Abstracts Archive - Page 2565 of 2607 - ACR Meeting Abstracts

Abstract Number: 584 • 2012 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and â1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seung Cheol Shim¹, Donghyuk Sheen², Mi Kyoung Lim¹ and Hyo Park¹, ¹Medicine, Eulji University Hospital, Daejeon, South Korea, ²Rheumatology, Eulji University Hospital, Daejeon, South Korea
Background/Purpose: Genetic factors provide over 90% of the susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The etiology…
Abstract Number: 585 • 2012 ACR/ARHP Annual Meeting
Relative Overexpression of Membrane-Bound Versus Soluble TNF in Human and Experimental Spondyloarthritis
Carmen Ambarus¹, Leonie M. van Duivenvoorde¹, Huriatul Masdar¹, Melissa N. van Tok², Paul P. Tak¹, Nataliya Yeremenko³ and Dominique L. Baeten³, ¹Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Macrophages and their pro-inflammatory cytokines, including TNF, are pivotal mediators of chronic synovitis in rheumatoid arthritis (RA) as well as spondyloarthritis (SpA). Despite similar…
Abstract Number: 586 • 2012 ACR/ARHP Annual Meeting
High Prevalence of Anti-CD-74 Antibodies with Specificity for the Class II-Associated Invariant Chain Peptide in Patients with Axial Spondyloarthritis but Not in Controls
Xenofon Baraliakos¹, Niklas T. Baerlecken², Frank Heldmann³, Torsten Witte⁴ and Jürgen Braun³, ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Clinical Immunology and Rheumatology, Medical University Hannover, Hannover, Germany, ³Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany
Background/Purpose: The pathogenesis of axial spondyloarthritis (axSpA) is still unclear. Based on the strong association with HLA-B27 and ERAP-1, T cells are believed to play…
Abstract Number: 587 • 2012 ACR/ARHP Annual Meeting
Brain MRI and Psychophysics Analysis Demonstrate Neuropathic Pain to Be a Component of Back Pain in Ankylosing Spondylitis
Q. Wu¹, Robert D. Inman² and Karen Davis³, ¹Research, Toronto Western Research Institute, Toronto, ON, Canada, ²Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ³Department of Surgery, Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: The mechanisms underlying pain in ankylosing spondylitis (AS) are unclear. The aim of this study was to investigate whether there is a neuropathic component…
Abstract Number: 588 • 2012 ACR/ARHP Annual Meeting
Discovery of Two Public T Cell Receptor Clonotypes in B27+ Ankylosing Spondylitis by Deep Repertoire Sequence Analysis
Malek Faham¹, Victoria Carlton² and Robert D. Inman³, ¹Research, Sequenta, Inc., South San Francisco, CA, ²Sequenta, Inc., South San Francisco, CA, ³Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: The strong association of AS with HLA-B27 implicates a T cell response restricted by this Class I MHC molecule, predicting that specific T Cell…
Abstract Number: 589 • 2012 ACR/ARHP Annual Meeting
NGF and Trka: A Novel Therapeutic Target in Chronic Inflammation
Siba P. Raychaudhuri¹, Ananya Datta Mitra² and Smriti K. Raychaudhuri², ¹Rheumatology, VA Sacramento Medical Center/UC Davis School of Medicine, Mather, CA, ²Rheumatology, VA Sacramento Medical Center, Mather, CA
Background/Purpose: Outside the nervous system, several studies have established the regulatory role of nerve growth factor (NGF) and its high affinity receptor, TrkA. A clinical…
Abstract Number: 590 • 2012 ACR/ARHP Annual Meeting
The Association Between KIR3DL1 Alleles and Psoriatic Arthritis
Remy Pollock¹, Jeffrey Berinstein², Arane Thavaneswaran², Fawnda Pellett³, Dafna D. Gladman⁴ and Vinod Chandran⁵, ¹Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁵Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Killer-cell immunoglobulin-like receptors (KIRs) are activating and inhibitory receptors that regulate NK and NK-T cells, which have been found in psoriatic plaques and synovial…
Abstract Number: 551 • 2012 ACR/ARHP Annual Meeting
Prevalence of Enthesitis in Psoriatic Patients: Agreement Between Clinical and Power Doppler Ultrasonography Exploration and Its Implications for the Classification of Psoriatic Arthritis
Jose Luis Fernandez-Sueiro¹, JA Pinto¹, S. Pertega-Diaz² and Carlos Fernandez-Lopez³, ¹Rheumatology Division, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, ²Epidemiology and Statistics, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, ³INIBIC- Complejo Hospitalario Universitario La Coruña(CHUAC). Rheumatology Division., La Coruña, Spain
Background/Purpose: Enthesitis constitutes one of the CASPAR stem criteria for the classification of psoriasis arthritis, however as enthesitis may be clinically silent many psoriatic patients…
Abstract Number: 552 • 2012 ACR/ARHP Annual Meeting
Simple Questions in the Dermatology Office May Reasonably Exclude, but Do Not Reliably Identify Psoriatic Arthritis Patients: Results From the Center of Excellence for Psoriasis and Psoriatic Arthritis
Neha Garg¹, Atul A. Deodhar², Benjamin Ehst³, Andrew Blauvelt⁴, Jennifer Ku⁵ and Brian Truong⁴, ¹Internal Medicine, Division of arthritis and rheumatic diseases, Oregon Health and Sciences University, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Dermatology, Oregon Health and Sciences University, Portland, OR, ⁴Oregon Health and Sciences University, Portland, OR, ⁵Arthritis and Rheumatic Diseases, Oregon Health and Science University, Portland, OR
Background/Purpose: Psoriatic arthritis (PsA) affects between 10-30% of patients with psoriasis (PsO), but is often missed when assessed in a dermatology clinic. The Center of…
Abstract Number: 553 • 2012 ACR/ARHP Annual Meeting
Identification of Axial Spondyloarthritis Among Patients with Chronic Back Pain in Primary Care – How Does Determination of HLA B27 Influence the Performance of Clinical Assessments of Inflammatory Back Pain?
Annalina Braun¹, Holger Gnann², Ertan Saracbasi¹, Joachim Grifka³, Uta Kiltz¹, Jürgen Braun⁴, Katrin Letschert⁵ and Jürgen Braun⁴, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Abteilung Biostatistik, GKM Gesellschaft für Therapieforschung mbH, München, Germany, ³Orthopedic Surgery, University of Regensburg, Bad Abbach, Germany, ⁴Institut für angewandte Statistik Dr. Jörg Schnitker GmbH, Bielefeld, Germany, ⁵Abbott Inc., Wiesbaden, Germany
Background/Purpose: The value of a combination of items defining inflammatory back pain (IBP) to screen for axial spondyloarthritis (axSpA) in primary care has recently been…
Abstract Number: 554 • 2012 ACR/ARHP Annual Meeting
A Reduction in Ultrasound Synovitis Score Discriminates Between Clinical Responders and Non-Responders and Is Predictive for a Favourable Clinical Outcome in Early Psoriartic Arthritis
Axel P. Nigg¹, Anna M. Malchus¹, Joerg C. Prinz², Mathias Gruenke³ and Hendrik Schulze-Koops⁴, ¹Division of Rheumatology, Medizinische Klinik IV, University of Munich, Munich, Germany, ²Psoriasis Center, Department of Dermatology, University of Munich, Munich, Germany, ³Division of Rheumatoloy, Medizinische Klinik IV, University of Munich, Munich, Germany, ⁴Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Accurate monitoring of disease activity in early PsA is limited by the potential underestimation of inflammation by clinical examination, the absence of disease-specific biochemical…
Abstract Number: 555 • 2012 ACR/ARHP Annual Meeting
Performances of the ASAS Axial Spondyloarthritis Criteria for Diagnosis and Classification Purposes in Patients Visiting a Rheumatologist Because of Chronic Back Pain: The Declic Study
Anna Moltó¹, Simon Paternotte², Denis Comet³, Cécile Hacquard-Bouder⁴, Martin Rudwaleit⁵, Pascal Claudepierre⁶, Désirée van der Heijde⁷ and Maxime Dougados¹, ¹Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, ²Rheumatology Department, Paris- Descartes University, Cochin hospital, Paris, France, ³Axonal, Nanterre, France, ⁴Abbott France, Rungis, France, ⁵Endokrinologikum Berlin, Berlin, Germany, ⁶Rheumatology, Henri Mondor Teaching Hospital, AP-HP, Créteil, France, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: To evaluate the performances at diagnosis (sensitivity [Se], specificity [Spe], positive and negative predictive values) and study visit (classification purpose) of the ASAS criteria…
Abstract Number: 556 • 2012 ACR/ARHP Annual Meeting
Eos Imaging Could Replace Conventional Computed Radiography for Ankylosis Assessment in Axial Spondyloarthritis
Anna Moltó¹, Veronique Freire², Antoine Feydy³, Simon Paternotte¹, Walter P. Maksymowych⁴, Mathilde Benhamou⁵, François Rannou⁵, Maxime Dougados¹ and Laure Gossec¹, ¹Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, ²Radiology B Department, Paris Descartes University, Cochin Hospital, APHP, Paris, France, Paris, France, ³Radiology B, Paris Descartes University, Côchin Hospital, APHP, Paris, France, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Physical Medicine and Rehabilitation Service, Paris-Descartes University, Cochin Hospital, Paris, France
Background/Purpose: EOS® is a new osteoarticular imaging modality with significantly lower radiation than conventional computed radiography (CR). However, the diagnostic performance of this 2D biplanar…
Abstract Number: 557 • 2012 ACR/ARHP Annual Meeting
Effect of Certolizumab Pegol On the Multiple Facets of Psoriatic Arthritis As Reported by Patients: 24 Week Patient Reported Outcome Results of a Phase 3 Double Blind Randomized Placebo-Controlled Study
Dafna D. Gladman¹, Roy Fleischmann², Geoffroy Coteur³, Franz Woltering⁴ and Philip J. Mease⁵, ¹Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, University Health Network, Toronto, ON, Canada, ²University of Texas Southwestern Medical Center at Dallas, Dallas, TX, ³UCB Pharma, Brussels, Belgium, ⁴UCB Pharma, Monheim, Germany, ⁵Seattle Rheumatology Associates, Seattle, WA
Background/Purpose: RAPID-PsA (NCT01087788) reports efficacy and safety of certolizumab pegol (CZP), a PEGylated Fc-free anti-TNF, in psoriatic arthritis (PsA).1 The effect of different imputation methodologies…
Abstract Number: 558 • 2012 ACR/ARHP Annual Meeting
Rapid Improvements in Patient Reported Outcomes with Certolizumab Pegol in Patients with Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis: 24 Week Results of a Phase 3 Double Blind Randomized Placebo-Controlled Study
Joachim Sieper¹, Alan J. Kivitz², A.M. Van Tubergen³, Atul A. Deodhar⁴, Geoffroy Coteur⁵, Franz Woltering⁶ and Robert B. M. Landewé⁷, ¹Medical Department I, Rheumatology, Charité University Medicine, Berlin, Germany, ²Altoona Center for Clinical Research, Duncansville, PA, ³Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Oregon Health & Science University, Portland, OR, ⁵UCB Pharma, Brussels, Belgium, ⁶UCB Pharma, Monheim, Germany, ⁷Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands
Background/Purpose: Axial spondyloarthritis (axSpA) is a form of spondyloarthritis (SpA) that includes both ankylosing spondylitis (AS) and non-radiographic axial SpA (nr-axSpA), as defined by the…

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