Alanna Weisman1, Baiju Shah1, Lorraine Lipscombe1 and Gillian Hawker1, 1University of Toronto, Toronto, ON, Canada, 2Women's College Hospital, Toronto, ON, Canada

    Background/Purpose: Knee osteoarthritis (OA) and type 2 diabetes commonly co-occur due to shared risk factors. Both knee OA and type 2 diabetes negatively impact health-related…
  • Abstract Number: 2000 • ACR Convergence 2022

    Tapering of Long-term, Low Dose Glucocorticoids in Senior Rheumatoid Arthritis Patients: Follow up of the Pragmatic, Multicentre, Placebo-controlled GLORIA Trial

    Abdullah Almayali1, Maarten Boers2, Linda Hartman3, Daniela OPRIS-BELINSKI4, Reinhard Bos5, Marc Kok6, Jose Pereira da Silva7, Eduard N Griep8, Ruth Klaasen9, CF Allaart10, Paul Baudoin11, Hennie Raterman12, Zoltan Szekanecz13, Frank Buttgereit14, Pavol MASARYK15, Willem Lems16, Maurizio Cutolo17 and Marieke ter Wee3, 1Amsterdam University Medical Centers, Vrije Universiteit, Purmerend, Noord-Holland, Netherlands, 2Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, 3Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands, 4Carol Davila University, Bucharest, Romania, 5Medical Centre Leeuwarden, Department of Rheumatology, Leeuwarden, Netherlands, 6Department of Rheumatology and Clinical immunology, Maasstad Hospital, Rotterdam, Netherlands, 7University of Coimbra, Rheumatology, Columbia, Portugal, 8Department of Rheumatology, Antonius Hospital, Leeuwarden, Netherlands, 9Department of Rheumatology, Meander Medical Center, Amersfoort, Netherlands, 10Leiden University Medical Center, Leiden, Netherlands, 11Reumazorg Flevoland, Almere, Netherlands, 12Department of Rheumatology, Northwest Clinics, Alkmaar, Netherlands, 13Division of Rheumatology, Faculty of Medicine, Debrecen, Hungary, 14Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany, 15National Institute for the Rheumatic Diseases, Piešťany, Slovakia, 16Amsterdam University Medical Centers, Amsterdam, Netherlands, 17Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genova, Italy

    Background/Purpose: Guidelines suggest glucocorticoids (GC) should be used as bridge therapy in rheumatoid arthritis (RA), but many patients are on chronic treatment, and the effects…
  • Abstract Number: 2027 • ACR Convergence 2022

    Labial and Parotid Salivary Gland Histopathology in Primary Sjögren’s Syndrome

    Uzma Nakshbandi1, Martha S. van Ginkel1, Silvia Liefers2, Hendrika Bootsma2, Fred Spijkervet2, Arjan Vissink1, Bert van der Vegt1 and Frans Kroese2, 1University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Salivary gland involvement is a hallmark of disease in primary Sjögren's syndrome (pSS). This is reflected by the prominent role of a positive biopsy…
  • Abstract Number: 2024 • ACR Convergence 2022

    Salivary Gland Ultrasound May Lead to a More Accurate Stratification of Patients with the Same Serological Profile in Sjögren’s Syndrome: Towards a Personalized Approach

    Silvia Fonzetti1, Francesco Ferro2, Gaetano La Rocca3, Giovanni Fulvio4, Inmaculada Concepción Navarro García5, Gianmaria Governato6, Valentina Donati7, Marta Mosca8 and Chiara Baldini4, 1Azienda Ospedaliera Universitaria Pisana, Pisa, Italy, 2Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy, 3University of Pisa, Rheumatology Unit, Palermo, Palermo, Italy, 4University of Pisa, Pisa, Pisa, Italy, 5Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, 6Azienda Ospedaliera Universitaria Pisana, Pisa, Pisa, Italy, 7Pathology Unit, University of Pisa, Pisa, Italy, 8Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

    Background/Purpose: Salivary gland ultrasound (SGUS) abnormalities have been increasingly recognized as possible biomarkers for Sjögren's Syndrome (SS) phenotypic stratification. However, to date few studies have…
  • Abstract Number: 2020 • ACR Convergence 2022

    Autophagy-related Risk Loci in Systemic Lupus Erythematous and Sjögren’s Disease

    Anna Nagel1, Bhuwan Khatri1, Marcin Radziszewski1, Mandi Wiley1, Anna Stolarczyk1, Michelle Joachims1, Kandice Tessneer1, Astrid Rasmussen1, Professor Simon Bowman2, Lida Radfar3, Roald Omdal4, Marie Wahren-Herlenius5, Blake Warner6, Torsten Witte7, Roland Jonsson8, Maureen Rischmueller9, Patrick Gaffney1, Judith James1, Lars Ronnblom10, Hal Scofield1, Xavier Mariette11, Marta Alarcon-Riquelme12, Fai Ng13, Gunnel Nordmark10, Qing Sun14, Kwangwoo Kim15, Sang-Cheol Bae16, Betty Tsao14, A. Darise Farris1 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University Hospitals Birmingham, Birmingham, United Kingdom, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Stavanger University, Stavanger, Norway, 5Karolinska Institutet, Stockholm, Sweden, 6National Institutes of Health, Bethesda, MD, 7MH-Hannover, Hannover, Germany, 8University of Bergen, Bergen, Norway, 9RheumatologySA, Adelaide, Australia, 10Uppsala University, Uppsala, Sweden, 11Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 12Center for Genomics and Oncological Research (GENYO), Granada, Spain, 13Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 14Medical University of South Carolina, Charleston, SC, 15Kyung Hee University, Seoul, Republic of Korea, 16Hanyang University Medical Center, Seoul, Republic of Korea

    Background/Purpose: Dysregulated autophagy is implicated in systemic lupus erythematous (SLE) and Sjögren's disease (SjD), including dysregulated expression of Autophagy-related gene 5 (ATG5) and Autophagy Related…
  • Abstract Number: 2026 • ACR Convergence 2022

    Serum and Tear Autoantibodies from nor Mice as Potential Diagnostic Indicators of Local and Systemic Inflammation in Sjögren’s Syndrome

    Shruti Singh Kakan1, Yaping Ju2, Maria Edman2 and Sarah Hamm-Alvarez3, 1Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California; Department of Ophthalmology, Keck School of Medicine, Roski Eye Institute, University of Southern California, Los Angeles, CA, 2Department of Ophthalmology, Keck School of Medicine, Roski Eye Institute, University of Southern California, Los Angeles, CA, 3Department of Ophthalmology, Keck School of Medicine, Roski Eye Institute, University of Southern California; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA

    Background/Purpose: Sjögren's Syndrome (SS) is an autoimmune disease characterized by infiltration of lymphocytes into lacrimal (LG) and salivary (SG) glands and their concurrent loss of…
  • Abstract Number: 2009 • ACR Convergence 2022

    Long-term Outcome of a Treat-to-target Strategy in Elderly-onset Rheumatoid Arthritis with Chronic Lung Diseases

    Manami Nomura1, Takahiko Sugihara2, Hiroyuki Baba1, Tatsuro Ishizaki3, Tadashi Hosoya1, Mari Kamiya1, Takumi Matsumoto2, Kanae Kubo4, Fumio Hirano5, Masayo Kojima6, Nobuyuki Miyasaka5, Shinsuke Yasuda5 and Masayoshi Harigai7, 1Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 3Human Care Research Team, Tokyo Metropolitan Institute of Gerontology., Tokyo, Japan, 4Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 5Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 6Department of Frailty Research, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Nagoya, Japan, 7Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

    Background/Purpose: Elderly patients with rheumatoid arthritis (RA) tend to have a higher risk for drug-related adverse events (AEs) than younger patients, and the effectiveness and…
  • Abstract Number: 1936 • ACR Convergence 2022

    A De Novo Dominant-negative PSMB8 mutation is Linked to a More Severe CANDLE-like Phenotype

    Sara Alehashemi1, Adriana Almeida de Jesus2, Jonas Johannes Papendorf3, Farzana Bhuyan4, Kat Uss5, Anvitha Metpally6, Bin Lin7, Sophia Park8, Thais C.L. Moura9, Renata R Dias9, Mayra B. Dorna9, Katia Kozu9, Adriana Sallum9, Lucia M. A. Campos9, Gijs Santen10, Jesper Kers10, Onno Teng11, Karin Palmblad12, Tom Huizinga10, Frédéric Ebstein13, Elke Krüger13 and Raphaela Goldbach-Mansky14, 1NIH/NIAID/TADS, Clarksville, MD, 2NIAID, NIH, Silver Spring, MD, 3Institut für Medizinische Biochemie und Molekularbiologie, Universitätsmedizin Greifswald, Greifswald, Germany, 4National Institutes of Health, Bethesda, MD, 5National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 6NIAID, NIH, Bethesda, MD, 7NIH, Bethesda, MD, 8NIAID, Bethesda, MD, 9Children's Hospital of the University of São Paulo, São Paulo, Brazil, 10Leiden University Medical Center, Leiden, Netherlands, 11Leiden University Medical Center, Leiderdorp, Netherlands, 12Karolinska University Hospital, Stockholm, Sweden, 13Institut für Medizinische Biochemie und Molekularbiologie (IMBM), Universitätsmedizin Greifswald, Greifswald, Germany, 14NIH/NIAID, Potomac, MD

    Background/Purpose: Homozygote (HM)/compound heterozygote (CH) and digenic (DG) mutations in proteasome subunits cause the autoinflammatory syndrome CANDLE, or proteasome-associated autoinflammatory syndrome (PRAAS). Inflammation is mediated…
  • Abstract Number: 1940 • ACR Convergence 2022

    Genetic Variants and Cytokine Signatures in Patients with Syndrome of Undifferentiated Recurrent Fevers

    Marci Macaraeg, Michael Matt, Grant Schulert, Elizabeth Baker and Elizabeth Handorf, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Unexplained, recurrent fevers are a common presentation to pediatric rheumatology and a cause of significant burden to affected families due to days of daycare…
  • Abstract Number: 1919 • ACR Convergence 2022

    Underdiagnosis and Undertreatment of Knee Osteoarthritis in Persons with Type 2 Diabetes: A Cross-sectional Study

    Lauren King1, Esther Waugh1, Ian Stanaitis2, Alanna Weisman1, Baiju Shah1, Lorraine Lipscombe1 and Gillian Hawker1, 1University of Toronto, Toronto, ON, Canada, 2Women's College Hospital, Toronto, ON, Canada

    Background/Purpose: Knee osteoarthritis (OA) and type 2 diabetes commonly co-occur due to shared risk factors. Concomitant knee OA makes type 2 diabetes management, particularly engaging…
  • Abstract Number: 1931 • ACR Convergence 2022

    NOD2 Mutations Are Associated with Upregulated Type 1 Interferon Gene Expression and Development of Granulomatous Hepatitis in Children with Autoimmune Hepatitis

    Esraa Eloseily1, Alexander Valencia2, Astha Malik2, Rebekah Karns2, Cyd Castro Rojas2, Mosab Alquraish2, Rebecca Marsh3, Alexei Grom4 and Alexander Miethke2, 1Division of Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Division of Gastroenterology, Hepatology & Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Division of Bone Marrow Transplantation & Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Mutations in the gene NOD2 encoding the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) which controls innate responses to LPS have been linked to Blau…
  • Abstract Number: 1407 • ACR Convergence 2022

    Longitudinal Lipid Profile and NT-proBNP Changes from Pre-clinical to Established Rheumatoid Arthritis: A 12 Years Follow up Explorative Study

    Reinder Raadsen1, Laurette van Boheemen1 and Michael Nurmohamed2, 1Reade Rheumatology Center, Amsterdam, Netherlands, 2Amsterdam University Medical Center, Kortenhoef, Netherlands

    Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased risk for developing cardiovascular diseases (CVD). This is partly due to the systemic inflammation characteristic to…
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