ACR Meeting Abstracts

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  • Abstract Number: 2019 • ACR Convergence 2023

    2023 EULAR Recommendations for the Management of Fatigue in People with Inflammatory Rheumatic and Musculoskeletal Diseases

    Emma Dures1, Bayram Farisogullari2, Eduardo Santos3, Anna Molto4, Caroline Feldthusen5, Claire Harris6, Corinna Elling-Audersch7, Deirdre Conolly8, Elena Elefante9, Fernando Estévez-López10, Ilaria Bini11, Jette Primdahl12, Kirsten Hoeper13, Marie Urban14, Mart van de Laar15, Marta Redondo16, Peter Böhm17, Raj Amarnani18, Rhys Hayward6, Rinie Geenen19, Simona Rednic20, Susanne Pettersson21, Tanja Thomsen22, Till Uhlig23, Valentin Ritschl24 and Pedro Machado25, 1Academic Rheumatology, Bristol Royal Infirmary; and Faculty of Health and Applied Sciences, University of the West of England, Bristol, United Kingdom, 2Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 3Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra (ESEnfC), Coimbra, Portugal, 4HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, 5Institute of Neuroscience and Physiology, University of Gothenburg, Department of Health and Rehabilitation, Unit of Physiotherapy, Sahlgrenska Academy, Gothenburg, Sweden, 6Northwick Park Hospital, London North West University Healthcare NHS Trust, Department of Rheumatology, London, United Kingdom, 7Deutsche Rheuma-Liga Bundesverband e.V., Patient Research Partner, Bonn, Germany, 8School of Medicine, Trinity College Dublin, Discipline of Occupational Therapy, Dublin, Ireland, 9Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, Pisa, Italy, 10Harvard T.H. Chan School of Public Health, Department of Social and Behavioral Sciences, Boston, MA, 11Anmar, Young, Rome, Italy, Rome, Italy, 12University Hospital of Southern Denmark, Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark, 13Hannover Medical School, Department of Rheumatology and Immunology, Hannover, Germany, 14University Hospitals Bristol, Research Design Service, Bristol, United Kingdom, 15University of Twente, Department of Psychology, Health and Technology, Enschede, Netherlands, 16Camilo José Cela University, Faculty of Heath Sciences, Madrid, Spain, 17German League against rheumatism, Forschungspartner, Bonn, Germany, 18Barts Health NHS Trust, Barts Health Rheumatology Service, London, United Kingdom, 19Utrecht University, Vorstenbosch, Netherlands, 20Prof Dr Simona Rednic, Cluj, Romania, 21Karolinska Institute, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, 22University of Copenhagen, Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases VRR, Rigshospitalet, Copenhagen, Denmark, 23Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, 24Medical University of Vienna, Vienna, Austria, 25Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, UK. Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS trust, London, UK., London, United Kingdom

    Background/Purpose: Fatigue is prevalent in people with inflammatory rheumatic and musculoskeletal diseases (I-RMDs) and recognized as one of the most challenging symptoms to manage (1).…
  • Abstract Number: 1990 • ACR Convergence 2023

    Effects of Exercise on Movement-Evoked Pain in People with Knee Osteoarthritis

    Ehyun Kim1, Tuhina Neogi2, Benjamin Senderling1, Mary Gheller1, Lee Marinko1, Michael LaValley3, Lukas Adamowicz4, Pirinka Georgiev4, Charmaine Demanuele4, Paul Wacnik4 and Deepak Kumar1, 1Boston University, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3Boston University School of Public Health, Arlington, MA, 4Pfizer Inc., Cambridge, MA

    Background/Purpose: Movement-evoked pain (MEP), i.e., pain that appears with or is made worse by movement, is a common complaint in people with knee osteoarthritis (OA).…
  • Abstract Number: 1987 • ACR Convergence 2023

    Clinical and Imaging Characteristics of Individuals Who Underwent Knee Replacement During Years 3 to 5 in the FORWARD Study: A Post Hoc Analysis

    Philip Conaghan1, Felix Eckstein2, Wolfgang Wirth3, Marc Hochberg4, Ali Guermazi5, Luping Zhao6 and Niti Goel7, 1University of Leeds, Leeds, United Kingdom, 2Paracelsus Medical University, Institute of Anatomy & Ludwig Boltzmann Institute, and Chondrometrics GmbH, Salzburg, Austria, 3Paracelsus Medical University, Institute of Anatomy & Ludwig Boltzmann Institute, and Chondrometrics GmbH, Freilassing, Germany, 4University of Maryland School of Medicine, Baltimore, MD, 5Boston University, Boston, MA, 6TrialSpark, New York, NY, 7TrialSpark, Duke University, Durham, NC

    Background/Purpose: Sprifermin is an investigational intra-articular (IA) recombinant human truncated fibroblast growth factor-18 (rhFGF-18) therapy evaluated to date in three knee osteoarthritis (KOA) trials (NCT00911469…
  • Abstract Number: 1980 • ACR Convergence 2023

    Movement Evoked Pain as an Outcome Measure in Patients with Knee Osteoarthritis

    Leila Bagherzadeh1, Schnitzer Thomas2, Santiago Espinosa-Salas1 and Joana Barroso3, 1Northwestern Physical Medicine and Rehabilitation Department, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Anesthesiology; Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Pain, being one of the most crucial symptoms associated with knee OA, serves as a significant outcome measure for the increasing number of studies…
  • Abstract Number: 1996 • ACR Convergence 2023

    Variation in Dual-energy X-ray Absorptiometry Reporting: A National Survey of Veterans Health Administration Clinics

    Karla Miller1, Melissa Steffen2, Kimberly McCoy2, Michelle Mengeling2, Heather Davila2, Shylo Wardyn2 and Samantha Solimeo2, 1University of Utah School of Medicine, Salt Lake City, UT, 2Department of Veterans Affairs, Iowa City VA HCS, Iowa City, IA

    Background/Purpose: Dual-energy x-ray absorptiometry (DXA) is an important tool to identify Veterans with osteoporosis, assess fracture risk, and monitor treatment response. Variability in DXA acquisition,…
  • Abstract Number: 1978 • ACR Convergence 2023

    Infrapatellar Fat Pad Size and Subcutaneous Fat in Knee Osteoarthritis Radiographic Progression: Data from the Osteoarthritis Initiative

    Kwanghoon Lee1, Marina Banuls-Mirete2, Alecio Lombardi3, Alexander Posis3, Eric Chang3, Nancy Lane4 and Monica Guma5, 1Dongguk University ilsan Hospital, San Diego, CA, 2Department of Medicine, University of California San Diego, San Diego, CA, 3University of California San Diego, San Diego, CA, 4University of California, Hillsborough, CA, 5University of California San Diego, La Jolla, CA

    Background/Purpose: Adipose tissue is associated with knee osteoarthritis (KOA) progression. This study aimed to determine the association of infrapatellar fat pad (IPFP) size and subcutaneous…
  • Abstract Number: 1186 • ACR Convergence 2023

    Presence of Erosions Is Not a Risk Factor for the Development of Knee OA in a Hand OA Population: The Framingham OA Study

    Tine Vanhaverbeke1, Gabriela Rabasa2, Ruth Wittoek1, Ida Kristin Haugen3 and David Felson2, 1Dept. of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium, 2Boston University, Boston, MA, 3Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Osteoarthritis (OA) is a prevalent musculoskeletal disease and can affect multiple joint sites in one patient. Studies have shown an association between hand and…
  • Abstract Number: 1724 • ACR Convergence 2023

    Human Embryonic Stem Cell-derived Mesenchymal Stem Cells Attenuates Experimental Pulmonary Fibrosis Through Mitochondria Transfer Mediated Anti-apoptotic and Immunomodulatory Effects

    Hanna Lee1, Suhee Kim2, Mingyo Kim2, Ok-Yi Jeong3 and Sang-Il Lee2, 1Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, South Korea, 2Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine and Hospital, JinJu, South Korea, 3Division of Rheumatology, Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea

    Background/Purpose: Interstitial lung disease (ILD) is a serious condition characterized by inflammation and fibrosis in the lung interstitium. The important subtypes of ILD include idiopathic…
  • Abstract Number: 1211 • ACR Convergence 2023

    Description of Self-Efficacy for Managing Symptoms and Emotions in a Large Rheumatology Clinic Population

    Rachel Dayno1, Michael George1, Kimberly DeQuattro2, Marissa Blum3, Sharon Kolasinski4 and Dana DiRenzo5, 1University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Media, PA, 3University of Pennsylvania, Cherry Hill, NJ, 4University of Pennsylvania, Philadephia, PA, 5University of Pennsylvania, Bala Cynwyd, PA

    Background/Purpose: Self-efficacy (SE) is the inner belief in one's ability to succeed in specific situations and tasks. SE for managing the symptoms and emotions associated…
  • Abstract Number: 1989 • ACR Convergence 2023

    Shared Variation Among Cartilage Thickness Change Maps and Baseline Clinical Features at the Initiation of Structural Knee Osteoarthritis

    Thomas Keefe1, Marc Niethammer1, Boqi Chen1, Zhengyang Shen1, Daniel Nissman1, Mary Catherine Minnig2, Yvonne Golightly3, J.S. Marron1 and Amanda Nelson1, 1University of North Carolina at Chapel Hill, Chapel Hill, NC, 2University of North Carolina at Chapel Hill, Durham, NC, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: To identify features of cartilage thickness change and baseline clinical indicators associated with the transition from normal to mildly reduced joint space as an…
  • Abstract Number: 1200 • ACR Convergence 2023

    Self-Reported Effectiveness of Cannabis for Arthritis-Related Pain

    Kristin Wipfler1, Joanna Zeiger2 and Kaleb Michaud3, 1FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, 2Canna Research Foundation, Boulder, CO, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Pain management remains a significant challenge for individuals with rheumatic diseases (RDs), often causing patients to seek complementary or alternative treatments to traditional medications.…
  • Abstract Number: 1221 • ACR Convergence 2023

    Familial Clustering of Dysbiotic Oral and Fecal Microbiomes in Juvenile Dermatomyositis (JDM)

    Albert Chow1, Sean Koester2, Evan Pepper-Tunick3, Peggy Lee4, Mary Eckert5, Laurie Brenchley6, Pamela Gardner6, Naisi Li2, adam Schiffenbauer7, Rita Volochayev7, Nastaran Bayat8, Jeffrey McLean9, Lisa Rider10, Susan Shenoi11, Anne Stevens12 and Neelendu Dey13, 1Loma Linda University, Loma Linda, CA, 2Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, 3Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA, 4Department of Oral Medicine, School of Dentistry, University of Washington, Seattle, WA, 5Center for Clinical and Translational Research, Seattle Children’s Research Institute, Seattle, WA, 6Office of the Clinical Director, NIDCR, National Institutes of Health, Bethesda, MD, 7Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, 8Social Scientific Systems, DLH Holdings Corp, Silver Spring, MD, 9Department of Periodontics, University of Washington, Seattle, WA, 10NIEHS, NIH, Bethesda, MD, 11Seattle Childrens Hospital, Mercer Island, WA, 12Janssen, Hansville, WA, 13Department of Medicine, Division of Gastroenterology, University of Washington, Seattle, WA

    Background/Purpose: JDM is a rare immune-mediated disease of childhood that is thought to result from genetic predisposition and environmental drivers, with documented links to microbial…
  • Abstract Number: 1733 • ACR Convergence 2023

    Platelet-Derived Growth Factor Is a Mediator of Disease in an Animal Model of Rheumatoid-Associated Interstitial Lung Disease

    Nozima Aripova1, Michael Duryee1, Amy Nelson1, Carlos Hunter1, Breanna Butler1, Bryant England1, Jill Poole1, Geoffrey Thiele1 and Ted R Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a leading cause of mortality in RA with limited treatment options as well as lack of available…
  • Abstract Number: 1991 • ACR Convergence 2023

    Therapeutic Efficacy of Intra Articular Injection of Human Bone Marrow Derived Mesenchymal Stem Cells in Knee Osteoarthritis; Randomized, Double-blind, Placebo-controlled Clinical Trial

    Ji Won Yang, Bong-Woo Lee, Jennifer Lee and Ji Hyeon Ju, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Background/Purpose: Osteoarthritis (OA) is severe and intractable musculoskeletal disease that eventually leads to joint failure and pain due to inflammation and joint injury. Mesenchymal stem…
  • Abstract Number: 1744 • ACR Convergence 2023

    Histological and Molecular Comparison in the Synovial Tissue of Patients with Active Rheumatoid Arthritis to Remission

    Selina Ohl1, Klaus Frommer1, Markus Rickert2, Stefan Rehart3, Ulf Müller-Ladner1 and Elena Neumann1, 1Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 2Dept. of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, 3Dept. of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital Frankfurt, Frankfurt, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which leads to local and systemic manifestations. Subsequently, the inflamed synovium drives the destruction of…
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