Abstracts Archive - Page 2575 of 2607 - ACR Meeting Abstracts

Abstract Number: 413 • 2012 ACR/ARHP Annual Meeting
α(1,2)-Linked Fucosylated Cytokines Are Upregulated in Rheumatoid Arthritis
Takeo Isozaki¹, Jeffrey H. Ruth², M. Asif Amin¹, Phillip L. Campbell¹, Christine M. Ha² and Alisa E. Koch³, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Glycosylation is a common post-translational modification of proteins in eukaryotes. Fucosylated glycans are synthesized by fucosyltransferases (futs). We previously reported that sialyl Lewisx, synthesized…
Abstract Number: 414 • 2012 ACR/ARHP Annual Meeting
First-Degree Relatives without Rheumatoid Arthritis Exhibit Reactivity to Multiple Anti-Citrullinated Protein Antibodies in Association with Rheumatoid Arthritis-Related Clinical Characteristics: Studies of the Etiology of Rheumatoid Arthritis
Kendra A. Young¹, Kevin D. Deane², Lezlie A. Derber³, Jan M. Hughes-Austin⁴, Michael H. Weisman⁵, Jane H. Buckner⁶, Ted R. Mikuls⁷, James R. O'Dell⁸, Richard M. Keating⁹, Peter K. Gregersen¹⁰, V. Michael Holers¹¹ and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, ⁴Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁶Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁷Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁸Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ⁹Rheumatology Section, The University of Chicago, Chicago, IL, ¹⁰Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ¹¹Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Prior to diagnosis of rheumatoid arthritis (RA), there are increases in the number of citrullinated proteins that anti-citrullinated protein antibodies (ACPA) target, suggesting an…
Abstract Number: 415 • 2012 ACR/ARHP Annual Meeting
Hypoxia-Induced Endogenous Prostaglandin E2 Negatively Regulates Hypoxia-Enhanced Aberrant Overgrowth of Rheumatoid Synovial Tissue
Hirofumi Mitomi¹, Hidehiro Yamada¹, Toshiko Nozaki Shibata¹, Hiroshi Ito¹, Yoshioki Yamasaki², So Nomoto³, Atsushi Kusaba⁴, Hiroki Yamashita⁴ and Shoichi Ozaki¹, ¹Internal Medicine, St. Marianna University, Kawasaki, Japan, ²Medicine, St. Marianna University, Kawasaki, Japan, ³Department of Orthopedic Surgery and Rheumatology, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan, ⁴Institute of Rheumatology, Ebina General Hospital, Ebina, Japan
Background/Purpose: During isometric exercise, the synovial joint tissue is prone to hypoxia, which is further enhanced in the presence of synovial inflammation. Hypoxia is also…
Abstract Number: 416 • 2012 ACR/ARHP Annual Meeting
Dyslipidaemia in Early Rheumatoid Arthritis Patients Is Common and Not Influenced by Two Years of Effective DMARD Therapy. the Opera Study
Torkell Ellingsen¹, Kim Horslev-Petersen², Merete L. Hetland³, Peter Junker⁴, Jan Podenphant⁵, Mikkel Ostergaard⁶ and Kristian Stengaard-Pedersen⁷, ¹Diagnostic Center, Regional Hospital, Silkeborg, Denmark, ²Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Graasten, Denmark, ³Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁴Dept of Internal Med C/Rheum, Odense University Hospital, Denmark, ⁵Department of Rheumatology, Copenhagen University Hospital at Gentofte, Glostrup, Denmark, ⁶Dept of Rheumatology RM, Copenhagen University Hospital at Glostrup, Denmark, ⁷Rheumatology, Arhus University Hospital, Denmark
Background/Purpose: In a cohort of early ( 3.2 during year 2, sulphasalazine (SZS) and hydroxychloroquine (HCQ) were added to MTX and if active disease persisted…
Abstract Number: 417 • 2012 ACR/ARHP Annual Meeting
The Potential Role of PTPRD Gene Copy Number Variation in Susceptibility to Rheumatoid Arthritis
Seung Cheol Shim¹, Donghyuk Sheen², Mi Kyoung Lim¹ and Hyo Park¹, ¹Medicine, Eulji University Hospital, Daejeon, South Korea, ²Rheumatology, Eulji University Hospital, Daejeon, South Korea
Background/Purpose: Since it is important to explore genetic variations associated with rheumatoid arthritis (RA), genome-wide association studies (GWAS) have led to the identification of RA…
Abstract Number: 418 • 2012 ACR/ARHP Annual Meeting
Immediate Early Response Gene X-1 Is Over-Expressed and Regulates Apoptosis and Cytokine Production in Rheumatoid Arthritis Synovial Fibroblasts
Akio Morinobu¹, Masaaki Fujita², Shino Tanaka³, Jun Saegusa⁴ and Shunichi Kumagai⁵, ¹Department of clinical pathology and immunology, Kobe university graduate school of medicine, Kobe 650-0017, Japan, ²Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Clinical Pathology and Immunology, Rheumatology and Clinical Immunology, Kobe, Japan, ⁴Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Center of rheumatic diseases, Shinko hospital, Kobe, Japan
Background/Purpose: Histone deacetylase inhibitors (HDACi) are potential therapeutic drugs for the treatment of rheumatoid arthritis (RA). We found that an HDACi up-regulates the gene expression…
Abstract Number: 419 • 2012 ACR/ARHP Annual Meeting
Epigenome Analysis of Rheumatoid Arthritis Synovial Fibroblasts Revealed TBX-5 As a Novel Transcription Factor in Chemokine Regulation
Emmanuel Karouzakis¹, Michelle Trenkmann², Renate E. Gay¹, Beat A. Michel¹, Steffen Gay¹ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland
Background/Purpose: Changes in DNA methylation and histone marks have been associated with diseases such as cancer, rheumatoid arthritis (RA) and systemic lupus erythematosus. Previously, we…
Abstract Number: 420 • 2012 ACR/ARHP Annual Meeting
Loss-of-Co-Homozygosity Mapping and Exome Sequencing of a Syrian Pedigree Identified the Candidate Causal Mutation Associated with Rheumatoid Arthritis
Yukinori Okada¹, Namrata Gupta², Daniel Mirel², Stacey Gabriel², Thurayya Arayssi³, Faten Mouassess⁴, Walid AL Achkar⁴, Layla Kazkaz⁵ and Robert M. Plenge⁶, ¹Division of Rheumatology, Immunology, and Allergy, 1.Brigham and Women's Hospital, Harvard Medical School, 2.Program in Medical and Population Genetics, Broad Institute, Boston, MA, ²The Broad Institute, Cambridge, MA, ³Internal Medicine, Weill Cornell Medical College-Qatar, Doha, Qatar, ⁴Human Genetics, Molecular Biology and Biotechnology, Damascus, Syria, ⁵Tishreen Hospital and the Syrian Association for Rheumatology, Damascus, Syria, Damascus, Syria, ⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Although there are >50 rheumatoid arthritis (RA) risk loci that contain common variants, there are no known genomic loci that harbor rare mutations…
Abstract Number: 421 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Factor, Not Antibodies to Citrullinated Proteins, Are Associated with High Disease Activity
Josef S. Smolen¹, Farideh Alasti² and Daniel Aletaha³, ¹Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Autoantibodies in general, and rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA) in particular, are a hallmark of RA. After their characterization, ACPA have…
Abstract Number: 422 • 2012 ACR/ARHP Annual Meeting
Antibodies to Citrulline From Rheumatoid Arthritis Patients Also Bind Homocitrulline
Mathias Scinocca¹, Radha Joseph², David A. Bell³, Ewa Cairns³ and Lillian J. Barra³, ¹Microbiology and Immunology, Schulich School of Medicine and Dentistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: Antibodies to citrullinated proteins/peptides (ACPA) are specific for Rheumatoid Arthritis (RA). One of ACPA’s targets is citrullinated fibrinogen (citfib) and it is found in…
Abstract Number: 423 • 2012 ACR/ARHP Annual Meeting
Sputa Autoantibodies in Patients with Established Rheumatoid Arthritis and Subjects At-Risk for Future Clinically Apparent Disease
Van C. Willis¹, M. Kristen Demoruelle², Lezlie A. Derber², Catherine J. Chartier-Logan¹, Mark Parish¹, Isabel Pedraza³, Michael H. Weisman⁴, Jill M. Norris⁵, V. Michael Holers⁶ and Kevin D. Deane², ¹Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Division of Pulmonary and Critical Care Medicine, Cedars Sinai Med Ctr, Los Angeles, CA, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Epidemiology, Colorado School of Public Health, Aurora, CO, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Elevations of rheumatoid arthritis (RA)-related autoantibodies (Abs) prior to the symptomatic onset of inflammatory arthritis (IA) suggest that autoimmunity in RA is initiated outside…
Abstract Number: 424 • 2012 ACR/ARHP Annual Meeting
Influence of Pregnancy On Disease Activity-Associated Genes in Rheumatoid Arthritis
Erik J. Peterson¹, Shreyasee Amin², Hatice Bilgic³, Emily Baechler Gillespie³, Jane E. Salmon⁴, Ann M. Reed⁵, Weihua Guan⁶ and Daniel L. Mueller¹, ¹Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³University of Minnesota Medical School, Minneapolis, MN, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, Mayo Clinic, Rochester, MN, ⁶University of Minnesota School of Public Health, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) disease activity can often quiesce during pregnancy. Nevertheless, most women will experience a disease flare postpartum (PP). We hypothesized that changes…
Abstract Number: 425 • 2012 ACR/ARHP Annual Meeting
Slug Is Induced by Benzo(a)Pyrene and EGF Through PI3K/Akt/mTOR Pathway and Is Closely Involved in the Regulation of the Invasive Properties of FLS in Rheumatoid Arthritis
Jaejoon Lee¹, Jiwon Hwang¹, Chan Hong Jeon², Joong Kyong Ahn³, Hoon-Suk Cha¹ and Eun-Mi Koh⁴, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, ³Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Seoul, South Korea
Background/Purpose: Slug, a Snail family of zinc finger transcription factor, plays a critical role in tumor proliferation, invasion and metastasis. We have previously shown that…
Abstract Number: 426 • 2012 ACR/ARHP Annual Meeting
Dickkopf-1 Stimulates Fibroblast-Like Synoviocyte Migration Through Janus Kinase Activation
Yubin Luo¹, Bryan Dieffenbach², Jung-Soo Song³, Jinseok Kim⁴, David L. Boyle⁵, Michael Karin⁶, Gary S. Firestein⁷ and Maripat Corr⁸, ¹Medicine, UCSD School of Medicine, La Jolla, CA, ²Medicine, UCSD School of Medicine, la Jolla, CA, ³Rheumatology, Chung-Ang University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Internal Medicine, Jeju National University Hospital, Jeju, Korea, South Korea, ⁵Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁶Departments of Pharmacology, UCSD School of Medicine, La Jolla, CA, ⁷Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁸Medicine, Univ of California-San Diego, La Jolla, CA
Background/Purpose: Wnt (wingless) pathway signaling has been implicated in patterning in embryogenesis and in adult wound healing and homeostasis. A canonical Wnt antagonist, Dickkopf-1 (DKK-1),…
Abstract Number: 427 • 2012 ACR/ARHP Annual Meeting
Epigenetic Features As Predictive Markers of Responsiveness to Epitope-Specific Therapy in Rheumatoid Arthritis
Roberto Spreafico¹, Maura Rossetti¹, Theodorus Van Der Broek¹, Olivia Morrow¹ and Salvatore Albani², ¹Translational Immunology, Sanford-Burnham Medical Research Institute, La Jolla, CA, ²Translational Research Program, Infectious and Inflammatory Diseases, Sanford-Burnham Medical Research Institute, La Jolla, CA
Background/Purpose: The focus of current research for new therapeutic approaches in Rheumatoid arthritis (RA) is shifting from mere suppression to induction and maintenance of tolerance.…

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