Abstracts Archive - Page 2573 of 2607 - ACR Meeting Abstracts

Abstract Number: 463 • 2012 ACR/ARHP Annual Meeting
Drug Survival, Efficacy and Predictors for Survival On Tocilizumab in Real-Life Patients with Rheumatoid Arthritis; Results From the Swedish Biologics Register
Helena Forsblad-d'Elia¹, Karin Bengtsson¹, Lars-Erik Kristensen² and Lennart TH Jacobsson¹, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ²Dept of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Faculty of Medicine, Malmö, Sweden
Background/Purpose: To evaluate drug survival, clinical response and predictors for drug survival for tocilizumab in patients with rheumatoid arthritis (RA) with inadequate response and/or adverse…
Abstract Number: 464 • 2012 ACR/ARHP Annual Meeting
Rituximab for Treatment of Rheumatoid Arthritis: Treatment Effectiveness in the Corrona Database
Leslie R. Harrold¹, George W. Reed¹, Robert P. Magner¹, Katherine C. Saunders², Jeffrey D. Greenberg³, Joel M. Kremer⁴, Ani John⁵, William Reiss⁵, Steve Zlotnick⁶ and Ashwini Shewade⁵, ¹University of Massachusetts Medical School, Worcester, MA, ²Corrona, LLC., Southborough, MA, ³New York Hospital for Joint Disease, New York, NY, ⁴Center for Rheumatology, Albany Medical College, Albany, NY, ⁵Genentech Inc., South San Francisco, CA, ⁶Genentech, Inc., a Member of the Roche Group, South San Francisco, CA
Background/Purpose: Rituximab (RTX) in combination with methotrexate is used for the treatment of adult RA with an inadequate response to TNF antagonists. We aimed to…
Abstract Number: 465 • 2012 ACR/ARHP Annual Meeting
The Comparative Effectiveness of Oral Methotrexate Versus Subcutaneous Methotrexate for the Treatment of Early Rheumatoid Arthritis
Glen S. Hazlewood¹, J. Carter Thorne², Janet E. Pope³, Gilles Boire⁴, Boulos Haraoui⁵, Carol A. Hitchon⁶, Edward Keystone⁷, Diane Tin⁸, CATCH Investigators⁹ and Vivian P. Bykerk¹⁰, ¹Medicine, University of Toronto, Toronto, ON, Canada, ²Southlake Regional Health Centre, Newmarket, ON, Canada, ³Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ⁴Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷University of Toronto, Toronto, ON, Canada, ⁸The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹Toronto, ON, Canada, ¹⁰Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: To determine the comparative effectiveness of subcutaneous (sc) versus oral methotrexate (MTX) as initial therapy for patients with early rheumatoid arthritis (ERA) in routine…
Abstract Number: 466 • 2012 ACR/ARHP Annual Meeting
Synovialitis Plus Articular Cartilage Monitoring Via Magnetic Resonance Imaging and Ultrasound Under Tocilizumab Therapy in Patients with Rheumatoid Arthritis
Maria Hoehle¹ and Michael Finkenstaedt², ¹Rheumatology, Hamburg, Germany, ²Private Practice for Radiology and Neuroradiology, Hamburg, Germany
Background/Purpose: To determine remission in RA, recent publications point out the importance of radiological parameters, besides scores like DAS28, TJC, SJC, CrP, patient global assessment,…
Abstract Number: 467 • 2012 ACR/ARHP Annual Meeting
Seropositive Rheumatoid Arthritis Patients with an Inadequate Response to Tumor Necrosis Factor Inhibitors Achieve Improved Clinical Effectiveness After Switching to Rituximab Versus Switching to an Alternative Tumor Necrosis Factor Inhibitor
Andrea Rubbert-Roth¹, Axel Finckh², Piercarlo Sarzi-Puttini³, Jacques-Eric Gottenberg⁴, Denis Choquette⁵, Victor Martínez Taboada⁶, Leonor Barile-Fabris⁷, Carol Chung⁸, Lykke Hinsch-Gylvin⁹ and Paul Emery¹⁰, ¹Internal Medicine I, University of Cologne, Cologne, Germany, ²Department of Medical Specialities, University of Geneva, Geneva, Switzerland, ³Rheumatology Unit, L Sacco University Hospital, Milan, Italy, ⁴Strasbourg University Hospital, Strasbourg, France, ⁵Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁶Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁷Instituto Mexicano del Seguro Social, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Mexico City, Mexico, ⁸Genentech Inc., South San Francisco, CA, ⁹F Hoffmann-La Roche Ltd, Basel, Switzerland, ¹⁰Division of Rheumatic & Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom
Background/Purpose: RA patients (pts) with an inadequate response (IR) to a tumor necrosis factor inhibitor (TNFi) may achieve greater benefit by switching to rituximab (RTX)…
Abstract Number: 468 • 2012 ACR/ARHP Annual Meeting
Adalimumab Treatment Is Associated with Decreased Concomitant Rheumatoid Arthritis Medication Use Over 24 Months
Daniel Furst¹, Neelufar Mozaffarian², Shannon Grant³, Mary Cifaldi², Jerry Clewell², Joel M. Kremer⁴ and James Shaw⁵, ¹Div of Rheumatology, UCLA Medical School, Los Angeles, CA, ²Abbott Laboratories, Abbott Park, IL, ³Axio Research LLC, Seattle, WA, ⁴Albany Medical College and The Center for Rheumatology, Albany, NY, ⁵Global Health Economics and Outcomes Research, Abbott Laboratories, Abbott Park, IL
Background/Purpose: Adalimumab (ADA) is an effective medication in the treatment of rheumatoid arthritis (RA). However, it is not clear whether the use of ADA is associated…
Abstract Number: 469 • 2012 ACR/ARHP Annual Meeting
Intra Articular Injections in Patients with Rheumatoid Arthritis: Analyses From the Behandelstrategiën Study
E. Gvozdenovic¹, L. Dirven¹, M. van den Broek², Kh Han³, T.H.E. Molenaar⁴, R. Landewe⁵, W.F. Lems⁶ and C.F. Allaart¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Maasstad hospital, Rotterdam, Netherlands, ⁴Dept of Rheumatology, Groene Hart Hospital, Gouda, Netherlands, ⁵Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology, VU University medical center, Amsterdam, Netherlands
Background/Purpose: Intra articular (IA) corticosteroid injections aim at amelioration of symptoms of local inflammation in rheumatoid arthritis (RA). Some patients also report a systemic effect.…
Abstract Number: 430 • 2012 ACR/ARHP Annual Meeting
Comprehensive Microrna Analysis Identifies Mir-24, Mir-26a, and Mir-125a-5p As Plasma Biomarkers for Rheumatoid Arthritis
Koichi Murata¹, Moritoshi Furu², Hiroyuki Yoshitomi³, Masahiro Ishikawa¹, Hideyuki Shibuya¹, Hiromu Ito² and Shuichi Matsuda¹, ¹Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ³Department of Innovation Center for Immunoregulation Technologies and Drugs, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose: MicroRNAs (miRNAs) are present in human plasma in a stable form despite the endogenous RNase activity. Plasma miRNAs are non-invasive biomarker for cancer detection…
Abstract Number: 431 • 2012 ACR/ARHP Annual Meeting
Basic and Clinical Significance of Interleukin 6 (IL-6) in AA Amyloidosis with RA
Kazuyuki Yoshizaki, Prabha Tiwari, Lokesh P. Tripathi, Shandar Ahmad, Kenji Mizuguchi, Teppei Nishikawa-Matsumura, Tomoyasu Isobe and Soken-Nakazawa J. Song, Osaka University, Osaka, Japan
Background/Purpose: Cytokine-induced hepatic serum amyloid A (SAA) is associated with the pathogenesis of AA amylodosis, a fatal disease with deposition of AA amyloid fibril on…
Abstract Number: 432 • 2012 ACR/ARHP Annual Meeting
Identification and Characterization of Fibrinogen-Specific T Cells in Patients with Rheumatoid Arthritis
Laura Su¹ and Mark M. Davis², ¹The Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Department of Microbiology and Immunlogy and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is a common, highly debilitating systemic inflammatory condition. To date, little is known about which autoantigens are involved in RA and…
Abstract Number: 433 • 2012 ACR/ARHP Annual Meeting
Genome Wide Association Analysis of Pain Reduction in Rheumatoid Arthritis Patients Treated with Anti-TNF Medication. Results of the DREAM and Danbio Registries
Marieke J.H. Coenen¹, Masha Umicevic-Mirkov², Hans Scheffer², Sophine B. Krintel³, Sita H. Vermeulen⁴, Julia S. Johansen³, Wietske Kievit⁵, Mart A.F.J. van de Laar⁶, Piet L.C.M. van Riel⁵, Barbara Franke² and Merete L. Hetland⁷, ¹Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Human Genetics (855), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³DANBIO and Department of Rheumatology, Copenhagen University Hospital at Glostrup, Glostrup, Denmark, ⁴Human Genetics and Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Department of Rheumatology and DREAM registry, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Department of Rheumatology and DREAM registry, Medisch Spectrum Twente & Twente University, Enschede, Netherlands, ⁷Copenhagen University Hospital Glostrup, Copenhagen, Denmark
Background/Purpose: Patients with rheumatoid arthritis (RA) rate pain relief as the highest priority in treatment outcome, and tumor necrosis factor inhibitors (anti-TNF) have proven very…
Abstract Number: 434 • 2012 ACR/ARHP Annual Meeting
IL-22 Mediated Pannus Formation in Autoimmune Arthritis Is PI3K/Akt/mTOR Dependent
Siba P. Raychaudhuri¹, Anupam Mitra¹, Ananya Datta Mitra², Christine Abria² and Smriti K. Raychaudhuri², ¹Rheumatology, VA Sacramento Medical CenterUC Davis School of Medicine, Mather, CA, ²Rheumatology, VA Sacramento Medical Center, Mather, CA
Background/Purpose: IL-22, a Th17 cytokine plays a key role in the formation of “pannus” in autoimmune arthritis such as rheumatoid arthritis (RA) and psoriatic arthritis…
Abstract Number: 435 • 2012 ACR/ARHP Annual Meeting
CIP2A Facilitates Apoptotic Resistance of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis Independent of c-Myc Expression
Jaejoon Lee¹, Jiwon Hwang¹, Jinseok Kim², Joong Kyong Ahn³, Hoon-Suk Cha¹ and Eun-Mi Koh⁴, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Internal Medicine, Jeju National University Hospital, Jeju, South Korea, ³Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Seoul, South Korea
Background/Purpose: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein that leads to cellular proliferation in cancer cells by stabilizing c-Myc protein.…
Abstract Number: 436 • 2012 ACR/ARHP Annual Meeting
Synthetic Anti-CCP Antibody Aggravated Severity of Animal Arthritis and Captured Citrullinated Antigen in the Serum of Patients with Rheumatoid Arthritis
Youngkyun Kim¹, Su-Jin Moon², Hyoju Yi² and Ji Hyeon Ju³, ¹1Convergent Research Consortium for Immunologic Disease, The Catholic University of Korea, Seoul, South Korea, ²Rheumatology, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ³Rheumatology, College of Medicine, The Catholic University of Korea & Stanford University, Seoul & Palo Alto, CA
Background/Purpose: Auto-antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the prognosis and diagnosis of rheumatoid arthritis (RA), and have been implicated in…
Abstract Number: 437 • 2012 ACR/ARHP Annual Meeting
SIRT6 Regulates Cigarette Smoke Induced MMP1 Expression in Rheumatoid Arthritis Synovial Fibroblasts
Anna Engler¹, Renate E. Gay², Beat A. Michel², Steffen Gay² and Caroline Ospelt², ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland
Background/Purpose: Cigarette smoking is the best-known environmental risk factor for the development of rheumatoid arthritis (RA). However, the molecular mechanisms involved in the association of…

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